Cognitive, behavioral, and autonomic correlates of mind wandering and perseverative cognition in major depression

Autonomic dysregulation has been hypothesized to play a role in the relationships between psychopathology and cardiovascular risk. An important transdiagnostic factor that has been associated with autonomic dysfunction is perseverative cognition (PC), mainly present in Major Depressive Disorder (MDD) in the form of rumination. As the ability to adaptively let our mind wander without ruminating is critical to mental health, this study aimed to examine the autonomic concomitants of functional vs. dysfunctional intrusive thoughts in MDD. Ambulatory heart rate (HR) and variability (HRV) of 18 MDD subjects and 18 healthy controls were recorded for 24 h. Approximately every 30 min during waking hours subjects reported their ongoing thoughts and moods using electronic diaries. Random regression models were performed. Compared to controls, MDD subjects were more often caught during episodes of PC. In both groups, PC required more effort to be inhibited and interfered more with ongoing activities compared to mind wandering (MW) (ps < 0.0001). This cognitive rigidity was mirrored by autonomic inflexibility, as PC was characterized by lower HRV (p < 0.0001) compared to MW. A worse mood was reported by MDD patients compared to controls, independently of their ongoing cognitive process. Controls, however, showed the highest mood worsening during PC compared to being on task and MW. HRV during rumination correlated with self-reported somatic symptoms on the same day and several dispositional traits. MDD subjects showed lower HRV during sleep, which correlated with hopelessness rumination. Results show that PC is associated with autonomic dysfunctions in both healthy and MDD subjects. Understanding when spontaneous thought is adaptive and when it is not may clarify its role in the etiology of mood disorders, shedding light on the still unexplained association between psychopathology, chronic stress, and risk for health

Dielectric losses in multi-layer Josephson junction qubits

We have measured the excited state lifetimes in Josephson junction phase and transmon qubits, all of which were fabricated with the same scalable multi-layer process. We have compared the lifetimes of phase qubits before and after removal of the isolating dielectric, SiNx, and find a four-fold improvement of the relaxation time after the removal. Together with the results from the transmon qubit and measurements on coplanar waveguide resonators, these measurements indicate that the lifetimes are limited by losses from the dielectric constituents of the qubits. We have extracted the individual loss contributions from the dielectrics in the tunnel junction barrier, AlOx, the isolating dielectric, SiNx, and the substrate, Si/SiO2, by weighing the total loss with the parts of electric field over the different dielectric materials. Our results agree well and complement the findings from other studies, demonstrating that superconducting qubits can be used as a reliable tool for high-frequency characterization of dielectric materials. We conclude with a discussion of how changes in design and material choice could improve qubit lifetimes up to a factor of four.Comment: 10 pages, 4 figures,and 4 table

Landscape Agency and Evenki-Iakut Reindeer Husbandry Along the Zhuia River, Eastern Siberia

This article is dedicated to the memory of Vasilii Nikolaeich Maksimov who drowned with his son while crossing the Zhuia River in 2012. The field research and laboratory analysis for this article was sponsored mainly by a grant from the Research Council of Norway (NFR 179316) within the multinational research framework “BOREAS: Histories from the North” organized by the European Science Foundation EUROCORES programme. A portion of the laboratory work, and the time for writing an analysis was made possible by an Advanced Grant from the European Research Council (ERC AdG 295458). The research could not have been carried out without the in-kind support, equipment and expertise of the Irkutsk State Technological University and the logistical support of the mining enterprise ‘Svetlyi’ based in Bodaibo. We are grateful to Iurii Vasil’evich Zharkov of the goldmining company Vitim and his uncle Iurii Alekseevich Zharkov of Svetlyi Ltd for professionally and reliably arranging ground transport for us and our equipment to and from the banks of the Zhuia River. We are also grateful to Iurii Konstantinovich Polititsyn, a lifetime resident of Svetlyi, who gave advice on sites of previous Evenki occupation and whose family helped us to navigate the river and organise the fieldwork. For this article, DGA was the principal investigator of the two grants, participated in most of the fieldwork, and composed this English text consulting Russian-language drafts prepared by EMI and OPV. EMI organized the fieldwork, conducted the trench digging, and prepared preliminary versions of the maps. OPV participated in the fieldwork, collected botanical samples, and participated in the interpretation of the pollen diagrams. ML participated in the fieldwork and conducted the phosphate analysis. The arduous work of identifying and counting the pollen grains, fungal spores and charcoal fragments was done by NVK in her laboratory in Irkutsk. We are indebted to our colleagues Drs. Ed Schofield and Dmitryi Mauquoy of the School of Geosciences at the University of Aberdeen for drafting the pollen diagrams and constructing the age-depth model and to Paul Ledger and Ilse Kamerling, also of the University of Aberdeen, for helping draft the final versions of the maps and figures.Peer reviewedPostprin

Traceable Coulomb Blockade Thermometry

We present a measurement and analysis scheme for determining traceable thermodynamic temperature at cryogenic temperatures using Coulomb blockade thermometry. The uncertainty of the electrical measurement is improved by utilizing two sampling digital voltmeters instead of the traditional lock-in technique. The remaining uncertainty is dominated by that of the numerical analysis of the measurement data. Two analysis methods are demonstrated: numerical fitting of the full conductance curve and measuring the height of the conductance dip. The complete uncertainty analysis shows that using either analysis method the relative combined standard uncertainty (k = 1) in determining the thermodynamic temperature in the temperature range from 20 mK to 200 mK is below 0.5 %. In this temperature range, both analysis methods produced temperature estimates that deviated from 0.39 % to 0.67 % from the reference temperatures provided by a superconducting reference point device calibrated against the Provisional Low Temperature Scale of 2000.Comment: 11 page

Comparison of risk factors for coronary heart disease morbidity versus mortality.

Despite declining rates, coronary heart disease remains a burdensome cause of death and disability worldwide. In on-going efforts to identify new environmental and genetic risk factors for the condition, events based on disease incidence are regarded as being preferable to those based on deaths. Incidence data, which may be derived from record linkage or medical examination in population-based cohort studies, are privileged because of their proximity to risk factor assessment, seemingly providing clearer insights into aetiology. By contrast, mortality data comprise not only the morbid event itself but, in the high probability of survival following a heart attack, prognosis. Owing to the often prohibitively high costs of medical examinations, or an absence of infrastructure for linkage of study members to morbidity registries, most investigators have to rely on death records. In a pooling of data from three large cohort studies whose participants had been linked to death and hospital registries for morbidity, for the first time, we assessed the relative utility of each ascertainment method by relating them to a range of established and emerging risk factors

State care in childhood and adult mortality: a systematic review and meta-analysis of prospective cohort studies

BACKGROUND: Removal from family of origin to state care can be a highly challenging childhood experience and is itself linked to an array of unfavourable outcomes in adult life. We aim to synthetise evidence on the risk of adult mortality in people with a history of state care in early life, and assess the association according to different contexts. METHODS: In this systematic review and meta-analysis, we focused on four health outcomes hypothesised to be associated with exposure to early state care: total mortality, cardiovascular disease, cancer, and suicide. We searched the electronic databases PubMed and Embase from inception to Jan 21, 2022, for studies fulfilling the following criteria: it was a prospective study in which the assessment of care was made up to 18 years of age; it included an unexposed comparator group; the focus of the study was temporary out-of-home care and not adoption; mortality surveillance was extended into adulthood; standard estimates of association (eg, relative risk, odds ratios, or hazard ratios) and variance (eg, CIs and SE) were provided; the study appeared in a peer-reviewed journal; and the study was published in English. An adapted Cochrane Risk of Bias Tool was used to assess study quality. We extracted estimates of association and variance from qualifying studies and augmented these findings with analyses of unpublished data from individual participants in two UK birth cohorts-ie, the 1958 and 1970 studies (total n=21 936). We computed hazard ratios with accompanying 95% CIs for care and each health outcome separately for each study, and then pooled the results using a random-effects meta-analysis. This review is registered at PROSPERO, CRD42021254665. FINDINGS: We identified 210 potentially eligible published articles, of which 14 met our inclusion criteria (two studies were unpublished). Of 3 223 580 individuals drawn from 13 studies, those who were exposed to care in childhood had twice the risk of total mortality in adulthood relative to those without a history of care in childhood (summary risk ratio 2·21 [95% CI 1·62-3·02]), with study-specific estimates varying between 1·04 and 5·77 (I2 =98%). Despite some attenuation, this association remained following adjustment for other measures of early-life adversity; extended into middle and older age; was stronger in higher-quality studies; and was of equal magnitude according to sex, geographical region, and birth year. There was some suggestion of sensitive periods of exposure to care, whereby individuals who entered state care for the first time in adolescence (2·47 [0·98-6·52]) had greater rates of mortality than those doing so early in the life course (1·75 [1·25-2·45]). In four studies including 534 890 people, children in care had more than three times the risk of completed suicide in adulthood relative to their unexposed peers (3·35 [2·41-4·68]), with study-specific estimates ranging between 2·42 and 5·85 (I2=72%). The magnitude of this association was weaker after adjustment for multiple covariates; in men than in women; and in lower-quality studies. INTERPRETATION: Our results for adult mortality suggest child protection systems, social policy, and health services following care graduation are insufficient to mitigate the adverse experiences that might have preceded placement into care and those that might accompany it. FUNDING: None

Mental health services and allocation of resources : where should the money flow? Reply

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