Non-syndromic oral clefts and risk of cancer: a systematic review

Objective: To discuss the risk of cancer among relatives of individuals with cleft lip and palate (CL/P), as well as the risk of CL/P among relatives of individuals with cancer, since studies published currently have suggested  an increased risk of cancer among relatives of cleft individuals. Design: A systematic literature review was carried out in accordance with the Cochrane Collaboration Group protocol, including literature search strategy, selection of papers through the inclusion and exclusion criteria, data extraction and quality assessment. PubMed, Scopus and ISI - Web of Science databases were systematically searched using the fallowing search strings: “cleft lip and palate” AND “cancer”, “oral clefts” AND “cancer” and “orofacial clefts” AND “cancer”. Results: From 653 studies accessed, 8 comprised the final sample: 6 investigating CL/P index cases and their family history of cancer and 2 investigating individuals with cancer and their family history for CL/P. The sample sizes were not homogeneous. Oral clefts, the type of cancer and the degree of kinship family were not categorized in all studies. Leukemia, breast cancer and colon cancer were the most cited types, even as first-and-second degree relatives. Conclusions: An increased risk of cancer among relatives of cleft individuals could not be entirely confirmed. However, studies with this specific purpose suggest that first-and-second degrees relatives of cleft individuals have some types of cancer more often than unexposed families, highlighting that future studies should expand their samples to investigate possible common molecular mechanisms that allow relating oral clefts and cancer

Evaluation of scientifi c production, patents and human resources training in the Brazilian nursing Avaliação da produção científi ca, patentes e formação de recursos humanos da Enfermagem Brasileira Evaluación de la producción científi ca, patentes y la

ABSTRACT Objective: to evaluate scientifi c production, patents and human resources training of nursing researchers with scholarships of research productivity (PQ) in National Counsel for Technological and Scientifi c Development (CNPq) in the 2000-2012 historic series; to verify the association between this production and characteristics of the researchers regarding gender, education and origin. Methods: this analytic cross-sectional study whose inclusion criterion was to be a nursing PQ/CNPq researcher during the period in question. We analyzed curriculum lattes of 208 researchers with scholarships between 2000 and 2012. For statistical analyses we used the SPSS ® software. Results: the study points to female predominance, concentration in the Southeast region and existence of an association between scientifi c production, patents and human resources training and education, gender and origin of the researcher. Conclusion: the study presents a signifi cant participation of nursing PQ/CNPq researchers in scientifi c production and in human resources training, and a modest involvement in the production of patents. Key words: Scientifi c Production Indicators; Researchers; Nursing. RESUMO Objetivo: avaliar produção científi ca, patentes e formação de recursos humanos de pesquisadores da enfermagem com bolsas de produtividade em pesquisa (PQ) no CNPq na série histórica 2000-2012; verifi car a associação entre esta produção e características dos pesquisadores quanto a sexo, formação e origem. Método: estudo transversal analítico cujo critério de inclusão foi ser pesquisador PQ/CNPq da enfermagem no período em questão. Foram analisados curriculum lattes de 208 pesquisadores com bolsas entre 2000-2012. Para as análises estatísticas utilizou-se o programa SPSS ® . Resultados: o estudo aponta predominância do sexo feminino, concentração na região Sudeste e existência de associação entre produção científi ca, patentes e formação de recursos humanos e a formação, sexo e origem do pesquisador. Conclusão: o estudo revela uma expressiva participação dos pesquisadores PQ/CNPq da enfermagem na produção científi ca e na formação de recursos humanos e tímida participação na produção de patentes. Descritores: Indicadores de Produção Científi ca; Pesquisadores; Enfermagem. RESUMEN Objetivo: evaluar la producción científi ca, patentes y formación de recursos humanos de enfermería investigadores con becas de productividad en investigación (PQ) en el CNPq en la serie temporal 2000-2012 y la existencia de una asociación entre estos tipos de producción y las características de los investigadores sexo, educación y origen. Método: estudio transversal cuyo criterio de inclusión fue ser un PQ investigador/enfermería CNPq en el período en cuestión

Ophthalmic changes in cleft lip and palate

ABSTRACT The current study aimed to analyze through a literature review evidence of association between ocular changes and non-syndromic cleft lip and/or palate (NSCL/P). A literature review was carried out in accordance with the Cochrane Collaboration Group protocol. PubMed, Scopus, Academic Google and ISI Web of Science databases were systematically searched. A total of 16 studies were accessed, and three made up the final sample.All three studied ocular abnormalities in patients with NSCL/P.The articles found ocular abnormalities in 6.21%, 17.54% and 1.03% of patients respectively.The presence of ocular abnormalities in patients with NSCL/P was significant in this systematic review, but the articles all agreed that future studies should explore the possibility of a greater occurrence of ocular changes in individuals with NSCL/P

Avaliação da produção científica, patentes e formação de recursos humanos da Enfermagem Brasileira

RESUMOObjetivo:avaliar produção científica, patentes e formação de recursos humanos de pesquisadores da enfermagem com bolsas de produtividade em pesquisa (PQ) no CNPq na série histórica 2000-2012; verificar a associação entre esta produção e características dos pesquisadores quanto a sexo, formação e origem.Método:estudo transversal analítico cujo critério de inclusão foi ser pesquisador PQ/CNPq da enfermagem no período em questão. Foram analisados curriculum lattes de 208 pesquisadores com bolsas entre 2000-2012. Para as análises estatísticas utilizou-se o programa SPSS®.Resultados:o estudo aponta predominância do sexo feminino, concentração na região Sudeste e existência de associação entre produção científica, patentes e formação de recursos humanos e a formação, sexo e origem do pesquisador.Conclusão:o estudo revela uma expressiva participação dos pesquisadores PQ/CNPq da enfermagem na produção científica e na formação de recursos humanos e tímida participação na produção de patentes

Clinical characteristics and outcomes of hospital-manifested COVID-19 among Brazilians

ABSTRACT: Objectives: To analyze the clinical characteristics and outcomes of admitted patients with the hospital- versus community-manifested COVID-19 and to evaluate the risk factors related to mortality in the first population. Methods: This retrospective cohort included consecutive adult patients with COVID-19, hospitalized between March and September 2020. The demographic data, clinical characteristics, and outcomes were extracted from medical records. Patients with hospital-manifested COVID-19 (study group) and those with community-manifested COVID-19 (control group) were matched by the propensity score model. Logistic regression models were used to verify the risk factors for mortality in the study group. Results: Among 7,710 hospitalized patients who had COVID-19, 7.2% developed symptoms while admitted for other reasons. Patients with hospital-manifested COVID-19 had a higher prevalence of cancer (19.2% vs 10.8%) and alcoholism (8.8% vs 2.8%) than patients with community-manifested COVID-19 and also had a higher rate of intensive care unit requirement (45.1% vs 35.2%), sepsis (23.8% vs 14.5%), and death (35.8% vs 22.5%) (P <0.05 for all). The factors independently associated with increased mortality in the study group were increasing age, male sex, number of comorbidities, and cancer. Conclusion: Hospital-manifested COVID-19 was associated with increased mortality. Increasing age, male sex, number of comorbidities, and cancer were independent predictors of mortality among those with hospital-manifested COVID-19 disease

Association of Country Income Level With the Characteristics and Outcomes of Critically Ill Patients Hospitalized With Acute Kidney Injury and COVID-19

Introduction: Acute kidney injury (AKI) has been identified as one of the most common and significant problems in hospitalized patients with COVID-19. However, studies examining the relationship between COVID-19 and AKI in low- and low-middle income countries (LLMIC) are lacking. Given that AKI is known to carry a higher mortality rate in these countries, it is important to understand differences in this population. Methods: This prospective, observational study examines the AKI incidence and characteristics of 32,210 patients with COVID-19 from 49 countries across all income levels who were admitted to an intensive care unit during their hospital stay. Results: Among patients with COVID-19 admitted to the intensive care unit, AKI incidence was highest in patients in LLMIC, followed by patients in upper-middle income countries (UMIC) and high-income countries (HIC) (53%, 38%, and 30%, respectively), whereas dialysis rates were lowest among patients with AKI from LLMIC and highest among those from HIC (27% vs. 45%). Patients with AKI in LLMIC had the largest proportion of community-acquired AKI (CA-AKI) and highest rate of in-hospital death (79% vs. 54% in HIC and 66% in UMIC). The association between AKI, being from LLMIC and in-hospital death persisted even after adjusting for disease severity. Conclusions: AKI is a particularly devastating complication of COVID-19 among patients from poorer nations where the gaps in accessibility and quality of healthcare delivery have a major impact on patient outcomes