Stability design criteria and volt var control for distribution system with single phase solid state transformers

Due to recent advancements in semiconductor technology, power electronic converters for high voltage, high power, and high frequency applications will soon be commercially available. Conventional single phase distribution transformers are replaced by solid state transformers (SST) in a distribution test system to investigate their interactive dynamics. Under certain circumstances, instabilities due to harmonic resonance are observed. A design criterion for solid state transformer during no load conditions has been proposed in order to avoid instability using an impedance-based analysis. Stability assessment is also extended to include the impact of distribution system voltages and system wide impedance analysis. It is shown that if the SST filters throughout the system are designed with regards to the proposed stability criterion, then system stability is guaranteed regardless of configuration. This leads to two resulting applications: (1) the order in which the SSTs are connected to the system will not generate instability if the criterion is satisfied, and (2) a system configuration change due to a fault will not produce instability. In distribution power systems, feeder voltages can be very sensitive to changes in load and/or distributed generation. A solid-state-transformer-based local voltage control strategy is introduced to reduce variability distribution system bus voltages. An on-line dynamic volt-var control (VVC) algorithm is proposed to regulate bus voltages by injecting or absorbing reactive power through a solid state transformer. The main goal of the algorithm is to enforce strict voltage constraints on the system voltages. The proposed control algorithm is validated in both a radial and meshed distribution system. --Abstract, page iii

Experimental Evaluation of Cache-Related Preemption Delay Aware Timing Analysis

In the presence of caches, preemptive scheduling may incur a significant overhead referred to as cache-related preemption delay (CRPD). CRPD is caused by preempting tasks evicting cached memory blocks of preempted tasks, which have to be reloaded when the preempted tasks resume their execution. In this paper we experimentally evaluate state-of-the-art techniques to account for the CRPD during timing analysis. We find that purely synthetically-generated task sets may yield misleading conclusions regarding the relative precision of different CRPD analysis techniques and the impact of CRPD on schedulability in general. Based on task characterizations obtained by static worst-case execution time (WCET) analysis, we shed new light on the state of the art

In the Treatment of Patients With Knee Joint Osteoarthritis, Are Platelet Rich Plasma Injections More Effective Than Hyaluronic Acid Injections?

Objective: The objective of this selective EBM review is to determine whether or not In the treatment of patients with knee joint osteoarthritis, are Platelet Rich Plasma injections more effective than Hyaluronic acid injections? Study Design: Review of one randomized double-blind trial, one randomized cohort study, and one randomized control trial published in the English language in the year 2012. Data Sources: All studies were published in peer-reviewed journals found via the use of PubMed. Outcome(s) Measured: Patients were divided into two groups: those who received platelet rich plasma injections (PRP) and those who received hyaluronic injections (HA). Efficacy of PRP injections was compared to the efficacy of HA injections. Outcomes were measured at baseline and various monthly intervals post treatment using WOMAC scores. In addition, outcomes were measured by giving the 11 point pain intensity Numeric Rating scale (NRS), IKDC, and KOOS scores. Results: In two studies, results of PRP injections versus HA injections reached statistical significance and proved to be an effective form of treatment in patients with knee osteoarthritis (p \u3c 0.01). In the third study, however, there was no statistical significance indicated in the use of PRP injections as compared to HA injections. More research studies are necessary to understand the full effect of PRP injections in the treatment of knee osteoarthritis. Conclusion: Overall, PRP injections alone cannot be the first line of treatment used for knee osteoarthritis. However, PRP injections are a safe and viable option for patients who do not benefit from other treatments like HA injections. They also tend to have a better effect on patients with lower-grade knee osteoarthritis

Uterine Perforation With Subtotal Small Bowel Prolapse – A Rare Complication of Dilatation and Curettage

Uterine perforation is the well known complication of induced abortion. We report a rare case of uterine perforation with subtotal prolapse of small bowel following first trimester abortion by an unqualified physician. Early surgical exploration with resection and anastomosis of bowel performed. Patient discharged uneventfully after postoperative recovery

FORMULATION, EVALUATION AND OPTIMIZATION OF SUSTAINED-RELEASE DRUG DELIVERY SYSTEM OF CISAPRIDE TABLET

Objective: Cisapride is a novel prokinetic agent is best candidate for GERD. Cisapride 20 mg can be given thrice in a day given along with Proton pump inhibitor. By developing the sustain release formulation of Cisapride, the frequency of both drug can be reduce to once only to obtain good therapeutic response. Methods: Cisapride SR Tablets were prepared by direct compression technique with HPMC K4M and HPMC K100M polymers. Followed by various evaluation tests including in vitro disintegration and dissolution, the formulation was optimized by 32 full factorial designs with drug release kinetic analysis, compatibility studies (FTIR) and stability studies. Results: Results of Preformulation studies of the Cisapride indicate that it has poor flow property and compressibility property. To improve the flow and compressibility property, it was beneficial to use the directly compressible grade components in the formulation of tablet. Results of DSC study shown that there is no change in drug’s melting peak after the preparation of tablet. Hydrophilic matrix of HPMC K4M and HPMC K100M in combination sustained the Cisapride release effectively for more than 12h. The result indicates that the combination of HPMCK4M and HPMCK100M can be successfully, On the basis of the preliminary trials in the present study a32 full factorial design was employed to study the effect of independent variables, i.e. concentration of HPMCK4M(X1) and concentration of HPMCK100M(X2)on dependent variables like% drug release Q2, Q6 and Q10. Drug release is also dependent on the size of matrix tablets so, size and surface area was kept constant. Factorial batches F018, F019, F020, and F021 give the f2 value 75-100. Factorial batch F019 gives the highest f2 value 86.04 and also all the hour’s drug release was within the specified limits. Conclusion: The prepared formulation of Cisapride sustains release matrix tablet was stable and effective in treatment

SCREENING AND CHARACTERISTIC STUDY OF ANTIMICROBIAL ACTINOMYCETES FROM NEAR-BY SOIL OF MEDICINAL PLANTS

Objective: Isolation and characterization study of actinomycetes from soil near medicinal plants in saurashtra region of Gujarat which can produce antimicrobial compounds.Methods: Present study 11 different medicinal plants 3 regions of saurashtra selected. Microflora part of soil was used. Different media used for isolation. Microscopic methods used for Study of colony characteristics, arial and vegetative mycelium color and morphological examination of isolates. Primary screening was done by using cross streak method while for secondary screening well diffusion techniques with thin layer chromatography and bioautography. Antimicrobial activity of most potent isolates check against test organisms. Different biochemical methods used for characterization of the most active isolate.Results: It was found that out of 66 actinomycetes isolates 45 (68.2 %) actinomycetes isolates were showing activity against test microbes. In the primary screening, 15 actinomycets isolates showed good antimicrobial activity. Out of these 15 actinomycetes isolates 5 isolates GOS1, JOS1, GOS3, GTF1 and JTF1 showing a broad spectrum of activity against microorganisms. It was found that out of this 5 isolates GOS1 was most potent antagonistic actinomycetes. Characterizations, as well as optimization studies of actinomycetes, isolates GOS1 which may use to produce new and useful antimicrobial compounds and other metabolites.Conclusion: It was concluded that actinomycetes isolates from different soil samples nearby medicinal plant area of saurashtra region are a good source to produce many useful antimicrobial compounds and other metabolites

Study the accuracy of salivary ferning test as a predictor of ovulation

Background: Women probably spent much of their adult life avoiding getting pregnant but when they are actively trying for a baby, it may be taking a little longer time than they hoped. So it is important for the women to know when they are ovulating. Recently, a small hand held microscope (KNOWHEN ovulation microscope) has been developed for the purpose of self-observing ferning patterns in saliva during female fertile period. The purpose of our study is to evaluate the accuracy of salivary ferning test by KNOWHEN ovulation microscope to predict the ovulation and to detect sensitivity and specificity of salivary ferning test and to correlate the salivary ferning with cervical mucus and Trans vaginal sonographic findings (TVS).Methods: This was a prospective observational type of study conducted on all healthy married women volunteers age between 21–40 years attending gynec OPD in sola civil hospital, Ahmedabad, with regular menstrual cycle From April 2016 to September 2016.Results: Salivary ferning test by KNOWHEN ovulation microscope is accurate method of detecting ovulation. Its accuracy was 86.5%.Conclusions: Salivary ferning test is a reliable test to detect fertile period of menstrual cycle. Hence can be use for monitoring ovulation instead of ultrasonography where facility of ultrasonography will not available. Detection of salivary ferning by KNOWHEN microscope has same accuracy as laboratory microscope. KNOWHEN microscope can be use by patient herself to detect fertile period

Endogenous, controlled expression of anti-HIV-1 broadly neutralizing antibody

Recently, researchers have identified a number of anti-HIV broadly neutralizing antibodies (bNAbs), such as VRC01 and N6, capable of targeting a broad range of HIV-1 strains. Passive immunization using these patient-derived bNAbs could provide temporary protection but are limited by the short antibody half-life. While current gene transfer technology allows sustained bNAb expression, it lacks the ability to control bNAb production in vivo resulting in possible autoimmunity. To address this issue of achieving controlled bNAb expression in vivo, we hypothesize that bNAb expression from transduced Flu-specific B cells can be activated and modulated by subsequent Flu immunizations in the Flu-preimmunized animal. In this preliminary study, we have constructed a bNAb (N6 and VRC01) -expressing murine retroviral vector (MIGR) and successfully transduced Flu-specific primary B cells. Following transfusion of these cells into Flu-immunized recipient mice, we observed an anamnestic N6 antibody response with subsequent Flu immunizations