Collaborating to Create Elder Friendly Communities in New Hampshire: A Scan of the Current Landscape

The fact that the population of the United States is aging is no surprise; the demographic projections are well documented. There have never been as many older adults living as there are today, and this number will only increase. Northern New England is aging more rapidly than the rest of the country, with Vermont, Maine, and New Hampshire having the oldest populations in term of median age (U.S. Census, 2014). New Hampshire is expected to be the fastest aging state in New England through 2030, with nearly one-third of its population being over the age of 65 (Norton, 2011). This phenomenon is anticipated to place substantial pressure on publicly-funded health programs and long-term services and supports in the Granite State. But the story of the aging of the population is not only about increased numbers. As longevity increases, the average age of the older population will see a dramatic increase. The number of persons over the age of 85 in the United States is expected to increase five-fold by 2040. As the possibility for functional limitations and disability increases with age, the need for long-term, formal, and informal supports is expected to increase as the number of older adults, particularly those over the age of 85 increases. In addition, women continue to live longer than men; on average, life expectancy for women is three years longer than for men. These factors create a complex picture of aging, which includes a growing population of older adults, a majority of whom will be women; and a growing number of those over the age of 85, who are more likely to require some type of assistance as they age. It is a mistake to look at our aging population in a singular way. Although we tend to make generalizations about older adults, as a group, they are more physiologically and socially diverse than any other age group (Brummel-Smith & Mosqueda, 2003). As we age, we become more and more diverse, as there are no two people who have had the same life experiences, shaping who we are over our lifetimes. The baby boomers (those born between 1946 and 1964) are likely to be the most diverse cohort of older adults we have seen to date, and it is likely that they will redefine our conception of age and aging. Older adults bring a diverse set of skills, talents, and knowledge that should be tapped as a significant natural resource to support a new and exciting vision of aging

Building an Aging Advocacy Network: Findings from the New Hampshire Senior Leadership Series

Public policy related to senior issues has not kept pace with the changes called for by an aging population. Advocacy is an important part of the policy landscape as it promotes a united effort to create change and encourage legislative action. Effective advocacy helps inform and educate policy makers, allows individuals to have their voices heard, builds stronger communities, and allows people to live more fulfilling lives. However, policy makers are inundated with causes to support, and it is easy for certain populations or causes to be lost in this process. This has been especially true for advocacy efforts around the needs of an aging population. At the legislative level, the older adult advocacy network is disjointed, underrepresented, and drowned out by groups that have stronger, moreformidable advocacy networks. The lack of a strong grassroots advocacy network for older adults is of growing concern as our population ages. This is a particularly important issue in New Hampshire as we are one of the oldest states in the nation (US Census, 2014). This paper examines the lack of advocacy for senior issues in the Granite State and explores strategies that can be employed to grow grass-roots leadership among older adults. The New Hampshire Senior Leadership Series, a program that provides support and training in advocacy and leadership skills, is highlighted as a promising practice to address this need. The series educates seniors in leadership skills necessary to advocate for legislative and policy changes that promote healthy aging, livable communities, and options to allow seniors to live and age in the communities of their choice. In order to ensure that New Hampshire residents have access to services and supports as they age, advocacy and leadership is a critical need. To determine the value of the Senior Leadership Series, a survey was developed and distributed to all Senior Leadership Series graduates. The survey aimed to determine how effective the series was at preparing participants to be community leaders and advocates

Accounting\u27s uses in exploitative human engineering: Theorizing citizenship, indirect rule and Britain\u27s imperial expansion

This historical study starts from the argument that financial economic quantification using accounting concepts and analysis has always been an essential and integral part of effective policies and activities for Britain\u27s empire building. Theories of citizenship are used in particular to examine the close association between accounting and imperial policies during British indirect rule in Fiji. Through an examination of archival data and other relevant source materials, the paper highlights the ways in which accounting helped translate imperial forms of oppression and injustice into everyday work practice. Indirect rule generally required the separation and subordination of the native population as subjects, and their exploitation within imperial hegemonic structures. This research is about a British regime of specific and deliberate power construct through which the indigenous population of subjects were oppressed and excluded from citizenship and from civil society. Focus is on the social, economic and institutional relations that determined a unique pattern of inequality and the way in which accounting was effectively mobilized to serve the aims of British imperialism through indirect rule

Sequential association of myogenic regulatory factors and E proteins at muscle-specific genes

<p>Abstract</p> <p>Background</p> <p>Gene expression in skeletal muscle is controlled by a family of basic helix-loop-helix transcription factors known as the myogenic regulatory factors (MRFs). The MRFs work in conjunction with E proteins to regulate gene expression during myogenesis. However, the precise mechanism by which the MRFs activate gene expression is unclear. In this work, we sought to define the binding profiles of MRFs and E proteins on muscle-specific genes throughout a time course of differentiation.</p> <p>Results</p> <p>We performed chromatin immunoprecipitation (ChIP) assays for myogenin, MyoD, Myf5 and E proteins over a time course of C₂C₁₂differentiation, resulting in several surprising findings. The pattern of recruitment is specific to each promoter tested. The recruitment of E proteins often coincides with the arrival of the MRFs, but the binding profile does not entirely overlap with the MRF binding profiles. We found that E12/E47 is bound to certain promoters during proliferation, but every gene tested is preferentially bound by HEB during differentiation. We also show that MyoD, myogenin and Myf5 have transient roles on each of these promoters during muscle differentiation. We also found that RNA polymerase II occupancy correlates with the transcription profile of these promoters. ChIP sequencing assays confirmed that MyoD, myogenin and Myf5 co-occupy promoters.</p> <p>Conclusions</p> <p>Our data reveal the sequential association of MyoD, myogenin, Myf5 and HEB on muscle-specific promoters. These data suggest that each of the MRFs, including Myf5, contribute to gene expression at each of the geness analyzed here.. The dynamic binding profiles observed suggest that MRFs and E proteins are recruited independently to promoters.</p

Transcriptional Control: An Activating Role for Arginine Methylation

AbstractA rare histone modification, arginine methylation, has been linked to activation of hormone-responsive genes. Interestingly, methylation of a lysine residue in the same histone is present prior to hormone activation, but is excluded from the active loci

The contrasting oceanography of the Rhodes Gyre and the Central Black Sea

The Rhodes Gyre, a prominent feature of the oceanography of the eastern Mediterranean, is modelled as a vertical, continuous flow, cylindrical reactor illuminated during the day at its upper end. If the Gyre is supposed to be in a steady state whilst the concentrations, C, of a chemical are being measured, the nett rate of formation or consumption of the chemical is given by -w d C/d z + u d C/d r, where w is the upward velocity of the water in the vertical, z , direction and u is the velocity of the water in the radial, r, direction. The behaviour of w and u is analysed to show that the Gyre may be used as a field laboratory in which rates of chemical change may be derived from depth profiles together with values of the surface velocities of the Gyre waters. In contrast, the central Black Sea is modelled as an ideal, strongly stratified sea in which the nett rates of formation or consumption of chemicals under steady state conditions are given by Ds d2C/ds 2, where s is the water density and Ds is an eddy diffusion coefficient. Computations reveal that, given better knowledge of its eddy diffusion coefficients, the Black Sea can also be treated as a field laboratory where rates of reaction mediated by bacteria may be derived from depth profiles

Distribution, Habitat Use, and Morphotypes of Feral Hogs (\u3ci\u3eSus scrofa\u3c/i\u3e) in Illinois

Feral hogs (Sus scrofa) recently have been introduced to Illinois. They are important to resource managers because of their potentially negative ecological and economic impacts. We assessed the distribution, habitat use, and body morphology of feral hogs in Illinois. We confirmed the occurrence of feral hogs in Fulton, Hardin, Johnson, Lawrence, Massac, Pope, Randolph, and Union counties. Forest and croplands probably are the most important habitats for feral hogs in Illinois. We found free-ranging hogs in Illinois included four previously described morphotypes with distinguishable physical/cranial characteristics: domestic hogs, feral hogs, hybrids, and Eurasian wild hogs. However, 32.6% of individuals were outside of these previously described morphotypes. External morphology and pelage usually were consistent with cranial analysis in determining morphotypes. Whole and dressed body weight regression indicated that dressed weight was about 85% of whole weight. We suggest that the goal of resource managers in Illinois should be to contain or eradicate existing feral hog populations. This should be addressed while populations are small and relatively isolated. If current practices continue, feral hogs have the potential to eventually increase in density and distribution throughout much of Illinois

Modelling of transport processes in concrete exposed to elevated temperatures – An alternative formulation for sorption isotherms

There is a significant need to understand, analyse and assess moisture transport in cementitious materials exposed to elevated temperatures in order to confidently predict the behaviour and ultimately the development of damage in safety critical applications such as nuclear reactor vessels, structures exposed to fire and well bore grouts. In view of this need a rigorous and robust formulation to describe water retention curves (sorption isotherms) as a function of temperature based on the evolution of physical parameters is presented. The model formulation is successfully validated against independent sets of experimental data up to temperatures of 80 °C. It is then further validated under isothermal drying conditions and then high temperature conditions through the numerical reproduction of laboratory experiments following implementation in a fully coupled hygro-thermo-mechanical finite element model. The new formulation is found to work well under a variety of conditions in a variety of cementitious material types

TBX2 represses PTEN in rhabdomyosarcoma and skeletal muscle.

Rhabdomyosarcoma (RMS) is the most frequent soft tissue sarcoma in children that shares many features of developing skeletal muscle. TBX2, a T-box family member, is highly upregulated in tumor cells of both major RMS subtypes where it functions as an oncogene. TBX2 is a repressor that is often overexpressed in cancer cells and functions in bypassing cell growth control, including the repression of the cell cycle regulators p14 and p21. We have found that TBX2 directly represses the tumor-suppressor phosphatase and tensin homolog (PTEN) in both RMS and normal muscle. Exogenous expression of TBX2 in normal muscle cells downregulates PTEN, and depletion or interference with TBX2 in RMS cells upregulates PTEN. Human RMS tumors show high levels of TBX2 and correspondingly low levels of PTEN. The expression of PTEN in clinical RMS samples is relatively uncharacterized, and we establish that suppression of PTEN is a frequent event in both subtypes of RMS. TBX2 represses PTEN by directly binding to the promoter and recruiting the histone deacetylase, HDAC1. RMS cells have high levels of activated AKT owing to the deregulation of phosphoinositide-3 kinase (PI3K) signaling, and depletion or interference with TBX2, which upregulates PTEN, results in a reduction of phospho-AKT. We have also found that the highly related T-box family member TBX3 does not repress PTEN in the muscle lineage. This work suggests that TBX2 is a central component of the PTEN/PI3K/AKT signaling pathway deregulation in RMS cells and that targeting TBX2 in RMS tumors may offer a novel therapeutic approach for RMS.Oncogene advance online publication, 21 December 2015; doi:10.1038/onc.2015.486