On the Sum of Fisher-Snedecor F Variates and its Application to Maximal-Ratio Combining

Capitalizing on the recently proposed Fisher-Snedecor F composite fading model, in this letter, we investigate the sum of independent but not identically distributed (i.n.i.d.) Fisher-Snedecor F variates. First, a novel closed-form expression is derived for the moment generating function of the instantaneous signal-to-noise ratio. Based on this, the corresponding probability density function and cumulative distribution function of the sum of i.n.i.d. Fisher- Snedecor F variates are derived, which are subsequently employed in the analysis of multiple branch maximal-ratio combining (MRC). Specifically, we investigate the impact of multipath and shadowed fading on the outage probability and outage capacity of MRC based receivers. In addition, we derive exact closed-form expressions for the average bit error rate of coherent binary modulation schemes followed by an asymptotic analysis which provides further insights into the effect of the system parameters on the overall performance. Importantly, it is shown that the effect of multipath fading on the system performance is more pronounced than that of shadowing.Comment: 5 pages, 3 figure

The role of Dark Matter interaction in galaxy clusters

We consider a toy model to analyze the consequences of dark matter interaction with a dark energy background on the overall rotation of galaxy clusters and the misalignment between their dark matter and baryon distributions when compared to {\Lambda}CDM predictions. The interaction parameters are found via a genetic algorithm search. The results obtained suggest that interaction is a basic phenomenon whose effects are detectable even in simple models of galactic dynamics.Comment: RevTeX 4.1, 5 pages, 3 figure

Consistency of linkage results across exams and methods in the Framingham Heart Study

BACKGROUND: The repeated measures in the Framingham Heart Study in the Genetic Analysis Workshop 13 data set allow us to test for consistency of linkage results within a study across time. We compared regression-based linkage to variance components linkage across time for six quantitative traits in the real data. RESULTS: The variance components approach found 11 significant linkages, the regression-based approach found 4. There was only one region that overlapped. Consistency between exams generally decreased as the time interval between exams increased. The regression-based approach showed higher consistency in linkage results across exams. CONCLUSION: The low consistency between exams and between methods may help explain the lack of replication between studies in this field

MILP approach for then design of vertical vapor-liquid separation vessels-comparison with heuristics

In this article we compare results from different heuristics approaches for the design of VLE separation vessels. In addition, we present an MILP approach that embeds the aforementioned heuristics and considers the discrete nature of the geometric variables. We show that different heuristics render different results and, while results from heuristics and MILP often coincide, significant departures occur.Fil: Fischer, Carlos Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo y Diseño. Universidad Tecnológica Nacional. Facultad Regional Santa Fe. Instituto de Desarrollo y Diseño; ArgentinaFil: Costa, André Hemerly L.. Universidade do Estado de Rio do Janeiro; BrasilFil: Bagajewicz, Miguel J.. Oklahoma State University; Estados Unido

A nationwide cohort study of slipped capital femoral epiphysis

Objectives To describe the epidemiology of slipped capital femoral epiphysis (SCFE), to examine associations with childhood obesity and socioeconomic deprivation, and to explore factors associated with diagnostic delays. Design Historic cohort study using linked primary and secondary care data from the Clinical Practice Research Datalink and Hospital Episode Statistics. Setting All contacts with healthcare services, including emergency presentations, outpatient appointments, inpatient admissions and primary care visits, within the UK National Health Service. Patients All individuals <16 years old with a diagnosis of SCFE and whose electronic medical record was held by one of 650 primary care practices in the UK between 1990 and 2013. Main outcome measures Annual incidence, missed opportunities for diagnosis and diagnostic delay. Results Over the 23-year period the incidence remained constant at 4.8 (95% CI 4.4 to 5.2) cases per 100,000 0–16-year-olds. There was a strong association with socioeconomic deprivation. Predisease obesity was also strongly associated with SCFE; mean predisease z-score of body mass index was 1.43 (95% CI 1.20 to 1.68) compared with the UK reference mean. Diagnostic delays were common, with most children (75.4%) having multiple primary care contacts with relevant symptomatology, and those who presented with knee pain having significantly longer diagnostic delay (median 161 (IQR 27–278) days) than those with hip pain (20 (5–126)) or gait abnormalities (21 (7–72)). Conclusions SCFE has a strong association with both area-level socioeconomic deprivation and predisease obesity. The majority of patients with SCFE are initially misdiagnosed and those presenting with knee pain are particularly at risk

Iron mobilization during lactation reduces oxygen stores in a diving mammal

© The Author(s), 2022. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Shero, M. R., Kirkham, A. L., Costa, D. P., & Burns, J. M. Iron mobilization during lactation reduces oxygen stores in a diving mammal. Nature Communications, 13(1), (2022): 4322, https://doi.org/10.1038/s41467-022-31863-7.The profound impacts that maternal provisioning of finite energy resources has on offspring survival have been extensively studied across mammals. This study shows that in addition to calories, high hemoprotein concentrations in diving mammals necessitates exceptional female-to-pup iron transfer. Numerous indices of iron mobilization (ferritin, serum iron, total-iron-binding-capacity, transferrin saturation) were significantly elevated during lactation in adult female Weddell seals (Leptonychotes weddellii), but not in skip-breeders. Iron was mobilized from endogenous stores for incorporation into the Weddell seal’s milk at concentrations up to 100× higher than terrestrial mammals. Such high rates of iron offload to offspring drew from the female’s own heme stores and led to compromised physiologic dive capacities (hemoglobin, myoglobin, and total body oxygen stores) after weaning their pups, which was further reflected in shorter dive durations. We demonstrate that lactational iron transfer shapes physiologic dive thresholds, identifying a cost of reproduction to a marine mammal.This research was conducted with support from NSF ANT-0838892 to DPC; ANT-0838937 and ANT-1246463 to JMB (which also supported ALK and MRS); and The Investment in Science Fund at WHOI to MRS

Changes in serum adipokines during natural extended fasts in female northern elephant seals

© The Author(s), 2021. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Rzucidlo, C. L., Sperou, E. S., Holser, R. R., Khudyakov, J., Costa, D. P., & Crocker, D. E. Changes in serum adipokines during natural extended fasts in female northern elephant seals. General and Comparative Endocrinology, 308, (2021): 113760, https://doi.org/10.1016/j.ygcen.2021.113760.Adipose tissue is essential to endotherms for thermoregulation and energy storage as well as functioning as an endocrine organ. Adipose derived hormones, or adipokines, regulate metabolism, energy expenditure, reproduction, and immune function in model systems but are less well studied in wildlife. Female northern elephant seals (NES) achieve high adiposity during foraging and then undergo natural fasts up to five weeks long during haul-outs associated with reproduction and molting, resulting in large changes in adipose reserves. We measured circulating levels of four adipokines: leptin, resistin, adiponectin, and kisspeptin-54, in 196 serum samples from female NES at the beginning and end of their breeding and molting fasts. We examined the relationships between these adipokines and life-history stage, adiposity, mass, cortisol, and an immune cytokine involved in the innate immune response interleukin 6 (IL-6). All four adipokines varied with life-history stage. Leptin concentrations were highest at the beginning of the breeding haul-out. Resistin concentrations were higher throughout the breeding haul-out compared to the molt haul-out. Adiponectin concentrations were highest at the beginning of both haul-outs. Kisspeptin-54 concentrations were highest at the end of the breeding haul-out. Leptin, resistin, and adiponectin were associated with measures of body condition, either adiposity, mass, or both. Resistin, adiponectin, and kisspeptin-54 were associated with circulating cortisol concentrations. Resistin was strongly associated with circulating IL-6, a multifunctional cytokine. Adiponectin was associated with glucose concentrations, suggesting a potential role in tissue-specific insulin sensitivity during life-history stages categorized by high adiposity. Increased cortisol concentrations late in lactation were associated with increased kisspeptin-54, suggesting a link to ovulation initiation in NES. This study suggests dramatic changes in circulating adipokines with life-history and body condition that may exert important regulatory roles in NES. The positive relationship between adiponectin and adiposity as well as the lack of a relationship between leptin and kisspeptin-54 differed from model systems. These differences from biomedical model systems suggest the potential for modifications of expression and function of adipose-derived hormones in species that undergo natural changes in adiposity as part of their life-history.This project was supported by a grant from the Office of Naval Research (#N00014-18-1-2822) to DPC and DEC and the Marine Life Joint Industry Program of the IAGOP. We thank the Año Nuevo State Reserve rangers for logistical support