Developing and maintaining national food safety control systems: Experiences from the WHO African region

The establishment of effective food safety systems is pivotal to ensuring the safety of the national food supply as well as food products for regional and international trade. The development, structure and implementation of modern food safety systems have been driven over the years by a number of developments. These developments include: a reorientation of quality assurance protocols; emphasis on the development of integrated and holistic food safety systems with a farm-to-table approach; increasedrecognition of the respective roles of the different stakeholders along the food chain; increased food trade coupled with obligations under trade agreements; and advances in the control of foodborne hazards. At its core, a modern food safety system includes enabling food laws, policies, regulations and standards; mechanisms for coordination; operational food inspection and laboratory services as well as national information,education and communication programmes. While progress has been made in some countries in the WHO African Region at modernizing their food safety systems, many others are still grappling with the basics for development of effective food control systems. The traditional food control systems in a number of African countries do not provide the concerned agencies with a clear mandate and authority to prevent food safety problems. Effective food control in a number of these countries is undermined by a number of challenges including limited awareness about food safety, inadequate enabling policy, outdated legislation and regulations; inadequate coordination; and inadequate capacity and resources for food safety. This paper reviews the components of a modern national food safety control system and examines efforts at strengthening national food safety control systems in the African Region. It includesexperiences from countries that have made efforts at strengthening their national food safety control systems in view of current developments. The paper further discusses some of the challenges of food control systems in the Region and prospects for improvements. It concludes by suggesting the way forward for improving national food safety control systems in the Region

The Different Artificial Sweeteners and Their Effects on Endothelial Cell/Blood Vessel Health: Possible Implications for Ringing in the Ear

Abstract: Background: Tinnitus, a condition whose remarkable symptom is ringing in the ear (RIE), is a problem plaguing people all around the world in varying degrees of severity, though it is most common and severe in older populations. Literature is lacking on its etiology. Therefore, it is difficult to diagnose and treat. Several possible components could play a role in the development of tinnitus including neurological, physiological, traumatic, dietary and vascular factors. No factor has yet been definitively linked to the development of tinnitus. Vascular health can be significantly impacted by diet- especially in regard to sugars. As artificial sweeteners are used widely in the American diet, they may play a significant role in vascular health. Objective: This project aims to investigate a possible connection between artificial sugars’ impact on vascular health and complaints of RIE among age groups through a patient survey and laboratory experiments. Methods: A survey assessing individuals’ demographic information, subjective severity of RIE and reported artificial sweetener consumption will be distributed to audiologists’ offices in major Ohio cities, via Qualtrics, where patients will complete them. Data collected will be analyzed for interrelationships among sugar intake, age and severity of RIE. In the laboratory, an ELISA assay will evaluate the effects of artificial sweeteners on endothelial cells- the same cells that comprise blood vessels- through quantifying stimulation of the Tie-2 survival and angiogenesis pathway via the cellular messenger pAKT

Parkinson's disease may disrupt overlapping subthalamic nucleus and pallidal motor networks.

There is an ongoing debate about differential clinical outcome and associated adverse effects of deep brain stimulation (DBS) in Parkinson's disease (PD) targeting the subthalamic nucleus (STN) or the globus pallidus pars interna (GPi). Given that functional connectivity profiles suggest beneficial DBS effects within a common network, the empirical evidence about the underlying anatomical circuitry is still scarce. Therefore, we investigate the STN and GPi-associated structural covariance brain patterns in PD patients and healthy controls. We estimate GPi's and STN's whole-brain structural covariance from magnetic resonance imaging (MRI) in a normative mid- to old-age community-dwelling cohort (n = 1184) across maps of grey matter volume, magnetization transfer (MT) saturation, longitudinal relaxation rate (R1), effective transversal relaxation rate (R2*) and effective proton density (PD*). We compare these with the structural covariance estimates in patients with idiopathic PD (n = 32) followed by validation using a reduced size controls' cohort (n = 32). In the normative data set, we observed overlapping spatially distributed cortical and subcortical covariance patterns across maps confined to basal ganglia, thalamus, motor, and premotor cortical areas. Only the subcortical and midline motor cortical areas were confirmed in the reduced size cohort. These findings contrasted with the absence of structural covariance with cortical areas in the PD cohort. We interpret with caution the differential covariance maps of overlapping STN and GPi networks in patients with PD and healthy controls as correlates of motor network disruption. Our study provides face validity to the proposed extension of the currently existing structural covariance methods based on morphometry features to multiparameter MRI sensitive to brain tissue microstructure

Equation of State and Thermometry of the 2D SU(NN) Fermi-Hubbard Model

We characterize the equation of state (EoS) of the SU($N>2$) Fermi-Hubbard Model (FHM) in a two-dimensional single-layer square optical lattice. We probe the density and the site occupation probabilities as functions of interaction strength and temperature for $N = 3, 4$ and 6. Our measurements are used as a benchmark for state-of-the-art numerical methods including determinantal quantum Monte Carlo (DQMC) and numerical linked cluster expansion (NLCE). By probing the density fluctuations, we compare temperatures determined in a model-independent way by fitting measurements to numerically calculated EoS results, making this a particularly interesting new step in the exploration and characterization of the SU($N$) FHM.Comment: 8 pages, 3 figures; Supplemental Materia

Evaluation of the Anticancer Activity of Bioactive Fraction G Extracted from \u3cem\u3ePavetta crassipes\u3c/em\u3e in Malignant Brain Tumor Cell Lines

Objective: Natural products have served as sources of lead compounds that are commonly used in the treatment of human diseases including cancer. Pavetta crassipes has been widely demonstrated to have ethnopharmacological potential in the management of malaria, gastrointestinal conditions, central nervous system behavioral disorders, hypertension, and cancer. The goal of our study was to evaluate the biological and molecular effects of Fraction G, obtained from the plant Pavetta crassipes, on glioblastoma invasive growth and survival. Methodology: The antiproliferative effects of Fraction G, obtained from Pavetta crassipes, was evaluated using the trypan blue exclusion, (3-(4, 5-Dimethylthiazol- 2yl)-2, 5-Diphenyltetrazolium Bromide; MTT), and lactate dehydrogenase (LDH) assays. Flow cytometry and Western blotting analyses were carried out to examine the effects of Fraction G on cell cycle check-points and its effects on epidermal growth factor receptor-mediated signaling of AKT and MAPK pathways. Results: In this paper, we report that the Fraction G obtained from the plant Pavetta crassipes induced a reduction in glioma cell viability and proliferation as well as induced an increase in apoptosis as evidenced by cleaved PARP, increased caspase 3/7 activity, and cell cycle arrest in the G0/G1 check point. Furthermore, we report that Fraction G inhibited the phosphorylation of AKT and MAPK following EGF treatment. Conclusion: Taken together, our results demonstrate that Fraction G has potent inhibitory effects on pathways involved in glioblastoma proliferation and survival

A Fermi-degenerate three-dimensional optical lattice clock

Strontium optical lattice clocks have the potential to simultaneously interrogate millions of atoms with a high spectroscopic quality factor of $4 \times 10^{-17}$. Previously, atomic interactions have forced a compromise between clock stability, which benefits from a large atom number, and accuracy, which suffers from density-dependent frequency shifts. Here, we demonstrate a scalable solution which takes advantage of the high, correlated density of a degenerate Fermi gas in a three-dimensional optical lattice to guard against on-site interaction shifts. We show that contact interactions are resolved so that their contribution to clock shifts is orders of magnitude lower than in previous experiments. A synchronous clock comparison between two regions of the 3D lattice yields a $5 \times 10^{-19}$ measurement precision in 1 hour of averaging time.Comment: 19 pages, 4 figures; Supplementary Material

Realizing Inclusive SAI: Contextualizing indicators to better evaluate gender and intergenerational inequity in SAI processes and outcomes - Cases from Southern and Western Africa

Despite increasing sustainable agricultural intensification (SAI) investments, indicators for detecting gender and intergenerational inequities in SAI costs and benefits sharing often remain overgeneralized, theoretical, or locally irrelevant. We examine the relative value of, and how to, customize standard SAI indicators to detect such inequities in specific socio-cultural contexts to enhance data collection for evidence-based decision making in fostering gender/youth inclusive SAI. Using focus-group discussions and key informant interviews among farmers and diverse government, NGO, private sector, and academic stakeholders in two districts in Malawi and three in Ghana, we assess the perceived roles, differentiated needs/ priorities of men, women and youth, and the sharing of SAI burdens and benefits within farming households. We investigate what context-appropriate questions to ask, to whom, and how, to collect reliable information on indicators of SAIinvestment inequities. Results illuminate context-specific, gendered and intergenerational factors shaping access to and ownership of productive resources, household decision making, SAI participation, and appropriateness of selected indicators. Combining farmers’ and local field-expert’ perspectives offers practical insights for customizing inequity indicators. Findings highlight advantages of local contextualization of SAI indicators, including insights on appropriate data-collection approaches that challenge orthodox survey/quantitative methods for detecting and assessing gender/age inequities to foster inclusive SAI