We are not raised by wolves: Decentering human exceptionalism in nature

Some of the earliest writings to which we have access introduce the myth of a human child raised by wolves. Enkidu is the “wild” friend of Gilgamesh in the eponymous Sumerian epic; Romulus and Remus of Rome are the infants who suckle from the she-wolf Lupa; and Mowgli's story has been told ever since he was conceived by Rudyard Kipling in The Jungle Book. While this wolf story might seem to imagine a friendly way of living with other-than-human beings, its contemporary uptake in media also serves as a prop for white supremacist orientations to the myth that reassert the primacy of “human” life, while always determining who counts as human. Nature, on this stage, is a savage, dangerous backdrop against which human cruelties and violence are portrayed as the “survival of the fittest.

Bending the Patient Safety Curve: How Much Can AI Help?

This paper reviews the current state of patient safety and the application of artificial intelligence (AI) techniques to patient safety. This paper defines patient safety broadly, not just inpatient care but across the continuum of care, including diagnostic errors, misdiagnosis, adverse events, injuries, and measurement issues. It outlines the major current uses of AI in patient safety and the relative adoption of these techniques in hospitals and health systems. It also outlines some of the limitations of these AI systems and the challenges with evaluation of these systems. Finally, it outlines the importance of developing a proactive agenda for AI in healthcare that includes marked increased funding of research and evaluation in this area

L'arôme de la marchandise. La commercialisation de l'olfactif

L'arôme de la marchandiseLa commercialisation de l'olfactifCet article montre comment la relation qu'entretiennent les Nord-Américains avec leur corps se fait maintenant par l'entremise de divers articles de toilette (savon, déodorant, rince-bouche) qui offrent au consommateur une protection contre le rejet social en éliminant ou en supprimant les odeurs corporelles indésirables. Les auteurs y relatent la petite histoire du marketing de ces produits et présentent un échantillonnage des identités olfactives idéales qui s'offrent aujourd'hui au consommateur avide de parfums ou d'eaux de toilette. Ils font ensuite état de l'utilisation croissante des fragrances pour augmenter l'intérêt du consommateur à l'égard de divers produits manufacturés en raffinant leur « aura ». Cet article se termine par une brève étude de la façon dont un régime de valeurs unique, américanisé, se répand maintenant à la grandeur de la planète, sans toutefois négliger le fait que ce régime est en voie de transformation et qu'il est parfois confronté à la résistance qu'opposent diverses traditions locales.The Aroma of the Commodity The Commercialization of SmellThis essay traces how the relationship of North Americans to their bodies has come to be mediated by various toiletry products (soap, déodorant, mouthwash) which promise to shield the consumer subject from social rejection by eliminating or suppressing unwanted body odours. The authors go on to describe the history and analyze the range of ideal olfactory identities currently available for adoption by the consumer subject through the purchase of perfumes or colognes. There follows a discussion of the growing use of scents to enhance the consumer appeal or " aura " of manufactured products. The article concludes with a brief examination of how a single, American-style regime of olfactory values is spreading around the world, but also shows how this regime is undergoing changes and has encountered résistance in various quarters

Generalized abstraction-refinement for game-based CTL lifted model checking

cation areas ranging from embedded system domains to system-level software and communication protocols. Software Product Line methods and architectures allow effective building many custom variants of a software system in these domains. In many of the applications, their rigorous verification and quality assurance are of paramount importance. Lifted model checking for system families is capable of verifying all their variants simultaneously in a single run by exploiting the similarities between the variants. The computational cost of lifted model checking still greatly depends on the number of variants (the size of configuration space), which is often huge. Variability abstractions have successfully addressed this configuration space explosion problem, giving rise to smaller abstract variability models with fewer abstract configurations. Abstract variability models are given as modal transition systems, which contain may (over-approximating) and must (under-approximating) transitions. Thus, they preserve both universal and existential CTL properties. In this work, we bring two main contributions. First, we define a novel game-based approach for variability-specific abstraction and refinement for lifted model checking of the full CTL, interpreted over 3-valued semantics. We propose a direct algorithm for solving a 3-valued (abstract) lifted model checking game. In case the result of model checking an abstract variability model is indefinite, we suggest a new notion of refinement, which eliminates indefinite results. This provides an iterative incremental variability-specific abstraction and refinement framework, where refinement is applied only where indefinite results exist and definite results from previous iterations are reused. Second, we propose a new generalized definition of abstract variability models, given as so-called generalized modal transition systems, by introducing the notion of (must) hyper-transitions. This results in more precise abstract models in which more CTL formulae can be proved or disproved. We integrate the newly defined generalized abstract variability models in the existing abstraction-refinement framework for game-based lifted model checking of CTL. Finally, we evaluate the practicality of this approach on several system families

Root Bacterial Endophytes Alter Plant Phenotype, but not Physiology

Plant traits, such as root and leaf area, influence how plants interact with their environment and the diverse microbiota living within plants can influence plant morphology and physiology. Here, we explored how three bacterial strains isolated from the Populus root microbiome, influenced plant phenotype. We chose three bacterial strains that differed in predicted metabolic capabilities, plant hormone production and metabolism, and secondary metabolite synthesis. We inoculated each bacterial strain on a single genotype of Populus trichocarpa and measured the response of plant growth related traits (root:shoot, biomass production, root and leaf growth rates) and physiological traits (chlorophyll content, net photosynthesis, net photosynthesis at saturating light–Asat, and saturating CO2–Amax). Overall, we found that bacterial root endophyte infection increased root growth rate up to 184% and leaf growth rate up to 137% relative to non-inoculated control plants, evidence that plants respond to bacteria by modifying morphology. However, endophyte inoculation had no influence on total plant biomass and photosynthetic traits (net photosynthesis, chlorophyll content). In sum, bacterial inoculation did not significantly increase plant carbon fixation and biomass, but their presence altered where and how carbon was being allocated in the plant host

Root bacterial endophytes alter plant phenotype, but not physiology

Plant traits, such as root and leaf area, influence how plants interact with their environment and the diverse microbiota living within plants can influence plant morphology and physiology. Here, we explored how three bacterial strains isolated from the Populus root microbiome, influenced plant phenotype. We chose three bacterial strains that differed in predicted metabolic capabilities, plant hormone production and metabolism, and secondary metabolite synthesis. We inoculated each bacterial strain on a single genotype of Populus trichocarpa and measured the response of plant growth related traits (root:shoot, biomass production, root and leaf growth rates) and physiological traits (chlorophyll content, net photosynthesis, net photosynthesis at saturating light–Asat, and saturating CO2–Amax). Overall, we found that bacterial root endophyte infection increased root growth rate up to 184% and leaf growth rate up to 137% relative to non-inoculated control plants, evidence that plants respond to bacteria by modifying morphology. However, endophyte inoculation had no influence on total plant biomass and photosynthetic traits (net photosynthesis, chlorophyll content). In sum, bacterial inoculation did not significantly increase plant carbon fixation and biomass, but their presence altered where and how carbon was being allocated in the plant host

Path integral Monte Carlo simulation of helium at negative pressures

Path integral Monte Carlo (PIMC) simulations of liquid helium at negative pressure have been carried out for a temperature range from the critical temperature to below the superfluid transition. We have calculated the temperature dependence of the spinodal line as well as the pressure dependence of the isothermal sound velocity in the region of the spinodal. We discuss the slope of the superfluid transition line and the shape of the dispersion curve at negative pressures.Comment: 6 pages, 7 figures, submitted to Physical Review B Revised: new reference, replaced figure

Axonal Degeneration of the Vagus Nerve in Parkinson's Disease—A High-Resolution Ultrasound Study

Background: Recent histopathological studies revealed degeneration of the dorsal motor nucleus early in the course of Parkinson's disease (PD). Degeneration of the vagus nerve (VN) axons following neurodegeneration of brainstem vagal nuclei should be detectable by high-resolution ultrasound (HRUS) as a thinning of the VNs.Methods: We measured both VNs cross-sectional area (VN-CSA) of 35 patients with PD and 35 age- and sex-matched healthy controls at the level of the thyroid gland using HRUS.Results: On both sides, the VN-CSA was significantly smaller in PD patients than in controls (right: 2.1 ± 0.4 vs. 2.3 ± 0.5 mm2, left 1.5 ± 0.4 vs. 1.8 ± 0.4 mm2; both p < 0.05). There was no correlation between the right or left VN-CSA and age, the Hoehn & Yahr stage, disease duration, the motor part of the Unified Parkinson's Disease Rating Scale score, the Montreal Cognitive Assessment score, or the Non-motor Symptoms Questionnaire, and Scale for Parkinson's disease score including its gastrointestinal domain.Conclusions: These findings provide evidencethat atrophy of the VNs in PD patients can be detected in-vivo by HRUS