The role of the circadian clock in animal models of mood disorders.

An association between circadian clock function and mood regulation is well established and has been proposed as a factor in the development of mood disorders. Patients with depression or mania suffer disturbed sleep-wake cycles and altered rhythms in daily activities. Environmentally disrupted circadian rhythms increase the risk of mood disorders in the general population. However, proof that a disturbance of circadian rhythms is causally involved in the development of psychiatric disorders remains elusive. Using clock gene mutants, manipulations of sleep-wake and light-dark cycles, and brain lesions affecting clock function, animal models have been developed to investigate whether circadian rhythm disruptions alter mood. In this review, selected animal models are examined to address the issue of causality between circadian rhythms and affective behavior

Kepler Observations of Transiting Hot Compact Objects

Kepler photometry has revealed two unusual transiting companions orbiting an early A-star and a late B-star. In both cases the occultation of the companion is deeper than the transit. The occultation and transit with follow-up optical spectroscopy reveal a 9400 K early A-star, KOI-74 (KIC 6889235), with a companion in a 5.2 day orbit with a radius of 0.08 Rsun and a 10000 K late B-star KOI-81 (KIC 8823868) that has a companion in a 24 day orbit with a radius of 0.2 Rsun. We infer a temperature of 12250 K for KOI-74b and 13500 K for KOI-81b. We present 43 days of high duty cycle, 30 minute cadence photometry, with models demonstrating the intriguing properties of these object, and speculate on their nature.Comment: 12 pages, 3 figures, submitted to ApJL (updated to correct KOI74 lightcurve

Discovery of Reflection Nebulosity Around Five Vega-like Stars

Coronagraphic optical observations of six Vega-like stars reveal reflection nebulosities, five of which were previously unknown. The nebulosities illuminated by HD 4881, HD 23362, HD 23680, HD 26676, and HD 49662 resemble that of the Pleiades, indicating an interstellar origin for dust grains. The reflection nebulosity around HD 123160 has a double-arm morphology, but no disk-like feature is seen as close as 2.5 arcsec from the star in K-band adaptive optics data. We demonstrate that uniform density dust clouds surrounding HD 23362, HD 23680 and HD 123160 can account for the observed 12-100 micron spectral energy distributions. For HD 4881, HD 26676, and HD 49662 an additional emission source, such as from a circumstellar disk or non-equilibrium grain heating, is required to fit the 12-25 micron data. These results indicate that in some cases, particularly for Vega-like stars located beyond the Local Bubble (>100 pc), the dust responsible for excess thermal emission may originate from the interstellar medium rather than from a planetary debris system.Comment: The Astrophysical Journal, in press for March, 2002 (32 pages, 13 figures

Redundant Function of REV-ERBα and β and Non-Essential Role for Bmal1 Cycling in Transcriptional Regulation of Intracellular Circadian Rhythms

The mammalian circadian clockwork is composed of a core PER/CRY feedback loop and additional interlocking loops. In particular, the ROR/REV/Bmal1 loop, consisting of ROR activators and REV-ERB repressors that regulate Bmal1 expression, is thought to “stabilize” core clock function. However, due to functional redundancy and pleiotropic effects of gene deletions, the role of the ROR/REV/Bmal1 loop has not been accurately defined. In this study, we examined cell-autonomous circadian oscillations using combined gene knockout and RNA interference and demonstrated that REV-ERBα and β are functionally redundant and are required for rhythmic Bmal1 expression. In contrast, the RORs contribute to Bmal1 amplitude but are dispensable for Bmal1 rhythm. We provide direct in vivo genetic evidence that the REV-ERBs also participate in combinatorial regulation of Cry1 and Rorc expression, leading to their phase-delay relative to Rev-erbα. Thus, the REV-ERBs play a more prominent role than the RORs in the basic clock mechanism. The cellular genetic approach permitted testing of the robustness of the intracellular core clock function. We showed that cells deficient in both REV-ERBα and β function, or those expressing constitutive BMAL1, were still able to generate and maintain normal Per2 rhythmicity. Our findings thus underscore the resilience of the intracellular clock mechanism and provide important insights into the transcriptional topologies underlying the circadian clock. Since REV-ERB function and Bmal1 mRNA/protein cycling are not necessary for basic clock function, we propose that the major role of the ROR/REV/Bmal1 loop and its constituents is to control rhythmic transcription of clock output genes

Lyman alpha emitting galaxies at 0.2 < z < 0.35 from GALEX spectroscopy

The GALEX (Galaxy Evolution Explorer) spectroscopic survey mode, with a resolution of about 8 A in the FUV (1350 - 1750 A) and about 20 A in the NUV (1950 - 2750 A) is used for a systematic search of Ly-a emitting galaxies at low redshift. This aims at filling a gap between high-redshift surveys and a small set of objects studied in detail in the nearby universe. A blind search of 7018 spectra extracted in 5 deep exposures (5.65 sq.deg) has resulted in 96 Ly-a emitting galaxy candidates in the FUV domain, after accounting for broad-line AGNs. The Ly-a EWs (equivalent width) are consistent with stellar population model predictions and show no trends as a function of UV color or UV luminosity, except a possible decrease in the most luminous that may be due to small-number statistics. Their distribution in EW is similar to that at z about 3 but their fraction among star-forming galaxies is smaller. Avoiding uncertain candidates, a sub-sample of 66 objects in the range 0.2 < z < 0.35 has been used to build a Ly-a LF (luminosity function). The incompleteness due to objects with significant Ly-a emission but a UV continuum too low for spectral extraction has been evaluated. A comparison with H-a LF in the same redshift domain is consistent with an average Ly-a/H-a of about 1 in about 15 % of the star-forming galaxies. A comparison with high-redshift Ly-a LFs implies an increase of the Ly-a luminosity density by a factor of about 16 from z about 0.3 to z about 3. By comparison with the factor 5 increase of the UV luminosity density in the same redshift range, this suggests an increase of the average Ly-a escape fraction with redshift.Comment: 18 pages, 9 figures, accepted for publication in Ap

The UV-Optical Galaxy Color-Magnitude Diagram. I. Basic Properties

We have analyzed the bivariate distribution of galaxies as a function of ultraviolet-optical colors and absolute magnitudes in the local universe. The sample consists of galaxies with redshifts and optical photometry from the Sloan Digital Sky Survey (SDSS) main galaxy sample matched with detections in the near-ultraviolet (NUV) and far-ultraviolet (FUV) bands in the Medium Imaging Survey being carried out by the Galaxy Evolution Explorer (GALEX) satellite. In the (NUV − r)_(0.1) versus M_(r,0.1) galaxy color-magnitude diagram, the galaxies separate into two well-defined blue and red sequences. The (NUV − r)_(0.1) color distribution at each M_(r,0.1) is not well fit by the sum of two Gaussians due to an excess of galaxies in between the two sequences. The peaks of both sequences become redder with increasing luminosity, with a distinct blue peak visible up to M_(r,0.1) ~ − 23. The r_(0.1)-band luminosity functions vary systematically with color, with the faint-end slope and characteristic luminosity gradually increasing with color. After correcting for attenuation due to dust, we find that approximately one-quarter of the color variation along the blue sequence is due to dust, with the remainder due to star formation history and metallicity. Finally, we present the distribution of galaxies as a function of specific star formation rate and stellar mass. The specific star formation rates imply that galaxies along the blue sequence progress from low-mass galaxies with star formation rates that increase somewhat with time to more massive galaxies with a more or less constant star formation rate. Above a stellar mass of ~10^(10.5) M_☉, galaxies with low ratios of current to past averaged star formation rate begin to dominate

The Calibration and Data Products of the Galaxy Evolution Explorer

We describe the calibration status and data products pertaining to the GR2 and GR3 data releases of the Galaxy Evolution Explorer (GALEX). These releases have identical pipeline calibrations that are significantly improved over the GR1 data release. GALEX continues to survey the sky in the Far Ultraviolet (FUV, ~154 nm) and Near Ultraviolet (NUV, ~232 nm) bands, providing simultaneous imaging with a pair of photon counting, microchannel plate, delay line readout detectors. These 1.25 degree field-of-view detectors are well-suited to ultraviolet observations because of their excellent red rejection and negligible background. A dithered mode of observing and photon list output pose complex requirements on the data processing pipeline, entangling detector calibrations and aspect reconstruction algorithms. Recent improvements have achieved photometric repeatability of 0.05 and 0.03 mAB in the FUV and NUV, respectively. We have detected a long term drift of order 1% FUV and 6% NUV over the mission. Astrometric precision is of order 0.5" RMS in both bands. In this paper we provide the GALEX user with a broad overview of the calibration issues likely to be confronted in the current release. Improvements are likely as the GALEX mission continues into an extended phase with a healthy instrument, no consumables, and increased opportunities for guest investigations.Comment: Accepted to the ApJS (a special GALEX issue

Ly alpha-emitting galaxies at 0.2 < z < 0.35 from GALEX spectroscopy

We have used the GALEX (Galaxy Evolution Explorer) spectroscopic survey mode, with a resolution of similar to 8 angstrom in the far-ultraviolet (FUV; 1350-1750 angstrom) and similar to 20 angstrom in the near-ultraviolet (NUV; 1950-2750 angstrom) for a systematic search of Ly alpha-emitting galaxies at low redshift. Our aim is to fill a gap between high-redshift surveys and a small set of objects studied in detail in the nearby universe. A blind search of 7018 spectra extracted in five deep exposures (5.65 deg(2)) has resulted in 96 Ly alpha-emitting galaxy candidates in the FUV domain after accounting for broad-line AGNs. The Ly alpha equivalent widths (EWs) are consistent with stellar population model predictions and show no trends as a function of UV color or UV luminosity, with the exception of a possible decrease in the most luminous objects that may be due to small-number statistics. The objects' distribution in EW is similar to that at z similar to 3, but their fraction among star-forming galaxies is smaller. Avoiding uncertain candidates, a subsample of 66 objects in the range 0.2 < z < 0.35 has been used to build a Ly alpha luminosity function (LF). The incompleteness due to objects with significant Ly alpha emission but a UV continuum too low for spectral extraction has been evaluated. A comparison with H alpha LFs in the same redshift domain is consistent with an average Ly alpha/H alpha of similar to 1 in about 15% of the star-forming galaxies. A comparison with high-redshift Ly alpha LFs implies an increase of the Ly alpha luminosity density by a factor of about 16 from z similar to 0.3 to z similar to 3. By comparison with the factor of 5 increase in the UV luminosity density in the same redshift range, this suggests an increase of the average Ly alpha escape fraction with redshift