Cost-effectiveness of financial incentives for smoking cessation in pregnancy

No abstract available

Tsunamis: geology, hazards and risks: introduction

A decade or so ago, if you had asked almost anyone in Europe or North America, they might not have recognized the word ‘tsunami’. The enormous and tragic event that swept across the shores of the Indian Ocean on 26 December 2004, followed only a few years later by the devastating tsunami caused by the March 2011 Great Tohoku earthquake off Japan, both with appalling loss of life, changed all that. Today, the words ‘tsunami warning issued’ seem to appear frequently on international ‘breaking news’, showing the extent to which we have become sensitized to the triggers that launch these deadly, but terrifyingly spectacular, natural events. Yet, great tsunamis and the tectonic events that cause them have not suddenly become more frequent. The historical records of old civilizations contain accounts of major inundations reaching back hundreds or thousands of years and sometimes even warnings to future generations – valuable, if they are heeded. What has changed, and has consequently raised the profile of tsunamis, is the exponential growth in world population over the last few 100 years, the great majority of whom live in coastal areas and are consequently exposed to hazard, along with instant global communication, which brings every large earthquake on Earth's plate margins directly and immediately onto our screens

Bypass of a protein roadblock by a replicative DNA helicase

Replicative DNA helicases generally unwind DNA as a single hexamer that encircles and translocates along one strand of the duplex while excluding the complementary strand (“steric exclusion”). In contrast, large T antigen (T-ag), the replicative DNA helicase of the Simian Virus 40 (SV40), is reported to function as a pair of stacked hexamers that pumps double-stranded DNA through its central channel while laterally extruding single-stranded DNA. Here, we use single-molecule and ensemble assays to show that T-ag assembled on the SV40 origin unwinds DNA efficiently as a single hexamer that translocates on single-stranded DNA in the 3′ to 5′ direction. Unexpectedly, T-ag unwinds DNA past a DNA-protein crosslink on the translocation strand, suggesting that the T-ag ring can open to bypass bulky adducts. Together, our data underscore the profound conservation among replicative helicase mechanisms while revealing a new level of plasticity in their interactions with DNA damage

Did a submarine landslide contribute to the 2011 Tohoku tsunami?

Many studies have modeled the Tohoku tsunami of March 11, 2011 as being due entirely to slip on an earthquake fault, but the following discrepancies suggest that further research is warranted. (1) Published models of tsunami propagation and coastal impact underpredict the observed runup heights of up to 40 m measured along the coast of the Sanriku district in the northeast part of Honshu Island. (2) Published models cannot reproduce the timing and high-frequency content of tsunami waves recorded at three nearshore buoys off Sanriku, nor the timing and dispersion properties of the waveforms at offshore DART buoy #21418. (3) The rupture centroids obtained by tsunami inversions are biased about 60 km NNE of that obtained by the Global CMT Project. Based on an analysis of seismic and geodetic data, together with recorded tsunami waveforms, we propose that, while the primary source of the tsunami was the vertical displacement of the seafloor due to the earthquake, an additional tsunami source is also required. We infer the location of the proposed additional source based on an analysis of the travel times of higher-frequency tsunami waves observed at nearshore buoys. We further propose that the most likely additional tsunami source was a submarine mass failure (SMF—i.e., a submarine landslide). A comparison of pre- and post-tsunami bathymetric surveys reveals tens of meters of vertical seafloor movement at the proposed SMF location, and a slope stability analysis confirms that the horizontal acceleration from the earthquake was sufficient to trigger an SMF. Forward modeling of the tsunami generated by a combination of the earthquake and the SMF reproduces the recorded on-, near- and offshore tsunami observations well, particularly the high-frequency component of the tsunami waves off Sanriku, which were not well simulated by previous models. The conclusion that a significant part of the 2011 Tohoku tsunami was generated by an SMF source has important implications for estimates of tsunami hazard in the Tohoku region as well as in other tectonically similar regions

Changing overwork culture: Stakeholder management for employee wellbeing and social sustainability in large Japanese companies

Effectively addressing overwork culture in business remains a challenge, despite growing concerns about its negative impacts on employee wellbeing and productivity. This paper investigates corporate social responsibility (CSR) initiatives and stakeholder management promoted by large Japanese companies to address overwork culture. Based on interviews with managers and stakeholders from 31 companies, the study reveals that despite being part of CSR, overwork reduction initiatives often come into conflict with entrenched institutional pressures. These pressures are embedded in a cultural-cognitive and institutional context that prioritises quality and cooperation over individual productivity. We argue that improving stakeholder relationships is vital for developing a healthy and productive workstyle and for reactivating institutional dynamics that are fundamental to employee wellbeing, productivity and broader social sustainability. By clarifying the role and processes of stakeholder management, this paper contributes to the discourse on overwork and CSR, offering new insights into how to effectively address overwork culture

The generation of tsunamis

Tsunamis are gravity-driven water waves. Most are generated by vertical displacement of the seabed that propagates through the water column to the sea surface. The resulting elevated surface wave collapses through gravity and then propagates outward from the source. Dispersion of the initial wave generates a multiple wave train. Tsunamis are mainly (∼80%) generated by earthquakes, but other mechanisms include subaerial and submarine landslides and volcanic collapse and eruption. Other, less frequent, tsunami mechanisms include bolide (asteroid) impact and weather events (meteotsunamis), but these are generated at the water surface, respectively, from external impact and from wind friction. The magnitude of a tsunamigenic earthquake has the main control on the tsunami, although “tsunami” earthquakes generate tsunamis much larger than expected from their earthquake source magnitude. Tsunamigenic earthquake mechanisms include interplate boundary rupture, splay faulting, and intraplate rupture. Landslide tsunami mechanisms include slumps and translational failures that may be initiated from either the bottom or the top. Landslide volume, water depth, and initial acceleration are the main controls on tsunami magnitude, although other factors such as the failure mechanism and the location of initiation are influential. There are three main aspects of a tsunami; (i) initial wave generation, (ii) propagation, and (iii) onland run-up. Initial wave generation from earthquakes is mainly from seabed vertical displacement, and a rule of thumb suggests that in most instances the maximum initial wave elevation is up to twice this. The maximum initial wave elevation from a landslide tsunami is theoretically determined by the ocean depth and thus could be thousands of meters. Local tsunami run-up elevations vary with source mechanism and vary considerably. Although dependent on local bathymetry and topography, these are likely to be more elevated and focused from submarine landslides than from earthquakes. The different mechanisms generate different tsunami wave frequencies; these determine travel distances, with the low frequency tsunamis from earthquakes traveling much farther than tsunamis from landslides, which are much higher frequency. Final onland run-up is mainly dependent on source mechanism as well as local offshore bathymetry and coastal topography

The importance of geologists and geology in tsunami science and tsunami hazard

Up until the late 1980s geology contributed very little to the study of tsunamis because most were generated by earthquakes which were mainly the domain of seismologists. In 1987–88 however, sediments deposited as tsunamis flooded land were discovered. Subsequently they began to be widely used to identify prehistorical tsunami events, providing a longer-term record than previously available from historical accounts. The sediments offered an opportunity to better define tsunami frequency that could underpin improved risk assessment. When over 2200 people died from a catastrophic tsunami in Papua New Guinea (PNG) in 1998, and a submarine landslide was controversially proven to be the mechanism, marine geologists provided the leadership that led to the identification of this previously unrecognized danger. The catastrophic tsunami in the Indian Ocean in 2004 confirmed the critical importance of sedimentological research in understanding tsunamis. In 2011, the Japan earthquake and tsunami further confirmed the importance of both sediments in tsunami hazard mitigation and the dangers from seabed sediment failures in tsunami generation. Here we recount the history of geological involvement in tsunami science and its importance in advancing understanding of the extent, magnitude and nature of the hazard from tsunamis

Challenging the view that lack of fibre causes childhood constipation

Objectives: To assess evidence supporting the view that ‘low fibre causes childhood constipation’. Design: Triangulation integrated three approaches: a systematic review NICE guideline CG99 examining effectiveness of increasing fibre; a cohort study, Avon Longitudinal Study of Parents and Children (ALSPAC), to assess if constipation (or hard stools) can precede fibre intake at weaning; and a literature search for twin studies to calculate heredity. Setting: CG99 examined the literature regarding the effectiveness of increasing fibre. ALSPAC asked parents about: hard stools at 4 weeks, 6 months and 2.5 years and constipation at age 4–10 years, as well as fibre intake at 2 years. Twin studies and data from ALSPAC were pooled to calculate concordance of constipation comparing monozygotic and dizygous twin pairs. Participants: CG99 reported six randomised controlled trials (RCTs). ALSPAC hard stool data from 6796 children at 4 weeks, 9828 at 6 months and 9452 at 2.5 years plus constipation data on 8401 at 4–10 years were compared with fibre intake at 2 years. Twin studies had 338 and 93 twin pairs and ALSPAC added a further 45. Results: Increasing fibre did not effectively treat constipation. Hard stools at 4 weeks predated fibre and at 6 months predicted lower fibre intake at 2 years (p=0.003). Heredity explained 59% of constipation. Conclusions: RCTs indicate that increasing fibre is not an effective treatment for constipation in children. Hard stools can precede and predict later fibre intake. Genetic inheritance explains most childhood constipation. Extended treatment with stool softeners may improve fibre intake and limit long-term damaging sequelae of constipation

A simple and efficient GIS tool for volume calculations of submarine landslides

A numeric tool is presented for calculating volumes of topographic voids such as slump scars of landslides, canyons or craters (negative/concave morphology), or alternatively, bumps and hills (positive/convex morphology) by means of digital elevation models embedded within a geographical information system (GIS). In this study, it has been used to calculate landslide volumes. The basic idea is that a (singular) event (landslide, meteorite impact, volcanic eruption) has disturbed an intact surface such that it is still possible to distinguish between the former (undisturbed) landscape and the disturbance (crater, slide scar, debris avalanche). In such cases, it is possible to reconstruct the paleo-surface and to calculate the volume difference between both surfaces, thereby approximating the volume gain or loss caused by the event. I tested the approach using synthetically generated land surfaces that were created on the basis of Shuttle Radar Topography Mission data. Also, I show the application to two real cases, (1) the calculation of the volume of the Masaya Slide, a submarine landslide on the Pacific continental slope of Nicaragua, and (2) the calculation of the void of a segment of the Fish River Canyon, Namibia. The tool is provided as a script file for the free GIS GRASS. It performs with little effort, and offers a range of interpolation parameters. Testing with different sets of interpolation parameters results in a small range of uncertainty. This tool should prove useful in surface studies not exclusively on earth