The Entrepreneurial Church: Mobilizing the Church to Bring Restoration to a Community in Chattanooga, Tennessee

The purpose of this project is form a team from the Body of Christ to open a grocery store as a restorative act in a “food desert” where the two socioeconomically distinct communities of Martin Luther King Jr. Boulevard and University of Tennessee intersect in Chattanooga, Tennessee. Martin Luther King Jr. Boulevard (MLK) is the current divider between the University of Tennessee at Chattanooga (UTC) neighborhood and the lower-income, historical African-American MLK neighborhood. The House, a university ministry situated in this intersection, serves as a catalyst for this project. Pastoral partnerships with local churches and with the university, combined with evaluation of the physical need of the MLK community, were the genesis for this initiative. Students from The House, area church members, and community leaders presently work together to steer the project. This project will be discussed in three parts. Part One describes the two communities. Part Two offers a theological reflection and includes a scriptural exploration of incarnation and restoration, a literature review, and an examination of current church-planting and missional models. Part Three discusses a strategy and timeline for implementing a pilot project. Initial stages of the project include vision-casting among neighborhood residents, local community foundations, churches, and university administrators. Pertinent steps involve discussing the community’s physical needs and the Church’s entrepreneurial role in meeting those needs. The pilot project entails crafting a business model and plan through a local entrepreneurial group. An assessment of the project strategy and goals is given. This paper concludes with suggesting steps forward to bring the store to fruition. Content Reader: Scot Sherman, ThM, Ph

Exoskeleton master controller with force-reflecting telepresence

A thorough understanding of the requirements for successful master-slave robotic systems is becoming increasingly desirable. Such systems can aid in the accomplishment of tasks that are hazardous or inaccessible to humans. Although a history of use has proven master-slave systems to be viable, system requirements and the impact of specifications on the human factors side of system performance are not well known. In support of the next phase of teleoperation research being conducted at the Armstrong Research Laboratory, a force-reflecting, seven degree of freedom exoskeleton for master-slave teleoperation has been concepted, and is presently being developed. The exoskeleton has a unique kinematic structure that complements the structure of the human arm. It provides a natural means for teleoperating a dexterous, possibly redundant manipulator. It allows ease of use without operator fatigue and faithfully follows human arm and wrist motions. Reflected forces and moments are remotely transmitted to the operator hand grip using a cable transmission scheme. This paper presents the exoskeleton concept and development results to date. Conceptual design, hardware, algorithms, computer architecture, and software are covered

Loose Ends for the Exomoon Candidate Host Kepler-1625b

The claim of an exomoon candidate in the Kepler-1625b system has generated substantial discussion regarding possible alternative explanations for the purported signal. In this work we examine in detail these possibilities. First, the effect of more flexible trend models is explored and we show that sufficiently flexible models are capable of attenuating the signal, although this is an expected byproduct of invoking such models. We also explore trend models using X and Y centroid positions and show that there is no data-driven impetus to adopt such models over temporal ones. We quantify the probability that the 500 ppm moon-like dip could be caused by a Neptune-sized transiting planet to be < 0.75%. We show that neither autocorrelation, Gaussian processes nor a Lomb-Scargle periodogram are able to recover a stellar rotation period, demonstrating that K1625 is a quiet star with periodic behavior < 200 ppm. Through injection and recovery tests, we find that the star does not exhibit a tendency to introduce false-positive dip-like features above that of pure Gaussian noise. Finally, we address a recent re-analysis by Kreidberg et al (2019) and show that the difference in conclusions is not from differing systematics models but rather the reduction itself. We show that their reduction exhibits i) slightly higher intra-orbit and post-fit residual scatter, ii) $\simeq$ 900 ppm larger flux offset at the visit change, iii) $\simeq$ 2 times larger Y-centroid variations, and iv) $\simeq$ 3.5 times stronger flux-centroid correlation coefficient than the original analysis. These points could be explained by larger systematics in their reduction, potentially impacting their conclusions.Comment: 21 pages, 4 tables, 11 figures. Accepted for publication in The Astronomical Journal, January 202

A recommended numbering scheme for influenza A HA subtypes.

Comparisons of residues between sub-types of influenza virus is increasingly used to assess the zoonotic potential of a circulating strain and for comparative studies across subtypes. An analysis of N-terminal cleavage sites for thirteen subtypes of influenza A hemagglutinin (HA) sequences, has previously been described by Nobusawa and colleagues. We have expanded this analysis for the eighteen known subtypes of influenza. Due to differences in the length of HA, we have included strains from multiple clades of H1 and H5, as well as strains of H5 and H7 subtypes with both high and low pathogenicity. Analysis of known structures of influenza A HA enables us to define amino acids which are structurally and functionally equivalent across all HA subtypes using a numbering system based on the mature HA sequence. We provide a list of equivalences for amino acids which are known to affect the phenotype of the virus.Funding provided by (DJS) Bill & Melinda Gates Foundation Global Health (http://www.gatesfoundation.org/) Grant # OPPGH5383, (DJS) European Union FP7 program ANTIGONE (http://cordis.europa.eu/programme/rcn/852_en.html) (278976) and (DJS) National Institute of Allergy and Infectious disease (http://www.niaid.nih.gov) Contract HHSN266200700010C. The funders had no role in the study design, data collection, analysis, decision to publish or preparation of the manuscript.This is the final published version. It originally appeared at http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0112302

Synthesis, structures and cytotoxicity studies of p-sulfonatocalix[4]arene lanthanide complexes

A number of p-sulfonatocalix[4]arene complexes of the lanthanides (Tb, Gd, and Eu) have been prepared, some in the presence of tetraazamacrocycle 1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid (DO3A), and fully characterised. Crystal structure determinations reveal lanthanide coordination at the sulfonate group, bridging several calixarene units, giving coordination polymers. All complexes in this study have been determined to be relatively non-toxic using in vitro cell assays with CC₅₀ values in the range 30–170 μM

The Butcher-Oemler Effect in High Redshift X-ray Selected Clusters

We are engaged in a wide-field, multi-colour imaging survey of X-ray selected clusters at intermediate and high redshift. We present blue fractions for the first 8 out of 29 clusters, covering almost a factor of 100 in X-ray luminosity. We find no correlation of blue fraction with redshift or X-ray luminosity. The lack of a correlation with L$_{X}$, places strong constraints on the importance of ram-pressure stripping as a driver of the Butcher-Oemler effect.Comment: 4 pages, 4 figures, to be puplished in the proceedings of the ''Sesto 2001-Tracing Cosmic Evolution with Galaxy Clusters'', Sesto 3-6 July 2001, Italy, eds, Stefano Borgan

Pilot Subjective Assessments During an Investigation of Separation Function Allocation Using a Human-In-The-Loop Simulation

Two human-in-the-loop simulation experiments were conducted to investigate allocation of separation assurance functions between ground and air and between humans and automation. The experiments modeled a mixed-operations concept in which aircraft receiving ground-based separation services shared the airspace with aircraft providing their own separation service (i.e., self-separation). The two experiments, one pilot-focused and the other controller-focused, addressed selected key issues of mixed operations and modeling an emergence of NextGen technologies and procedures. This paper focuses on the results of the subjective assessments of pilots collected during the pilot-focused human-in-the-loop simulation, specifically workload and situation awareness. Generally the results revealed that across all conditions, pilots' perceived workload was low to medium, with the highest reported levels of workload occurring when the pilots experienced a loss of separation during the scenario. Furthermore, the results from the workload data and situation awareness data were complimentary such that when pilots reported lower levels of workload they also experienced higher levels of situation awareness

Profiling invasive Plasmodium falciparum merozoites using an integrated omics approach

The symptoms of malaria are brought about by blood-stage parasites, which are established when merozoites invade human erythrocytes. Our understanding of the molecular events that underpin erythrocyte invasion remains hampered by the short-period of time that merozoites are invasive. To address this challenge, a Plasmodium falciparum gamma-irradiated long-lived merozoite (LLM) line was developed and investigated. Purified LLMs invaded erythrocytes by an increase of 10–300 fold compared to wild-type (WT) merozoites. Using an integrated omics approach, we investigated the basis for the phenotypic difference. Only a few single nucleotide polymorphisms within the P. falciparum genome were identified and only marginal differences were observed in the merozoite transcriptomes. By contrast, using label-free quantitative mass-spectrometry, a significant change in protein abundance was noted, of which 200 were proteins of unknown function. We determined the relative molar abundance of over 1100 proteins in LLMs and further characterized the major merozoite surface protein complex. A unique processed MSP1 intermediate was identified in LLM but not observed in WT suggesting that delayed processing may be important for the observed phenotype. This integrated approach has demonstrated the significant role of the merozoite proteome during erythrocyte invasion, while identifying numerous unknown proteins likely to be involved in invasion