Yearly update : exascale projections for 2013.

The HPC architectures of today are significantly different for a decade ago, with high odds that further changes will occur on the road to Exascale. This paper discusses the %E2%80%9Cperfect storm%E2%80%9D in technology that produced this change, the classes of architectures we are dealing with, and probable trends in how they will evolve. These properties and trends are then evaluated in terms of what it likely means to future Exascale systems and applications.

Near Real-Time Measurement of Forces Applied by An Optical Trap to A Rigid Cylindrical Object

An automated data acquisition and processing system is established to measure the force applied by an optical trap to an object of unknown composition in real time. Optical traps have been in use for the past 40 years to manipulate microscopic particles, but the magnitude of applied force is often unknown and requires extensive instrument characterization. Measuring or calculating the force applied by an optical trap to nonspherical particles presents additional difficulties which are also overcome with our system. Extensive experiments and measurements using well-characterized objects were performed to verify the system performance

Conceptual Framework to Articulate Teachers’ Knowledge in an Interdisciplinary, Skills-Centered, Ever-Evolving School

We examined the growth of teachers knowledge in the context of interdisciplinary teaching which has been adopted by many educational settings in the last decade Following teams of interdisciplinary teachers in design sessions for two school years we sought to reveal what knowledge emerges and how it expands under these conditions Our findings point to the need for a new framework to discuss knowledge growth outside of one discipline We articulate the different knowledge components that emerged and offer a framework to capture teachers knowledge in interdisciplinary teaching model KIT This framework is sensitive to the context in which teachers work and can be useful to articulate teachers knowledge in other dynamic teaching and learning context

Near Real-Time Measurement of Forces Applied by An Optical Trap to A Rigid Cylindrical Object

An automated data acquisition and processing system is established to measure the force applied by an optical trap to an object of unknown composition in real time. Optical traps have been in use for the past 40 years to manipulate microscopic particles, but the magnitude of applied force is often unknown and requires extensive instrument characterization. Measuring or calculating the force applied by an optical trap to nonspherical particles presents additional difficulties which are also overcome with our system. Extensive experiments and measurements using well-characterized objects were performed to verify the system performance

Sam68 exerts separable effects on cell cycle progression and apoptosis

BACKGROUND: The RNA-binding protein Sam68 has been implicated in a number of cellular processes, including transcription, RNA splicing and export, translation, signal transduction, cell cycle progression and replication of the human immunodeficiency virus and poliovirus. However, the precise impact it has on essential cellular functions remains largely obscure. RESULTS: In this report we show that conditional overexpression of Sam68 in fibroblasts results in both cell cycle arrest and apoptosis. Arrest in G1 phase of the cell cycle is associated with decreased levels of cyclins D1 and E RNA and protein, resulting in dramatically reduced Rb phosphorylation. Interestingly, cell cycle arrest does not require the specific RNA binding ability of Sam68. In marked contrast, induction of apoptosis by Sam68 absolutely requires a fully-functional RNA binding domain. Moreover, the anti-cancer agent trichostatin A potentiates Sam68-driven apoptosis. CONCLUSIONS: For the first time we have shown that Sam68, an RNA binding protein with multiple apparent functions, exerts functionally separable effects on cell proliferation and survival, dependent on its ability to bind specifically to RNA. These findings shed new light on the ability of signal transducing RNA binding proteins to influence essential cell function. Moreover, the ability of a class of anti-cancer therapeutics to modulate its ability to promote apoptosis suggests that Sam68 status may impact some cancer treatments