Roundabout Oxford Podcast Episode 12: Podcasts and Podcasting

This time Roundabout Oxford goes meta as we talk podcasts and podcasting in our podcast! Interviews feature Blake Thompson, host of Beyond the Square and Oxford Charger podcasts; Adam Clemons and Abigail Norris-Davidson, interviewees for BBC\u27s Breaking Mississippi podcast; and Alex Langhart, head of University Health Services, What\u27s Plaguing U

Sedation and Acute Encephalopathy in a Pediatric Patient Following Ingestion of Delta-8-Tetrahydrocannabinol Gummies

BACKGROUND Delta-8 tetrahydrocannabinol (delta-8 THC) is an isomer of delta-9-tetrahydrocannabinol (delta-9 THC), the primary psychoactive cannabinoid in the marijuana plant. Typically found at lower concentrations in marijuana, delta-8 THC exhibits psychoactive properties similar to delta-9 THC. Products containing delta-8 THC are readily available across the US and currently there is a lack of available confirmatory testing specific to delta-8 THC as there is cross-reactivity to other naturally occurring cannabinoids in standard immunoassays. Pediatric exposures to this substance are on the rise. CASE REPORT We present a case with laboratory confirmation of a previously healthy 2-year-old girl ingesting approximately 15 mg/kg of delta-8 THC gummies. The patient arrived minimally responsive and requiring intubation for encephalopathy. Laboratory confirmation of delta-8 THC exposure is not routinely available with common testing modalities. A urine drug screen preformed in the hospital was positive for delta-9 THC. With the collaboration of the Drug Enforcement Administration\u27s Toxicology Testing Program, detection and confirmation of delta-8 THC was performed in the serum and urine using liquid chromatography-quadrupole time-of-flight mass spectrometry. CONCLUSIONS The prevalence of delta-8 THC-containing products in the illicit drug market is increasing rapidly. Delta-8 THC products are now available in gas stations and in headshops. The clinical presentation of delta-8 THC exposure is similar to known effects of delta-9 THC exposure. These similarities limit the clinicians\u27 abilities to determine the specific substance ingested. Symptomatic and supportive care remains an effective treatment for cannabinoid toxicity

Inhibition of Interleukin-1-Induced Effects in Synoviocytes Transduced with the Human IL-1 Receptor Antagonist cDNA Using an Adenoviral Vector

Overview summary Adenovirus-mediated gene transfer into the cells of the synovial membrane may provide a means to deliver therapeutically active proteins for the local modification of the immune response in inflammatory arthropathies. In this study, we infected type B human synoviocytes in vitro and rabbit synovial lining membrane in vivo with a recombinant human adenovirus containing the cDNA for the human interleukin-1 receptor antagonist protein (IL-1ra). Expression of human IL-1ra was observed both in the transduced synoviocytes in vitro and in the microenvironment of the transduced rabbit synovial membrane in vivo, and the functional activity of the transgenic IL-1ra was suggested by in vitro inhibition of interleukin-1 (IL-1)-induced prostaglandin E2 (PGE2) production and by in vivo inhibition of IL-1-induced glycosaminoglycan (GAG) degradation.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/63124/1/hum.1995.6.3-307.pd

Pulmonary Inflammation Induced by Incomplete or Inactivated Adenoviral Particles

Overview summary The amount of pulmonary inflammation induced in mice by intratracheal administration of high doses of adenoviral vectors was compared to that induced by viral particles that lack the ability to express the genes that they contain. The number of inflammatory cells infiltrating the lung 6 days after particle administration was similar between animals receiving normal versus defective adenoviral particles.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/63169/1/hum.1995.6.12-1553.pd

The College News, 1945-02-14, Vol. 31, No. 15

Bryn Mawr College student newspaper. Merged with The Haverford News in 1968 to form the Bi-college News (with various titles from 1968 on). Published weekly (except holidays) during the academic year

Physical modelling to demonstrate the feasibility of screw piles for offshore jacket supported wind energy structures

Screw piles potentially offer quieter installation and enhanced axial tensile capacity over straight shafted driven piles. As such, they have been suggested as a possible foundation solution for offshore jacket supported wind turbines in deeper water. To investigate the feasibility of their use in this setting, centrifuge testing of six model screw piles of different designs was conducted to measure the installation requirements and ultimate axial capacity of the piles in very-dense and medium-dense sand. The screw piles were designed to sustain loads generated by an extreme design scenario using published axial capacity and torque prediction formulae. Single and double-helix designs, including an optimised design, intended to minimise installation requirements, with reduced geometry were installed and tested in-flight. Piles in the medium-dense sand for example had significant installation requirements of up to 18.4MNm (torque) and 28.8MN (vertical force) which were accurately predicted using correlations with cone resistance data (CPT). Existing axial capacity design methods did not perform well for these large-scale screw piles, overestimating compressive and tensile capacities. Revised analytical methods for installation and axial capacity estimates are proposed here based on the centrifuge test results

PDMS Sponges with Embedded Carbon Nanotubes as Piezoresistive Sensors for Human Motion Detection

Porous piezoresistive sensors offer promising flexible sensing functionality, such as human joint motion detection and gesture identification. Herein, a facile fabrication method is developed using a microwave-based rapid porogen removal technique for the manufacturing of porous nanocomposite sponges consisting of polydimethylsiloxane (PDMS) and well-dispersed carbon nanotubes (CNTs). The porogen amounts and CNT loadings are varied to tailor the porosity and electrical properties of the porous sensors. The sponges are characterized by a scanning electron microscope (SEM) to compare their microstructures, validate the high-quality CNT dispersion, and confirm the successful nanofiller embedding within the elastomeric matrix. Sponges with a 3 wt% CNT loading demonstrate the highest piezoresistive sensitivity. Experimental characterization shows that the sponges with low porosity have long durability and minimal strain rate dependence. Additionally, the developed sponges with 3 wt% CNTs are employed for the human motion detection using piezoresistive method. One experiment includes fingertip compression measurements on a prosthetic hand. Moreover, the sensors are attached to the chest, elbow, and knee of a user to detect breathing, running, walking, joint bending, and throwing motions.This research was funded by the support of the Vice President for Research and Partnerships of the University of Oklahoma. Open Access fees paid for in whole or in part by the University of Oklahoma Libraries.Ye