RITU (SEASON), RITUCHARYA AND PRAKRITI- A CONCEPTUAL STUDY

The Prakriti (genetic constitution) and Kala (season) are extra ordinarily related with each other from the origin of a Prakriti due to many common and mutual factors. Naturally the effect of Kala on the Prakriti is unavoidable. The off springs from the conjugation of same Sukra (sperm) and Shonita (ovum) are not alike by Prakriti, because the time of conception or fertilization of the ovum might be different. The prominent Doshas during the time of conception has got definite role in the formation of Prakriti during conception, as well as after birth also. If the time predominates the Vata dosha, there must be certain qualities of Vata Dosha, even though the conjugating Sukra and Shonita may be of different Dosha. In such cases the chances of mixed Prakriti is more. The Charakacharya said that, a chance of Sama prakriti find is very difficult or rare. Most of the Prakrities are Vatala, Pittala and Sleshmala with predominance of Vata, Pitta and Kapha respectively. The season has great role in the genetic constitution because the fertilization of ovum also depends upon the time. Sushruta said, after the cessation of the Rajo darshana (menstrual period) the 12 nights are useful for fertilization only. The modern physiology also states that the mature ovum get discharged through one of the two ovaries, every month, on or around the 14th day of cycle and so the period round about the 14th day is best for definite conception. This clearly shows the relation of Kala (season) and Prakriti (genetic constitution) since its origin and again ahead throughout the life time. Nowadays, the nature is changing its qualities due to various atmospheric changes like pollution, space experiments, heavy industrialization and population crisis. So while studying the effects of Kala (season) one has to face the hyper/ hypo and perverted faculties of Kala (season) which are affecting the generations. So the study of Kala (season) in respect of its various effects on Prakriti (genetic constitution), will be the essential thing in future. As per Ayurveda, Ritucharya (seasonal lifestyle) should be followed for prevention of diseases arising from variations in Tridosha due to Kala (season). In present study, we tried to advocate Ritucharya (seasonal lifestyle) with respect to Prakriti (genetic constitution)

Performance evaluation of a manually operated paddy drum seeder - a cost saving technology for paddy cultivation

 A study was conducted at farmer field to evaluate performance of mechanized paddy cultivation (T1), mechanized paddy cultivation with incorporation of Dhaincha before direct sowing of paddy seed (T2) and the traditional farmer practice (T3).  Consecutive three years of data were obtained for analysis and different crop growth parameters were measured like panicle length, number of tillers, grain yield etc. for each treatment.  It was found that the average grain yield for three years in different treatments T1 and T2 was enhanced by 10% and 14% respectively when compared with farmer practice.  Average cost of cultivation was reduced by 25% in treatment T2 where green manuring crop (Dhaincha) was grown and incorporated in soil with indigenous plough before paddy seeding.  Study also revealed that due to mechanized cultivation practices, the crop was ready to harvest eight to ten days early than farmer’s practices.  The experiment well proved to raise the socio-economic status of the farmers by changing their strategy towards mechanized organic paddy cultivation.   Keywords: drum seeder, mechanization, green manuring crop, growth parameters

A Study of Wireless Sensor Networks to Comprehend their Relevance to Different Applications, Journal of Telecommunications and Information Technology, 2020, nr 2

Wireless sensor networks (WSNs) have experienced enormous growth, both in terms of the technology used and their practical applications. In order to understand the features of WSNs that make the solution suitable for a specific purpose, one needs to be aware of the theoretical concepts behind and technological aspects of WSNs. In this paper, the significance of WSNs is illustrated, with a particular emphasis placed on their demands and on understanding researchrelated problems. A review of the literature available is presented as well. Detailed discussions concerning sensor node architecture, different types of sensors used and their relevance for various types of WSNs is presented, highlighting the need to achieve application-specific requirements without degrading service quality. Multipath and cluster-based routing protocols are compared in order to analyze QoS requirements they are capable of satisfying, and their suitability for different application areas is reviewed. This survey highlights the performance of different routing protocols, therefore providing guidelines enabling each of the routing techniques to be used, in an efficient manner, with factors such as specific network structure, protocol operation and routing path construction taken into consideration in order to achieve better performanc

Detection of prostate cancer-specific transcripts in extracellular vesicles isolated from post-DRE urine

Background: The measurement of gene expression in post-digital rectal examination (DRE) urine specimens provides a non-invasive method to determine a patient’s risk of prostate cancer. Many currently available assays use whole urine or cell pellets for the analysis of prostate cancer-associated genes, although the use of extracellular vesicles (EVs) has also recently been of interest. We investigated the expression of prostate-, kidney-, and bladder- specific transcripts and known prostate cancer biomarkers in urine EVs. Methods: Cell pellets and EVs were recovered from post-DRE urine specimens, with the total RNA yield and quality determined by Bioanalyzer. The levels of prostate, kidney, and bladder- associated transcripts in EVs were assessed by TaqMan qPCR and targeted sequencing. Results: RNA was more consistently recovered from the urine EV specimens, with over 80% of the patients demonstrating higher RNA yields in the EV fraction as compared to urine cell pellets. The median EV RNA yield of 36.4 ng was significantly higher than the median urine cell pellet RNA yield of 4.8 ng. Analysis of the post-DRE urine EVs indicated that prostate-specific transcripts were more abundant than kidney- or bladder-specific transcripts. Additionally, patients with prostate cancer had significantly higher levels of the prostate cancer-associated genes PCA3 and ERG. Conclusions: Post-DRE urine EVs are a viable source of prostate-derived RNAs for biomarker discovery and prostate cancer status can be distinguished from analysis of these specimens. Continued analysis of urine EVs offers the potential discovery of novel biomarkers for pre- biopsy prostate cancer detection

Mayo Adhesive Probability Score Does Not Have Prognostic Ability in Locally Advanced Renal Cell Carcinoma

Nephrectomy remains standard treatment for renal cell carcinoma (RCC). The Mayo Adhesive Probability (MAP) score is predictive of adherent perinephric fat and associated surgical complexity, and is determined by assessing perinephric fat and stranding. MAP has additionally predicted progression-free survival (PFS), though primarily reported in stage T1-T2 RCC. Here, we examine MAP’s ability to predict overall survival (OS) and PFS in T3-T4 RCC. From our prospectively maintained RCC database, patients that underwent radical nephrectomy (2009-2016) with available abdominal imaging (<90 days preop) and T3/T4 RCC underwent MAP scoring. Survival analyses were conducted with MAP scores as individual (0-5) and dichotomized (0-3 vs 4-5) using Kaplan-Meier method. Multivariable Cox proportional hazard regression models for PFS and OS were built with backward elimination. 141 patients were included. 134 (95%) and 7 (5%) had pT3 and pT4 disease, respectively. 46.1% of patients had an inferior vena cava thrombus. Mean MAP score was 3.22±1.52, with 75 (53%) patients having a score between 0-3 and 66 (47%) having a score of 4-5. Both male gender (p=0.006) and clear cell histology (p=0.012) were associated with increased MAP scores. On Kaplan-Meier and multivariable analysis, no significant associations were identified between MAP and PFS (HR=1.01, 95% CI 0.85-1.20, p=0.93) or OS (HR=1.01, 95% CI 0.84-1.21, p=0.917). In this cohort of patients with locally advanced RCC, high MAP scores were not predictive of worse PFS or OS

epiCaPture: a urine DNA methylation test for early detection of aggressive prostate cancer

Purpose Liquid biopsies that noninvasively detect molecular correlates of aggressive prostate cancer (PCa) could be used to triage patients, reducing the burdens of unnecessary invasive prostate biopsy and enabling early detection of high-risk disease. DNA hypermethylation is among the earliest and most frequent aberrations in PCa. We investigated the accuracy of a six-gene DNA methylation panel (Epigenetic Cancer of the Prostate Test in Urine [epiCaPture]) at detecting PCa, high-grade (Gleason score greater than or equal to 8) and high-risk (D'Amico and Cancer of the Prostate Risk Assessment] PCa from urine. Patients and Methods Prognostic utility of epiCaPture genes was first validated in two independent prostate tissue cohorts. epiCaPture was assessed in a multicenter prospective study of 463 men undergoing prostate biopsy. epiCaPture was performed by quantitative methylation-specific polymerase chain reaction in DNA isolated from prebiopsy urine sediments and evaluated by receiver operating characteristic and decision curves (clinical benefit). The epiCaPture score was developed and validated on a two thirds training set to one third test set. Results Higher methylation of epiCaPture genes was significantly associated with increasing aggressiveness in PCa tissues. In urine, area under the receiver operating characteristic curve was 0.64, 0.86, and 0.83 for detecting PCa, high-grade PCa, and highrisk PCa, respectively. Decision curves revealed a net benefit across relevant threshold probabilities. Independent analysis of two epiCaPture genes in the same clinical cohort provided analytical validation. Parallel epiCaPture analysis in urine and matched biopsy cores showed added value of a liquid biopsy. Conclusion epiCaPture is a urine DNA methylation test for high-risk PCa. Its tumor specificity out-performs that of prostate-specific antigen (greater than 3 ng/mL). Used as an adjunct to prostate-specific antigen, epiCaPture could aid patient stratification to determine need for biopsy

A Study of Wireless Sensor Networks to Comprehend their Relevance to Different Applications

Wireless sensor networks (WSNs) have experienced enormous growth, both in terms of the technology used and their practical applications. In order to understand the features of WSNs that make the solution suitable for a specific purpose, one needs to be aware of the theoretical concepts behind and technological aspects of WSNs. In this paper, the significance of WSNs is illustrated, with a particular emphasis placed on their demands and on understanding researchrelated problems. A review of the literature available is presented as well. Detailed discussions concerning sensor node architecture, different types of sensors used and their relevance for various types of WSNs is presented, highlighting the need to achieve application-specific requirements without degrading service quality. Multipath and cluster-based routing protocols are compared in order to analyze QoS requirements they are capable of satisfying, and their suitability for different application areas is reviewed. This survey highlights the performance of different routing protocols, therefore providing guidelines enabling each of the routing techniques to be used, in an efficient manner, with factors such as specific network structure, protocol operation and routing path construction taken into consideration in order to achieve better performance

Differentiated Service Model-Supported Cluster-Based Routing in Wireless Sensor Networks

Wireless Sensor Network finds its extensive use in healthcare applications for the transfer of time-critical data through wireless connectivity. The primary cause of network failure is the transfer of time-critical multimedia data. The article presents a new dfferentiated service modelsupported (DSM) cluster-based routing in wireless sensor networks (WSNs) that overcomes the above issue. DSM prioritizes the transfer of dfferent flow types based on packet type and packet size. The employment of computational offlading minimizes delay for critical and small-sized data packets and by carrying out data reduction of large-sized packets at proxy server. It outperforms the existing protocols in terms of energy efficiency, throughput, and reliability by prioritizing the transfer of time-critical health application data