Mechanics Liens - Allocation Among Multi-Unit Projects Under Virginia Law

In several recent decisions the Virginia Supreme Court and the Federal District Court for the Eastern District of Virginia have ruled on the validity of blanket or joint mechanic\u27s liens. The blanket lien, as may be inferred from its name, is used to encumber more than one property unit in a single action. Its benefit is sought when an artisan or material supplier has improved two or more units in one transaction, and there has been a failure of remuneration. The mechanic\u27s lien gives the artisan a preferred status among creditors, and therefore its immunity to attack is of critical importance. The validity of blanket liens has been questioned in several recent decisions where a partial release of the attached property adversely affected the interests of parties other than the mechanic and his debtor, and where a single lien is sought for benefits bestowed under separate contracts. This comment will focus upon the application of the blanket lien with respect to multi-unit development in Virginia, considering both the typical subdivided property and its newer cousin, the condominium

TERMINALIDADE DA VIDA E DIRETIVA ANTECIPADAS DE VONTADE DO PACIENTE

Trabalho destinado à análise crítica das diretivas antecipadas de vontade, admitidas a partir da Resolução nº 1.995 de 2012 do CFM. Conceituação de eutanásia, distanásia e ortotanásia, bem como análise principiológica da dignidade da pessoa humana e embate constitucional. Inovações e modificações trazidas pela Resolução e estudo de questões controversas decorrentes

RESILIENT Part 2: A Randomized, Open-Label Phase III Study of Liposomal Irinotecan Versus Topotecan in Adults With Relapsed Small Cell Lung Cancer

PURPOSE The phase III RESILIENT trial compared second-line liposomal irinotecan with topotecan in patients with small cell lung cancer (SCLC). PATIENTS AND METHODS Patients with SCLC and progression on or after first-line platinum-based chemotherapy were randomly assigned (1:1) to intravenous (IV) liposomal irinotecan (70 mg/m(2) every 2 weeks in a 6-week cycle) or IV topotecan (1.5 mg/m(2) daily for 5 consecutive days, every 3 weeks in a 6-week cycle). The primary end point was overall survival (OS). Key secondary end points included progression-free survival (PFS) and objective response rate (ORR). RESULTS Among 461 randomly assigned patients, 229 received liposomal irinotecan and 232 received topotecan. The median follow-up was 18.4 months. The median OS was 7.9 months with liposomal irinotecan versus 8.3 months with topotecan (hazard ratio [HR], 1.11 [95% CI, 0.90 to 1.37]; P = .31). The median PFS per blinded independent central review (BICR) was 4.0 months with liposomal irinotecan and 3.3 months with topotecan (HR, 0.96 [95% CI, 0.77 to 1.20]; nominal P = .71); ORR per BICR was 44.1% (95% CI, 37.6 to 50.8) and 21.6% (16.4 to 27.4), respectively. Overall, 42.0% and 83.4% of patients receiving liposomal irinotecan and topotecan, respectively, experienced grade >= 3 related treatment-emergent adverse events (TEAEs). The most common grade >= 3 related TEAEs were diarrhea (13.7%), neutropenia (8.0%), and decreased neutrophil count (4.4%) with liposomal irinotecan and neutropenia (51.6%), anemia (30.9%), and leukopenia (29.1%) with topotecan. CONCLUSION Liposomal irinotecan and topotecan demonstrated similar median OS and PFS in patients with relapsed SCLC. Although the primary end point of OS was not met, liposomal irinotecan demonstrated a higher ORR than topotecan. The safety profile of liposomal irinotecan was consistent with its known safety profile; no new safety concerns emerged

Excited State Chemical Dynamics: Beyond the Born-Oppenheimer Approximation

Thesis (Ph.D.)--University of Washington, 2017-06Herein, numerical approaches for describing the time evolution of molecular systems in nonequilibrium, and excited electronic states using the tools of non-adiabatic molecular dynamics will be built up from the full molecular Hamiltonian and associated quantum mechanical equation of motion. This common formalism, from which all of the approximate methods emerge, is rst presented in detail. The working equations for these methods, which are found to naturally arise from successive approximations to the quantum mechanical treatment of all molecular degrees of freedom, and presented along with details of their implementations in electronic structure programs utilizing atom-centered basis sets. Specic scientic studies and methodological developments relying on the resulting methods are then presented to highlight the utility of the developments. A central theme throughout this document will be to exploit the disparate timescales on which the heavy and light particles comprising molecular systems evolve through the combination of explicitly time dependent methods (in a mixed quantum-classical framework), and the tools of time-dependent perturbation theory to extract the temporal evolution of molecular systems in far-from-equilibrium conditions

Understanding Beam Induced Electronic Excitations in Materials

A time dependent self consistent field based method for determining the rates of electronic excitations induced in materials by the presence of external point charges is presented. The method utilizes the full scalar potential of the external point charge in the interaction Hamiltonian instead of relying on multipolar expansions thereof. A general method is presented for determining the conditions under which dipole selection rules are adequate to describe the electronic response of the material to perturbation by external point charges. The position dependence of point charge induced transition rates between the ground and lowest few excited electronic states was resolved for a small polybenzoid. Notably, electronic excitations that are optically forbidden can be strongly allowed for particular positions of the perturbing point charge. Application of the methods detailed here can lead to an improved understanding of the electronic response of materials under irradiation by beams of charged particles