Synthesis and antifungal activity investigation of a novel clotrimazole derivative

Azole antifungal agents disrupt fungal ergosterol synthesis that is essential for the formation of fungal cell membrane by preventing 14-α-demethylase enzyme from binding to its substrate. Clotrimazole is one of the first generations of azole antifungal agents. To discover a novel azole antifungal agent, biphenyl derivative was synthesised together with clotrimazole by multistep linear synthesis. Structures of synthesised azole agents have been validated by spectral analysis and potential antifungal activity of both compounds was determined on an yeast, E.coli and M.luteus by using a disk diffusion method. Clotrimazole and its biphenyl derivative were active against yeast but a novel compound resulted less activity than clotrimazole. Antibacterial effect was not observed for either azole agents. DOI: http://dx.doi.org/10.5564/mjc.v14i0.194 Mongolian Journal of Chemistry 14 (40), 2013, p28-3

Mongolian Herders’ Evaluation of Rangeland Ecosystems Services, Values, and Changes over the Past Decade

Mongolia\u27s rangeland is one of the largest remaining contiguous ecosystems encompassing 2.6% of the global grasslands, and almost three-fourths of the country\u27s territory provides essential ecosystem services (ESS) for over 3 million Mongolians and 71 million livestock. The well-being of 171,605 pastoral households directly depends on the rangelands receiving provisional services in the forms of nutrition, material use and energy, regulatory services, and cultural services. This study explored herders\u27 perceptions of these ESS, their evaluation for ESS values, and observations of ESS change for the last decade. The study found that Mongolian herders have more benefits from provisional ESS (on average, 10 out of 18 identified), including nutritional and material use (four out of six and nine respectively), and energy services (two types out of three). An average herder household said to receive eight types of regulatory services out of 10, including environment regulation, storage/sequestration, erosion control, disease, and pest control, flood and wind protection, water cycle, soil formation and climate regulation, and six cultural services out of seven such as experiential and intellectual interactions with nature, historical and cultural heritage, both symbolic and religious-spiritual customs and nomadic identity and pride. The herders most valued the provisioning services, followed by regulatory services, and reported a declining trend in provisioning ESS for the past decade, while, in their views, non-provisioning services remained the same. Herders\u27 reported about the exploitation of local ecosystems by external companies without sharing benefits with pastoral communities and contributing to the ESS restoration and maintenance, which was the expression of the common rangeland marginalization narrative. The study recommends necessary policies and actions to ensure equitable benefit distribution derived from rangelands to support adaptive capacity and well-being of pastoral communities, essentially acknowledge the importance of non-provisional ESS across various levels

Redefining Palliative Care-A New Consensus-Based Definition.

The International Association for Hospice and Palliative Care developed a consensus-based definition of palliative care (PC) that focuses on the relief of serious health-related suffering, a concept put forward by the Lancet Commission Global Access to Palliative Care and Pain Relief. The main objective of this article is to present the research behind the new definition. The three-phased consensus process involved health care workers from countries in all income levels. In Phase 1, 38 PC experts evaluated the components of the World Health Organization definition and suggested new/revised ones. In Phase 2, 412 International Association for Hospice and Palliative Care members in 88 countries expressed their level of agreement with the suggested components. In Phase 3, using results from Phase 2, the expert panel developed the definition. The consensus-based definition is as follows: Palliative care is the active holistic care of individuals across all ages with serious health-related suffering due to severe illness and especially of those near the end of life. It aims to improve the quality of life of patients, their families and their caregivers. The definition includes a number of bullet points with additional details as well as recommendations for governments to reduce barriers to PC. Participants had significantly different perceptions and interpretations of PC. The greatest challenge faced by the core group was trying to find a middle ground between those who think that PC is the relief of all suffering and those who believe that PC describes the care of those with a very limited remaining life span

Redefining palliative care-a new consensus-based definition

Context: The International Association for Hospice and Palliative Care developed a consensus-based definition of palliative care (PC) that focuses on the relief of serious health-related suffering, a concept put forward by the Lancet Commission Global Access to Palliative Care and Pain Relief. Objective: The main objective of this article is to present the research behind the new definition. Methods: The three-phased consensus process involved health care workers from countries in all income levels. In Phase 1, 38 PC experts evaluated the components of the World Health Organization definition and suggested new/revised ones. In Phase 2, 412 International Association for Hospice and Palliative Care members in 88 countries expressed their level of agreement with the suggested components. In Phase 3, using results from Phase 2, the expert panel developed the definition. Results: The consensus-based definition is as follows: Palliative care is the active holistic care of individuals across all ages with serious health-related suffering due to severe illness and especially of those near the end of life. It aims to improve the quality of life of patients, their families and their caregivers. The definition includes a number of bullet points with additional details as well as recommendations for governments to reduce barriers to PC. Conclusion: Participants had significantly different perceptions and interpretations of PC. The greatest challenge faced by the core group was trying to find a middle ground between those who think that PC is the relief of all suffering and those who believe that PC describes the care of those with a very limited remaining life span

Guidance on a better integration of aquaculture, fisheries, and other activities in the coastal zone: from tools to practical examples

This guidance document provides a comprehensive assessment of the conflicts and synergies between fisheries, aquaculture and other activities in the coastal zone in six COEXIST case study areas. It forms deliverable D5.2 of the COEXIST project and synthesises deliverable D5.1, which provides a more detailed description of the methods used and results. This document also accounts for the views and expectations of stakeholders that were raised at the COEXIST stakeholder workshop held in Bergen, Norway, parallel to the ICES (International Council for the Exploration of the Sea) Annual Science Conference 2012. Over 30 stakeholders representing a variety of sectors, including aquaculture, fisheries, coastal zone management, tourism and energy, as well as 20 members from the COEXIST project and ICES representatives, attended this event. The stakeholders and COEXIST members were from Denmark, Finland, France, Germany, Ireland, Italy, Norway, Portugal, Spain, the Netherlands and the United Kingdom. The workshop aims were firstly to communicate the COEXIST project results and progress to stakeholders and the second major aim was to receive stakeholder feedback on the development of best practice guidance for spatial planning to integrate fisheries, aquaculture and further demands in the coastal zone

Crystal structure of tri-chlorido-(4'-ferrocenyl-2,2':6',2''-terpyridine-κ(3) N,N',N'')iridium(III) aceto-nitrile disolvate

10.1107/S2056989015003473Acta Crystallographica Section E: Structure Reports Online713m69-m7