Heparin-binding Epidermal Growth Factor-like Growth Factor Links Hepatocyte Priming with Cell Cycle Progression during Liver Regeneration

The mechanisms that regulate the transition between the initial priming phase and DNA replication in liver regeneration are poorly understood. To study this transition, we compared events occurring after standard two-thirds partial hepatectomy, which elicits full regeneration, with response to a reduced hepatectomy, one-third partial hepatectomy (1/3PH), which leads to little DNA replication. Although the initial response to partial hepatectomy at the priming phase appeared to be similar between the two procedures, cell cycle progression was significantly blunted in 1/3PH mice. Among the main defects observed in 1/3PH mice were an almost complete deficiency in retinoblastoma phosphorylation and the lack of increase in kinase activity associated with cyclin E. We report that, in two-thirds partial hepatectomy mice, the expression of heparin-binding epidermal growth factor-like growth factor (HB-EGF) preceded the start of DNA replication and was not detectable in 1/3PH animals. Injection of HB-EGF into 1/3PH mice resulted in a >15-fold increase in DNA replication. Moreover, we show that hepatocyte DNA replication was delayed in HB-EGF knock-out mice. In summary, we show that HB-EGF is a key factor for hepatocyte progression through G(1)/S transition during liver regeneration

Exploring the Relationship between Noise Sensitivity, Annoyance and Health-Related Quality of Life in a Sample of Adults Exposed to Environmental Noise

The relationship between environmental noise and health is poorly understood but of fundamental importance to public health. This study estimated the relationship between noise sensitivity, noise annoyance and health-related quality of life in a sample of adults residing close to the Auckland International Airport, New Zealand. A small sample (n = 105) completed surveys measuring noise sensitivity, noise annoyance, and quality of life. Noise sensitivity was associated with health-related quality of life; annoyance and sleep disturbance mediated the effects of noise sensitivity on health

Confucianism in action

Californiaxiv, 373 p.; 23 cm

The Nivison Annals

In his last essay just weeks before his death at the age of 91, David S. Nivison says, "Breaking into a formal system - such as a chronology - must be like breaking into a code. If you are successful, success will show right off." Since the late 1970's Nivison has focused his scholarship on breaking the code of Three Dynasties (Xia, Shang, Zhou) chronology by establishing an innovative methodology based on mourning periods, astronomical phenomenon, and numerical manipulations derived from them. Nivison is most readily known in the field for revising (and then revising again) the date of the Zhou conquest of Shang, and for his theory that Western Zhou kings employed two calendars (His so-called "Two yuan" theory), the second being set in effect upon the death of the new king's predecessor and counted from the completion of post-mourning rites for him (i.e., a "second 'first' year"). Nivison's enabling discovery that the Bamboo Annal (BA) had a historical basis was initially designed to make Wang Guowei's analysis of lunar phase terms (the so-called "Four quarter" theory that separated each month into four quarters) work for Western Zhou bronze inscriptions. In order to do so he had to assume that some inscriptions used a second yuan counted from completion of mourning. The king's death was the most important event late in a reign, so this implied that a king's reign-of-record was normally counted from the second yuan, omitting initial mourning years. It follows that when the unexpressed mourning years are forgotten (or edited out) but the dates of the beginning and end of the dynasty are still known, the remaining reigns-of-record cluster toward the beginning and end, and a reign in the middle is enlarged. Problems, ideas, and solutions like the one described above are found throughout this new collection of important works on chronology, astronomy, and historiography

The Nivison Annals

In his last essay just weeks before his death at the age of 91, David S. Nivison says, "Breaking into a formal system - such as a chronology - must be like breaking into a code. If you are successful, success will show right off." Since the late 1970's Nivison has focused his scholarship on breaking the code of Three Dynasties (Xia, Shang, Zhou) chronology by establishing an innovative methodology based on mourning periods, astronomical phenomenon, and numerical manipulations derived from them. Nivison is most readily known in the field for revising (and then revising again) the date of the Zhou conquest of Shang, and for his theory that Western Zhou kings employed two calendars (His so-called "Two yuan" theory), the second being set in effect upon the death of the new king's predecessor and counted from the completion of post-mourning rites for him (i.e., a "second 'first' year"). Nivison's enabling discovery that the Bamboo Annal (BA) had a historical basis was initially designed to make Wang Guowei's analysis of lunar phase terms (the so-called "Four quarter" theory that separated each month into four quarters) work for Western Zhou bronze inscriptions. In order to do so he had to assume that some inscriptions used a second yuan counted from completion of mourning. The king's death was the most important event late in a reign, so this implied that a king's reign-of-record was normally counted from the second yuan, omitting initial mourning years. It follows that when the unexpressed mourning years are forgotten (or edited out) but the dates of the beginning and end of the dynasty are still known, the remaining reigns-of-record cluster toward the beginning and end, and a reign in the middle is enlarged. Problems, ideas, and solutions like the one described above are found throughout this new collection of important works on chronology, astronomy, and historiography