Islands of conformational stability for Filopodia

Filopodia are long, thin protrusions formed when bundles of fibers grow outwardly from a cell surface while remaining closed in a membrane tube. We study the subtle issue of the mechanical stability of such filopodia and how this depends on the deformation of the membrane that arises when the fiber bundle adopts a helical configuration. We calculate the ground state conformation of such filopodia, taking into account the steric interaction between the membrane and the enclosed semiflexible fiber bundle. For typical filopodia we find that a minimum number of fibers is required for filopodium stability. Our calculation elucidates how experimentally observed filopodia can obviate the classical Euler buckling condition and remain stable up to several tens of . We briefly discuss how experimental observation of the results obtained in this work for the helical-like deformations of enclosing membrane tubes in filopodia could possibly be observed in the acrosomal reactions of the sea cucumber Thyone, and the horseshoe crab Limulus. Any realistic future theories for filopodium stability are likely to rely on an accurate treatment of such steric effects, as analysed in this work

The provision of education and training for healthcare professionals through the medium of the internet

This paper describes a new initiative to provide Internet based courses to student and professional occupational therapists in four centres in the UK, Belgium the Netherlands and Sweden. The basis of this collaborative Occupational Therapy Internet School (OTIS) is the concept of the “Virtual College”. This comprises the design and implementation of a sophisticated Internet-based system through which courses can be managed, prepared and delivered online in an effective fashion, and where students can communicate both with the staff and their peers. The aim is to support and facilitate the whole range of educational activities within a remote electronic environment. A major feature of the course organisation is the adoption of a problem-based approach in which students will collaborate internationally to propose effective intervention in given case study scenarios. The paper outlines the rationale for OTIS, the content and structure of the courseware, the technical specification of the system and evaluation criteria. In addition to the more conventional web-based learning facilities generally offered, a number of agent-based approaches are being adopted to assist in the management of the course by ensuring the proper delivery of course materials and to assist the functioning of project groups. </p

System and market failures: the unavailability of magnesium sulphate for the treatment of eclampsia and pre-eclampsia in Mozambique and Zimbabwe.

Low cost and effective drugs, such as magnesium sulphate, need to be included in initiatives to improve access to essential medicines in Afric

Instabilities in droplets spreading on gels

We report a novel surface-tension driven instability observed for droplets spreading on a compliant substrate. When a droplet is released on the surface of an agar gel, it forms arms/cracks when the ratio of surface tension gradient to gel strength is sufficiently large. We explore a range of gel strengths and droplet surface tensions and find that the onset of the instability and the number of arms depend on the ratio of surface tension to gel strength. However, the arm length grows with an apparently universal law L ~ t^{3/4}

Stoichiometry control of sputtered CuCl thin films: Influence on ultraviolet emission properties

We demonstrate that the chemical composition of the sputtered CuCl thin films could be finely controlled by adjusting the bias to the substrate. The films deposited without any intentional bias were Cl rich (CuCl1+x), a bias of −22 V yielded stoichiometric CuCl, and a further increase in the negative bias resulted in Cl deficient films (CuCl1−x). The crystalline and optical properties were found to be associated with the chemical composition. Cl rich films showed a deep level green emission at around 515 nm in addition to ultraviolet (UV) excitonic emission. The stoichiometric films have higher optical quality, exhibiting a sharp UV emission at around 385 nm at room temperature, compared to nonstoichiometric samples. Visible luminescence related to deep level defects was not observed in the stoichiometric films. Changes in energy of the flux from the target and the subsequent ion bombardment on the substrate surface are correlated with the variations in chemical composition and their impact on the film microstructure and UV emission

Perserverance measures and attainment in first year computing science students.

We investigate the link between concepts of perseverance such as conscientiousness and grit, and the academic attainment of first year computing students. We review the role that perseverance plays in learning models, as well as describing the trait of conscientiousness in the Five Factor Model of personality. We outline research that links this trait with academic success, before focussing on more recent, narrower conceptualisations of perseverance such as academic tenacity and grit. We describe one of the questionnaire tools that have been used to assess the construct of grit. We give details of an investigation that looked for correlations between student responses to Duckworth's Grit Survey, the Big Five Inventory (BFI) Personality Survey and summative attainment scores in a first year programming course. The results suggest a weak but significant correlation between conscientiousness, grit and programming achievement. We discuss these results as well as the limitations of the method used. Finally, we make some observations about the importance of these concepts in Computer Science education and outline further work in this area

Hysterectomy, endometrial ablation, and levonorgestrel releasing intrauterine system (Mirena) for treatment of heavy menstrual bleeding : cost effectiveness analysis

Peer reviewedPublisher PD

New Discoveries from the Arecibo 327 MHz Drift Pulsar Survey Radio Transient Search

We present Clusterrank, a new algorithm for identifying dispersed astrophysical pulses. Such pulses are commonly detected from Galactic pulsars and rotating radio transients (RRATs), which are neutron stars with sporadic radio emission. More recently, isolated, highly dispersed pulses dubbed fast radio bursts (FRBs) have been identified as the potential signature of an extragalactic cataclysmic radio source distinct from pulsars and RRATs. Clusterrank helped us discover 14 pulsars and 8 RRATs in data from the Arecibo 327 MHz Drift Pulsar Survey (AO327). The new RRATs have DMs in the range $23.5 - 86.6$ pc cm$^{-3}$ and periods in the range $0.172 - 3.901$ s. The new pulsars have DMs in the range $23.6 - 133.3$ pc cm$^{-3}$ and periods in the range $1.249 - 5.012$ s, and include two nullers and a mode-switching object. We estimate an upper limit on the all-sky FRB rate of $10^5$ day$^{-1}$ for bursts with a width of 10 ms and flux density $\gtrsim 83$ mJy. The DMs of all new discoveries are consistent with a Galactic origin. In comparing statistics of the new RRATs with sources from the RRATalog, we find that both sets are drawn from the same period distribution. In contrast, we find that the period distribution of the new pulsars is different from the period distributions of canonical pulsars in the ATNF catalog or pulsars found in AO327 data by a periodicity search. This indicates that Clusterrank is a powerful complement to periodicity searches and uncovers a subset of the pulsar population that has so far been underrepresented in survey results and therefore in Galactic pulsar population models.Comment: 41 pages, 16 figures, 4 tables, accepted by ApJ; added minor corrections to final ApJ proo

Increasing Pilots Understanding of Future Automation State an Evaluation of an Automation State and Trajectory Prediction System

A pilot in the loop flight simulation study was conducted at NASA Langley Research Center to evaluate a trajectory prediction system. The trajectory prediction system computes a five-minute prediction of the lateral and vertical path of the aircraft given the current and intent state of the automation. The prediction is shown as a graphical representation so the pilots can form an accurate mental model of the future state. Otherwise, many automation changes and triggers are hidden from the flight crew or need to be consolidated to understand if a change will occur and the exact timing of the change. Varying dynamic conditions like deceleration can obscure the future trajectory and the ability to meet constraints, especially in the vertical dimension. Current flight deck indications of flight path assume constant conditions and do not adequately support the flight crew to make correct judgments regarding constraints. The study was conducted using ten commercial airline crews from multiple airlines, paired by airline to minimize procedural effects. Scenarios spanned a range of conditions that provided evaluation in a realistic environment with complex traffic and weather conditions. In particular, scenarios probed automation state and loss of state awareness. The technology was evaluated and contrasted with current state-of-the-art flight deck capabilities modeled from the Boeing 787. Objective and subjective data were collected from aircraft parameters, questionnaires, audio/video recordings, head/eye tracking data, and observations. This paper details findings about the trajectory prediction system including recommendations about further study

Supporting the learning of deaf students in higher education: a case study at Sheffield Hallam University

This article is an examination of the issues surrounding support for the learning of deaf students in higher education (HE). There are an increasing number of deaf students attending HE institutes, and as such provision of support mechanisms for these students is not only necessary but essential. Deaf students are similar to their hearing peers, in that they will approach their learning and require differing levels of support dependant upon the individual. They will, however, require a different kind of support, which can be technical or human resource based. This article examines the issues that surround supporting deaf students in HE with use of a case study of provision at Sheffield Hallam University (SHU), during the academic year 1994-95. It is evident that by considering the needs of deaf students and making changes to our teaching practices that all students can benefit