Numerical calibration of the stable poisson loaded specimen

An analytical calibration of the Stable Poisson Loaded (SPL) specimen is presented. The specimen configuration is similar to the ASTM E-561 compact-tension specimen with displacement controlled wedge loading used for R-Curve determination. The crack mouth opening displacements (CMOD's) are produced by the diametral expansion of an axially compressed cylindrical pin located in the wake of a machined notch. Due to the unusual loading configuration, a three-dimensional finite element analysis was performed with gap elements simulating the contact between the pin and specimen. In this report, stress intensity factors, CMOD's, and crack displacement profiles are reported for different crack lengths and different contacting conditions. It was concluded that the computed stress intensity factor decreases sharply with increasing crack length, thus making the SPL specimen configuration attractive for fracture testing of brittle, high modulus materials

Rats, Mice, and People: Rodent Biology and Management

Farm Management,

On the mechanical properties of N-functionalised dipeptide gels

The properties of a hydrogel are controlled by the underlying network that immobilizes the solvent. For gels formed by the self-assembly of a small molecule, it is common to show the primary fibres that entangle to form the network by microscopy, but it is difficult to access information about the network. One approach to understand the network is to examine the effect of the concentration on the rheological properties, such that G cx, where G is the storage modulus and c is the concentration. A number of reports link the exponent x to a specific type of network. Here, we discuss a small library of gels formed using functionalized dipeptides, and describe the underlying networks of these gels, using microscopy, small angle scattering and rheology. We show that apparently different networks can give very similar values of x

Halo Properties in Cosmological Simulations of Self-Interacting Cold Dark Matter

We present a comparison of halo properties in cosmological simulations of collisionless cold dark matter (CDM) and self-interacting dark matter (SIDM) for a range of dark matter cross sections. We find, in agreement with various authors, that CDM yields cuspy halos that are too centrally concentrated as compared to observations. Conversely, SIDM simulations using a Monte Carlo N-body technique produce halos with significantly reduced central densities and flatter cores with increasing cross section. We introduce a concentration parameter based on enclosed mass that we expect will be straightforward to determine observationally, unlike that of Navarro, Frenk & White, and provide predictions for SIDM and CDM. SIDM also produces more spherical halos than CDM, providing possibly the strongest observational test of SIDM. We discuss our findings in relation to various relevant observations as well as SIDM simulations of other groups. Taking proper account of simulation limitations, we find that a dark matter cross section per unit mass of sigma_DM ~= 10^{-23}-10^{-24} cm^2/GeV is consistent with all current observational constraints.Comment: 14 pages, submitted to Ap

Dynamic Spin-Polarized Resonant Tunneling in Magnetic Tunnel Junctions

Precisely engineered tunnel junctions exhibit a long sought effect that occurs when the energy of the electron is comparable to the potential energy of the tunneling barrier. The resistance of metal-insulator-metal tunnel junctions oscillates with an applied voltage when electrons that tunnel directly into the barrier's conduction band interfere upon reflection at the classical turning points: the insulator-metal interface, and the dynamic point where the incident electron energy equals the potential barrier inside the insulator. A model of tunneling between free electron bands using the exact solution of the Schroedinger equation for a trapezoidal tunnel barrier qualitatively agrees with experiment.Comment: 4pgs, 3 fig

Passive immunotherapy against Aβ in aged APP-transgenic mice reverses cognitive deficits and depletes parenchymal amyloid deposits in spite of increased vascular amyloid and microhemorrhage

BACKGROUND: Anti-Aβ immunotherapy in transgenic mice reduces both diffuse and compact amyloid deposits, improves memory function and clears early-stage phospho-tau aggregates. As most Alzheimer disease cases occur well past midlife, the current study examined adoptive transfer of anti-Aβ antibodies to 19- and 23-month old APP-transgenic mice. METHODS: We investigated the effects of weekly anti-Aβ antibody treatment on radial-arm water-maze performance, parenchymal and vascular amyloid loads, and the presence of microhemorrhage in the brain. 19-month-old mice were treated for 1, 2 or 3 months while 23-month-old mice were treated for 5 months. Only the 23-month-old mice were subject to radial-arm water-maze testing. RESULTS: After 3 months of weekly injections, this passive immunization protocol completely reversed learning and memory deficits in these mice, a benefit that was undiminished after 5 months of treatment. Dramatic reductions of diffuse Aβ immunostaining and parenchymal Congophilic amyloid deposits were observed after five months, indicating that even well-established amyloid deposits are susceptible to immunotherapy. However, cerebral amyloid angiopathy increased substantially with immunotherapy, and some deposits were associated with microhemorrhage. Reanalysis of results collected from an earlier time-course study demonstrated that these increases in vascular deposits were dependent on the duration of immunotherapy. CONCLUSIONS: The cognitive benefits of passive immunotherapy persist in spite of the presence of vascular amyloid and small hemorrhages. These data suggest that clinical trials evaluating such treatments will require precautions to minimize potential adverse events associated with microhemorrhage

Dysregulation of Na+/K+ ATPase by amyloid in APP+PS1 transgenic mice

BACKGROUND: The pathology of Alzheimer's disease (AD) is comprised of extracellular amyloid plaques, intracellular tau tangles, dystrophic neurites and neurodegeneration. The mechanisms by which these various pathological features arise are under intense investigation. Here, expanding upon pilot gene expression studies, we have further analyzed the relationship between Na+/K+ ATPase and amyloid using APP+PS1 transgenic mice, a model that develops amyloid plaques and memory deficits in the absence of tangle formation and neuronal or synaptic loss. RESULTS: We report that in addition to decreased mRNA expression, there was decreased overall Na+/K+ ATPase enzyme activity in the amyloid-containing hippocampi of the APP+PS1 mice (although not in the amyloid-free cerebellum). In addition, dual immunolabeling revealed an absence of Na+/K+ ATPase staining in a zone surrounding congophilic plaques that was occupied by dystrophic neurites. We also demonstrate that cerebral Na+/K+ ATPase activity can be directly inhibited by high concentrations of soluble Aβ. CONCLUSIONS: The data suggest that the reductions in Na+/K+ ATPase activity in Alzheimer tissue may not be purely secondary to neuronal loss, but may results from direct effects of amyloid on this enzyme. This disruption of ion homeostasis and osmotic balance may interfere with normal electrotonic properties of dendrites, blocking intraneuronal signal processing, and contribute to neuritic dystrophia. These results suggest that therapies aimed at enhancing Na+/K+ ATPase activity in AD may improve symptoms and/or delay disease progression

The magnetic manipulation of surface plasmons - Consideration of possible technologies

Copyright © 2008 PIERSAn as yet unexploited mechanism for producing controlled shifts in the frequency of lightwaves via their temporary conversion to surface plasmons propagating on a ferromagnetic surface or under the action of applied magnetic fields is introduced. Indirect evidence of the observation of this phenomena is presented and the technological possibilities it might offer are explored and discussed

Efficient Quantum Circuits for Schur and Clebsch-Gordan Transforms

The Schur basis on n d-dimensional quantum systems is a generalization of the total angular momentum basis that is useful for exploiting symmetry under permutations or collective unitary rotations. We present efficient (size poly(n,d,log(1/\epsilon)) for accuracy \epsilon) quantum circuits for the Schur transform, which is the change of basis between the computational and the Schur bases. These circuits are based on efficient circuits for the Clebsch-Gordan transformation. We also present an efficient circuit for a limited version of the Schur transform in which one needs only to project onto different Schur subspaces. This second circuit is based on a generalization of phase estimation to any nonabelian finite group for which there exists a fast quantum Fourier transform.Comment: 4 pages, 3 figure