The Study of Low-Light Sights Reliability Test System in High and Low Temperature Environment

In a certain period of time Products and system complete the required function under the condition of rules, the ability is called the reliability. Reliability is an important factor to reflect the quality of products, is the focus of the weapons and equipment quality. There is no guarantee reliability, even the most advanced equipment can not also play a role. In this paper, the design of test system is mainly used for small arms LOW-LIGHT SIGHTS sight reliability test. The shimmer sight reliability tests provide light stress, electrical stress, thermal stress and other stress environment. Detection shimmer sight working conditions, on failure of the automatic screening and recording

Research on the development of island tourism market for college students - a case study of Dongji Island

In recent years, with the acceleration of the process of economic globalization, China's rapid economic growth and increasingly convenient transportation, college students' tourism activities are increasing. At the same time, the uniqueness of Island tourism resources determines the irreplaceable industrial status of Island tourism. Dongji Island, affiliated to Zhoushan City, Zhejiang Province, has extremely rich natural and cultural resources, and its tourism industry has a high correlation with college students. In view of this, based on the analysis of the current situation of the island tourism industry in Dongji Island, reasonable island tourism development and external publicity measures are proposed for college students

Semi-Supervised Panoptic Narrative Grounding

Despite considerable progress, the advancement of Panoptic Narrative Grounding (PNG) remains hindered by costly annotations. In this paper, we introduce a novel Semi-Supervised Panoptic Narrative Grounding (SS-PNG) learning scheme, capitalizing on a smaller set of labeled image-text pairs and a larger set of unlabeled pairs to achieve competitive performance. Unlike visual segmentation tasks, PNG involves one pixel belonging to multiple open-ended nouns. As a result, existing multi-class based semi-supervised segmentation frameworks cannot be directly applied to this task. To address this challenge, we first develop a novel SS-PNG Network (SS-PNG-NW) tailored to the SS-PNG setting. We thoroughly investigate strategies such as Burn-In and data augmentation to determine the optimal generic configuration for the SS-PNG-NW. Additionally, to tackle the issue of imbalanced pseudo-label quality, we propose a Quality-Based Loss Adjustment (QLA) approach to adjust the semi-supervised objective, resulting in an enhanced SS-PNG-NW+. Employing our proposed QLA, we improve BCE Loss and Dice loss at pixel and mask levels, respectively. We conduct extensive experiments on PNG datasets, with our SS-PNG-NW+ demonstrating promising results comparable to fully-supervised models across all data ratios. Remarkably, our SS-PNG-NW+ outperforms fully-supervised models with only 30% and 50% supervision data, exceeding their performance by 0.8% and 1.1% respectively. This highlights the effectiveness of our proposed SS-PNG-NW+ in overcoming the challenges posed by limited annotations and enhancing the applicability of PNG tasks. The source code is available at https://github.com/nini0919/SSPNG.Comment: ACM MM 202

Continued nucleic acid tests for SARS-CoV-2 following discharge of patients with COVID-19 in Lu’an, China

Background Studies have shown that discharged Coronavirus disease 2019 (COVID-19) patients have retested positive for SARS-CoV-2 during a follow-up RT-PCR test. We sought to assess the results of continued nucleic acid testing for SARS-CoV-2 patients in COVID-19 patients after they were discharged in Lu’an, China. Methods We conducted RT-PCR tests on sputum, throat swabs, fecal or anal swabs, and urine samples collected from 67 COVID-19 patients following discharge. Samples were collected on the 7th and 14th days following discharge. Patients testing positive on the 7th or 14th day were retested after 24 hours until they tested negative twice. Results Seventeen (17/67, 25.4%) discharged COVID-19 patients had a positive RT-PCR retest for SARS-CoV-2. Among them, 14 (82.4%) were sputum positive, five (29.4%) were throat swab positive, seven (41.2%) were fecal or anal swab positive, one (5.9%) was urine sample positive, five (29.4%) were both sputum and throat swab positive, four (23.5%) were both sputum and fecal test positive, and one (5.9%) was positive of all four specimens. The shortest period of time between discharge and the last positive test was 7 days, the longest was 48 days, and the median was 16 days. The proportion of positive fecal or anal swab tests increased from the third week. The median Cq cut-off values after onset were 26.7 after the first week, 37.7 the second to sixth week, and 40 after the sixth week. There were no significant differences between the RT-PCR retest positive group and the unrecovered positive group. Conclusions There was a high proportion of patients who retested positive for COVID-19. Discharge criteria have remained fairly consistent so we encourage regions affected by COVID-19 to appropriately amend their current criteria

Effects of Self-Esteem on the Association between Negative Life Events and Suicidal Ideation in Adolescents

Negative life events (NLEs) increase the risk of suicidal ideation (SI) in adolescents. However, it is not known whether the association between NLEs and SI can be moderated by self-esteem and varies with gender. The aim of the current paper was to examine gender differences in the association of SI with NLEs in adolescents, and assess the effects of self-esteem on the association and their gender variations. We conducted a school-based health survey in 15 schools in China between November 2013 and January 2014. A total of 9704 participants aged 11–19 years had sociodemographic data reported and self-esteem (Rosenberg self-esteem scale), NLEs, and SI measured. Multivariate-adjusted logistic regression was used to calculate the odds ratio (OR) of having SI in relation to NLEs. Increased risk of SI was significantly associated with NLEs (adjusted OR 2.19, 95%CI 1.94–2.47), showing no gender differences (in females 2.38, 2.02–2.80, in males 1.96, 1.64–2.36, respectively). The association was stronger in adolescents with high esteem (2.93, 2.34–3.68) than those with low esteem (2.00, 1.65–2.42) (ORs ratio 1.47, p = 0.012). The matched figures in females were 3.66 (2.69–4.99) and 2.08 (1.61–2.70) (1.76, p = 0.006), while in males these figures were 2.27(1.62–3.19) and 1.89 (1.41–2.53) (1.20, p = 0.422), respectively. Self-esteem had moderate effects on the association between NLEs and SI in adolescents, mainly in females. NLEs, self-esteem, and gender need to be incorporated into future intervention programs to prevent SI in adolescents

Neutrophil-to-lymphocyte ratio and incident end-stage renal disease in Chinese patients with chronic kidney disease: results from the Chinese Cohort Study of Chronic Kidney Disease (C-STRIDE)

Abstract Background Chronic kidney disease (CKD) leads to end-stage renal failure and cardiovascular events. An attribute to these progressions is abnormalities in inflammation, which can be evaluated using the neutrophil-to-lymphocyte ratio (NLR). We aimed to investigate the association of NLR with the progression of end stage of renal disease (ESRD), cardiovascular disease (CVD) and all-cause mortality in Chinese patients with stages 1–4 CKD. Methods Patients with stages 1–4 CKD (18–74 years of age) were recruited at 39 centers in 28 cities across 22 provinces in China since 2011. A total of 938 patients with complete NLR and other relevant clinical variables were included in the current analysis. Cox regression analysis was used to estimate the association between NLR and the outcomes including ESRD, CVD events or all-cause mortality. Results Baseline NLR was related to age, hypertension, serum triglycerides, total serum cholesterol, CVD history, urine albumin to creatinine ratio (ACR), chronic kidney disease-mineral and bone disorder (CKD-MBD), hyperlipidemia rate, diabetes, and estimated glomerular filtration rate (eGFR). The study duration was 4.55 years (IQR 3.52–5.28). Cox regression analysis revealed an association of NLR and the risk of ESRD only in patients with stage 4 CKD. We did not observe any significant associations between abnormal NLR and the risk of either CVD or all-cause mortality in CKD patients in general and CKD patients grouped according to the disease stages in particular. Conclusion Our results suggest that NLR is associated with the risk of ESRD in Chinese patients with stage 4 CKD. NLR can be used in risk assessment for ESRD among patients with advanced CKD; this application is appealing considering NLR being a routine test. Trial registration ClinicalTrials.gov Identifier NCT03041987. Registered January 1, 2012. (retrospectively registered) ( https://www.clinicaltrials.gov/ct2/show/NCT03041987?term=Chinese+Cohort+Study+of+Chronic+Kidney+Disease+%28C-STRIDE%29&rank=1 )https://deepblue.lib.umich.edu/bitstream/2027.42/148285/1/12967_2019_Article_1808.pd

Extensive Crosstalk between O-GlcNAcylation and Phosphorylation Regulates Akt Signaling

O-linked N-acetylglucosamine glycosylations (O-GlcNAc) and O-linked phosphorylations (O-phosphate), as two important types of post-translational modifications, often occur on the same protein and bear a reciprocal relationship. In addition to the well documented phosphorylations that control Akt activity, Akt also undergoes O-GlcNAcylation, but the interplay between these two modifications and the biological significance remain unclear, largely due to the technique challenges. Here, we applied a two-step analytic approach composed of the O-GlcNAc immunoenrichment and subsequent O-phosphate immunodetection. Such an easy method enabled us to visualize endogenous glycosylated and phosphorylated Akt subpopulations in parallel and observed the inhibitory effect of Akt O-GlcNAcylations on its phosphorylation. Further studies utilizing mass spectrometry and mutagenesis approaches showed that O-GlcNAcylations at Thr 305 and Thr 312 inhibited Akt phosphorylation at Thr 308 via disrupting the interaction between Akt and PDK1. The impaired Akt activation in turn resulted in the compromised biological functions of Akt, as evidenced by suppressed cell proliferation and migration capabilities. Together, this study revealed an extensive crosstalk between O-GlcNAcylations and phosphorylations of Akt and demonstrated O-GlcNAcylation as a new regulatory modification for Akt signaling

Investigating site-specific interactions and probing their role in modifying the acid-strength in framework architectures

The ability to adroitly tailor acid-strength using specifically-engineered bimetallic nanoporous materials has been investigated with a view to exploiting their potential in solid-acid catalysed transformations. Further, it has been demonstrated that through site-specific interactions, extra-framework zinc ions can suitably modify the acidity of Brønsted acid sites, to stimulate diverse catalytic responses, when combined with isomorphously-substituted framework metal cations within porous architectures, for the Beckmann rearrangement of cyclohexanone oxime and in the isopropylation of benzene