Urokinase signaling through its receptor protects against anoikis by increasing BCL-xL expression levels.

The acquired capabilities of resistance to apoptotic cell death and tissue invasion are considered to be obligate steps in tumor progression. The binding of the serine protease urokinase (uPA) to its receptor (uPAR) plays a central role in the molecular events coordinating tumor cell adhesion, migration, and invasion. Here we investigate whether uPAR signaling may also prevent apoptosis following loss of anchorage (anoikis) or DNA damage. If nontransformed human retinal pigment epithelial cells are pre-exposed to uPA or to its noncatalytic amino-terminal region (residues 1-135), they exhibit a markedly reduced susceptibility to anoikis as well as to UV-induced apoptosis. This anti-apoptotic effect is retained by a uPA-derived synthetic peptide corresponding to the receptor binding domain and is inhibited by anti-uPAR polyclonal antibodies. Furthermore, the stable reduction of uPA or uPAR expression by RNA interference leads to an increased susceptibility to UV-, cisplatin-, and detachment-induced apoptosis. In particular, the level of uPAR expression positively correlates with cell resistance to anoikis. The protective ability of uPA is prevented by UO126, LY294002, by an MAPK targeting small interference RNA, and by a dominant negative Akt variant. Accordingly, incubation of retinal pigment epithelial cells with uPA elicits a time-dependent enhancement of MAPK and phosphatidylinositol 3-kinase activities as well as the transcriptional activation of Bcl-xL anti-apoptotic factor. Vice versa, the silencing of Bcl-xL expression prevents uPA protection from anoikis. In conclusion, the data show that ligand engagement of uPAR promotes cell survival by activating Bcl-xL transcription through the MEK/ERK- and phosphatidylinositol 3-kinase/Akt-dependent pathways

Fifty Years of PMV Model: Reliability, Implementation and Design of Software for Its Calculation

In most countries, PMV is the reference index for the assessment of thermal comfort conditions in mechanically conditioned environments. It is also the basis to settle input values of the operative temperature for heating and cooling load calculations, sizing of equipment, and energy calculations according to EN 16798-1 and 16798-2 Standards. Over the years, great effort has been spent to study the reliability of PMV, whereas few investigations were addressed to its calculation. To study this issue, the most significant apps devoted to its calculation have been compared with a reference software compliant with EN ISO 7730 and the well-known ASHRAE Thermal Comfort Tool. It has been revealed that only few apps consider all six variables responsible for the thermal comfort. Relative air velocity is not considered by ASHRAE Thermal Comfort Tool and, finally, the correction of basic insulation values due to body movements introduced by EN ISO 7730 and EN ISO 9920 Standards has only been considered in one case. This implies that most software and apps for the calculation of PMV index should be used with special care, especially by unexperienced users. This applies to both research and application fields

Cuerpas encarceladas. Violencias y resistencias

El presente trabajo se encuentra realizado en el marco del Proyecto de Extensión “Mujeres (des) habitando encierros”, dirigido por Irma Colanzi y codirigido por María Belén del Manzo, correspondiente a la Facultad de Psicología de la Universidad Nacional de La Plata. Trabajamos a lo largo de este desarrollo un concepto central para nuestras prácticas: cuerpas en situación de encierro punitivo. Abordamos cómo pensamos las cuerpas, las violencias que las atraviesan, social e institucionalmente, y las resistencias que ellas mismas crean ante las distintas situaciones que transitan. Desde una mirada feminista, con perspectiva de género y de Derechos Humanos, problematizamos cómo fue construido el cuerpo desde el discurso hegemónico, a partir de lo cual conceptualizamos el término cuerpas. Utilizar dicho término corresponde a un posicionamiento político que define y orienta nuestras prácticas. Por este motivo realizamos un abordaje y una explicación teórica de dicho concepto. Con una mirada situacional, apuntamos a la especificidad de la población con la que trabajamos, por lo que nos resulta central realizar una revisión y evaluación de este concepto. Esto nos permite poner en discusión otras miradas posibles, pensar futuras intervenciones y evaluar el devenir del proyecto mismo como así también nuestras prácticas como profesionales.The present work is carried out within the framework of the Extension Project ‘Women (in) habiting confinement’, directed by Irma Colanzi and co-directed by María Belén del Manzo, corresponding to the Faculty of Psychology of the National University of La Plata. We work throughout this development a central concept for our practices: corps in a situation of punitive confinement. We approach how we think the bodies, the violence that crosses them socially and institutionally and the resistance that they themselves create in the different situations they are going through. From a feminist perspective, with a perspective of gender and Human Rights, we problematized how the body was constructed from the hegemonic discourse, from which we conceptualized the term bodies. Using this term corresponds to a political position that defines and guides our practices. For this reason we perform an approach and a theoretical explanation of this concept. With a situational look, we aim at the specificity of the population with which we work, so it is central to us to review and evaluate this concept. This allows us to discuss other possible perspectives, to think about future interventions and to evaluate the evolution of the project itself as well as our practices as professionals.Facultad de Psicologí

Cuerpas encarceladas : Violencias y resistencias

El presente trabajo se encuentra realizado en el marco del Proyecto de Extensión “Mujeres (des) habitando encierros”, dirigido por Irma Colanzi y codirigido por María Belén del Manzo, correspondiente a la Facultad de Psicología de la Universidad Nacional de La Plata. Trabajamos a lo largo de este desarrollo un concepto central para nuestras prácticas: cuerpas en situación de encierro punitivo. Abordamos cómo pensamos las cuerpas, las violencias que las atraviesan social e institucionalmente y las resistencias que ellas mismas crean ante las distintas situaciones que transitan. Desde una mirada feminista, con perspectiva de género y de Derechos Humanos, problematizamos cómo fue construído el cuerpo desde el discurso hegemónico, a partir de lo cual conceptualizamos el término cuerpas. Utilizar dicho término corresponde a un posicionamiento político que define y orienta nuestras prácticas. Por este motivo realizamos un abordaje y una explicación teórica de dicho concepto. Con una mirada situacional, apuntamos a la especificidad de la población con la que trabajamos, por lo que nos resulta central realizar una revisión y evaluación de este concepto. Esto nos permite poner en discusión otras miradas posibles, pensar futuras intervenciones y evaluar el devenir del proyecto mismo como así también nuestras prácticas como profesionales.The present work is carried out within the framework of the Extension Project "Women (in) habiting confinement", directed by Irma Colanzi and co-directed by María Belén del Manzo, corresponding to the Faculty of Psychology of the National University of La Plata. We work throughout this development a central concept for our practices: corps in situation of punitive confinement. We approach how we think the bodies, the violence that crosses them socially and institutionally and the resistance that they themselves create in the different situations they are going through. From a feminist perspective, with a perspective of gender and Human Rights, We problematized how the body was constructed from the hegemonic discourse, from which we conceptualized the term bodies. Using this term corresponds to a political positioning that defines and guides our practices. For this reason we perform an approach and a theoretical explanation of this concept. With a situational look, we aim at the specificity of the population with which we work, so it is central to us to review and evaluate this concept. This allows us to discuss other possible perspectives, to think about future interventions and to evaluate the evolution of the project itself as well as our practices as professionals.Facultad de Psicologí

Cuerpas encarceladas : Violencias y resistencias

El presente trabajo se encuentra realizado en el marco del Proyecto de Extensión “Mujeres (des) habitando encierros”, dirigido por Irma Colanzi y codirigido por María Belén del Manzo, correspondiente a la Facultad de Psicología de la Universidad Nacional de La Plata. Trabajamos a lo largo de este desarrollo un concepto central para nuestras prácticas: cuerpas en situación de encierro punitivo. Abordamos cómo pensamos las cuerpas, las violencias que las atraviesan social e institucionalmente y las resistencias que ellas mismas crean ante las distintas situaciones que transitan. Desde una mirada feminista, con perspectiva de género y de Derechos Humanos, problematizamos cómo fue construído el cuerpo desde el discurso hegemónico, a partir de lo cual conceptualizamos el término cuerpas. Utilizar dicho término corresponde a un posicionamiento político que define y orienta nuestras prácticas. Por este motivo realizamos un abordaje y una explicación teórica de dicho concepto. Con una mirada situacional, apuntamos a la especificidad de la población con la que trabajamos, por lo que nos resulta central realizar una revisión y evaluación de este concepto. Esto nos permite poner en discusión otras miradas posibles, pensar futuras intervenciones y evaluar el devenir del proyecto mismo como así también nuestras prácticas como profesionales.The present work is carried out within the framework of the Extension Project "Women (in) habiting confinement", directed by Irma Colanzi and co-directed by María Belén del Manzo, corresponding to the Faculty of Psychology of the National University of La Plata. We work throughout this development a central concept for our practices: corps in situation of punitive confinement. We approach how we think the bodies, the violence that crosses them socially and institutionally and the resistance that they themselves create in the different situations they are going through. From a feminist perspective, with a perspective of gender and Human Rights, We problematized how the body was constructed from the hegemonic discourse, from which we conceptualized the term bodies. Using this term corresponds to a political positioning that defines and guides our practices. For this reason we perform an approach and a theoretical explanation of this concept. With a situational look, we aim at the specificity of the population with which we work, so it is central to us to review and evaluate this concept. This allows us to discuss other possible perspectives, to think about future interventions and to evaluate the evolution of the project itself as well as our practices as professionals.Facultad de Psicologí

Cuerpas encarceladas : Violencias y resistencias

El presente trabajo se encuentra realizado en el marco del Proyecto de Extensión “Mujeres (des) habitando encierros”, dirigido por Irma Colanzi y codirigido por María Belén del Manzo, correspondiente a la Facultad de Psicología de la Universidad Nacional de La Plata. Trabajamos a lo largo de este desarrollo un concepto central para nuestras prácticas: cuerpas en situación de encierro punitivo. Abordamos cómo pensamos las cuerpas, las violencias que las atraviesan social e institucionalmente y las resistencias que ellas mismas crean ante las distintas situaciones que transitan. Desde una mirada feminista, con perspectiva de género y de Derechos Humanos, problematizamos cómo fue construído el cuerpo desde el discurso hegemónico, a partir de lo cual conceptualizamos el término cuerpas. Utilizar dicho término corresponde a un posicionamiento político que define y orienta nuestras prácticas. Por este motivo realizamos un abordaje y una explicación teórica de dicho concepto. Con una mirada situacional, apuntamos a la especificidad de la población con la que trabajamos, por lo que nos resulta central realizar una revisión y evaluación de este concepto. Esto nos permite poner en discusión otras miradas posibles, pensar futuras intervenciones y evaluar el devenir del proyecto mismo como así también nuestras prácticas como profesionales.The present work is carried out within the framework of the Extension Project "Women (in) habiting confinement", directed by Irma Colanzi and co-directed by María Belén del Manzo, corresponding to the Faculty of Psychology of the National University of La Plata. We work throughout this development a central concept for our practices: corps in situation of punitive confinement. We approach how we think the bodies, the violence that crosses them socially and institutionally and the resistance that they themselves create in the different situations they are going through. From a feminist perspective, with a perspective of gender and Human Rights, We problematized how the body was constructed from the hegemonic discourse, from which we conceptualized the term bodies. Using this term corresponds to a political positioning that defines and guides our practices. For this reason we perform an approach and a theoretical explanation of this concept. With a situational look, we aim at the specificity of the population with which we work, so it is central to us to review and evaluate this concept. This allows us to discuss other possible perspectives, to think about future interventions and to evaluate the evolution of the project itself as well as our practices as professionals.Facultad de Psicologí

Cuerpas encarceladas. Violencias y resistencias

El presente trabajo se encuentra realizado en el marco del Proyecto de Extensión “Mujeres (des) habitando encierros”, dirigido por Irma Colanzi y codirigido por María Belén del Manzo, correspondiente a la Facultad de Psicología de la Universidad Nacional de La Plata. Trabajamos a lo largo de este desarrollo un concepto central para nuestras prácticas: cuerpas en situación de encierro punitivo. Abordamos cómo pensamos las cuerpas, las violencias que las atraviesan, social e institucionalmente, y las resistencias que ellas mismas crean ante las distintas situaciones que transitan. Desde una mirada feminista, con perspectiva de género y de Derechos Humanos, problematizamos cómo fue construido el cuerpo desde el discurso hegemónico, a partir de lo cual conceptualizamos el término cuerpas. Utilizar dicho término corresponde a un posicionamiento político que define y orienta nuestras prácticas. Por este motivo realizamos un abordaje y una explicación teórica de dicho concepto. Con una mirada situacional, apuntamos a la especificidad de la población con la que trabajamos, por lo que nos resulta central realizar una revisión y evaluación de este concepto. Esto nos permite poner en discusión otras miradas posibles, pensar futuras intervenciones y evaluar el devenir del proyecto mismo como así también nuestras prácticas como profesionales.The present work is carried out within the framework of the Extension Project ‘Women (in) habiting confinement’, directed by Irma Colanzi and co-directed by María Belén del Manzo, corresponding to the Faculty of Psychology of the National University of La Plata. We work throughout this development a central concept for our practices: corps in a situation of punitive confinement. We approach how we think the bodies, the violence that crosses them socially and institutionally and the resistance that they themselves create in the different situations they are going through. From a feminist perspective, with a perspective of gender and Human Rights, we problematized how the body was constructed from the hegemonic discourse, from which we conceptualized the term bodies. Using this term corresponds to a political position that defines and guides our practices. For this reason we perform an approach and a theoretical explanation of this concept. With a situational look, we aim at the specificity of the population with which we work, so it is central to us to review and evaluate this concept. This allows us to discuss other possible perspectives, to think about future interventions and to evaluate the evolution of the project itself as well as our practices as professionals.Facultad de Psicologí

Cuerpas encarceladas : Violencias y resistencias

El presente trabajo se encuentra realizado en el marco del Proyecto de Extensión “Mujeres (des) habitando encierros”, dirigido por Irma Colanzi y codirigido por María Belén del Manzo, correspondiente a la Facultad de Psicología de la Universidad Nacional de La Plata. Trabajamos a lo largo de este desarrollo un concepto central para nuestras prácticas: cuerpas en situación de encierro punitivo. Abordamos cómo pensamos las cuerpas, las violencias que las atraviesan social e institucionalmente y las resistencias que ellas mismas crean ante las distintas situaciones que transitan. Desde una mirada feminista, con perspectiva de género y de Derechos Humanos, problematizamos cómo fue construído el cuerpo desde el discurso hegemónico, a partir de lo cual conceptualizamos el término cuerpas. Utilizar dicho término corresponde a un posicionamiento político que define y orienta nuestras prácticas. Por este motivo realizamos un abordaje y una explicación teórica de dicho concepto. Con una mirada situacional, apuntamos a la especificidad de la población con la que trabajamos, por lo que nos resulta central realizar una revisión y evaluación de este concepto. Esto nos permite poner en discusión otras miradas posibles, pensar futuras intervenciones y evaluar el devenir del proyecto mismo como así también nuestras prácticas como profesionales.The present work is carried out within the framework of the Extension Project "Women (in) habiting confinement", directed by Irma Colanzi and co-directed by María Belén del Manzo, corresponding to the Faculty of Psychology of the National University of La Plata. We work throughout this development a central concept for our practices: corps in situation of punitive confinement. We approach how we think the bodies, the violence that crosses them socially and institutionally and the resistance that they themselves create in the different situations they are going through. From a feminist perspective, with a perspective of gender and Human Rights, We problematized how the body was constructed from the hegemonic discourse, from which we conceptualized the term bodies. Using this term corresponds to a political positioning that defines and guides our practices. For this reason we perform an approach and a theoretical explanation of this concept. With a situational look, we aim at the specificity of the population with which we work, so it is central to us to review and evaluate this concept. This allows us to discuss other possible perspectives, to think about future interventions and to evaluate the evolution of the project itself as well as our practices as professionals.Facultad de Psicologí

Cellular and Molecular Mechanism of Pulmonary Fibrosis Post-COVID-19: Focus on Galectin-1, -3, -8, -9

Pulmonary fibrosis is a consequence of the pathological accumulation of extracellular matrix (ECM), which finally leads to lung scarring. Although the pulmonary fibrogenesis is almost known, the last two years of the COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its post effects added new particularities which need to be explored. Many questions remain about how pulmonary fibrotic changes occur within the lungs of COVID-19 patients, and whether the changes will persist long term or are capable of resolving. This review brings together existing knowledge on both COVID-19 and pulmonary fibrosis, starting with the main key players in promoting pulmonary fibrosis, such as alveolar and endothelial cells, fibroblasts, lipofibroblasts, and macrophages. Further, we provide an overview of the main molecular mechanisms driving the fibrotic process in connection with Galactin-1, -3, -8, and -9, together with the currently approved and newly proposed clinical therapeutic solutions given for the treatment of fibrosis, based on their inhibition. The work underlines the particular pathways and processes that may be implicated in pulmonary fibrosis pathogenesis post-SARS-CoV-2 viral infection. The recent data suggest that galectin-1, -3, -8, and -9 could become valuable biomarkers for the diagnosis and prognosis of lung fibrosis post-COVID-19 and promising molecular targets for the development of new and original therapeutic tools to treat the disease

Exploring the Question: “Does Empathy Work in the Same Way in Online and In-Person Therapeutic Settings?”

Providing remote psychotherapy using technology is a growing practice, especially since the outbreak of the COVID-19 pandemic. Even if in numerous studies video conferencing psychotherapy (VCP) was found to be clinically effective, some doubts continue to exist about how the psychotherapeutic alliance works in the online setting, and the characteristics of the empathic process are still poorly understood. This is an exploratory study aimed at analyzing the degree of empathy between the psychotherapist and client pair, and the degree of support perceived by the client who shall be referred to as the patient interchangeably in this study, comparing the sessions in person with those online, during the current pandemic, in order to discriminate the impact of empathy in the digital setting. The sample analyzed was composed of 23 patients with different severity of pathology engaged in online and in-person therapeutic sessions with five psychotherapists of different theoretical leanings. The scores of the support and empathy scale, obtained by both members of the psychotherapeutic couple in the two settings, were analyzed and compared. The test used belongs to an Italian adaptation of the Empathic Understanding (EU) of the Relationship Inventory. What emerged from comparing the scores was interesting: Unlike the psychotherapists, the patients perceived their therapists as significantly more empathic and supportive in the remote setting. These are rather important data, because the literature documents that client empathic perception measures represent a more accurate measure of the empathic relationship and, in general, can predict a good treatment outcome. Although these results need further investigation, they represent an important contribution in filling the scientific gap in the understanding of digital empathy. Also, this study provides new insights for future research on the characteristics and impact empathy has on the practice of remote psychotherapy