A THEORETICAL AND EMPIRICAL INVESTIGATION OF THE SUPPLY RESPONSE IN THE U.S. BEEF-CATTLE INDUSTRY

This paper investigates the response of beef cattle producers to changes in the price of cattle. Previous research has suggested that there may be a negative short-run supply response to a permanent increase in the price of cattle. We build a dynamic, rational expectations model that predicts that the supply response is generally positive, even for permanent shocks in the short run, and nests the negative supply response as a special case for appropriately restricted demand shocks. Using annual US time series data (1930-1997) and a simultaneous-equations econometric approach, we find a positive short-run supply response in the cow market and mixed evidence in the heifer market.Demand and Price Analysis, Livestock Production/Industries,

Reducing the rare event: lessons from the implementation of a ventilator bundle.

The ventilator-associated event (VAE) is a potentially avoidable complication of mechanical ventilation (MV) associated with poor outcomes. Although rare, VAEs and other nosocomial events are frequently targeted for quality improvement efforts consistent with the creed to 'do no harm'. In October 2016, VA Greater Los Angeles (GLA) was in the lowest-performing decile of VA medical centres on a composite measure of quality, owing to GLA's relatively high VAE rate. To decrease VAEs, we sought to reduce average MV duration of patients with acute respiratory failure to less than 3 days by 1 July 2017. In our first intervention (period 1), intensive care unit (ICU) attending physicians trained residents to use an existing ventilator bundle order set; in our second intervention (period 2), we updated the order set to streamline order entry and incorporate new nurse-driven and respiratory therapist (RT)-driven spontaneous awakening trial (SAT) and spontaneous breathing trial (SBT) protocols. In period 1, the proportion of eligible patients with SAT and SBT orders increased from 29.9% and 51.2% to 67.4% and 72.6%, respectively, with sustained improvements through December 2017. Mean MV duration decreased from 7.2 days at baseline to 5.5 days in period 1 and 4.7 days in period 2; statistical process control charts revealed no significant differences, but the difference between baseline and period 2 MV duration was statistically significant at p=0.049. Bedside audits showed RTs consistently performed indicated SBTs, but there were missed opportunities for SATs due to ICU staff concerns about the SAT protocol. The rarity of VAEs, small population of ventilated patients and infrequent use of sedative infusions at GLA may have decreased the opportunity to achieve staff acceptance and use of the SAT protocol. Quality improvement teams should consider frequency of targeted outcomes when planning interventions; rare events pose challenges in implementation and evaluation of change

Dismembered: Native Disenrollment and the Battle for Human Rights

While the number of federally recognized Native nations in the United States are increasing, the population figures for existing tribal nations are declining. This depopulation is not being perpetrated by the federal government, but by Native governments that are banishing, denying, or disenrolling Native citizens at an unprecedented rate. Since the 1990s, tribal belonging has become more of a privilege than a sacred right. Political and legal dismemberment has become a national phenomenon with nearly eighty Native nations, in at least twenty states, terminating the rights of indigenous citizens.The first comprehensive examination of the origins and significance of tribal disenrollment, Dismembered examines this disturbing trend, which often leaves the disenrolled tribal members with no recourse or appeal. At the center of the issue is how Native nations are defined today and who has the fundamental rights to belong. By looking at hundreds of tribal constitutions and talking with both disenrolled members and tribal officials, the authors demonstrate the damage this practice is having across Indian Country and ways to address the problem.https://scholarship.richmond.edu/bookshelf/1328/thumbnail.jp

Estimating the global costs of hearing loss

Objective: To estimate the global costs of hearing loss in 2019. Design: Prevalence-based costing model. Study sample: Hearing loss data from the 2019 Global Burden of Disease study. Additional non-hearing related health care costs, educational support, exclusion from the labour force in countries with full employment and societal costs posed by lost quality of life were determined. All costs were reported in 2019 purchasing power parity (PPP) adjusted international dollars. Results: Total global economic costs of hearing loss exceeded $981 billion. 47$49 billion. Conclusion: This analysis highlights major economic consequences of not taking action to address hearing loss worldwide. Small reductions in prevalence and/or severity of hearing loss could avert substantial economic costs to society. These cost estimates can also be used to help in modelling the cost effectiveness of interventions to prevent/tackle hearing loss and strengthen the case for investment

Testing the Temporal Limits of Lures and Toxicants for Trapping Fruit Flies (Diptera: Tephritidae): Additional Weathering Studies of Solid Bactrocera and Zeugodacus Male Lures and Associated Insecticidal Strips

Detection of pestiferous fruit flies (Diptera: Tephritidae) relies largely on traps baited with male-specific attractants. Surveillance programs in Florida and California use liquid methyl eugenol (ME, attractive to males of Bactrocera dorsalis (Hendel)) and liquid cue-lure (CL, attractive to males of Zeugodacus cucurbitae (Coquillett)) mixed with the toxicant naled to bait detection traps. However, this practice requires considerable time and may subject personnel to health risks. Recent work indicates that solid male lures deployed with a separate insecticidal (DDVP) strip are as effective as the standard liquid formulations. Specifically, solid ME and CL dispensers and DDVP strips were weathered for 6 or 12 weeks under summer conditions in AZ and FL and subsequently field tested in Hawaii. Results showed that (i) solid ME dispensers weathered for 6 weeks, but not 12 weeks, were as attractive as fresh liquid ME, and (ii) solid CL dispensers and the insecticidal strips were as effective as fresh liquid formulation for at least 12 weeks. The present study expands upon these earlier findings and addresses two specific questions: Could solid ME dispensers be deployed for 8 or 10 weeks without loss of effectiveness? Could solid CL dispensers and insecticidal strips be deployed for intervals even longer than 12 weeks? Adopting the same protocol noted above, the present study indicates that effective field longevities are 10 weeks for solid ME dispensers, at least 20 weeks for solid CL dispensers, and 12 weeks for the DDVP strips. Comparisons are drawn with related studies, and implications for tephritid surveillance programs are discussed

Development of an integrated cognitive behavioral therapy for anxiety and opioid use disorder: Study protocol and methods

Opioid use disorder is a highly disabling psychiatric disorder, and is associated with both significant functional disruption and risk for negative health outcomes such as infectious disease and fatal overdose. Even among those who receive evidence-based pharmacotherapy for opioid use disorder, many drop out of treatment or relapse, highlighting the importance of novel treatment strategies for this population. Over 60% of those with opioid use disorder also meet diagnostic criteria for an anxiety disorder; however, efficacious treatments for this common co-occurrence have not be established. This manuscript describes the rationale and methods for a behavioral treatment development study designed to develop and test an integrated cognitive-behavioral therapy for those with co-occurring opioid use disorder and anxiety disorders. The aims of the study are (1) to develop and pilot test a new manualized cognitive behavioral therapy for co-occurring opioid use disorder and anxiety disorders, (2) to test the efficacy of this treatment relative to an active comparison treatment that targets opioid use disorder alone, and (3) to investigate the role of stress reactivity in both prognosis and recovery from opioid use disorder and anxiety disorders. Our overarching aim is to investigate whether this new treatment improves both anxiety and opioid use disorder outcomes relative to standard treatment. Identifying optimal treatment strategies for this population are needed to improve outcomes among those with this highly disabling and life-threatening disorder.This study was funded by NIDA grant DA035297. The funding source had no involvement in the study design, analysis and interpretation of data, writing of the report, or the decision to submit the article for publication. (DA035297 - NIDA)Accepted manuscrip

Deletions of neuraminidase and resistance to oseltamivir may be a consequence of restricted receptor specificity in recent H3N2 influenza viruses

<p>Abstract</p> <p>Background</p> <p>Influenza viruses attach to cells via sialic acid receptors. The viral neuraminidase (NA) is needed to remove sialic acids so that newly budded virions can disperse. Known mechanisms of resistance to NA inhibitors include mutations in the inhibitor binding site, or mutations in the hemagglutinin that reduce avidity for sialic acid and therefore reduce the requirement for NA activity.</p> <p>Results</p> <p>Influenza H3N2 isolates A/Oklahoma/323/03 (Fujian-like), A/Oklahoma/1992/05 (California-like), and A/Oklahoma/309/06 (Wisconsin-like) lost NA activity on passage in MDCK cells due to internal deletions in the NA-coding RNA segment. The viruses grow efficiently in MDCK cells despite diminished NA activity. The full length NA enzyme activity is sensitive to oseltamivir but replication of A/Oklahoma/323/03 and A/Oklahoma/309/06 in MDCK cells was resistant to this inhibitor, indicating that NA is not essential for replication. There was no change in HA activity or sequence after the NA activity was lost but the three viruses show distinct, quite restricted patterns of receptor specificity by Glycan Array analysis. Extensive predicted secondary structure in RNA segment 6 that codes for NA suggests the deletions are generated by polymerase skipping over base-paired stem regions. In general the NA deletions were not carried into subsequent passages, and we were unable to plaque-purify virus with a deleted NA RNA segment.</p> <p>Conclusion</p> <p>H3N2 viruses from 2003 to the present have reduced requirement for NA when passaged in MDCK cells and are resistant to NA inhibitors, possibly by a novel mechanism of narrow receptor specificity such that virus particles do not self-aggregate. These viruses delete internal regions of the NA RNA during passage and are resistant to oseltamivir. However, deletions are independently generated at each passage, suggesting that virus with a full length NA RNA segment initiates the first round of infection.</p

The Utility Of The Pectoralis Myocutaneous Flap In The Management Of Select Cervical Esophageal Anastomotic Complications

AbstractObjective: The majority of cervical esophageal anastomotic complications can be successfully managed nonoperatively. A small group of patients may have anastomotic strictures or leakage and fistula formation that are chronic and resistant to nonoperative therapy. The purpose of this study was to review our experience with the use of the pectoralis myocutaneous flap to treat these patients. Methods: Since April 1992, four patients have undergone pectoralis myocutaneous flap repair of cervical esophageal anastomotic complications at our institution. Two patients had chronic strictures, one patient underwent prophylactic repair with a pectoralis myocutaneous flap to prevent stricture formation, and one patient had a chronic anastomotic fistula. The pectoralis myocutaneous flap was harvested in the standard fashion. The technique of anastomotic repair is described. The medical records were retrospectively reviewed to determine patient characteristics and our results. Results: Two suture line leaks developed: one small, contained leak required no intervention, and the other resolved with cervical drainage. Pneumonia, seroma at the site of the pectoralis myocutaneous flap donor, transient hoarseness, and partial skin graft loss occurred in one case each. There were no deaths. Hospital stay ranged from 12 to 22 days. A good functional result was obtained in three patients. Conclusion: Our results show that pectoralis myocutaneous flap repair of select cervical anastomotic complications is safe and well tolerated even in patients with complicated problems. (J Thorac Cardiovasc Surg 1998;115:1250-4

Trapping Pestiferous Fruit Flies (Diptera: Tephritidae): Additional Studies on the Performance of Solid Bactrocera Male Lures and Separate Insecticidal Strips Relative to Standard Liquid Lures

Detection of pestiferous Bactrocera fruit flies relies largely on traps baited with male-specific attractants. Surveillance programs in Florida and Cali- fornia use liquid methyl eugenol (ME, attractive to males of B. dorsalis (Hendel)) and liquid cue-lure (CL, attractive to males of B. cucurbitae (Coquillett)) mixed with the toxicant naled to bait traps. However, the application of the liquids requires considerable time and may subject personnel to health risks from inadvertent exposure to the lure and the insecticide. Recent studies have shown that solid dispensers containing a toxicant perform as well or better than liquid lures, but the combination of lure and toxicant in the same solid dispenser faces registration problems. Fewer studies have assessed the efficacy of solid, and separate, lures and toxicants, but existing data are promising. Here, we present the results of two independent studies that further assess the effectiveness of solid ME and CL lures and their associated, but separate, insecticidal strips. The first study, conducted exclusively in Hawaii over a 12 week period, found that captures of B. dorsalis or B. cucurbitae males were similar between traps baited with the standard liquid formulation and traps baited with solid lure dispensers and either 1 or 2 insecti- cidal strips. In the second study, solid lure dispensers and associated insecticide strips were weathered for 6 or 12 weeks under summer conditions in Arizona and Florida, where high temperatures were presumed to result in high volatility and thus provide a rigorous test of field longevity. Aged materials were shipped to Hawaii for testing against fresh (non-weathered) lures and insecticidal strips in wild populations. The results were fairly consistent between Arizona- and Florida- weathered devices and indicated that (i) solid ME dispensers were effective for 6 weeks but lost significant attractancy at 12 weeks and (ii) CL solid lures and the insecticidal strips were effective for at least 12 weeks. Collectively, these findings provide additional evidence that surveillance programs could switch to solid lures and toxicants and maintain a high level of detection sensitivity