Five-brane Instantons vs Flux-induced Gauging of Isometries

In five-dimensional heterotic M-theory there is necessarily nonzero background flux, which leads to gauging of an isometry of the universal hypermultiplet moduli space. This isometry, however, is poised to be broken by M5-brane instanton effects. We show that, similarly to string theory, the background flux allows only brane instantons that preserve the above isometry. The zero-mode counting for the M5 instantons is related to the number of solutions of the Dirac equation on their worldvolume. We investigate that equation in the presence of generic background flux and also, in a particular case, with nonzero worldvolume flux.Comment: 27 pages; reference adde

Scrapie prevalence in sheep of susceptible genotype is declining in a population subject to breeding for resistance

<p>Abstract</p> <p>Background</p> <p>Susceptibility of sheep to scrapie infection is known to be modulated by the PrP genotype of the animal. In the Netherlands an ambitious scrapie control programme was started in 1998, based on genetic selection of animals for breeding. From 2002 onwards EU regulations required intensive active scrapie surveillance as well as certain control measures in affected flocks.</p> <p>Here we analyze the data on genotype frequencies and scrapie prevalence in the Dutch sheep population obtained from both surveillance and affected flocks, to identify temporal trends. We also estimate the genotype-specific relative risks to become a detected scrapie case.</p> <p>Results</p> <p>We find that the breeding programme has produced a steady increase in the level of genetic scrapie resistance in the Dutch sheep population. We also find that a significant decline in the prevalence of scrapie in tested animals has occurred a number of years after the start of the breeding programme. Most importantly, the estimated scrapie prevalence level per head of susceptible genotype is also declining significantly, indicating that selective breeding causes a population effect.</p> <p>Conclusions</p> <p>The Dutch scrapie control programme has produced a steady rise in genetic resistance levels in recent years. A recent decline in the scrapie prevalence per tested sheep of susceptible prion protein genotype indicates that selective breeding causes the desired population effect.</p

Eradication of scrapie with selective breeding: are we nearly there?

<p>Abstract</p> <p>Background</p> <p>Following EU decision 2003/100/EC Member States have recently implemented sheep breeding programmes to reduce the prevalence of sheep with TSE susceptible prion genotypes. The present paper investigates the progress of the breeding programme in the Netherlands. The PrP genotype frequencies were monitored through time using two sets of random samples: one set covers the years 2005 to 2008 and is taken from national surveillance programme; the other is taken from 168 random sheep farms in 2007. The data reveal that although the level of compliance to the breeding programme has been high, the frequency of susceptible genotypes varies substantially between farms. The 168 sheep farms are a subset of 689 farms participating in a postal survey inquiring about management and breeding strategies. This survey aimed to identify how much these strategies varied between farms, in order to inform assessment of the expected future progress towards eradication of classical scrapie.</p> <p>Results</p> <p>On the one hand, we found that compliance to the national breeding program has been high, and the frequency of resistant genotypes is expected to increase further in the next few years. On the other hand, we observed a large variation in prevalence of the scrapie resistant PrP genotype ARR between farms, implicating a large variation of genetic resistance between farms. Substantial between-flock differences in management and breeding strategies were found in the postal survey, suggesting considerable variation in risk of scrapie transmission between farms.</p> <p>Conclusions</p> <p>Our results show that although there has been a good progress in the breeding for scrapie resistance and the average farm-level scrapie susceptibility in the Netherlands has been significantly reduced, still a considerable proportion of farms contain high frequencies of susceptible genotypes in their sheep population. Since 2007 the breeding for genetic resistance is voluntarily again, and participation to selective breeding can decrease as a result of this. This, together with the patterns of direct and indirect contact between sheep farms, might present a challenge of the aim of scrapie eradication. Communication to sheep owners of the effect of the breeding programme thus far, and of the prospects for classical scrapie eradication in The Netherlands might be essential for obtaining useful levels of participation to the voluntary continuation of the breeding programme.</p

Supergravity description of spacetime instantons

We present and discuss BPS instanton solutions that appear in type II string theory compactifications on Calabi-Yau threefolds. From an effective action point of view these arise as finite action solutions of the Euclidean equations of motion in four-dimensional N=2 supergravity coupled to tensor multiplets. As a solution generating technique we make use of the c-map, which produces instanton solutions from either Euclidean black holes or from Taub-NUT like geometries.Comment: 35 pages, some clarifications adde

D=4, N=2 Gauged Supergravity in the Presence of Tensor Multiplets

Using superspace techniques we construct the general theory describing D=4, N=2 supergravity coupled to an arbitrary number of vector and scalar--tensor multiplets. The scalar manifold of the theory is the direct product of a special Kaehler and a reduction of a Quaternionic-Kaehler manifold. We perform the electric gauging of a subgroup of the isometries of such manifold as well as ``magnetic'' deformations of the theory discussing the consistency conditions arising in this process. The resulting scalar potential is the sum of a symplectic invariant part (which in some instances can be recast into the standard form of the gauged N =2 theory) and of a non--invariant part, both giving new deformations. We also show the relation of such theories to flux ompactifications of type II string theories.Comment: LaTeX, 26 pages. v2 Improved discussion in sect. 4 and references adde

A preliminary analysis of in-depth accident data for powered two-wheelers and bicycles in Europe

Despite progress from scientific and technological advancements, road safety remains a major issue worldwide. Road accident impacts such as fatalities, injuries and property damage consist considerable costs borne not only by involved people but society as well. This study aims to present preliminary findings of in-depth accident analysis for two-wheelers (bicycles and powered two wheelers – PTWs) across six countries in Europe. Data regarding the conditions underlying accident occurrence are presented, including time and date, weather, vehicle and road conditions and rider-related parameters such as age, intoxication and use of protective equipment. In addition, a Two Step Cluster Analysis is implemented in order to explore any possible classification of the analysed cases. It appears that two clusters are formed: the first includes more favourable conditions (“no wind, no drugs, good lighting”) while the second consists of less favourable conditions for road safety (“windy, lighting, unknown DUI condition”). This hints at a meaningful separation of the examination of two-wheeler accidents when the influence of outside factors is considerable. The inclusion of different but representative areas across Europe offers robustness and transferability to the data and respective results

De Sitter vacua from N=2 gauged supergravity

Typical de Sitter (dS) vacua of gauged supergravity correspond to saddle points of the potential and often the unstable mode runs into a singularity. We explore the possibility to obtain dS points where the unstable mode goes on both sides into a supersymmetric smooth vacuum. Within N=2 gauged supergravity coupled to the universal hypermultiplet, we have found a potential which has two supersymmetric minima (one of them can be flat) and these are connected by a de Sitter saddle point. In order to obtain this potential by an Abelian gauging, it was important to include the recently proposed quantum corrections to the universal hypermultiplet sector. Our results apply to four as well as five dimensional gauged supergravity theories.Comment: 25 pages, 1 figure, add refs and corrected typo