Short-Term, Voluntary Exercise Affects Morpho-Functional Maturation of Adult-Generated Neurons in Rat Hippocampus

none5noPhysical exercise is a well-proven neurogenic stimulus, promoting neuronal progenitor proliferation and affecting newborn cell survival. Besides, it has beneficial effects on brain health and cognition. Previously, we found that three days of physical activity in a very precocious period of adult-generated granule cell life is able to antedate the appearance of the first GABAergic synaptic contacts and increase T-type Ca2+ channel expression. Considering the role of GABA and Ca2+ in fostering neuronal maturation, in this study, we used short-term, voluntary exercise on a running wheel to investigate if it is able to induce long-term morphological and synaptic changes in newborn neurons. Using adult male rats, we found that: (i) three days of voluntary physical exercise can definitively influence the morpho-functional maturation process of newborn granule neurons when applied very early during their development; (ii) a significant percentage of new neurons show more mature morphological characteristics far from the end of exercise protocol; (iii) the long-term morphological effects result in enhanced synaptic plasticity. Present findings demonstrate that the morpho-functional changes induced by exercise on very immature adult-generated neurons are permanent, affecting the neuron maturation and integration in hippocampal circuitry. Our data contribute to underpinning the beneficial potential of physical activity on brain health, also performed for short times.Davide Lattanzi, David Savelli, Marica Pagliarini, Riccardo Cuppini, Patrizia AmbroginiLattanzi, Davide; Savelli, David; Pagliarini, Marica; Cuppini, Riccardo; Ambrogini, Patrizi

Taking the long view on short-run marginal emissions: how much carbon does flexibility and energy storage save?

Grid-scale electricity storage will play a crucial role in the transition of power systems towards zero carbon. During the transition, investments need to be channeled towards technologies and locations that enable zero carbon operation in the long term, while also delivering security of supply and value for money. We discuss metrics and market signals that are needed to guide this transition towards clean, secure and affordable solutions. Paradoxically, carbon metrics play an important role, but become less effective as a decision tool once the system approaches zero carbon. We critically assess the role of marginal and average emission and question the allocation of marginal emissions in systems where combinations of renewables and storage deliver flexibility. We conclude that, for strategic investments, short-term market signals may not always deliver sufficiently fast or far-sighted outcomes and operational decisions need to consider the merit order of demand as well as supply

Panta Rhei benchmark dataset: socio-hydrological data of paired events of floods and droughts

As the adverse impacts of hydrological extremes increase in many regions of the world, a better understanding of the drivers of changes in risk and impacts is essential for effective flood and drought risk management and climate adaptation. However, there is currently a lack of comprehensive, empirical data about the processes, interactions and feedbacks in complex human-water systems leading to flood and drought impacts. Here we present a benchmark dataset containing socio-hydrological data of paired events, i.e., two floods or two droughts that occurred in the same area. The 45 paired events occurred in 42 different study areas and cover a wide range of socio-economic and hydro-climatic conditions. The dataset is unique in covering both floods and droughts, in the number of cases assessed, and in the quantity of socio-hydrological data. The benchmark dataset comprises: 1) detailed review style reports about the events and key processes between the two events of a pair; 2) the key data table containing variables that assess the indicators which characterise management shortcomings, hazard, exposure, vulnerability and impacts of all events; 3) a table of the indicators-of-change that indicate the differences between the first and second event of a pair. The advantages of the dataset are that it enables comparative analyses across all the paired events based on the indicators-of-change and allows for detailed context- and location-specific assessments based on the extensive data and reports of the individual study areas. The dataset can be used by the scientific community for exploratory data analyses e.g. focused on causal links between risk management, changes in hazard, exposure and vulnerability and flood or drought impacts. The data can also be used for the development, calibration and validation of socio-hydrological models. The dataset is available to the public through the GFZ Data Services (Kreibich et al. 2023, link for review: https://dataservices.gfz-potsdam.de/panmetaworks/review/923c14519deb04f83815ce108b48dd2581d57b90ce069bec9c948361028b8c85/).</p

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Broken families. Gender, family, and mutual assistance in New France: widows, widowers, and orphans in eighteenth-century Quebec / Josette Brun ; A &quot;painful dependence&quot;: female begging letters and the familial economy of obligation / Nancy Christie ; Itineraries of marriage and widowhood in nineteenth-century Montreal / Bettina Bradbury ; Marginal by definition? stepchildren in Quebec, 1866-1920/ Peter Gossage -- Bachelors and spinsters. The invention of the margin as an invention of the family: the case of rural Quebec in the eighteenth and nineteenth centuries / Ollivier Hubert ; The peddler&#39;s tale: radical religion and family marginality in the journal of Ralph Merry, 1804-1863 / J.I. Little ; &quot;Old maidism itself&quot;: spinsterhood in eighteenth- and nineteenth-century literary and life-writing texts from maritime Canada / Gwendolyn Davies ; Matthews and Marillas: bachelors and spinsters in Prince Edward Island in 1881 / Michele Stairs -- Institutions and marginality. The lunatic fringe: families, madness, and institutional confinement in Victorian Ontario / James Moran, David Wright, and Mat Savelli ; Orphans in Quebec: on the margins of which family? Denyse Baillargeon ; Nova Scotia and its unmarried mothers, 1945-1975 / Suzanne Morton ; Grizzled old men and lonely widows: constructing the single elderly as a social problem in Canada&#39;s welfare state, 1945-1967 / James Struthers ; The family as pathology: psychology, social science and history construct the nuclear family, 1945-1980 / Michael Gauvrea

Small Cell Cervical Carcinoma in Pregnancy: Therapeutic Options for an Aggressive Cancer Diagnosis

Neuroendocrine small cell cervical carcinoma is an aggressive cancer which accounts for approximately 1 to 3% of all cervical neoplasms. Therapy must be altered in pregnancy to optimize maternal–fetal outcomes. A 39-year-old woman presented for a routine prenatal visit and was noted to have a grossly abnormal cervix. Cervical biopsies confirmed small cell carcinoma. At 19 weeks' gestation, chemotherapy was initiated. The patient delivered at 34 weeks' gestation to initiate radiation therapy. Six months later, she was diagnosed with metastatic disease and died from cancer complications. In pregnancy, treatment modalities for small cell cervical carcinoma are based on the patient's gestational age at diagnosis. While aggressive early treatment is preferred, platinum-based chemotherapy can be initiated in the second trimester and radiation therapy delayed until delivery. Small cell cervical carcinoma complicating pregnancy requires aggressive treatment. Chemotherapy in the second trimester with planned delayed radiation therapy, may optimize fetal outcomes

α-Tocopherol and Hippocampal Neural Plasticity in Physiological and Pathological Conditions.

Neuroplasticity is an "umbrella term" referring to the complex, multifaceted physiological processes that mediate the ongoing structural and functional modifications occurring, at various time- and size-scales, in the ever-changing immature and adult brain, and that represent the basis for fundamental neurocognitive behavioral functions; in addition, maladaptive neuroplasticity plays a role in the pathophysiology of neuropsychiatric dysfunctions. Experiential cues and several endogenous and exogenous factors can regulate neuroplasticity; among these, vitamin E, and in particular α-tocopherol (α-T), the isoform with highest bioactivity, exerts potent effects on many plasticity-related events in both the physiological and pathological brain. In this review, the role of vitamin E/α-T in regulating diverse aspects of neuroplasticity is analyzed and discussed, focusing on the hippocampus, a brain structure that remains highly plastic throughout the lifespan and is involved in cognitive functions. Vitamin E-mediated influences on hippocampal synaptic plasticity and related cognitive behavior, on post-natal development and adult hippocampal neurogenesis, as well as on cellular and molecular disruptions in kainate-induced temporal seizures are described. Besides underscoring the relevance of its antioxidant properties, non-antioxidant functions of vitamin E/α-T, mainly involving regulation of cell signaling molecules and their target proteins, have been highlighted to help interpret the possible mechanisms underlying the effects on neuroplasticity