Structural Macroeconometrics

Methodologies for analyzing the forces that move and shape national economies have advanced markedly in the last thirty years, enabling economists as never before to unite theoretical and empirical research and align measurement with theory. In Structural Macroeconometrics , David DeJong and Chetan Dave provide the unified overview and in-depth treatment analysts need to apply these latest theoretical models and empirical techniques. The authors' emphasis throughout is on time series econometrics. DeJong and Dave detail methods available for solving dynamic structural models and casting solutions in the form of statistical models with empirical implications that may be analyzed either analytically or numerically. They present the full range of methodologies for characterizing and evaluating these empirical implications, including calibration exercises, method-of-moment procedures, and likelihood-based procedures, both classical and Bayesian. The book is complete with a rich array of implementation algorithms, sample empirical applications, and supporting computer code. Structural Macroeconometrics is tailored specifically to equip readers with a set of practical tools that can be used to expedite their entry into the field. DeJong and Dave's uniquely accessible, how-to approach makes this the ideal textbook for graduate students seeking an introduction to macroeconomics and econometrics and for advanced students pursuing applied research in macroeconomics. The book's historical perspective, along with its broad presentation of alternative methodologies, makes it an indispensable resource for academics and professionals.methodologies, research, measurement, theory, analysis, models, empirical, technique, statistical, computer, numerical

A Systematic Review of the Health Impacts of Mass Earth Movements (Landslides)

Background. Mass ground movements (commonly referred to as ‘landslides’) are common natural hazards that can have significant economic, social and health impacts. They occur as single events, or as clusters, and are often part of ‘disaster’ chains, occurring secondary to, or acting as the precursor of other disaster events. Whilst there is a large body of literature on the engineering and geological aspects of landslides, the mortality and morbidity caused by landslides is less well documented. As far as we are aware, this is the first systematic review to examine the health impacts of landslides. Methods. The MEDLINE, EMBASE, CINAHL, SCOPUS databases and the Cochrane library were systematically searched to identify articles which considered the health impacts of landslides. Case studies, case series, primary research and systematic reviews were included. News reports, editorials and non-systematic reviews were excluded. Only articles in English were considered. The references of retrieved papers were searched to identify additional articles. Findings. 913 abstracts were reviewed and 143 full text articles selected for review. A total of 27 papers reporting research studies were included in the review (25 from initial search, 1 from review of references and 1 from personal correspondence). We found a limited number of studies on the physical health consequences of landslides. Only one study provided detail of the causes of mortality and morbidity in relation a landslide event. Landslides cause significant mental health impacts, in particular the prevalence of PTSD may be higher after landslides than other types of disaster, though these studies tend to be older with only 3 papers published in the last 5 years, with 2 being published 20 years ago, and diagnostic criteria have changed since they were produced. Discussion. We were disappointed at the small number of relevant studies, and the generally poor documentation of the health impacts of landslides. Mental health impacts were better documented, though some of the studies are now quite old. Further research on the health impacts of landslides needs to be undertaken to support those responding to landslide disasters and to aid disaster risk mitigation advocacy

Entropy Balance and Dispersive Oscillations in Lattice Boltzmann Models

We conduct an investigation into the dispersive post-shock oscillations in the entropic lattice-Boltzmann method (ELBM). To this end we use a root finding algorithm to implement the ELBM which displays fast cubic convergence and guaranties the proper sign of dissipation. The resulting simulation on the one-dimensional shock tube shows no benefit in terms of regularization from using the ELBM over the standard LBGK method. We also conduct an experiment investigating of the LBGK method using median filtering at a single point per time step. Here we observe that significant regularization can be achieved.Comment: 18 pages, 4 figures; 13/07/2009 Matlab code added to appendi

Refugee Children: Education in Emergencies for Empowerment

A famous Nigerian proverb says, “It takes an entire village to raise a child.” Today, when the world is facing one of the greatest migration crisis it has encountered, as a global village, the world as a whole would have to get together to solve the issue and ensure that children who are the most vulnerable victims of forced migration do not get impacted immeasurably. The United Nations High Commissioner for Refugees (UNHCR) report 2015, hints at an alarming status, that of the world's total refugee population, about 51 percent are children below 18. The United Nations Children's Fund (UNICEF) has already launched a campaign ‘No Lost Generation' that is focused on providing access to quality education to refugee children. Lebanon which is encountering a great rush of Syrian refugees had started in 2014, a program called ‘Reaching All Children with Education' (RACE). The British Council has even gone a step further in providing online support to aspirants of higher education. They have started a program called ‘Language and Academic Skills and E-Learning Resource' (LASER). It aims at providing entry level competence to people from 18–25 to enrol in tertiary education. The Bolivarian Republic of Venezuela has provided unrestricted access to education, to migrants at all levels and given a right to free education to all refugee children. However, the gravity of the problem is so very huge that a major gap in providing access to education and receiving it still exists for the refugee children. DOI: 10.5281/zenodo.337218

On the Evolutionary History of Stars and their Fossil Mass and Light

The total extragalactic background radiation can be an important test of the global star formation history (SFH). Using direct observational estimates of the SFH, along with standard assumptions about the initial mass function (IMF), we calculate the total extragalactic background radiation and the observed stellar density today. We show that plausible SFHs allow a significant range in each quantity, but that their ratio is very tightly constrained. Current estimates of the stellar mass and extragalactic background are difficult to reconcile, as long as the IMF is fixed to the Salpeter slope above 1 Msun. The joint confidence interval of these two quantities only agrees with that determined from the allowed range of SFH fits at the 3-sigma level, and for our best-fit values the discrepancy is about a factor of two. Alternative energy sources that contribute to the background, such as active galactic nuclei (AGN), Population III stars, or decaying particles, appear unlikely to resolve the discrepancy. However, changes to the IMF allow plausible solutions to the background problem. The simplest is an average IMF with an increased contribution from stars around 1.5--4 Msun. A ``paunchy'' IMF of this sort could emerge as a global average if low mass star formation is suppressed in galaxies experiencing rapid starbursts. Such an IMF is consistent with observations of star-forming regions, and would help to reconcile the fossil record of star formation with the directly observed SFH.Comment: 21 pages, 7 figures, 3 tables; submitted to Monthly Notice

Conflict between the axiom of Unviersal Jurisdiction and State Sovereignty with Regard to International Crimes by the Head(S) of State(S): A Study with Reference to Immunological Protections

Not availabl

Numerical calibration of the stable poisson loaded specimen

An analytical calibration of the Stable Poisson Loaded (SPL) specimen is presented. The specimen configuration is similar to the ASTM E-561 compact-tension specimen with displacement controlled wedge loading used for R-Curve determination. The crack mouth opening displacements (CMOD's) are produced by the diametral expansion of an axially compressed cylindrical pin located in the wake of a machined notch. Due to the unusual loading configuration, a three-dimensional finite element analysis was performed with gap elements simulating the contact between the pin and specimen. In this report, stress intensity factors, CMOD's, and crack displacement profiles are reported for different crack lengths and different contacting conditions. It was concluded that the computed stress intensity factor decreases sharply with increasing crack length, thus making the SPL specimen configuration attractive for fracture testing of brittle, high modulus materials

The growth of galaxies in cosmological simulations of structure formation

We use hydrodynamic simulations to examine how the baryonic components of galaxies are assembled, focusing on the relative importance of mergers and smooth accretion in the formation of ~L_* systems. In our primary simulation, which models a (50\hmpc)^3 comoving volume of a Lambda-dominated cold dark matter universe, the space density of objects at our (64-particle) baryon mass resolution threshold, M_c=5.4e10 M_sun, corresponds to that of observed galaxies with L~L_*/4. Galaxies above this threshold gain most of their mass by accretion rather than by mergers. At the redshift of peak mass growth, z~2, accretion dominates over merging by about 4:1. The mean accretion rate per galaxy declines from ~40 M_sun/yr at z=2 to ~10 M_sun/yr at z=0, while the merging rate peaks later (z~1) and declines more slowly, so by z=0 the ratio is about 2:1. We cannot distinguish truly smooth accretion from merging with objects below our mass resolution threshold, but extrapolating our measured mass spectrum of merging objects, dP/dM ~ M^a with a ~ -1, implies that sub-resolution mergers would add relatively little mass. The global star formation history in these simulations tracks the mass accretion rate rather than the merger rate. At low redshift, destruction of galaxies by mergers is approximately balanced by the growth of new systems, so the comoving space density of resolved galaxies stays nearly constant despite significant mass evolution at the galaxy-by-galaxy level. The predicted merger rate at z<~1 agrees with recent estimates from close pairs in the CFRS and CNOC2 redshift surveys.Comment: Submitted to ApJ, 35 pp including 15 fig

Passive immunotherapy against Aβ in aged APP-transgenic mice reverses cognitive deficits and depletes parenchymal amyloid deposits in spite of increased vascular amyloid and microhemorrhage

BACKGROUND: Anti-Aβ immunotherapy in transgenic mice reduces both diffuse and compact amyloid deposits, improves memory function and clears early-stage phospho-tau aggregates. As most Alzheimer disease cases occur well past midlife, the current study examined adoptive transfer of anti-Aβ antibodies to 19- and 23-month old APP-transgenic mice. METHODS: We investigated the effects of weekly anti-Aβ antibody treatment on radial-arm water-maze performance, parenchymal and vascular amyloid loads, and the presence of microhemorrhage in the brain. 19-month-old mice were treated for 1, 2 or 3 months while 23-month-old mice were treated for 5 months. Only the 23-month-old mice were subject to radial-arm water-maze testing. RESULTS: After 3 months of weekly injections, this passive immunization protocol completely reversed learning and memory deficits in these mice, a benefit that was undiminished after 5 months of treatment. Dramatic reductions of diffuse Aβ immunostaining and parenchymal Congophilic amyloid deposits were observed after five months, indicating that even well-established amyloid deposits are susceptible to immunotherapy. However, cerebral amyloid angiopathy increased substantially with immunotherapy, and some deposits were associated with microhemorrhage. Reanalysis of results collected from an earlier time-course study demonstrated that these increases in vascular deposits were dependent on the duration of immunotherapy. CONCLUSIONS: The cognitive benefits of passive immunotherapy persist in spite of the presence of vascular amyloid and small hemorrhages. These data suggest that clinical trials evaluating such treatments will require precautions to minimize potential adverse events associated with microhemorrhage

Dysregulation of Na+/K+ ATPase by amyloid in APP+PS1 transgenic mice

BACKGROUND: The pathology of Alzheimer's disease (AD) is comprised of extracellular amyloid plaques, intracellular tau tangles, dystrophic neurites and neurodegeneration. The mechanisms by which these various pathological features arise are under intense investigation. Here, expanding upon pilot gene expression studies, we have further analyzed the relationship between Na+/K+ ATPase and amyloid using APP+PS1 transgenic mice, a model that develops amyloid plaques and memory deficits in the absence of tangle formation and neuronal or synaptic loss. RESULTS: We report that in addition to decreased mRNA expression, there was decreased overall Na+/K+ ATPase enzyme activity in the amyloid-containing hippocampi of the APP+PS1 mice (although not in the amyloid-free cerebellum). In addition, dual immunolabeling revealed an absence of Na+/K+ ATPase staining in a zone surrounding congophilic plaques that was occupied by dystrophic neurites. We also demonstrate that cerebral Na+/K+ ATPase activity can be directly inhibited by high concentrations of soluble Aβ. CONCLUSIONS: The data suggest that the reductions in Na+/K+ ATPase activity in Alzheimer tissue may not be purely secondary to neuronal loss, but may results from direct effects of amyloid on this enzyme. This disruption of ion homeostasis and osmotic balance may interfere with normal electrotonic properties of dendrites, blocking intraneuronal signal processing, and contribute to neuritic dystrophia. These results suggest that therapies aimed at enhancing Na+/K+ ATPase activity in AD may improve symptoms and/or delay disease progression