Distinguishing between Neutrinos and time-varying Dark Energy through Cosmic Time

We study the correlations between parameters characterizing neutrino physics and the evolution of dark energy. Using a fluid approach, we show that time-varying dark energy models exhibit degeneracies with the cosmic neutrino background over extended periods of the cosmic history, leading to a degraded estimation of the total mass and number of species of neutrinos. We investigate how to break degeneracies and combine multiple probes across cosmic time to anchor the behaviour of the two components. We use Planck CMB data and BAO measurements from the BOSS, SDSS and 6dF surveys to present current limits on the model parameters, and then forecast the future reach from the CMB Stage-4 and DESI experiments. We show that a multi-probe analysis of current data provides only marginal improvement on the determination of the individual parameters and no reduction of the correlations. Future observations will better distinguish the neutrino mass and preserve the current sensitivity to the number of species even in case of a time-varying dark energy component.Comment: 10 pages, 7 figures, minor updates to match the version accepted by Phys. Rev.

Density Evolution and Functional Threshold for the Noisy Min-Sum Decoder

This paper investigates the behavior of the Min-Sum decoder running on noisy devices. The aim is to evaluate the robustness of the decoder in the presence of computation noise, e.g. due to faulty logic in the processing units, which represents a new source of errors that may occur during the decoding process. To this end, we first introduce probabilistic models for the arithmetic and logic units of the the finite-precision Min-Sum decoder, and then carry out the density evolution analysis of the noisy Min-Sum decoder. We show that in some particular cases, the noise introduced by the device can help the Min-Sum decoder to escape from fixed points attractors, and may actually result in an increased correction capacity with respect to the noiseless decoder. We also reveal the existence of a specific threshold phenomenon, referred to as functional threshold. The behavior of the noisy decoder is demonstrated in the asymptotic limit of the code-length -- by using "noisy" density evolution equations -- and it is also verified in the finite-length case by Monte-Carlo simulation.Comment: 46 pages (draft version); extended version of the paper with same title, submitted to IEEE Transactions on Communication

OPA1 processing controls mitochondrial fusion and is regulated by mRNA splicing, membrane potential, and Yme1L

OPA1, a dynamin-related guanosine triphosphatase mutated in dominant optic atrophy, is required for the fusion of mitochondria. Proteolytic cleavage by the mitochondrial processing peptidase generates long isoforms from eight messenger RNA (mRNA) splice forms, whereas further cleavages at protease sites S1 and S2 generate short forms. Using OPA1-null cells, we developed a cellular system to study how individual OPA1 splice forms function in mitochondrial fusion. Only mRNA splice forms that generate a long isoform in addition to one or more short isoforms support substantial mitochondrial fusion activity. On their own, long and short OPA1 isoforms have little activity, but, when coexpressed, they functionally complement each other. Loss of mitochondrial membrane potential destabilizes the long isoforms and enhances the cleavage of OPA1 at S1 but not S2. Cleavage at S2 is regulated by the i-AAA protease Yme1L. Our results suggest that mammalian cells have multiple pathways to control mitochondrial fusion through regulation of the spectrum of OPA1 isoforms

Prebiotic, Probiotic, and Synbiotic Supplementation in Chronic Kidney Disease: A Systematic Review and Meta-analysis

Gut dysbiosis has been implicated in the pathogenesis of chronic kidney disease (CKD). Restoring gut microbiota with prebiotic, probiotic, and synbiotic supplementation has emerged as a potential therapeutic intervention but has not been systematically evaluated in the CKD population.This is a systematic review. A structured search of MEDLINE, CINAHL, EMBASE, Cochrane Central Register of Controlled Trials, and the International Clinical Trials Register Search Portal was conducted for articles published since inception until July 2017. Included studies were randomized controlled trials investigating the effects of prebiotic, probiotic, and/or synbiotic supplementation (>1\ua0week) on uremic toxins, microbiota profile, and clinical and patient-centered outcomes in adults and children with CKD.Sixteen studies investigating 645 adults met the inclusion criteria; 5 investigated prebiotics, 6 probiotics, and 5 synbiotics. The quality of the studies (Grades of Recommendation, Assessment, Development and Evaluation) ranged from moderate to very low. Prebiotic, probiotic, and synbiotic supplementation may have led to little or no difference in serum urea (9 studies, 345 participants: mean difference [MD] -0.30\ua0mmol/L, 95% confidence interval [CI] -2.20 to 1.61, P\ua0=\ua0.76, I\ua0=\ua053%), indoxyl sulfate (4 studies, 144 participants: MD -0.02\ua0mg/dL, 95% CI -0.09 to 0.05, P\ua0=\ua0.61, I\ua0=\ua00%), and p-cresyl sulfate (4 studies, 144 participants: MD -0.13\ua0mg/dL, 95% CI -0.41 to 0.15, P\ua0=\ua0.35, I\ua0=\ua00%). Prebiotic supplementation may have slightly reduced serum urea concentration (4 studies, 105 participants: MD -2.23\ua0mmol/L, 95% CI -3.83 to -0.64, P\ua0=\ua0.006, I\ua0=\ua011). Of the 2 studies investigating microbiota changes, synbiotic interventions significantly increased Bifidobacterium. Supplement effects on clinical outcomes were uncertain.There is limited evidence to support the use of prebiotics, probiotics, and/or synbiotics in CKD management

Feedback control optimisation of ESR experiments

Numerically optimised microwave pulses are used to increase excitation efficiency and modulation depth in electron spin resonance experiments performed on a spectrometer equipped with an arbitrary waveform generator. The optimisation procedure is sample-specific and reminiscent of the magnet shimming process used in the early days of nuclear magnetic resonance -- an objective function (for example, echo integral in a spin echo experiment) is defined and optimised numerically as a function of the pulse waveform vector using noise-resilient gradient-free methods. We found that the resulting shaped microwave pulses achieve higher excitation bandwidth and better echo modulation depth than the pulse shapes used as the initial guess. Although the method is theoretically less sophisticated than simulation based quantum optimal control techniques, it has the advantage of being free of the linear response approximation; rapid electron spin relaxation also means that the optimisation takes only a few seconds. This makes the procedure fast, convenient, and easy to use. An important application of this method is at the final stage of the implementation of theoretically designed pulse shapes: compensation of pulse distortions introduced by the instrument. The performance is illustrated using spin echo and out-of-phase electron spin echo envelope modulation experiments. Interface code between Bruker SpinJet arbitrary waveform generator and Matlab is included in versions 2.2 and later of the Spinach library

Discovery of a ~23 Mjup Brown Dwarf Orbiting ~700 AU from the Massive Star HIP 78530 in Upper Scorpius

We present the discovery of a substellar companion on a wide orbit around the ~2.5 Msun star HIP 78530, which is a member of the 5 Myr-old Upper Scorpius association. We have obtained follow-up imaging over two years and show that the companion and primary share common proper motion. We have also obtained JHK spectroscopy of the companion and confirm its low surface gravity, in accordance with the young age of the system. A comparison with Drift-Phoenix synthetic spectra indicates an effective temperature of 2800+/-200 K and a comparison with template spectra of young and old dwarfs indicates a spectral type of M8+/-1. The mass of the companion is estimated to be 19-26 Mjup based on its bolometric luminosity and the predictions of evolutionary models. The angular separation of the companion is 4.5", which at the distance of the primary star, 156.7 pc, corresponds to a projected separation of ~710 AU. This companion features one of the lowest mass ratios (~0.009) of any known companion at separations greater than 100 AU.Comment: To appear in ApJ, 9 pages, 9 figure

Characterization of Low-mass, Wide-separation Substellar Companions to Stars in Upper Scorpius: Near-infrared Photometry and Spectroscopy

We present new 0.9-2.45 $\mu$m spectroscopy ($R \sim 1000$), and $Y$, $J$, $H$, $K_s$, $L^\prime$ photometry, obtained at Gemini North, of three low-mass brown dwarf companions on wide orbits around young stars of the Upper Scorpius OB association: HIP 78530 B, [PGZ2001] J161031.9-191305 B, and GSC 06214-00210 B. We use these data to assess the companions' spectral type, temperature, surface gravity and mass, as well as the ability of the BT-Settl and Drift-Phoenix atmosphere models to reproduce the spectral features of young substellar objects. For completeness, we also analyze the archival spectroscopy and photometry of the Upper Scorpius planetary mass companion 1RXS J160929.1-210524 b. Based on a comparison with model spectra we find that the companions, in the above order, have effective temperatures of 2700, 2500, 2300 and 1700 K. These temperatures are consistent with our inferred spectral types, respectively M7 $\beta$, M9 $\gamma$, M9 $\gamma$, and L4 $\gamma$. From bolometric luminosities estimated from atmosphere model spectra adjusted to our photometry, and using evolution models at 5-10 Myr, we estimate masses of 21-25, 28-70, 14-17 and 7-12 $M_{\rm Jup}$, respectively. J1610-1913 B appears significantly over-luminous for its inferred temperature, which explains its higher mass estimate. Synthetic spectra based on the BT-Settl and Drift-Phoenix atmosphere models generally offer a good fit to our observed spectra, although our analysis has highlighted a few problems. For example, the best fits in the individual near-infrared bands occur at different model temperatures. Also, temperature estimates based on a comparison of the broadband magnitudes and colors of the companions to synthetic magnitudes from the models are systematically lower than the temperature estimates based on a comparison with synthetic spectra.Comment: 16 pages, 8 figures, published in the Astrophysical Journa

Metalexicography as Knowledge Graph

This short paper presents preliminary considerations regarding LexBib, a corpus, bibliography, and domain ontology of Lexicography and Dictionary Research, which is currently being developed at University of Hildesheim. The LexBib project is intended to provide a bibliographic metadata collection made available through an online reference platform. The corresponding full texts are processed with text mining methods for the generation of additional metadata, such as term candidates, topic models, and citations. All LexBib content is represented and also publicly accessible as RDF Linked Open Data. We discuss a data model that includes metadata for publication details and for the text mining results, and that considers relevant standards for an integration into the LOD cloud