Reality conditions for Ashtekar variables as Dirac constraints

We show that the reality conditions to be imposed on Ashtekar variables to recover real gravity can be implemented as second class constraints a la Dirac. Thus, counting gravitational degrees of freedom follows accordingly. Some constraints of the real theory turn out to be non-polynomial, regardless of the form, polynomial or non-polynomial, taken for the reality conditions. We comment upon the compatibility of our approach with the recently proposed Wick transform point of view, as well as on some alternatives for dealing with such second class constraints.Comment: 16 pages, plain LaTeX, submitted to Class. Quant. Grav. E-mail: [email protected]

Ganglion-specific splicing of TRPV1 underlies infrared sensation in vampire bats.

Vampire bats (Desmodus rotundus) are obligate blood feeders that have evolved specialized systems to suit their sanguinary lifestyle. Chief among such adaptations is the ability to detect infrared radiation as a means of locating hotspots on warm-blooded prey. Among vertebrates, only vampire bats, boas, pythons and pit vipers are capable of detecting infrared radiation. In each case, infrared signals are detected by trigeminal nerve fibres that innervate specialized pit organs on the animal's face. Thus, vampire bats and snakes have taken thermosensation to the extreme by developing specialized systems for detecting infrared radiation. As such, these creatures provide a window into the molecular and genetic mechanisms underlying evolutionary tuning of thermoreceptors in a species-specific or cell-type-specific manner. Previously, we have shown that snakes co-opt a non-heat-sensitive channel, vertebrate TRPA1 (transient receptor potential cation channel A1), to produce an infrared detector. Here we show that vampire bats tune a channel that is already heat-sensitive, TRPV1, by lowering its thermal activation threshold to about 30 °C. This is achieved through alternative splicing of TRPV1 transcripts to produce a channel with a truncated carboxy-terminal cytoplasmic domain. These splicing events occur exclusively in trigeminal ganglia, and not in dorsal root ganglia, thereby maintaining a role for TRPV1 as a detector of noxious heat in somatic afferents. This reflects a unique organization of the bat Trpv1 gene that we show to be characteristic of Laurasiatheria mammals (cows, dogs and moles), supporting a close phylogenetic relationship with bats. These findings reveal a novel molecular mechanism for physiological tuning of thermosensory nerve fibres

Loop Variables for compact two-dimensional quantum electrodynamics

Variables parametrized by closed and open curves are defined to reformulate compact U(1) Quantum Electrodynamics in the circle with a massless fermion field. It is found that the gauge invariant nature of these variables accommodates into a regularization scheme for the Hamiltonian and current operators that is specially well suited for the study of the compact case. The zero mode energy spectrum, the value of the axial anomaly and the anomalous commutators this model presents are hence determined in a manifestly gauge invariant manner. Contrary to the non compact case, the zero mode spectrum is not equally spaced and consequently the theory does not lead to the spectrum of a free scalar boson. All the states are invariant under large gauge transformations. In particular, that is the case for the vacuum, and consequently the $\theta$-dependence does not appear.Comment: 24 pages, 1 figure, to be published in Phys. Rev.

Matone's Relation in the Presence of Gravitational Couplings

The prepotential in N=2 SUSY Yang-Mills theories enjoys remarkable properties. One of the most interesting is its relation to the coordinate on the quantum moduli space $u=$ that results into recursion equations for the coefficients of the prepotential due to instantons. In this work we show, with an explicit multi-instanton computation, that this relation holds true at arbitrary winding numbers. Even more interestingly we show that its validity extends to the case in which gravitational corrections are taken into account if the correlators are suitably modified. These results apply also to the cases in which matter in the fundamental and in the adjoint is included. We also check that the expressions we find satisfy the chiral ring relations for the gauge case and compute the first gravitational correction.Comment: 21 page

Autosomal Resequence Data Reveal Late Stone Age Signals of Population Expansion in Sub-Saharan African Foraging and Farming Populations

BACKGROUND:A major unanswered question in the evolution of Homo sapiens is when anatomically modern human populations began to expand: was demographic growth associated with the invention of particular technologies or behavioral innovations by hunter-gatherers in the Late Pleistocene, or with the acquisition of farming in the Neolithic? METHODOLOGY/PRINCIPAL FINDINGS:We investigate the timing of human population expansion by performing a multilocus analysis of > or = 20 unlinked autosomal noncoding regions, each consisting of approximately 6 kilobases, resequenced in approximately 184 individuals from 7 human populations. We test the hypothesis that the autosomal polymorphism data fit a simple two-phase growth model, and when the hypothesis is not rejected, we fit parameters of this model to our data using approximate Bayesian computation. CONCLUSIONS/SIGNIFICANCE:The data from the three surveyed non-African populations (French Basque, Chinese Han, and Melanesians) are inconsistent with the simple growth model, presumably because they reflect more complex demographic histories. In contrast, data from all four sub-Saharan African populations fit the two-phase growth model, and a range of onset times and growth rates is inferred for each population. Interestingly, both hunter-gatherers (San and Biaka) and food-producers (Mandenka and Yorubans) best fit models with population growth beginning in the Late Pleistocene. Moreover, our hunter-gatherer populations show a tendency towards slightly older and stronger growth (approximately 41 thousand years ago, approximately 13-fold) than our food-producing populations (approximately 31 thousand years ago, approximately 7-fold). These dates are concurrent with the appearance of the Late Stone Age in Africa, supporting the hypothesis that population growth played a significant role in the evolution of Late Pleistocene human cultures

Relocation risky for bumblebee colonies

Climate change impacts on bumblebees converge across continentsFil: Lozier, Jeffrey. University of Alabama; Estados UnidosFil: Cameron, Sydney. University of Illinois; Estados UnidosFil: Duennes, Michelle. University of Illinois; Estados UnidosFil: Strange, James. State University of Utah; Estados UnidosFil: Williams, Paul. Natural History Museum; Reino UnidoFil: Goulson, David. University of Sussex; Reino UnidoFil: Brown, Mark. University of London; Reino UnidoFil: Morales, Carolina Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte. Instituto de Investigaciones en Biodiversidad y Medioambiente. Universidad Nacional del Comahue. Centro Regional Universidad Bariloche. Instituto de Investigaciones en Biodiversidad y Medioambiente; ArgentinaFil: Jepsen, Sarina. Xerces Society; Estados Unido

Comparative Field Trial Effect of <em>Brucella</em> spp. Vaccines on Seroconversion in Goats and Their Possible Implications to Control Programs

The aim of this study was to determine the seroprevalence of Brucella spp. in a goat flock and the seroconversion of three groups of animals vaccinated with Rev-1 (Brucella melitensis), RB51, and RB51-SOD (Brucella abortus) to estimate the level of protection conferred on susceptible females. Seventy-two animals were used by group. Goats were older than 3 months, seronegative to brucellosis, not vaccinated previously, and kept within positive flocks. Vaccinated animals received 2 mL of product subcutaneously in the neck region. The first block was injected with Rev-1; the second received RB51, and the third group was injected with RB51-SOD. Follow-up sampling was performed at 30, 60, 90, and 365 days postvaccination. The general prevalence of brucellosis for the three groups was 1.2% (95%CI:0.5–2.7). The seroconversion rate by day 30 after vaccination was 77.7% (95%CI:61.9–88.2) for goats vaccinated with Rev-1. At 365 days post vaccination, the percentage of seropositive goats declined to 13.8% (95%CI:6.0–28.6). At day 365 after vaccination, 2.7% (95%CI:0.4–14.1) and 5.5% (95%CI:1.5–18.1) of animals vaccinated with RB51 and RB51-SOD, respectively, became positive. Results show that the seroconversion induced by Brucella abortus RB51 and RB51-SOD vaccines is lower than that by Brucella melitensis Rev-1