The Kinematic Properties of the Extended Disks of Spiral Galaxies: A Sample of Edge-On Galaxies

We present a kinematic study of the outer regions (R_25<R<2 R_25) of 17 edge-on disk galaxies. Using deep long-slit spectroscopy (flux sensitivity a few 10^-19 erg s^-1 cm^-2 arcsec^-2), we search for H-alpha emission, which must be emitted at these flux levels by any accumulation of hydrogen due to the presence of the extragalactic UV background and any other, local source of UV flux. We present results from the individual galaxy spectra and a stacked composite. We detect H-alpha in many cases well beyond R_25 and sometimes as far as 2 R_25. The combination of sensitivity, spatial resolution, and kinematic resolution of this technique thus provides a powerful complement to 21-cm observations. Kinematics in the outer disk are generally disk-like (flat rotation curves, small velocity dispersions) at all radii, and there is no evidence for a change in the velocity dispersion with radius. We place strong limits, few percent, on the existence of counter-rotating gas out to 1.5 R_25. These results suggest that thin disks extend well beyond R_25; however, we also find a few puzzling anomalies. In ESO 323-G033 we find two emission regions that have velocities close to the systemic velocity rather than the expected rotation velocity. These low relative velocities are unlikely to be simply due to projection effects and so suggest that these regions are not on disk-plane, circular orbits. In MCG-01-31-002 we find emission from gas with a large velocity dispersion that is co-rotating with the inner disk.Comment: 18 pages, 14 figures, accepted for publication in Ap

The Orbit of the Companion to HD 100453A: Binary-Driven Spiral Arms in a Protoplanetary Disk

HD 100453AB is a 10+/-2 Myr old binary whose protoplanetary disk was recently revealed to host a global two-armed spiral structure. Given the relatively small projected separation of the binary (1.05", or ~108 au), gravitational perturbations by the binary seemed to be a likely driving force behind the formation of the spiral arms. However, the orbit of these stars remained poorly understood, which prevented a proper treatment of the dynamical influence of the companion on the disk. We observed HD 100453AB between 2015-2017 utilizing extreme adaptive optics systems on the Very Large Telescope and Magellan Clay Telescope. We combined the astrometry from these observations with published data to constrain the parameters of the binary's orbit to a=1.06"+/-0.09", e=0.17+/-0.07, and i=32.5+/- 6.5 degrees. We utilized publicly available ALMA CO data to constrain the inclination of the disk to i~28 degrees, which is relatively co-planar with the orbit of the companion and consistent with previous estimates from scattered light images. Finally, we input these constraints into hydrodynamical and radiative transfer simulations to model the structural evolution of the disk. We find that the spiral structure and truncation of the circumprimary disk in HD 100453 are consistent with a companion-dirven origin. Furthermore, we find that the primary star's rotation, its outer disk, and the companion exhibit roughly the same direction of angular momentum, and thus the system likely formed from the same parent body of material.Comment: 28 pages, 11 figures, Accepted to Ap

Revised SED of the triple protostellar system VLA 1623-2417

VLA 1623$-$2417 is a triple protostellar system deeply embedded in Ophiuchus A. Sources A and B have a separation of 1.1", making their study difficult beyond the submillimeter regime. Lack of circumstellar gas emission suggested that VLA 1623$-$2417 B has a very cold envelope and is much younger than source A, generally considered the prototypical Class 0 source. We explore the consequences of new ALMA Band 9 data on the spectral energy distribution (SED) of VLA 1623$-$2417 and their inferred nature. Using dust continuum observations spanning from centimeter to near-infrared wavelengths, the SED of each component in VLA 1623$-$2417 is constructed and analysed. The ALMA Band 9 data presented here show that the SED of VLA 1623$-$2417 B does not peak at 850 $\mu$m as previously expected, but instead presents the same shape as VLA 1623$-$2417 A at wavelengths shorter than 450 $\mu$m. The results presented here indicate that the previous assumption that the flux in $Herschel$ and Spitzer observations is solely dominated by VLA 1623$-$2417 A is not valid, and instead, VLA 1623$-$2417 B most likely contributes a significant fraction of the flux at $\lambda~<$ 450 $\mu$m. These results, however, do not explain the lack of circumstellar gas emission and puzzling nature of VLA 1623$-$2417 B.Comment: 6 pages, 2 figures, accepted to A&A letters to the edito

Role of Polarized G Protein Signaling in Tracking Pheromone Gradients

SummaryYeast cells track gradients of pheromones to locate mating partners. Intuition suggests that uniform distribution of pheromone receptors over the cell surface would yield optimal gradient sensing. However, yeast cells display polarized receptors. The benefit of such polarization was unknown. During gradient tracking, cell growth is directed by a patch of polarity regulators that wanders around the cortex. Patch movement is sensitive to pheromone dose, with wandering reduced on the up-gradient side of the cell, resulting in net growth in that direction. Mathematical modeling suggests that active receptors and associated G proteins lag behind the polarity patch and act as an effective drag on patch movement. In vivo, the polarity patch is trailed by a G protein-rich domain, and this polarized distribution of G proteins is required to constrain patch wandering. Our findings explain why G protein polarization is beneficial and illuminate a novel mechanism for gradient tracking

Polyhydramnios among women in a cluster-randomized trial of ultrasound during prenatal care within five low and low-middle income countries: A secondary analysis of the first look study

Background: In many low and low-middle income countries, the incidence of polyhydramnios is unknown, in part because ultrasound technology is not routinely used. Our objective was to report the incidence of polyhydramnios in five low and low-middle income countries, to determine maternal characteristics associated with polyhydramnios, and report pregnancy and neonatal outcomes.Methods: We performed a secondary analysis of the First Look Study, a multi-national, cluster-randomized trial of ultrasound during prenatal care. We evaluated all women enrolled from Guatemala, Pakistan, Zambia, Kenya and the Democratic Republic of Congo (DRC) who received an examination by prenatal ultrasound. We used pairwise site comparisons with Tukey-Kramer adjustment and multivariable logistic models with general estimating equations to control for cluster-level effects. The diagnosis of polyhydramnios was confrimed by an U.S. based radiologist in a majority of cases (62%).Results: We identified 305/18,640 (1.6%) cases of polyhydramnios. 229 (75%) cases were from the DRC, with an incidence of 10%. A higher percentage of women with polyhydramnios experienced obstructed labor (7% vs 4%) and fetal malposition (4% vs 2%). Neonatal death was more common when polyhydramnios was present (OR 2.43; CI 1.15, 5.13).Conclusions: Polyhydramnios occured in these low and low-middle income countries at a rate similar to high-income contries except in the DRC where the incidence was 10%. Polyhydramnios was associated with obstructed labor, fetal malposition, and neonatal death

Responses to Conflict and Cooperation in Adolescents with Anxiety and Mood Disorders

This study examined patterns of behavioral and emotional responses to conflict and cooperation in adolescents with anxiety/mood disorders and healthy peers. We compared performance on and emotional responses to the Prisoner’s Dilemma (PD) game, an economic exchange task involving conflict and cooperation, between adolescents with anxiety/depressive disorders (A/D) (N=21) and healthy comparisons (n=29). Participants were deceived to believe their co-player (a pre-programmed computer algorithm) was another study participant. A/D adolescents differed significantly from comparisons in patterns of play and emotional response to the game. Specifically, A/D participants responded more cooperatively to cooperative overtures from their co-players; A/D girls also reported more anger toward co-players than did comparison girls. Our findings indicate that A/D adolescents, particularly females, respond distinctively to stressful social interchanges. These findings offer a first step toward elucidating the mechanisms underlying social impairment in youth with internalizing disorders

Within-day improvement in a behavioural display: wild birds 'warm up'

Permission to archive accepted author manuscript.Motor performance describes the vigour or skill required to perform a particular display. It is a behaviourally salient variable in birdsong and other animal displays, but little is known about within-individual variation in performance over short timescales. The metric ‘frequency excursion’ (FEX) quantifies birdsong performance as cumulative frequency modulation per unit time. We measured FEX in a large sample of recordings from free-living male Adelaide's warblers, Setophaga adelaidae. Our objectives were to quantify natural variation in performance and test the hypotheses that performance (1) improves as a function of recent practise, (2) decreases over consecutive repetitions of a single song type, (3) improves with rest between songs, (4) varies by singing mode and (5) changes during vocal interactions with neighbours. We found significant variation in performance among individuals and song types. Consecutive repetition of a song type, rest between songs, singing mode and vocal interaction did not strongly affect performance. Performance consistently increased with song order, however, indicating that males warm up during morning singing. This is the first demonstration of such an effect in a sexual display. The warm-up effect may explain the prevalence of intense dawn singing in birds (dawn chorus), if rivals engage in an arms race to warm up.Ye

Abnormal Attention Modulation of Fear Circuit Function in Pediatric Generalized Anxiety Disorder

1. Context. Considerable work implicates abnormal neural activation and disrupted attention to facial-threat cues in adult anxiety disorders. However, in pediatric anxiety, no research has examined attention modulation of neural response to threat cues. 2. Objective. To determine whether attention modulates amygdala and cortical responses to facial threat cues differentially in adolescents with generalized anxiety disorder (GAD) and healthy adolescents. 3. Design. Case-control study. 4. Setting. Government clinical research institute. 5. Participants. Adolescent volunteers, 15 with GAD and 20 diagnosis-free. 6. Main Outcome Measure(s). Blood oxygenation level-dependent (BOLD) signal, as measured via functional magnetic resonance imaging (fMRI). During fMRI scans, participants completed a face-emotion rating task that systematically manipulated attention. 7. Results. While attending to their own subjective fear, patients, but not controls, showed greater activation to fearful than to happy faces (small volume corrected p’s \u3c .05) in a distributed network including the amygdala, ventral PFC (vPFC), and anterior cingulate cortex (ACC). Right amygdala findings appeared particularly strong. Functional connectivity analyses demonstrated positive correlations among the amygdala, vPFC, and cingulate. 8. Conclusions. Findings provide the first evidence in juveniles that GAD-associated patterns of pathological fear-circuit activation are particularly evident during certain attention states. Specifically, fear-circuit hyperactivation occurred in an attention state involving focus on subjectively-experienced fear. These findings underscore the importance of attention and its interaction with emotion in shaping function of the adolescent human fear circuit