Evaluating characteristics of an active coastal spreading area combining geophysical data with satellite, aerial, and unmanned aerial vehicles images

The northern region of the Maltese archipelago is experiencing lateral spreading landslide processes. This region is characterized by cliffs with a hard coralline limestone outcropping layer sitting on a thick layer of clay. Such a geological configuration causes coastal instability that results in lateral spreading which predispose to rockfalls and topplings all over the cliff slopes. The aim of this research was to develop a methodology for evaluating cliff erosion/retreat using the integration of geomatics and geophysical techniques. Starting from a 3D digital model of the Selmun promontory, generated by unmanned aerial vehicle (UAV) photogrammetry, it was possible to map the fractures and conduct geophysical measurements such as electrical resistivity tomography and ground penetrating radar for the identification and mapping of vertical fractures affecting the hard coralline limestone plateau, and to create a 3D geological model of the study area. In addition to this, high-accuracy orthophotos from UAV that were captured between 1957 and 2021 were georeferenced into a GIS and compared to aerial and satellite images. The movement and evolution of boulders and cracks in rocks were then vectorized to highlight, track and quantify the phenomenon through time. The results were used to derive a qualitative assessment of the coastal variations in the geometric properties of the exposed discontinuity surfaces to evaluate the volumes and the stop points of the observed rockfalls. The outcomes of this research were finally imported in a GIS which offers an easy approach for the collection and processing of coastal monitoring data. In principle, such a system could help local authorities to address social, economic and environmental issues of pressing importance as well as facilitate effective planning in view of a risk mitigation strategy

Evaluating characteristics of an active coastal spreading area combining geophysical data with satellite, aerial, and unmanned aerial vehicles images

The northern region of the Maltese archipelago is experiencing lateral spreading landslide processes. This region is characterized by cliffs with a hard coralline limestone outcropping layer sitting on a thick layer of clay. Such a geological configuration causes coastal instability that results in lateral spreading which predispose to rockfalls and topplings all over the cliff slopes. The aim of this research was to develop a methodology for evaluating cliff erosion/retreat using the integration of geomatics and geophysical techniques. Starting from a 3D digital model of the Selmun promontory, generated by unmanned aerial vehicle (UAV) photogrammetry, it was possible to map the fractures and conduct geophysical measurements such as electrical resistivity tomography and ground penetrating radar for the identification and mapping of vertical fractures affecting the hard coralline limestone plateau, and to create a 3D geological model of the study area. In addition to this, high-accuracy orthophotos from UAV that were captured between 1957 and 2021 were georeferenced into a GIS and compared to aerial and satellite images. The movement and evolution of boulders and cracks in rocks were then vectorized to highlight, track and quantify the phenomenon through time. The results were used to derive a qualitative assessment of the coastal variations in the geometric properties of the exposed discontinuity surfaces to evaluate the volumes and the stop points of the observed rockfalls. The outcomes of this research were finally imported in a GIS which offers an easy approach for the collection and processing of coastal monitoring data. In principle, such a system could help local authorities to address social, economic and environmental issues of pressing importance as well as facilitate effective planning in view of a risk mitigation strategy.peer-reviewe

Two-particle correlations in azimuthal angle and pseudorapidity in inelastic p + p interactions at the CERN Super Proton Synchrotron

Results on two-particle ΔηΔϕ correlations in inelastic p + p interactions at 20, 31, 40, 80, and 158 GeV/c are presented. The measurements were performed using the large acceptance NA61/SHINE hadron spectrometer at the CERN Super Proton Synchrotron. The data show structures which can be attributed mainly to effects of resonance decays, momentum conservation, and quantum statistics. The results are compared with the Epos and UrQMD models.ISSN:1434-6044ISSN:1434-605

Tapering glucocorticoids and risk of flare in rheumatoid arthritis on biological disease-modifying antirheumatic drugs (bDMARDs)

Introduction: Glucocorticoids are still a mainstream of rheumatoid arthritis (RA) treatment. Reducing glucocorticoids should be attempted in all patients. However, choosing the right tapering strategy is challenging. The primary aim of our study is to determine the dose-response association between glucocorticoid tapering and risk of flare in RA. Methods: We conducted a case-crossover study to determine the factors associated to higher risk of flare in patients with RA. In case-crossover studies time-varying factors are assessed before events (hazard periods) and before control periods. We defined hazard periods as the 6 months immediately preceding flares of RA. Control periods were the 6 months prior to visits without flare. Exposure of interest was the tapering of glucocorticoids to various doses. Results: 508 patients with RA were included in the study and 267 (52.5%) had at least a flare and served as the case-crossover study population. 1545 visits were available for analysis and 345 (22.3%) flares were recorded. Discontinuation of glucocorticoids (ie, tapering to doses of 0 mg/day) and tapering to 0-2.5 mg/day was associated with higher risk of flare (adjusted OR (aOR) of 1.45, 95% CI: 1.13 to 2.24 and aOR of 1.37; 95% CI: 1.06 to 2.01, respectively). Tapering to doses >2.5 mg/day was not associated with significantly higher risk of flare. Conclusions: We found that tapering to doses of >2.5 mg/day was generally effective in terms of risk of flare. Flare risk was higher when glucocorticoids were tapered to doses ≤2.5 mg/day. Our study might help design new tapering strategies in patients with RA on biological disease-modifying antirheumatic drugs

Bone loss occurs in Inflammatory Rheumatic Musculoskeletal Diseases (iRMD) patients treated with low dose glucocorticoids, but is prevented by anti-osteoporosis medications

Background: The negative effects of glucocorticoids (GCs) on the bone depend on dose and treatment duration. However, it is unclear whether a safe dose exists, especially for patients with inflammatory rheumatic musculoskeletal diseases (iRMDs). Methods: We conducted a longitudinal cohort study on women with iRMD. Bone mineral density and fractures were assessed prospectively and compared to a matched cohort. Kaplan-Meier curves with log-rank test were made for iRMD (stratified for glucocorticoid use and dosage) and matched cohort respectively. Multivariable Cox regression survival models were also employed to analyze the effect of GCs on fracture. Results: 884 women with iRMD and 1,766 controls (age, T-score, and 10-year fracture risk matched) were included in the study and followed for up to 6 years. BMD levels decreased significantly in all GCs users not receiving anti-osteoporosis treatment (-4.26% p 0.0011, -4.23% p 0.0422, -2.66% p 0.0006 for ≥5 mg/day, 2.5 mg to 5 mg and 0 to 2.5 mg/day of prednisolone, respectively). Anti-osteoporotic treatment (largely bisphosphonates) prevented bone loss only in patients receiving less than 5 mg/day of prednisone. Fracture incidence was greater in patients with iRMD compared to controls but only GC doses above 5 mg/day were associated with significantly higher risk of fracture. Conclusion: GC doses as low as 2.5 mg/day were associated with BMD loss in iRMD but this effect was preventable. BMD loss in patients taking ≥5 mg/day was not totally prevented by anti-osteoporotic medications currently used in clinical practice, resulting in higher risk of fracture. This article is protected by copyright. All rights reserved

Incidence of Disease Flare After BNT162b2 Coronavirus Disease 2019 Vaccination in Patients With Rheumatoid Arthritis in Remission

Incidence of Disease Flare After BNT162b2 Coronavirus Disease 2019 Vaccination in Patients With Rheumatoid Arthritis in Remission

Factors associated with radiographic progression in rheumatoid arthritis starting biological diseases modifying anti-rheumatic drugs (bDMARDs)

Background: Biological DMARDs (bDMARDs) have been proven to prevent joint damage and bone erosions. Nevertheless, approximately 15% of rheumatoid arthritis (RA) patients on bDMARDs will progress despite good control of joint inflammation. Objectives: The objective of our study is to investigate the factors associated with radiological progression of patients treated with bDMARDs. Design: We conducted a retrospective analysis of longitudinally collected data on RA patients starting bDMARDs. Methods: Presence or development of new erosions was assessed by a skilled rheumatologist at the time of the visit (baseline and 12 months thereafter). To determine the predictors of erosions, we employed multivariable logistic regression models. Discriminatory capacity for the prediction of new erosion development was assessed with receiver operating characteristic (ROC) curve, which was based on the logistic regression model. Results: A total of 578 RA patients starting bDMARDs were included in the study. Overall, 46 patients (approximately 10%) had radiographic progression (at least one new erosion) at 12 months of follow-up. The factors independently associated with higher risk of developing new erosions while on bDMARD were younger age, high disease activity at baseline, not being treated with cDMARDs, and presenting with erosions at baseline. In addition, we built a predictive model that can accurately foresee new erosions (AUC 0.846) in patients receiving bDMARDs. Conclusion: We found that baseline erosive disease, higher disease activity during treatment, younger age, and monotherapy were the factors independently associated with the development of bone erosions. Our study may inform future targeted intervention in RA patients at risk of radiographic progression

Rheumatoid arthritis and myasthenia gravis: a case-based review of the therapeutic options

Introduction: Myasthenia gravis is an autoimmune disease affecting the neuromuscular junction, often associated with other autoimmune diseases, including rheumatoid arthritis. Patients with rheumatoid arthritis present an increased prevalence of myasthenia gravis compared to the general population. While these two diseases share some therapeutic options, such as glucocorticoids, methotrexate, and rituximab, there are no guidelines for treating concomitant disease. We aim to review the available evidence and to discuss the efficacy and safety of the therapeutic options in patients with rheumatoid arthritis associated with myasthenia gravis. Method: We described three patients with rheumatoid arthritis associated with myasthenia gravis and we performed a systematic review of the associated literature. Results: A 48-year-old man and two women (48 and 55 years old) with concomitant diagnoses of active rheumatoid arthritis and well-controlled myasthenia gravis are described. They were treated with methotrexate, leflunomide, upadacitinib, and adalimumab. None of them experienced changes in their myasthenic symptoms. We found 9 additional cases from our literature review. Methotrexate, rituximab, upadacitinib, diphenyl sulfone, auranofin, and loxoprofen sodium did not show an impact on the seven patients with previously well-controlled myasthenia. Glucocorticoids, methotrexate, and rituximab proved effective in active myasthenia gravis and arthritis. Conflicting data emerged for Tumor-necrosis factor inhibitors. Conclusions: Although the available evidence remains scarce, we consider glucocorticoids, methotrexate, and rituximab as safe and effective options. The role of tumor-necrosis factor inhibitors remains uncertain. Eventually, Janus Kinase inhibitors are a novel interesting option for these patients. Key Points • To date, the only evidence on the treatment of patients with rheumatoid arthritis and concomitant myasthenia gravis derives from case reports. • Based on the review of the available case reports and on the cases we described, we consider glucocorticoids, methotrexate, and rituximab as safe and effective options, while the role of Tumor-necrosis factor inhibitors remains uncertain. • Based on the cases we described, Janus Kinase inhibitors are a novel interesting option for patients with concomitant rheumatoid arthritis and myasthenia gravis

Effects on Serum Inflammatory Cytokines of Cholecalciferol Supplementation in Healthy Subjects with Vitamin D Deficiency

The effects of different cholecalciferol supplementation regimens on serum inflammatory cytokines in healthy subjects with vitamin D deficiency are still lacking. This is a single-center, open-label, randomized, parallel group study involving healthy subjects deficient in vitamin D (baseline 25OHD < 20 ng/mL) receiving oral cholecalciferol with three different dosing regimens: Group A: 10,000 IU/day for 8 weeks followed by 1000 IU/day for 4 weeks; Group B: 50,000 IU/week for 12 weeks and Group C: 100,000 IU every other week for 12 weeks. IL-17A, IL-6, IL-8, IL-10, IL-23 and TNFα were measured at baseline and at week 4, 8, 12, and 16. 75 healthy subjects were enrolled (58.7% female), with an average age of 34.1 ± 10.2 years. No statistical differences were observed among groups at baseline for either IL-6, IL-17A, IL-23, IL-8 or IL-10 at any time point; TNFα was indetectable. Concerning the whole sample, the time trend analysis showed a statistically significant linear trend for decreasing values over the treatment period for IL-6 (p = 0.016) and IL-17A (p = 0.006), while no significant time trends were observed for the other teste cytokines. No significant differences were found in the serum concentrations of the tested cytokines between week 12 and week 16. In young healthy individuals deficient in vitamin D, cholecalciferol administration showed a decrease in the serum IL-6 and IL-17A concentrations, without marked differences using the three regimens

Engineering Geological and Geophysical Investigations to Characterise the Unstable Rock Slope of the Sopu Promontory (Gozo, Malta)

Different engineering geological and geophysical investigations were performed at the Sopu promontory in the island of Gozo (Malta), involved in an impressive lateral spreading process due to the superimposition of a stiff limestone (ULC) on a ductile clay (BC). The applied techniques include: traditional geological and engineering geological surveys, unmanned aerial vehicles (UAV) survey, electrical resistivity tomography (ERT) survey, ground-penetrating radar (GPR) investigations, single-station seismic ambient noise measurements, and array seismic ambient noise measurements. The integration of the obtained results allowed us to reconstruct a subsoil model of the promontory that includes features related to the local geology of the slope and to the landslide process, as well as to define a conceptual model that describes the main evolution phases of the expansion process. The presence of back-tilted rock blocks with no features of polarization of Rayleigh waves evidenced the different failure mechanism of the rigid UCL plateau at the Sopu promontory with respect to the Selmun promontory, located in the close island of Malta, where the lateral spreading due to the same geological setting tends to produce unstable rock blocks with a toppling mechanism. This result encourages further future observations and analyses of this topic