Review of the International Play Policies and Their Contribution To Supporting a Child\u27s Right to Play

Play is recognised as a fundamental children\u27s right protected by the United Nations Convention on the Rights of the Child. Despite legal and constitutional requirements for ensuring children\u27s right to play, there are few international policies dedicated to play. This paper seeks to use a critical discourse analysis lens to compare the current international policies dedicated to play and identify examples of good practice and perceived barriers to the successful development and implementation of play policies

Perceived Social Support and Stress: a Study of 1st Year Students in Ireland

Social support is consistently associated with positive outcomes for students, in terms of wellbeing and academic achievement. For first year students, social support offers a way to deal with stressors associated with the challenge of transitioning to university. The current research was conducted with a range of first year students (n = 315) early in their first semester in university. Both male and female students reported moderate levels of social support and perceived stress, while those with higher levels of social support reported lower levels of stress. Gender differences were apparent in both the levels and sources of social support that students perceived as available to them. Female students reported higher levels of social support and stress than males, suggesting that university initiatives for enhancing social support and dealing with stress may require a gender-specific focus. The results are discussed in terms of recommendations for developing students’ social supports during first year, in order to mitigate for the experience of stress and to enhance student experience of their educational journey

It\u27s Not What You Do Its the Way That You Do It: the Influence of Obesity on the Speed and Accuracy of a Discrete Aiming Task

The ability to control speed and accuracy of goal directed aiming tasks underpins many activities of daily living. Recent evidence has begun to suggest that obesity can affect the control of movement. This study evaluated perceptual motor control of 183 normal weight, overweight, and obese participants using a discrete Fitts’ task on a digital tablet. In addition, we manipulated tablet orientation to determine whether tablet orientation influences task difficulty with the view to increase the task’s constraints. Our study found that the traditional relationship between target distance and target width hold true for each of the three weight groups in both tablet orientations. Interestingly, no significant differences were found for movement time between the groups, while movement kinematics differed between weight groups. Obese participants demonstrated significantly higher peak acceleration values in the horizontal tablet orientation when compared to their normal weight and overweight counterparts. Further to this, obese participants made significantly more errors than normal weight and overweight groups. These findings suggest that obese individuals have altered control strategies compared to their normal weight peers. © 2018, Springer-Verlag GmbH Germany, part of Springer Nature

The presence of cytochrome c1 in the purple sulfur bacterium Chromatium vinosum

AbstractA cytochrome-enriched preparation derived from Chromatium vinosum chromatophores has been used to demonstrate the presence of a previously undetected high potential cytochrome c in C. vinosum. The reduced cytochrome has α, β and Soret band maxima at 552–553, 523 and 422 nm respectively and a probable Mr of 31 000. The cytochrome appears to have Em near +245 mV. These properties of the C. vinosum cytochrome suggest that it is similar to cytochrome c1

Exploring Enablers and Barriers to Educator Engagement in Teaching Innovation

This paper explores the literature related to educator engagement in teaching, learning, assessment and feedback innovation (further referred to here as ‘teaching innovation’) in higher education institutions, describing the main enablers and barriers to innovation. These include consideration of formal and informal learning opportunities for educators, the role of management and leadership, as well as recognition and reward systems, teaching-research conflict, workload and time demands, and policies and procedures. These are examined within the Job Demands-Resources (JD-R) model as job resources and job demands to facilitate understanding of how these may influence educator engagement in teaching innovation in interaction with each other, as well as the educator’s personal resources. Literature-informed recommendations are also made on how higher education institutions can create an organisational climate conducive to educator engagement in teaching innovation

Fine motor skill performance in Irish children

Background Motor skills are the basis for any bodily movement. They allow children to read, write, walk, talk and play sports. These skills play a central role in children's lives and specifically allow them to be physically active and healthy. However there is currently a lack of knowledge in relation to the level of fine motor skills in children both in Ireland and internationally. Fine motor skills are an essential component of numerous activities of daily life such as dressing and feeding and in addition to academic practices such as handwriting. Methods This cross-sectional study used the Bruininks-Oseretsky Test of Motor Proficiency, Second Edition (BOT-2) to evaluate the fine motor skill proficiency of Irish primary school children (N=139) between the age of 6-12 years. A second measure involving a handheld pendulum was also used to determine children's sensory motor coordination levels with visual stimuli, auditory stimuli and a combination of both (multisensory). Results In terms of fine motor skill proficiency, only 1st class children were found to be meeting the expected levels, while 3rd and 5th class children were found to score below the normative values for age and gender. There was a significant effect for gender, with boys being found to demonstrate higher levels of motor skill proficiency compared to girls. In addition, the investigation into sensory motor coordination levels of children also demonstrated an effect for age. The oldest children were found to demonstrate the best levels of coordination across visual, auditory and multisensory conditions. Discussion These low levels of fine motor skill proficiency might impede performance of everyday life activities as well as children's willingness to participate in physical activity (Bouffard, 1996; Cairney et al 2005, 2006). This lower level of fine motor skill proficiency for older Irish children in addition to the observed gender differences could be as a result of different societal, cultural and environment influences

Parallelism and divergence in immune responses: a comparison of expression levels in two lakes

Question: How do immune phenotypes differ between infected and uninfected wild individuals, and is the effect the same in different populations? Organisms: Threespine stickleback (Gasterosteus aculeatus) from two lake populations on the island of North Uist, Scotland, sampled in May 2015. Methods: For each fish, we recorded length, sex, reproductive status, condition, and parasitic infection. We measured the expression levels of eight genes that act as key markers of immune system function using qPCR, and then examined the relationship between measured factors and immune gene expression profiles within each population. Conclusions: Populations differed significantly in their immune gene expression profiles. Within each population, multiple factors, including condition, reproductive status, and Schistocephalus solidus infection levels, were found to correlate with expression levels of different arms of the immune system

Deep Metabolomics of a High-Grade Serous Ovarian Cancer Triple-Knockout Mouse Model

High-grade serous carcinoma (HGSC) is the most common and deadliest ovarian cancer (OC) type, accounting for 70–80% of OC deaths. This high mortality is largely due to late diagnosis. Early detection is thus crucial to reduce mortality, yet the tumor pathogenesis of HGSC remains poorly understood, making early detection exceedingly difficult. Faithfully and reliably representing the clinical nature of human HGSC, a recently developed triple-knockout (TKO) mouse model offers a unique opportunity to examine the entire disease spectrum of HGSC. Metabolic alterations were investigated by applying ultra-performance liquid chromatography–mass spectrometry (UPLC–MS) to serum samples collected from these mice at premalignant, early, and advanced stages of HGSC. This comprehensive analysis revealed a panel of 29 serum metabolites that distinguished mice with HGSC from controls and mice with uterine tumors with over 95% accuracy. Meanwhile, our panel could further distinguish early-stage HGSC from controls with 100% accuracy and from advanced-stage HGSC with over 90% accuracy. Important identified metabolites included phospholipids, sphingomyelins, sterols, N-acyltaurine, oligopeptides, bilirubin, 2(3)-hydroxysebacic acids, uridine, N-acetylneuraminic acid, and pyrazine derivatives. Overall, our study provides insights into dysregulated metabolism associated with HGSC development and progression, and serves as a useful guide toward early detection

Burden of Migraine in Patients With Preventive Treatment Failure Attending European Headache Specialist Centers: Real-World Evidence From the BECOME Study

Migraña; Fracaso del tratamiento; Productividad laboralMigraine; Treatment failure; Work productivityMigranya; Fracàs del tractament; Productivitat laboralIntroduction Migraine is consistently ranked as one of the most disabling neurological conditions in the world, often causing a substantial impairment of daily activities and quality of life. It also carries a high economic burden of direct and indirect healthcare costs. Patients with difficult-to-treat migraine often cycle through different preventive therapies, but real-world prospective evidence describing the burden of migraine in patients with prior preventive treatment failure (PPTF) in Europe is limited. In BECOME, we aimed to characterize and assess the prevalence and burden of migraine in patients with PPTF attending specialist headache centers in Europe and Israel. Furthermore, we assessed this burden in pre-specified subgroups based on the frequency of monthly migraine days (MMD) and number of PPTFs. Methods BECOME was a prospective, non-interventional study conducted in two concurrent parts across 17 countries in Europe and Israel. In part 1, patients visiting the centers over a 3-month period were screened for frequency of PPTF, MMD, and other characteristics. In part 2, patients from part 1 with ≥ 1 PPTF and ≥ 4 MMD were enrolled, and impact of migraine on patient-reported outcomes, and healthcare resource utilization (HRU) were examined. Results In part 1 (n = 20,837), 62.2% of patients reported ≥ 1 PPTF. In part 2 (n = 2419), 15.3% of patients reported ≥ 4 PPTF. In part 2, the migraine burden measured by the EuroQoL 5 dimensions 5 level (EQ-5D-5L) questionnaire indicated an impact of at least moderate severity in performing usual activities in 26.5% of patients, pain/discomfort in 51.2%, and 26.1% reported being at least moderately anxious/depressed. Most patients reported a severe impact on daily activities and disability due to migraine. Abnormal Hospital Anxiety and Depression subscale scores of ≥ 11 were observed in 29% (anxiety) and 19.8% (depression) of the population. In part 2, analysis of HRU showed 21.2% patients visited an emergency department and 8.4% were hospitalized for headache/migraine in the past year. Conclusions This study provides real-world evidence of the high personal, social, and HRU burden of migraine in Europe and Israel.This study was funded by Novartis Pharma AG, Basel, Switzerland. The study sponsor participated in the study design, data collection, data review, data analysis and writing of the report. The Rapid Service Fee was funded by Novartis Pharma AG, Basel, Switzerland

Cook like a Boss Online: an adapted intervention during the COVID-19 pandemic that effectively improved children’s perceived cooking competence, movement competence and wellbeing

BACKGROUND: The COVID-19 pandemic has further exacerbated physical inactivity, poor dietary intake and reduced mental wellbeing, contributing factors to non-communicable diseases in children. Cooking interventions are proposed as having a positive influence on children’s diet quality. Motor skills have been highlighted as essential for performance of cooking skills, and this movement may contribute to wellbeing. Additionally, perceived competence is a motivator for behaviour performance and thus important for understanding intervention effectiveness. Therefore, this research aimed to assess the effectiveness of an adapted virtual theory-based cooking intervention on perceived cooking competence, perceived movement competence and wellbeing. METHODS: The effective theory-driven and co-created ‘Cook Like A Boss’ was adapted to a virtual five day camp-styled intervention, with 248 children across the island of Ireland participating during the pandemic. Pre- and post-intervention assessments of perceived cooking competence, perceived movement competence and wellbeing using validated measurements were completed through online surveys. Bivariate Correlations, paired samples t-tests and Hierarchical multiple regression modelling was conducted using SPSS to understand the relationships between the variables and the effect of the intervention. RESULTS: 210 participants had matched survey data and were included in analysis. Significant positive correlations were shown between perceived cooking competence, perceived movement competence and wellbeing (P < 0.05). Children’s perceived cooking competence (P < 0.001, medium to large effect size), perceived movement competence (P < 0.001, small to medium effect size) and wellbeing (P = 0.013, small effect size) all significantly increased from pre to post intervention. For the Hierarchical regression, the final model explained 57% of the total variance in participants’ post-intervention perceived cooking competence. Each model explained a significant amount of variance (P < 0.05). Pre-intervention perceived cooking competence, wellbeing, age and perceived movement competence were significant predictors for post-intervention perceived cooking competence in the final model. CONCLUSION: The ‘Cook Like A Boss’ Online intervention was an adapted virtual outreach intervention. It provides initial evidence for the associations between perceived cooking competence, perceived movement and wellbeing as well as being effective in their improvement. This research shows the potential for cooking to be used as a mechanism for targeting improvements in not only diet quality but also movement and wellbeing. TRIAL REGISTRATION: NCT05395234. Retrospectively registered on 26th May 2022. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12966-022-01378-x