High-TC_C superconductivity in La3Ni2O7\mathrm{La_3Ni_2O_7} based on the bilayer two-orbital t-J model

The recently discovered high-T$_C$ superconductor La$_3$Ni$_2$O$_7$ has sparked renewed interest in the unconventional superconductivity. Here we study the unconventional superconductivity in pressurized La$_3$Ni$_2$O$_7$ based on a bilayer two-orbital $t-J$ model, using the renormalized mean-field theory. Our results reveal a robust $s^\pm-$wave pairing driven by the inter-layer $d_{z^2}$ magnetic coupling, which exhibits a transition temperature within the same order of magnitude as the experimentally observed $T_c \sim 80$ K. We obtain a comprehensive superconducting phase diagram in the doping plane. Notably, the La$_3$Ni$_2$O$_7$ under pressure is found situated roughly in the optimal doping regime of the phase diagram. When the $d_{x^2-y^2}$ orbital becomes close to half-filling, $d-$wave and $d+is$ pairing can emerge from the system. We discuss the interplay between the Fermi surface topology and different pairing symmetries. The stability of the $s^\pm-$wave pairing against Hund's coupling and other magnetic exchange couplings is examined.Comment: 8 pages, 8 figure

Effects of pulsed anodic oxide on the intermixing in InGaAs/GaAs and LnGaAs/AlGaAs quantum wells

Intermixing in InGaAs/AlGaAs quantum well structures was studied with and without an anodic oxide cap by rapid thermal annealing. Blueshifts in the photoluminescence (PL) energy were observed. Anodic oxide was demonstrated to suppress the blueshift noticeably. The suppression of the blueshift was attributed to a strain reduction.published_or_final_versio

Recent Advances on the Machine Learning Methods in Identifying DNA Replication Origins in Eukaryotic Genomics

The initiate site of DNA replication is called origins of replication (ORI) which is regulated by a set of regulatory proteins and plays important roles in the basic biochemical process during cell growth and division in all living organisms. Therefore, the study of ORIs is essential for understanding the cell-division cycle and gene expression regulation so that scholars can develop a new strategy against genetic diseases by using the knowledge of DNA replication. Thus, the accurate identification of ORIs will provide key clues for DNA replication research and clinical medicine. Although, the conventional experiments could provide accurate results, they are time-consuming and cost ineffective. On the contrary, bioinformatics-based methods can overcome these shortcomings. Especially, with the emergence of DNA sequences in the post-genomic era, it is highly expected to develop high throughput tools to identify ORIs based on sequence information. In this review, we will summarize the current progress in computational prediction of eukaryotic ORIs including the collection of benchmark dataset, the application of machine learning-based techniques, the results obtained by these methods, and the construction of web servers. Finally, we gave the future perspectives on ORIs prediction. The review provided readers with a whole background of ORIs prediction based on machine learning methods, which will be helpful for researchers to study DNA replication in-depth and drug therapy of genetic defect

β-AR Blockers Suppresses ER Stress in Cardiac Hypertrophy and Heart Failure

Long-term β-adrenergic receptor (β-AR) blockade reduces mortality in patients with heart failure. Chronic sympathetic hyperactivity in heart failure causes sustained β-AR activation, and this can deplete Ca(2+) in endoplasmic reticulum (ER) leading to ER stress and subsequent apoptosis. We tested the effect of β-AR blockers on ER stress pathway in experimental model of heart failure.ER chaperones were markedly increased in failing hearts of patients with end-stage heart failure. In Sprague-Dawley rats, cardiac hypertrophy and heart failure was induced by abdominal aortic constriction or isoproterenol subcutaneous injection. Oral β-AR blockers treatment was performed in therapy groups. Cardiac remodeling and left ventricular function were analyzed in rats failing hearts. After 4 or 8 weeks of banding, rats developed cardiac hypertrophy and failure. Cardiac expression of ER chaperones was significantly increased. Similar to the findings above, sustained isoproterenol infusion for 2 weeks induced cardiac hypertrophy and failure with increased ER chaperones and apoptosis in hearts. β-AR blockers treatment markedly attenuated these pathological changes and reduced ER stress and apoptosis in failing hearts. On the other hand, β-AR agonist isoproterenol induced ER stress and apoptosis in cultured cardiomyocytes. β-AR blockers largely prevented ER stress and protected myocytes against apoptosis. And β-AR blockade significantly suppressed the overactivation of CaMKII in isoproterenol-stimulated cardiomyocytes and failing hearts in rats.Our results demonstrated that ER stress occurred in failing hearts and this could be reversed by β-AR blockade. Alleviation of ER stress may be an important mechanism underlying the therapeutic effect of β-AR blockers on heart failure

Anodic-oxide-induced intermixing in GaAs-AlGaAs quantum-well and quantum-wire structures

Anodic oxides of GaAs were shown to enhance the intermixing in GaAs-AlGaAs quantum wells (QW) during rapid thermal processing. Proximity of the anodic oxide to the QW has been shown to influence the photoluminescence (PL) energy shift due to intermixing. Anodic oxide induced intermixing has been used to enhance quantum-wire PL in the structures grown on V-groove patterned GaAs substrates. This has been attributed to enhanced lateral confinement in these structures. Injection of defects such as group-III vacancies or interstitials was considered to be driving force for the intermixing.published_or_final_versio

ieee access special section editorial multimedia analysis for internet of things

Big data processing includes both data management and data analytics. The data management step requires efficient cleaning, knowledge extraction, and integration and aggregation methods, whereas Internet-of-Multimedia-Things (IoMT) analysis is based on knowledge modeling and interpretation, which is more often performed by exploiting deep learning architectures. In the past couple of years, merging conventional and deep learning methodologies has exhibited great promise in ingesting multimedia big data, exploring the paradigm of transfer learning, association rule mining, and predictive analytics etc

Towards an optimal therapy strategy for myogenous TMD, physiotherapy compared with occlusal splint therapy in an RCT with therapy-and-patient-specific treatment durations

Appendix. Threshold of signs and symptoms. Post-hoc power analysis on measures of effectiveness. Two-way ANOVA statistical analysis for pain intensity. Rules for progressing and ending splint therapy. Rules for progressing and ending physiotherapy. A stepped-care model including two possible therapies. (PDF 86 kb

Molecular Cloning of the Genes Encoding the PR55/Bβ/δ Regulatory Subunits for PP-2A and Analysis of Their Functions in Regulating Development of Goldfish, Carassius auratus

The protein phosphatase-2A (PP-2A), one of the major phosphatases in eukaryotes, is a heterotrimer, consisting of a scaffold A subunit, a catalytic C subunit and a regulatory B subunit. Previous studies have shown that besides regulating specific PP-2A activity, various B subunits encoded by more than 16 different genes, may have other functions. To explore the possible roles of the regulatory subunits of PP-2A in vertebrate development, we have cloned the PR55/B family regulatory subunits: β and δ, analyzed their tissue specific and developmental expression patterns in Goldfish ( Carassius auratus). Our results revealed that the full-length cDNA for PR55/Bβ consists of 1940 bp with an open reading frame of 1332 nucleotides coding for a deduced protein of 443 amino acids. The full length PR55/Bδ cDNA is 2163 bp containing an open reading frame of 1347 nucleotides encoding a deduced protein of 448 amino acids. The two isoforms of PR55/B display high levels of sequence identity with their counterparts in other species. The PR55/Bβ mRNA and protein are detected in brain and heart. In contrast, the PR55/Bδ is expressed in all 9 tissues examined at both mRNA and protein levels. During development of goldfish, the mRNAs for PR55/Bβ and PR55/Bδ show distinct patterns. At the protein level, PR55/Bδ is expressed at all developmental stages examined, suggesting its important role in regulating goldfish development. Expression of the PR55/Bδ anti-sense RNA leads to significant downregulation of PR55/Bδ proteins and caused severe abnormality in goldfish trunk and eye development. Together, our results suggested that PR55/Bδ plays an important role in governing normal trunk and eye formation during goldfish development

A phase 4 multicentre, 2×2 factorial randomised, double-blind, placebo-controlled trial to investigate the efficacy and safety of tobramycin inhalation solution for Pseudomonas aeruginosa eradication in bronchiectasis:Erase

Chronic Pseudomonas aeruginosa (PA) infection significantly contributes to morbidity and mortality in bronchiectasis patients. Initiating antibiotics early may lead to the eradication of PA. Here we outline the design of a trial (ERASE; NCT06093191) assessing the efficacy and safety of inhaled tobramycin, alone or with oral ciprofloxacin, in bronchiectasis patients with a new isolation of PA. This multicentre, 2×2 factorial randomised, double-blind, placebo-controlled, parallel-group trial includes a 2-week screening period, a 12-week treatment phase (with a combination of ciprofloxacin or a placebo at initial 2 weeks) and a 24-week follow-up. 364 adults with bronchiectasis and a new PA isolation will be randomly assigned to one of four groups: placebo (inhaled saline and ciprofloxacin placebo twice daily), ciprofloxacin alone (750 mg ciprofloxacin and inhaled saline twice daily), inhaled tobramycin alone (inhaled 300 mg tobramycin and ciprofloxacin placebo twice daily) or a combination of both drugs (inhaled 300 mg tobramycin and 750 mg ciprofloxacin twice daily). The primary objective of this study is to assess the proportion of patients successfully eradicating PA in each group by the end of the study. Efficacy will be evaluated based on the eradication rate of PA at other time points (12, 24 and 36 weeks), the occurrence of exacerbations and hospitalisations, time to first pulmonary exacerbations, patient-reported outcomes, symptom measures, pulmonary function tests and the cost of hospitalisations. To date no randomised trial has evaluated the benefit of different PA eradication strategies in bronchiectasis patients. The ERASE trial will therefore generate crucial data to inform future clinical guidelines.</p