Theoretical hypervelocity ballistic limit for single or double plates using nonlinear modal analysis

The original research on the use on nonlinear vibration technique to solve for the hypervelocity ballistic limit for double plates is examined. Such structure is commonly found in typical Space Station design where the incoming space or man-made debris would be fragmented upon hitting the outer plate (shield) and the subsequent impact on the main wall would result in a much reduced damge of the space station or spacecraft. The existing few theoretical impact equations do not agree well with each other. The existing computer code bumper used at NASA-Johnson Space Center appears to predict an unconservative ballistic limit when compared with experimental data where the velocity ranges from 3 km/s to 8 km/s. Such unconservative prediction is unacceptable from a practical safe design point of view. The bumper code is based on Wilkinson's (1968) paper and his equations have not been improved nor modified even though they are viewed with suspicion due to lack of agreement with experiments. To make matters worse, there is not another theory which is better than Wilkinson's equation and the designers are forced to use purely empirical Nysmith (1969) or semiempirical equations developed by Cour-Palais in 1969. The Cour-Palais equations were later modified empirically in 1989. The purpose of the present investigation is to examine the many assumptions of the Wilkinson equation. An attempt is made to present design charts based on the modified-Wilkinson equation so that the designer can get a feel of the ranges of the parameters which are of interest and discard a huge range of parameters, thus, significantly reducing the number of test shots required. The analysis is based on a solution of the governing nonlinear differential equations for a plate, assuming axisymmetric behavior using polar coordinates

General amyloid inhibitors? A critical examination of the inhibition of IAPP amyloid formation by inositol stereoisomers.

Islet amyloid polypeptide (IAPP or amylin) forms amyloid deposits in the islets of Langerhans; a process that is believed to contribute to the progression of type 2 diabetes and to the failure of islet transplants. An emerging theme in amyloid research is the hypothesis that the toxic species produced during amyloid formation by different polypeptides share common features and exert their effects by common mechanisms. If correct, this suggests that inhibitors of amyloid formation by one polypeptide might be effective against other amyloidogenic sequences. IAPP and Aβ, the peptide responsible for amyloid formation in Alzheimers disease, are particularly interesting in this regard as they are both natively unfolded in their monomeric states and share some common characteristics. Comparatively little effort has been expended on the design of IAPP amyloid inhibitors, thus it is natural to inquire if Aβ inhibitors are effective against IAPP, especially since no IAPP inhibitors have been clinically approved. A range of compounds inhibit Aβ amyloid formation, including various stereoisomers of inositol. Myo-, scyllo-, and epi-inositol have been shown to induce conformational changes in Aβ and prevent Aβ amyloid fibril formation by stabilizing non-fibrillar β-sheet structures. We investigate the ability of inositol stereoisomers to inhibit amyloid formation by IAPP. The compounds do not induce a conformational change in IAPP and are ineffective inhibitors of IAPP amyloid formation, although some do lead to modest apparent changes in IAPP amyloid fibril morphology. Thus not all classes of Aβ inhibitors are effective against IAPP. This work provides a basis of comparison to work on polyphenol based inhibitors of IAPP amyloid formation and helps provide clues as to the features which render them effective. The study also helps provide information for further efforts in rational inhibitor design

Transport Exponents of Sturmian Hamiltonians

We consider discrete Schr\"odinger operators with Sturmian potentials and study the transport exponents associated with them. Under suitable assumptions on the frequency, we establish upper and lower bounds for the upper transport exponents. As an application of these bounds, we identify the large coupling asymptotics of the upper transport exponents for frequencies of constant type. We also bound the large coupling asymptotics uniformly from above for Lebesgue-typical frequency. A particular consequence of these results is that for most frequencies of constant type, transport is faster than for Lebesgue almost every frequency. We also show quasi-ballistic transport for all coupling constants, generic frequencies, and suitable phases.Comment: 30 page

Visualizing Object Oriented Software in Three Dimensions

There is increasing evidence that it is possible to perceive and understand increasingly comple x information systems if they are displayed a s graphical objects in a three dimensional space . Object-oriented software provides an interestin g test case - there is a natural mapping fro m software objects to visual objects . In this paper we explore two areas. 1) Information perception : we are running controlled experiments to determine empirically if our initial premise is valid; how much more (or less) can be understoo d in 3D than in 2D? 2) Layout: our strategy is to combine partially automatic layout with manua l layout. This paper presents a brief overview of the project, the software architecture and some preliminary empirical results

A conceptual framework for interactive virtual storytelling

This paper presents a framework of an interactive storytelling system. It can integrate five components: management centre, evaluation centre, intelligent virtual agent, intelligent virtual environment, and users, making possible interactive solutions where the communication among these components is conducted in a rational and intelligent way. Environment plays an important role in providing heuristic information for agents through communicating with the management centre. The main idea is based on the principle of heuristic guiding of the behaviour of intelligent agents for guaranteeing the unexpectedness and consistent themes