Application of TVS Models for SEED Simulation of a Variety of TVS Devices

Accurate Models of Transient Voltage Suppression (TVS) Devices Are Important for Determining the Suitability of Electrostatic Discharge (ESD) Protection Strategies Early in the Design Process. an Improved TVS Model is Used in the Following Paper to Represent a Variety of TVS Devices, Including a Snapback Device, Non-Snapback Device, and a Varistor. the Models Include Recent Improvements to Represent Conductivity Modulation and the overall Shape of the TVS Device\u27s Transient Response. the Models Are Tuned based on Characterizations of These Protection Devices using a Transmission Line Pulse (TLP) and Are Then Used in a System Efficient ESD Design (SEED) Simulation to Predict the Transient Voltages and Currents in a System Consisting of an Off-Chip TVS, an IC with On-Chip ESD Protection, and a PCB Trace in Between. Simulated Transient Voltage and Current Waveforms Closely Match Measurements Both When Testing the TVS Devices by Themselves and in SEED Simulations. Peak and Quasistatic Currents through the TVS and On-Chip Diode Were Typically Captured within About 10% or Less Across the Devices Tested While Varying Both the Rise Time and Level of the Injected TLP

Modeling an ESD Gun Discharge to a USB Cable

When an electrostatic discharge (ESD) gun discharges to a USB cable, the routing and quality of the cable impacts the waveform seen at the printed circuit board (PCB) connected to the cable and the ability of an on-board transient voltage suppressor (TVS) to protect sensitive electronics. The impact of cable configurations during ESD gun contact discharge tests was investigated for multiple cable configurations. Injection to a cable pin whose shield is \u27floating\u27 at the injection site can cause a double-peak in the ESD waveform at the PCB and a lower maximum stress level than when the cable shield is connected to the return plane. Poor shielding of the USB connector can further induce a pre-pulse effect, where a smaller ESD pulse arrives at the PCB before the main pulse. This pre-pulse can result in poor firing of the TVS device and thus worsen ESD stress at a sensitive IC. Circuit models were developed to anticipate and explain both of these phenomena. These models were incorporated into a system-level transient simulation including models of a PCB with a TVS and a pair of on-chip diodes. This system-level model was able to predict the quasi-static and peak voltages and currents at the on-chip diode during 1-8 kV ESD contact-discharge tests with various USB cable configurations to within less than 30%. These models were used to develop test and design guidelines to account for the impact of the quality and configuration of a USB cable during an ESD discharge

A Physics-Based Model For Snapback-Type ESD Protection Devices

A simplified physical-based model for deep-snapback transient voltage suppressors (TVS) is developed in this article. While based on physics, the number of parameters and components is minimized, so the model can be tuned easily from available measurements of the packaged TVS. SPICE convergence issues seen in previous snapback device models are eliminated by adding nonlinear damping components to the model. No convergence issues were seen among any of the simulations performed for this study, which includes transmission-line pulse tests with multiple levels and rise times. The proposed model was used to represent two different TVS devices and was validated in both device- and system-level simulations. Simulations of quasi-static and transient behavior matched measurement results within about 20% among all the tested cases

Blooms of cyanobacteria in a temperate Australian lagoon system post and prior to European settlement

Blooms of noxious N2 fixing cyanobacteria such as Nodularia spumigena are a recurring problem in some estuaries; however, the historic occurrence of such blooms in unclear in many cases. Here we report the results of a palaeoecological study on a temperate Australian lagoon system (the Gippsland Lakes) where we used stable isotopes and pigment biomarkers in dated cores as proxies for eutrophication and blooms of cyanobacteria. Pigment proxies show a clear signal, with an increase in cyanobacterial pigments (echinenone, canthaxanthin and zeaxanthin) in the period coinciding with recent blooms. Another excursion in these proxies was observed prior to the opening of an artificial entrance to the lakes in 1889, which markedly increased the salinity of the Gippsland Lakes. A coincident increase in the sediment organic-carbon content in the period prior to the opening of the artificial entrance suggests that the bottom waters of the lakes were more stratified and hypoxic, which would have led to an increase in the recycling of phosphorus. After the opening of the artificial entrance, there was a  ∼  60-year period with low values for the cyanobacterial proxies as well as a low sediment organic-carbon content suggesting a period of low bloom activity associated with the increased salinity of the lakes. During the 1940s, the current period of re-eutrophication commenced, as indicated by a steadily increasing sediment organic-carbon content and cyanobacterial pigments. We suggest that increasing nitrogen inputs from the catchment led to the return of hypoxia and increased phosphorus release from the sediment, which drove the re-emergence of cyanobacterial blooms

Intradural Spinal Cord Stimulation: Performance Modeling of a New Modality

Introduction: Intradural spinal cord stimulation (SCS) may offer significant therapeutic benefits for those with intractable axial and extremity pain, visceral pain, spasticity, autonomic dysfunction and related disorders. A novel intradural electrical stimulation device, limited by the boundaries of the thecal sac, CSF and spinal cord was developed to test this hypothesis. In order to optimize device function, we have explored finite element modeling (FEM).Methods: COMSOL®Multiphysics Electrical Currents was used to solve for fields and currents over a geometric model of a spinal cord segment. Cathodic and anodic currents are applied to the center and tips of the T-cross component of the electrode array to shape the stimulation field and constrain charge-balanced cathodic pulses to the target area.Results: Currents from the electrode sites can move the effective stimulation zone horizontally across the cord by a linear step method, which can be diversified considerably to gain greater depth of penetration relative to standard epidural SCS. It is also possible to prevent spread of the target area with no off-target action potential.Conclusion: Finite element modeling of a T-shaped intradural spinal cord stimulator predicts significant gains in field depth and current shaping that are beyond the reach of epidural stimulators. Future studies with in vivo models will investigate how this approach should first be tested in humans

Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19

IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19. Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19. DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 non–critically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022). INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (n = 257), ARB (n = 248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; n = 10), or no RAS inhibitor (control; n = 264) for up to 10 days. MAIN OUTCOMES AND MEASURES The primary outcome was organ support–free days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes. RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ support–free days among critically ill patients was 10 (–1 to 16) in the ACE inhibitor group (n = 231), 8 (–1 to 17) in the ARB group (n = 217), and 12 (0 to 17) in the control group (n = 231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ support–free days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively). CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes. TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570

Measurements on planktonic cyanobacteria : sinking, survival & turgor

EThOS - Electronic Theses Online ServiceGBUnited Kingdo

Assimilation of diazotrophic nitrogen into pelagic food webs

The fate of diazotrophic nitrogen (N(D)) fixed by planktonic cyanobacteria in pelagic food webs remains unresolved, particularly for toxic cyanophytes that are selectively avoided by most herbivorous zooplankton. Current theory suggests that N(D) fixed during cyanobacterial blooms can enter planktonic food webs contemporaneously with peak bloom biomass via direct grazing of zooplankton on cyanobacteria or via the uptake of bioavailable N(D) (exuded from viable cyanobacterial cells) by palatable phytoplankton or microbial consortia. Alternatively, N(D) can enter planktonic food webs post-bloom following the remineralization of bloom detritus. Although the relative contribution of these processes to planktonic nutrient cycles is unknown, we hypothesized that assimilation of bioavailable N(D) (e.g., nitrate, ammonium) by palatable phytoplankton and subsequent grazing by zooplankton (either during or after the cyanobacterial bloom) would be the primary pathway by which N(D) was incorporated into the planktonic food web. Instead, in situ stable isotope measurements and grazing experiments clearly documented that the assimilation of N(D) by zooplankton outpaced assimilation by palatable phytoplankton during a bloom of toxic Nodularia spumigena Mertens. We identified two distinct temporal phases in the trophic transfer of N(D) from N. spumigena to the plankton community. The first phase was a highly dynamic transfer of N(D) to zooplankton with rates that covaried with bloom biomass while bypassing other phytoplankton taxa; a trophic transfer that we infer was routed through bloom-associated bacteria. The second phase was a slowly accelerating assimilation of the dissolved-N(D) pool by phytoplankton that was decoupled from contemporaneous variability in N. spumigena concentrations. These findings provide empirical evidence that N(D) can be assimilated and transferred rapidly throughout natural plankton communities and yield insights into the specific processes underlying the propagation of N(D) through pelagic food webs

Sinking velocities of phytoplankton measured on a stable density gradient by laser scanning

Two particular difficulties in measuring the sinking velocities of phytoplankton cells are preventing convection within the sedimenting medium and determining the changing depth of the cells. These problems are overcome by using a density-stabilized sedimentation column scanned by a laser. For freshwater species, a suspension of phytoplankton is layered over a vertical density gradient of Percoll solution; as the cells sink down the column their relative concentration is measured by the forward scattering of light from a laser beam that repeatedly scans up and down the column. The Percoll gradient stabilizes the column, preventing vertical mixing by convection, radiation or perturbation of density by the descending cells. Measurements were made on suspensions of 15 μm polystyrene microspheres with a density of 1050 kg m(−3); the mean velocity was 6.28 μm s(−1), within 1.5% of that calculated by the Stokes equation, 6.36 μm s(−1). Measurements made on the filamentous cyanobacterium Planktothrix rubescens gave mean velocities within the theoretical range of values based on the range of size, shape, orientation and density of the particles in a modified Stokes equation. Measurements on marine phytoplankton may require density gradients prepared with other substances