Journal Staff

BACKGROUND: It has been hypothesised that an upregulation of the neuropeptide substance P (SP) and its preferred receptor, the neurokinin-1 receptor (NK-1 R), is a causative factor in inducing tenocyte hypercellularity, a characteristic of tendinosis, through both proliferative and antiapoptotic stimuli. We have demonstrated earlier that SP stimulates proliferation of human tenocytes in culture. AIM: The aim of this study was to investigate whether SP can mediate an antiapoptotic effect in tumour necrosis factor-α (TNF-α)-induced apoptosis of human tenocytes in vitro. RESULTS: A majority (approximately 75%) of tenocytes in culture were immunopositive for TNF Receptor-1 and TNF Receptor-2. Exposure of the cells to TNF-α significantly decreased cell viability, as shown with crystal violet staining. TNF-α furthermore significantly increased the amount of caspase-10 and caspase-3 mRNA, as well as both BID and cleaved-poly ADP ribosome polymerase (c-PARP) protein. Incubation of SP together with TNF-α resulted in a decreased amount of BID and c-PARP, and in a reduced lactate dehydrogenase release, as compared to incubation with TNF-α alone. The SP effect was blocked with a NK-1 R inhibitor. DISCUSSION: This study shows that SP, through stimulation of the NK-1 R, has the ability to reduce TNF-α-induced apoptosis of human tenocytes. Considering that SP has previously been shown to stimulate tenocyte proliferation, the study confirms SP as a potent regulator of cell-turnover in tendon tissue, capable of stimulating hypercellularity through different mechanisms. This gives further support for the theory that the upregulated amount of SP seen in tendinosis could contribute to hypercellularity

The XVII Amendment’s impact to Economy, Politics, and European Immigration during Prohibition in the United States

Prohibition occurred between the years 1920 to 1933. The United States Congress ratified the XVII amendment prohibiting the sale, manufacture, and transport of intoxicating liquors. During these years United States emerged from its involvement in World War I, experienced the Roaring Twenties, and felt the impact of the Great Depression. The era historically transformed the United States during the period of thirteen years. Upon the ratification of XVIII amendment, the Volstead Act became the enforcing mechanism of the law, Prohibition took effect within the United States on January 17, 1920. The economy, law enforcement and European immigration were all sectors uniquely affected during the Prohibition era in the United States. The United States government political fallout occurred because they believed the ratification would positively impact the country’s economy, however; the government lost tax revenues immediately after the tax on liquor sales halted. The law’s goal was to eliminate all liquor within the United States. The government did not expect illegal smuggling nor the establishment of a bootlegging industry. The closure of saloons led to an illegal development of underground speakeasies. Alcohol smugglers thrived, while the National Anti-Saloon League influenced distinguished members of Congress and the government with their use of “pressure politics.” The Treasury Department assigned a Prohibition Unit agency known as the Federal Bureau of Investigation to follow paper tracks and anonymous tips about speakeasies and illegal smuggling. The United States endowed Border Patrol with law enforcement authority allowing them to make arrests without warrants on any violation of immigration laws. Immigrants found opportunities sidestepping the law and built speakeasies to supplement their incomes. Germans, Italians, and Irish Americans were all targeted because of citizens preconceived prejudices against immigrants in the United States

Identification of WISE J000100.45+065259.6 as an M8.5+T5 Spectral Binary Candidate

[not part of RNAAS note] We report the discovery of WISE J000100.45+065259.6 as a very low mass star/brown dwarf spectral binary candidate, on the basis of low resolution near-infrared spectroscopy obtained with IRTF/SpeX. Decomposition of the spectrum indicates component types of M8.5+T5 with a predicted $\Delta{J}$ = 3.5. As the majority of confirmed spectral binary candidates to date are very closely-separated systems ($\rho$ $\lesssim$ 3 AU; $P$ $\lesssim$ 15~yr), this source may provide mass measurements across the hydrogen burning limit within the decade.Comment: 3 pages, 1 figure, accepted to Research Notes of the AA

A Formula for Disobedience: Jansenism, Gender and the Feminist Paradox

Research for this article was supported by the Erasmus Institute of the University of Notre Dame and the Center for Seventeenth- and Eighteenth-Century Studies at the University of California, Los Angeles

Vices of distrust

One of the first things that comes to mind when we think of the special issue’s theme, “Trust in a Social and Digital World” is the epidemic of ‘fake news’ and a cluster of trust- relevant vices we commonly associate with those who share it, click on it, and believe it. Fake news consumers are, among other things, gullible and naïve. (How many times have you seen someone share the increasingly dated and non-binding Facebook privacy message hoax, or a meme that includes a dramatic picture and a powerful looking statistic, but no references to that statistic?) Many are also dogmatic: intellectually and/or emotionally tied to a view point, and as a result, too quick to uncritically trust whatever aligns with it. Gullibility, naivety, and dogmatism are all examples of vices that lead to us trust when we shouldn’t. The effects of these kinds of vices can be dangerous. (So dangerous, in fact, that in August 2019, the United States F.B.I. for the first time listed ‘conspiracy theories’ as among the top domestic terror threats.) Our aim here, however, is to explore the other side of the coin: those character vices that lead us to refrain from trusting when we should trust. For ease of reference, call these vices of distrust. Vices of distrust are dangerous in their own right, and in ways that often harm others along with oneself. The three vices of distrust we want explore—with a particular focus on their manifestations online—are: closemindedness, emulousness, and arrogance. Each contributes to vicious distrust in its own distinctive way

The Orbit of the L dwarf + T dwarf Spectral Binary SDSS J080531.84+481233.0

[abridged] We report four years of radial velocity monitoring observations of SDSS J080531.84+481233.0 that reveal significant and periodic variability, confirming the binary nature of the source. We infer an orbital period of 2.02$\pm$0.03 yr, a semi-major axis of 0.76$^{+0.05}_{-0.06}$ AU, and an eccentricity of 0.46$\pm$0.05, consistent with the amplitude of astrometric variability and prior attempts to resolve the system. Folding in constraints based on the spectral types of the components (L4$\pm$0.7 and T5.5$\pm$1.1), corresponding effective temperatures, and brown dwarf evolutionary models, we further constrain the orbital inclination of this system to be nearly edge-on (90$^o\pm$19$^o$), and deduce a large system mass ratio (M$_2$/M$_1$ = 0.86$^{+0.10}_{-0.12}$), substellar components (M$_1$ = 0.057$^{+0.016}_{-0.014}$ M$_{\odot}$, M$_2$ = 0.048$^{+0.008}_{-0.010}$ M$_{\odot}$), and a relatively old system age (minimum age = 4.0$^{+1.9}_{-1.2}$ Gyr). The measured projected rotational velocity of the primary ($v\sin{i}$ = 34.1$\pm$0.7 km/s) implies that this inactive source is a rapid rotator (period $\lesssim$ 3 hr) and a viable system for testing spin-orbit alignment in very-low-mass multiples. The combination of well-determined component atmospheric properties and masses near and/or below the hydrogen minimum mass make SDSS J0805+4812AB an important system for future tests of brown dwarf evolutionary models.Comment: 15 pages, 11 figures, accepted for publication to Ap