Perceived Family Life Quality in Junior Secondary School Students in Hong Kong

The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link.The present longitudinal study examined perceived family functioning and related socio-demographic correlates from the perspective of adolescents in Hong Kong. Results showed that adolescent perceptions of family functioning based on different indicators gradually deteriorated over time. Regarding the socio-demographic correlates, (a) boys had more favourable perceived family functioning than did girls; (b) adolescents from non-intact families had poorer perceived family functioning than those from intact families; and (c) economically disadvantaged adolescents had poorer perceived family functioning than non-economically disadvantaged adolescents. Results also revealed that adolescents’ perceived family functioning was positively related to positive youth devel- opment. Analyses further indicated that perceived family functioning and positive youth development were concurrently and longitudinally related

Investigation into Life Enhancement and Positivity – Theoretical and Empirical Studies on Life Satisfaction

Life satisfaction is an important subject for academic and policy attention at individual, societal, and global levels. However, there are longstanding controversies in the research regarding life satisfaction. Confusing use of life satisfaction-related concepts have been identified. Repositioning the concept of life satisfaction and critically reviewing life-related satisfaction studies will clarify these confusions. This analytical commentary presents knowledge on a popular but contested subject, that of life-related satisfaction. This topic is the focus of my selected publications, in which I seek to reconceptualise and reframe the discussion to provide a more comprehensive and meaningful framework for life satisfaction. In addition, I seek to redirect future studies, applications, and policies, ultimately leading to more enabled and resilient societies. Specifically, this analytical commentary illustrates the current state of knowledge, providing an in-depth and systematic evaluation of the current terminologies related to life satisfaction and well-being; and highlights the urgency for change. In this analytical commentary, I seek to consider what authentic life satisfaction is. Based on my selected published works, together with the professional context in which the publications were written, this analytical commentary will focus on and: I. recognise the deficiencies and problems of contemporary understandings and use of relevant terms and concepts; II. make reference to philosophical and psychological thoughts; ix III. review literature within theoretically triangular axes as a frame of reference, namely, life-deep, life-wide, and life-long; and IV. propose a new theoretical framework entitled ‘Life Enhancement and Positivity’ (LEP). Shifting the paradigm, LEP is formulated to be more meaningful, comprehensive, precise, and parsimonious, considering both structures and dynamics of life. Two major structural domains are outlined. Among my published works, I have selected seven peer-reviewed papers that will serve as the body of work for this analytical commentary. Five of the papers were published in internationally recognised journals, and two are articles within two academic reference books published by the University of Hong Kong and Hong Kong Polytechnic University respectively. Under the common theme of life satisfaction, they address different research targets (for example, older and younger cohorts), variables (for example, health-related, psychosocial-related, and work-related) and methods (for example, quantitative and qualitative). These publications, as original contributions to the field, aid the construction of a new meta-level framework that aims to address the aforementioned controversies and ambiguities within the context of a complex and intricate situation as well as to serve as a guide towards a new direction

A Rapid Segmentation-Insensitive "Digital Biopsy" Method for Radiomic Feature Extraction: Method and Pilot Study Using CT Images of Non-Small Cell Lung Cancer.

Quantitative imaging approaches compute features within images' regions of interest. Segmentation is rarely completely automatic, requiring time-consuming editing by experts. We propose a new paradigm, called "digital biopsy," that allows for the collection of intensity- and texture-based features from these regions at least 1 order of magnitude faster than the current manual or semiautomated methods. A radiologist reviewed automated segmentations of lung nodules from 100 preoperative volume computed tomography scans of patients with non-small cell lung cancer, and manually adjusted the nodule boundaries in each section, to be used as a reference standard, requiring up to 45 minutes per nodule. We also asked a different expert to generate a digital biopsy for each patient using a paintbrush tool to paint a contiguous region of each tumor over multiple cross-sections, a procedure that required an average of <3 minutes per nodule. We simulated additional digital biopsies using morphological procedures. Finally, we compared the features extracted from these digital biopsies with our reference standard using intraclass correlation coefficient (ICC) to characterize robustness. Comparing the reference standard segmentations to our digital biopsies, we found that 84/94 features had an ICC >0.7; comparing erosions and dilations, using a sphere of 1.5-mm radius, of our digital biopsies to the reference standard segmentations resulted in 41/94 and 53/94 features, respectively, with ICCs >0.7. We conclude that many intensity- and texture-based features remain consistent between the reference standard and our method while substantially reducing the amount of operator time required

Prévalence des attitudes et comportements inadaptés face à l’alimentation chez des adolescentes de la région de Montréal

La présente étude fait partie d'un projet de recherche portant sur les habitudes alimentaires des adolescentes et les facteurs de vulnérabilité aux troubles alimentaires. Nous présentons ici les résultats ayant trait à la pré valence des préoccupations et des troubles liés à T alimentation dans un groupe, nonre présentatif, de 1162 adolescentes de la région de Montréal. Les items de deux échelles souvent employées dans le domaine révèlent que le tiers des filles sont insatisfaites de leur corps et que 14% d'entre elles adoptent des attitudes et comportements inadaptés face à l'alimentation. À l'aide de différents critères, on estime la prévalence de l'anorexie nerveuse à environ 0,6% et celle de la boulimie nerveuse entre 0,5 et 2,5 %. Ces résultats se comparent à ceux rappor tés dans d'autres centres urbains occidentaux et font ressortir l'urgence de sensibiliser la population et les milieux de la santé québécois aux troubles alimentaires.The following study is part of a research project on the eating habits of adolescent girls and on the vulnerability factors concerning eating disorders. Here the authors focus on the prevalence of various concerns and problems linked to eating habits within a non-representative group of 1,162 adolescents in the Montréal region. Two parameters frequently used in the field reveal that a third of the girls are unhappy with their body and that 14 % of the sampling adopts unhealty attitudes and behaviours in regard to eating habits. Based on several criteria, the prevalence of nervous anorexia is estimated at approximately 0.6 % and that of nervous boulimia at between 0.5 and 2.5 %. These results are comparable to those obtained in other major urban centres of the Western world. In addition, they point to the urgent need to increase awareness among the population and the Québec healthcare field on the subject of eating disorders

Poster 196: Predicting Chronic Stinger Syndrome Using the Mean Subaxial Space Available for the Cord Index (MSCSAC): A Case Report

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/147133/1/pmr2s89a.pd

WiSARD: A Labeled Visual and Thermal Image Dataset for Wilderness Search and Rescue

Sensor-equipped unoccupied aerial vehicles (UAVs) have the potential to help reduce search times and alleviate safety risks for first responders carrying out Wilderness Search and Rescue (WiSAR) operations, the process of finding and rescuing person(s) lost in wilderness areas. Unfortunately, visual sensors alone do not address the need for robustness across all the possible terrains, weather, and lighting conditions that WiSAR operations can be conducted in. The use of multi-modal sensors, specifically visual-thermal cameras, is critical in enabling WiSAR UAVs to perform in diverse operating conditions. However, due to the unique challenges posed by the wilderness context, existing dataset benchmarks are inadequate for developing vision-based algorithms for autonomous WiSAR UAVs. To this end, we present WiSARD, a dataset with roughly 56,000 labeled visual and thermal images collected from UAV flights in various terrains, seasons, weather, and lighting conditions. To the best of our knowledge, WiSARD is the first large-scale dataset collected with multi-modal sensors for autonomous WiSAR operations. We envision that our dataset will provide researchers with a diverse and challenging benchmark that can test the robustness of their algorithms when applied to real-world (life-saving) applications

Poster 260: Inadvertent Cervical Radicular Artery Injection Using a Pencil‐Point (Whitacre) Needle: A Case Report

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/147116/1/pmr2s216b.pd

Poster 277: Cervical Transforaminal Epidural Steroid Injection in the Management of a Stinger Injury: A Case Report

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/146964/1/pmr2s124a.pd

Repurposing screen identifies mebendazole as a clinical candidate to synergise with docetaxel for prostate cancer treatment

BACKGROUND: Docetaxel chemotherapy in prostate cancer has a modest impact on survival. To date, efforts to develop combination therapies have not translated into new treatments. We sought to develop a novel therapeutic strategy to tackle chemoresistant prostate cancer by enhancing the efficacy of docetaxel. METHODS: We performed a drug-repurposing screen by using murine-derived prostate cancer cell lines driven by clinically relevant genotypes. Cells were treated with docetaxel alone, or in combination with drugs (n = 857) from repurposing libraries, with cytotoxicity quantified using High Content Imaging Analysis. RESULTS: Mebendazole (an anthelmintic drug that inhibits microtubule assembly) was selected as the lead drug and shown to potently synergise docetaxel-mediated cell killing in vitro and in vivo. Dual targeting of the microtubule structure was associated with increased G2/M mitotic block and enhanced cell death. Strikingly, following combined docetaxel and mebendazole treatment, no cells divided correctly, forming multipolar spindles that resulted in aneuploid daughter cells. Liposomes entrapping docetaxel and mebendazole suppressed in vivo prostate tumour growth and extended progression-free survival. CONCLUSIONS: Docetaxel and mebendazole target distinct aspects of the microtubule dynamics, leading to increased apoptosis and reduced tumour growth. Our data support a new concept of combined mebendazole/docetaxel treatment that warrants further clinical evaluation