85 research outputs found

    SYNERGISTIC EFFECT OF SILVER NANOPARTICLES WITH DOXYCYCLINE AGAINST KLEBSIELLA PNEUMONIA

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    Objective: Green synthesis, characterization of silver nanoparticles (AgNPs) and study of the synergistic effect of AgNPs with antibiotic doxycycline against Klebsiella pneumonia.Methods: AgNps were synthesized from bacteria isolated from samples obtained from petroleum soil. After characterization of the nanoparticles, the antibacterial activity of the nanoparticle was studied, and simultaneously the same nanoparticle was used in combination with doxycycline antibiotic.Results: It was observed that compared to the effects of AgNps and antibiotic alone, the collective effect on both of them was more evident, which indicate the synergistic effect of the two components.Conclusion: These findings highlight the potential for AgNPs to enhance the activity of doxycycline antibiotic against Klebsiella pneumonia infections.Keywords: Silver nanoparticle, Green Synthesis, Klebsiella Pneumonia, Doxycyclin

    Initial‐valued first‐order fuzzy differential equation in Bi‐level inventory model with fuzzy demand

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    In the present paper, two methods for the solution of an initial valued first ordered fuzzy differential equation are presented and applied in a fuzzy EOQ model. The constructed model is a bi‐level inventory problem involving wholesaler‐retailers‐customers. The wholesaler buys and sells the item instantaneously to several retailers. In the next level, the retailers sell the units to customers with a time dependent imprecise demand, which introduce the fuzzy nature in the differential equation. The selling price of the item is a step‐wise time dependent decreasing function. The fuzzy objectives are transformed into crisp one following fuzzy extension principle and centroid formula. The model is illustrated through Interactive Fuzzy Decision Making (IFDM) and Multi Objective Genetic Algorithm (MOGA) and the results from two methods are compared. First Published Online: 14 Oct 201

    N-(6-{2-[6-(2,2-Dimethyl­propanamido)-2-pyrid­yl]eth­yl}-2-pyrid­yl)-2,2-dimethyl­propanamide

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    The title compound, C22H30N4O2, lies about a crystallographic inversion center. The whole mol­ecule is disordered over two positions with a refined occupancy ratio of 0.636 (10):0.364 (10). The pyridine rings are approximately planar, with maximum deviations of 0.033 (10) and 0.063 (17) Å for the major and minor components, respectively. The mean planes of the pyridine rings form dihedral angles of 17 (2)° in the major component and 18 (2)° in the minor component with the respective formamide groups attached to them. In the crystal packing, inter­molecular N—H⋯O and C—H⋯O hydrogen bonds link the mol­ecules into two-dimensional networks parallel to the ab plane

    2,7-Dimethyl-1,8-naphthyridine

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    The asymmetric unit of the title compound, C10H10N2, contains one half-mol­ecule with the two shared C atoms lying on a twofold rotation axis. The 1,8-naphthyridine is almost planar with a dihedral angle of 0.42 (3)° between the fused pyridine rings. In the crystal, mol­ecules are linked into infinite chains along the c axis by inter­molecular C—H⋯N hydrogen bonds, generating R 2 2(8) ring motifs. In addition, the crystal structure is further stabilized by C—H⋯π inter­actions

    Quinoxaline-2-carbonitrile

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    In the title compound, C9H5N3, the quinoxaline ring is essentially planar, with a maximum deviation of 0.012 (1) Å. Short inter­molecular distances between the centroids of the 2,3-dihydro­pyrazine and benzene rings [3.6490 (5) Å] indicate the existence of π⋯π inter­actions. In the crystal packing, the mol­ecules are linked via two pairs of inter­molecular C—H⋯N inter­actions, forming R 2 2 (8) and R 2 2 (10) ring motifs; these mol­ecules are further linked into a two-dimensional network parallel to (1 0 2) via another C–H⋯N inter­action

    N-(6-Bromo­meth­yl-2-pyrid­yl)acetamide

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    The title acetamide compound, C8H9BrN2O, crystallizes with three crystallographically independent mol­ecules (A, B and C) in the asymmetric unit. In mol­ecule A, the mean plane through the acetamide unit is inclined at a dihedral angle of 4.40 (11)° with respect to the pyridine ring [10.31 (12) and 2.27 (11)°, respectively, for mol­ecules B and C]. In the crystal structure, mol­ecules are inter­connected into sheets parallel to the ac plane by N—H⋯O, C—H⋯Br, C—H⋯O and C—H⋯N hydrogen bonds. The structure is further stabilized by weak inter­molecular C—H⋯π inter­actions
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