14,970 research outputs found
Power to the Workers? A qualitative study of workers' experiences of a 4-day working week
The pandemic has resulted in seismic shifts to all aspects of our lives, including views concerning the organisation of work. One impact is the acceleration of workers questioning traditional life stages, of work then retirement, and what they want out of life (Cable & Gratton, 2022) As quality of life is acknowledged as a driving force for many employees leaving their current jobs (Fuller & Kerr, 2022), the implications of a four-day working week are currently being investigated (Miller, 2022). Drawing on a small-scale study at an automotive supplier, based in the North-East of England, this case study will present findings from qualitative interviews conducted with employees who are experiencing a newly established 4-day working week. From the findings presented, discussions will highlight implications of this shift in the organisation of the working week for employees across the organisation. It is intended that the findings and discussions will raise relevant, contemporary questions for the business community more generally
The Trypanosoma cruzi enzyme TcGPXI is a glycosomal peroxidase and can be linked to trypanothione reduction by glutathione or tryparedoxin.
Trypanosoma cruzi glutathione-dependent peroxidase I (TcGPXI) can reduce fatty acid, phospholipid, and short chain organic hydroperoxides utilizing a novel redox cycle in which enzyme activity is linked to the reduction of trypanothione, a parasite-specific thiol, by glutathione. Here we show that TcGPXI activity can also be linked to trypanothione reduction by an alternative pathway involving the thioredoxin-like protein tryparedoxin. The presence of this new pathway was first detected using dialyzed soluble fractions of parasite extract. Tryparedoxin was identified as the intermediate molecule following purification, sequence analysis, antibody studies, and reconstitution of the redox cycle in vitro. The system can be readily saturated by trypanothione, the rate-limiting step being the interaction of trypanothione with the tryparedoxin. Both tryparedoxin and TcGPXI operate by a ping-pong mechanism. Overexpression of TcGPXI in transfected parasites confers increased resistance to exogenous hydroperoxides. TcGPXI contains a carboxyl-terminal tripeptide (ARI) that could act as a targeting signal for the glycosome, a kinetoplastid-specific organelle. Using immunofluorescence, tagged fluorescent proteins, and biochemical fractionation, we have demonstrated that TcGPXI is localized to both the glycosome and the cytosol. The ability of TcGPXI to use alternative electron donors may reflect their availability at the corresponding subcellular sites
The Bloch-Okounkov correlation functions, a classical half-integral case
Bloch and Okounkov's correlation function on the infinite wedge space has
connections to Gromov-Witten theory, Hilbert schemes, symmetric groups, and
certain character functions of \hgl_\infty-modules of level one. Recent works
have calculated these character functions for higher levels for \hgl_\infty
and its Lie subalgebras of classical type. Here we obtain these functions for
the subalgebra of type of half-integral levels and as a byproduct, obtain
-dimension formulas for integral modules of type at half-integral level.Comment: v2: minor changes to the introduction; accepted for publication in
Letters in Mathematical Physic
Tentative Evidence for Relativistic Electrons Generated by the Jet of the Young Sun-like Star DG Tau
Synchrotron emission has recently been detected in the jet of a massive
protostar, providing further evidence that certain jet formation
characteristics for young stars are similar to those found for highly
relativistic jets from AGN. We present data at 325 and 610 MHz taken with the
GMRT of the young, low-mass star DG Tau, an analog of the Sun soon after its
birth. This is the first investigation of a low-mass YSO at at such low
frequencies. We detect emission with a synchrotron spectral index in the
proximity of the DG Tau jet and interpret this emission as a prominent bow
shock associated with this outflow. This result provides tentative evidence for
the acceleration of particles to relativistic energies due to the shock impact
of this otherwise very low-power jet against the ambient medium. We calculate
the equipartition magnetic field strength (0.11 mG) and particle energy
(4x10^40 erg), which are the minimum requirements to account for the
synchrotron emission of the DG Tau bow shock. These results suggest the
possibility of low energy cosmic rays being generated by young Sun-like stars.Comment: 19 pages, 2 figures, accepted for publication in ApJ Letter
Analyzing IPv7 and RPCs
Courseware and interrupts, while practical in theory, have not until recently been considered unproven. Given the trends in semantic communication, researchers obviously note the improvement of RPCs, demonstrates the key importance of complexity theory. In order to address this problem, we use self-learning modalities to confirm that model checking [21] can be made symbiotic, meta- morphic, and constant-time [5]
Spin polarization of carriers in InGaAs self-assembled quantum rings inserted in GaAs-AlGaAs resonant tunneling devices
In this work, we have investigated transport and polarization resolved photoluminescence (PL) of n-type GaAs-AlGaAs resonant tunneling diodes (RTDs) containing a layer of InGaAs self-assembled quantum rings (QRs) in the quantum well (QW). All measurements were performed under applied voltage, magnetic fields up to 15 T and using linearly polarized laser excitation. It was observed that the QRs’ PL intensity and the circular polarization degree (CPD) oscillate periodically with applied voltage under high magnetic fields at 2 K. Our results demonstrate an effective voltage control of the optical and spin properties of InGaAs QRs inserted into RTDs
White matter integrity as a predictor of response to treatment in first episode psychosis
The integrity of brain white matter connections is central to a patient's ability to respond to pharmacological interventions. This study tested this hypothesis using a specific measure of white matter integrity, and examining its relationship to treatment response using a prospective design in patients within their first episode of psychosis. Diffusion tensor imaging data were acquired in 63 patients with first episode psychosis and 52 healthy control subjects (baseline). Response was assessed after 12 weeks and patients were classified as responders or non-responders according to treatment outcome. At this second time-point, they also underwent a second diffusion tensor imaging scan. Tract-based spatial statistics were used to assess fractional anisotropy as a marker of white matter integrity. At baseline, non-responders showed lower fractional anisotropy than both responders and healthy control subjects (P < 0.05; family-wise error-corrected), mainly in the uncinate, cingulum and corpus callosum, whereas responders were indistinguishable from healthy control subjects. After 12 weeks, there was an increase in fractional anisotropy in both responders and non-responders, positively correlated with antipsychotic exposure. This represents one of the largest, controlled investigations of white matter integrity and response to antipsychotic treatment early in psychosis. These data, together with earlier findings on cortical grey matter, suggest that grey and white matter integrity at the start of treatment is an important moderator of response to antipsychotics. These findings can inform patient stratification to anticipate care needs, and raise the possibility that antipsychotics may restore white matter integrity as part of the therapeutic response
Multiple-Scattering Suppression by Cross Correlation
We describe a new method for characterizing particles in turbid media by cross correlating the scattered intensity fluctuations at two nearby points in the far field. The cross-correlation function selectively emphasizes single scattering over multiple scattering. The usual dynamic light-scattering capability of inferring particle size from decay rate is thus extended to samples that are so turbid as to be visually opaque. The method relies on single-scattering speckle being physically larger than multiple-scattering speckle. With a suitable optical geometry to select nearby points in the far field or equivalently slightly different scattering wave vectors (of the same magnitude), the multiple-scattering contribution to the cross-correlation function may be reduced and in some cases rendered insignificant. Experimental results demonstrating the feasibility of this approach are presented. (C) 1997 Optical Society of America
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