Nonlinear delay reaction-diffusion systems with nonlocal initial conditions having affine growth

We consider a class of abstract evolution reaction-diffusion systems with delay and nonlocal initial data of the form $$\begin{cases} \displaystyle u'(t)\in Au(t)+F(t,u_t,v_t)&\text{for } t\in \mathbb{R}_+,\\ v'(t)\in Bv(t)+G(t,u_t,v_t) & \text{for } t\in \mathbb{R}_+,\\ u(t)=p(u,v)(t)& \text{for } t\in [-\tau_1,0],\\ v(t)=q(u,v)(t)& \text{for } t\in [-\tau_2,0], \end{cases}$$ where $\tau_i\geq 0$, $i=1,2$, $A$ and $B$ are two $m$-dissipative operators acting in two Banach spaces, the perturbations $F$ and $G$ are continuous, while the history functions $p$ and $q$ are nonexpansive functions with affine growth. We prove an existence result of $C^0$-solutions for the above problem and we give an example to illustrate the effectiveness of our abstract theory

COMPARATIVE STUDY OF PIGMENTS ON REGENERANTS FROM IN VITRO AND SPONTANEOUS FLORA OF THYMUS sp.

This paper presents the quantitative determination of pigments extract of Thymus sp. from in vitro culture and spontaneous flora. For in vitro culture were used phytohormones (indoleacetic acid-IAA, indole-3-butyric acid-IBA and benzylaminopurine-BAP) in order to obtain a high yield in development of Thymus sp. plants. The source of spontaneous flora of Thymus sp. was Bacau (Magura), Romania. The biochemical investigations realised on Thymus sp. using Thin Layer Chromatography and the UV-Vis spectrophotometry showed that the production of assimilating pigments is influenced by growth and lighting conditions of plants

EXPERIMENTAL MONTAGE USED TO STUDY THE VIBRATION OF THE DRILL TOOL IN THE PROCESS OF MANUFACTURING THE BRONZE MATERIALS

In this paper we present the experimental setup used to study the vibration of the drill tool, during the drilling of the bronze products. In this paper the vibrations are analyzed during the drilling on the universal lathe machines. This time, the tool is fixed in the movable boring head and will make a translation movement with constant feeding, and the workpiece spins around its axis of symmetry and it is fixed in the spindle head stock of the universal lathe machin

CONTRIBUTIONS TO THE STUDY OF THE VIBRATIONS FREQUENCY OF THE DRILL TOOL IN THE PROCESS OF MANUFACTURING THE BRONZE MATERIALS

In this paper we present the experimental testings used to study the vibration of the drill tool, during the drilling of the bronze products. We have used the experimental setup presented in Miriţoiu (2013)[1]. In this paper the vibrations are analyzed during the drilling on the universal lathe machines. The main purpose of to find a correlation between the cutting speed and the frequency of the vibration by using the experimental results and the regression analysi

Dynamic Change Management for Minimal Impact on Dependability and Performance in Autonomic Service-Oriented Architectures

Dynamic change management in an autonomic, service-oriented infrastructure is likely to disrupt the critical services delivered by the infrastructure. Furthermore, change management must accommodate complex real-world systems, where dependability and performance objectives are managed across multiple distributed service components. This paper presents a change management framework that enables the assessment and minimization of service delivery disruptions. The framework builds on a few general principles. First, change management systems handle both external change requests, like software upgrades, and changes to mitigate internal events, like faults. Second, the impact on service delivery is assessed as the impact on the business values of the performance and dependability objectives across all services. The goal is to schedule change operations in order to maximize the business value across all service objectives over a long time horizon. These principles are achieved with a distributed design: change operation scheduling and business value optimization are performed by an orchestrator, while the impact assessment on specific objectives is distributed to objective-specific modules that employ domain-specific models for estimation and prediction. 1

The Clash of the Titans: COVID-19, Carbapenem-Resistant <i>Enterobacterales,</i> and First <i>mcr-1</i>-Mediated Colistin Resistance in Humans in Romania

(1) Background: Antibiotic resistance and coronavirus disease-19 (COVID-19) represent a dual challenge in daily clinical practice, inducing a high burden on public health systems. Hence, we aimed to dynamically evaluate the impact of COVID-19 on patients with carbapenem-resistant Enterobacterales (CRE) urinary tract infections (UTIs), as well as the antibiotic resistance trends after the onset of the pandemic. (2) Methods: We conducted a prospective study including patients with CRE UTIs who were enrolled both pre- and during the pandemic from 2019 to 2022. We further performed a standardized and comparative clinical, paraclinical, and microbiological assessment between patients with and without COVID-19. (3) Results: A total of 87 patients with CRE UTIs were included in this study (46 pre-pandemic and 41 during the pandemic, of which 21 had associated Severe Acute Respiratory Syndrome Coronavirus-2 infection). Klebsiella pneumoniae was the main etiological agent of the UTIs, with the majority of strains (82.7%) being carbapenemase producers (mainly OXA-48 producers), while five of the 34 colistin-resistant isolates were harboring the mobile colistin resistance-1 (mcr-1) gene. COVID-19 patients presented a significantly worse outcome with higher rates of intensive care unit (ICU) admissions (66.7% for COVID patients vs. 18.2% for non-COVID patients, p p K. pneumoniae, impaired liver and kidney function, and an inappropriate initial empiric antibiotic therapy. (4) Conclusions: COVID-19 showed a pronounced negative impact on patients with CRE UTIs, with significantly longer hospitalizations and higher ICU admissions and mortality rates

Specific Local Predictors That Reflect the Tropism of Endometriosis&mdash;A Multiple Immunohistochemistry Technique

Ectopic endometrial epithelium associates a wide spectrum of symptomatology. Their evolution can be influenced by inflammatory and vascular changes, that affect not only the structure and cell proliferation rate, but also symptoms. This prospective study involved tissue samples from surgically treated patients, stained using classical histotechniques and immunohistochemistry. We assessed ectopic endometrial glands (CK7+, CK20&minus;), adjacent blood vessels (CD34+), estrogen/progesterone hormone receptors (ER+, PR+), inflammatory cells (CD3+, CD20+, CD68+, Tryptase+), rate of inflammatory cells (Ki67+) and oncoproteins (BCL2+, PTEN+, p53+) involved in the development of endometriosis/adenomyosis. A CK7+/CK20&minus; expression profile was present in the ectopic epithelium and differentiated it from digestive metastases. ER+/PR+ were present in all cases analyzed. We found an increased vascularity (CD34+) in the areas with abdominal endometriosis and CD3+&minus;:T-lymphocytes, CD20+&minus;:B-lymphocytes, CD68+:macrophages, and Tryptase+: mastocytes were abundant, especially in cases with adenomyosis as a marker of proinflammatory microenvironment. In addition, we found a significantly higher division index-(Ki67+) in the areas with adenomyosis, and inactivation of tumor suppressor genes-p53+ in areas with neoplastic changes. The inflammatory/vascular/hormonal mechanisms trigger endometriosis progression and neoplastic changes increasing local pain. Furthermore, they may represent future therapeutic targets. Simultaneous-multiple immunohistochemical labelling represents a valuable technique for rapidly detecting cellular features that facilitate comparative analysis of the studied predictors