Point-and-click at the reference desk

https://deepblue.lib.umich.edu/bitstream/2027.42/154710/1/1995_Sendi_et_al_Point-and-click.pd

Development efforts between high tech firms and academic libraries: A case study of one library's experience

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/154694/1/1992_Sendi_Development_Efforts.pd

Ask a Librarian Instant Messaging/Text Reference Service User Feedback Report (Winter 2017)

This report describes the process and results of user feedback received regarding the University of Michigan Library's Ask a Librarian instant messaging (IM) and texting reference service between February 6, 2017 and March 31, 2017. During the winter 2017 semester, Ask a Librarian IM service providers sought feedback about users’ IM service experience, focusing on their opinions of a particular session, their motivation for use of the IM service, and ideas for service enhancements.https://deepblue.lib.umich.edu/bitstream/2027.42/139892/1/Ask a Librarian IM Feedback Final Report.pd

Deep Learning of Sea Surface Temperature Patterns to Identify Ocean Extremes

We performed an out-of-distribution (OOD) analysis of ∼12,000,000 semi-independent 128 × 128 pixel2 sea surface temperature (SST) regions, which we define as cutouts, from all nighttime granules in the MODIS R2019 Level-2 public dataset to discover the most complex or extreme phenomena at the ocean’s surface. Our algorithm (ULMO) is a probabilistic autoencoder (PAE), which combines two deep learning modules: (1) an autoencoder, trained on ∼150,000 random cutouts from 2010, to represent any input cutout with a 512-dimensional latent vector akin to a (non-linear) Empirical Orthogonal Function (EOF) analysis; and (2) a normalizing flow, which maps the autoencoder’s latent space distribution onto an isotropic Gaussian manifold. From the latter, we calculated a log-likelihood (LL) value for each cutout and defined outlier cutouts to be those in the lowest 0.1% of the distribution. These exhibit large gradients and patterns characteristic of a highly dynamic ocean surface, and many are located within larger complexes whose unique dynamics warrant future analysis. Without guidance, ULMO consistently locates the outliers where the major western boundary currents separate from the continental margin. Prompted by these results, we began the process of exploring the fundamental patterns learned by ULMO thereby identifying several compelling examples. Future work may find that algorithms such as ULMO hold significant potential/promise to learn and derive other, not-yet-identified behaviors in the ocean from the many archives of satellite-derived SST fields. We see no impediment to applying them to other large remote-sensing datasets for ocean science (e.g., SSH and ocean color)

Diagnóstico, detección de fallas, propuestas de solución y modernización al sistema de carga alto horno uno siderúrgica Huachipato

88 p.Muchas de las grandes empresas que ya llevan varios años operando en nuestro país, se están viendo enfrentadas al dilema de qué hacer con sus maquinas y equipamientos que ya están completando su vida útil. Una de las opciones es renovar las instalaciones por completo asumiendo los costos que esto significa. La otra opción es reconvertir o potenciar sus equipos prolongando la vida útil de estos. Por esto el “retrofit” cobra una gran relevancia al recuperar y potenciar equipos de alto costo, a una fracción de su costo original.En la presente memoria abordamos el problema de la obsolescencia del sistema de carga del “alto horno uno” de la compañía siderúrgica Huachipato, dependiente del grupo CAP. El sistema en la actualidad entra cada vez más en una incertidumbre sobre su confiabilidad. Los ciclos de mantenimiento son cada vez más complejos y consumen más recursos.Por lo anterior, en esta memoria se presenta:(a) Un levantamiento del sistema, (b) La descripción de su funcionamiento actual,(c) La identificación de los puntos de conflicto.(d) Y una propuesta para la solución de los mismos./ABSTRACT: Most of the great companies that have been working for a long time in our country are facing the problem of what to do with all the machines and different equipment they have used in all its lifespan. One of the options is to get rid of them by renewing every device, even though the cost is high. But on the other hand, it is possible to enhance the machines so they can extend the lifespan and continue using their equipment. That is why the retrofit has a relevant importance, as it gets back the machines and maximizes the lifespan of expensive equipment, costing less that their original price. In this memorandum we approach the problem of the obsolescence of the load’s system of the blast furnace of the steel company Huachipato, dependant on the PSC group, which nowadays is in a state of uncertainty because of its reliability in terms of maintenance, as the processes are more complex and use up more resources. For the former reasons, this memorandum presents:(a) A survey data collection of the system.(b) The description of its actual operation.(c) An identification of the problem.(d) And approaching to the solution of the conflicts

High-content siRNA screening of the kinome identifies kinases involved in Alzheimer's disease-related tau hyperphosphorylation

<p>Abstract</p> <p>Background</p> <p>Neurofibrillary tangles (NFT), a cardinal neuropathological feature of Alzheimer's disease (AD) that is highly correlated with synaptic loss and dementia severity, appear to be partly attributable to increased phosphorylation of the microtubule stabilizing protein tau at certain AD-related residues. Identifying the kinases involved in the pathologic phosphorylation of tau may provide targets at which to aim new AD-modifying treatments.</p> <p>Results</p> <p>We report results from a screen of 572 kinases in the human genome for effects on tau hyperphosphorylation using a loss of function, high-throughput RNAi approach. We confirm effects of three kinases from this screen, the eukaryotic translation initiation factor 2 α kinase 2 (EIF2AK2), the dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A (DYRK1A), and the A-kinase anchor protein 13 (AKAP13) on tau phosphorylation at the 12E8 epitope (serine 262/serine 356). We provide evidence that EIF2AK2 effects may result from effects on tau protein expression, whereas DYRK1A and AKAP13 are likely more specifically involved in tau phosphorylation pathways.</p> <p>Conclusions</p> <p>These findings identify novel kinases that phosphorylate tau protein and provide a valuable reference data set describing the kinases involved in phosphorylating tau at an AD-relevant epitope.</p

Resistance to autosomal dominant Alzheimer's disease in an APOE3 Christchurch homozygote: a case report.

We identified a PSEN1 (presenilin 1) mutation carrier from the world's largest autosomal dominant Alzheimer's disease kindred, who did not develop mild cognitive impairment until her seventies, three decades after the expected age of clinical onset. The individual had two copies of the APOE3 Christchurch (R136S) mutation, unusually high brain amyloid levels and limited tau and neurodegenerative measurements. Our findings have implications for the role of APOE in the pathogenesis, treatment and prevention of Alzheimer's disease

Calmodulin-binding transcription activator 1 (CAMTA1) alleles predispose human episodic memory performance

Little is known about the genes and proteins involved in the process of human memory. To identify genetic factors related to human episodic memory performance, we conducted an ultra-high-density genome-wide screen at > 500000 single nucleotide polymorphisms (SNPs) in a sample of normal young adults stratified for performance on an episodic recall memory test. Analysis of this data identified SNPs within the calmodulin-binding transcription activator 1 (CAMTA1) gene that were significantly associated with memory performance. A follow up study, focused on the CAMTA1 locus in an independent cohort consisting of cognitively normal young adults, singled out SNP rs4908449 with a P-value of 0.0002 as the most significant associated SNP in the region. These validated genetic findings were further supported by the identification of CAMTA1 transcript enrichment in memory-related human brain regions and through a functional magnetic resonance imaging experiment on individuals matched for memory performance that identified CAMTA1 allele-specific upregulation of medial temporal lobe brain activity in those individuals harboring the ‘at-risk' allele for poorer memory performance. The CAMTA1 locus encodes a purported transcription factor that interfaces with the calcium-calmodulin system of the cell to alter gene expression patterns. Our validated genomic and functional biological findings described herein suggest a role for CAMTA1 in human episodic memor