Thermal screening effects in a ferromagnet

Journal ArticleIn considering the theory of spin waves,1 we have examined elementary excitations of the Hamiltonian and lowest-order interactions among these excitations, in cases when j(Rij) is a very long-ranged, oscillatory interaction.2 As numerical computation is required, we are preparing to program the IBM 7094 for this project. In the course of this preparation, we have, however, obtained a result which is independent of the details of the calculation

Convection of Plasmaspheric Plasma into the Outer Magnetosphere and Boundary Layer Region: Initial Results

We present initial results on the modeling of the circulation of plasmaspheric- origin plasma into the outer magnetosphere and low-latitude boundary layer (LLBL), using a dynamic global core plasma model (DGCPM). The DGCPM includes the influences of spatially and temporally varying convection and refilling processes to calculate the equatorial core plasma density distribution throughout the magnetosphere. We have developed an initial description of the electric and magnetic field structures in the outer magnetosphere region. The purpose of this paper is to examine both the losses of plasmaspheric-origin plasma into the magnetopause boundary layer and the convection of this plasma that remains trapped on closed magnetic field lines. For the LLBL electric and magnetic structures we have adopted here, the plasmaspheric plasma reaching the outer magnetosphere is diverted anti-sunward primarily along the dusk flank. These plasmas reach X = -15 R(sub E) in the LLBL approximately 3.2 hours after the initial enhancement of convection and continues to populate the LLBL for 12 hours as the convection electric field diminishes

Control strategies for the regulation of protease clipping during mAb production in CHO cells

In cell culture based protein production, host cell proteases have the potential to cause unwelcome proteolytic cleavage against a product of interest. This cleavage can be hard to predict and avoid during product development and may even result in development termination if significant proteolytic clipping is identified. Thus, in an effort to overcome the limitations that protease cleavage poses on protein production, we propose, test, and evaluate cell culture methods which can reduce or eliminate unwanted protease activity. In this work, we evaluate three methods for the regulation of proteolytic clipping profiles of a protease susceptible broadly neutralizing HIV mAb product (CAP256-VRC26.25) [1] in CHO cells. Two culture methods aim to reduce the product residence time inside the bioreactor for reduced contact time with the host protease. These methods include using a (fed-batch) draw/fill strategy and a (continuous) perfusion approach. The third method entails the use of inhibitor molecules during culture to regulate proteolytic activity inside the bioreactor. Each method has been shown to be effective in reducing product clipping, and we further asses the approaches based on cell growth, cell productivity/titer, process feasibility, and level of clipping elimination. This work demonstrates the suitability of using specialized culturing options and offers potential solutions when faced with proteolytic problems. References: [1] – Ivleva, V., Lei, P., Cheng, K.C., Arnold, F., Investigating product quality of HIV monoclonal antibody CAP256 by LC-MS analysis. In preparatio

Part 1: Defining unproven cellular therapies

Given the potential of cell-based products, including stem/progenitor cells and immune cells, there is a global effort to introduce these therapies into the clinic to correct organ dysfunctions, to treat cancer and to abrogate autoimmune diseases and a wide variety of pathological conditions [1–3]. Relatively easy access to these cells, obtained from marrow, adipose, cord blood and other human tissues, provides tremendous opportunity for translational research, particularly for indications with no satisfactory medical solution for patients with “unmet medical needs.” Prenatal and adult stem cells (including induced pluripotent stem cells have significant potential to rebuild tissues and correct dysfunctional organs in human diseases

Variation in Suicide Risk among Subgroups of Sexual and Gender Minority College Students

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/163395/2/sltb12637_am.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/163395/1/sltb12637.pd

Infection of Cultured Human Endothelial Cells by Legionella pneumophila

Legionella pneumophila is a gram-negative pathogen that causes a severe pneumonia known as Legionnaires' disease. Here, we demonstrate for the first time that L. pneumophila infects and grows within cultured human endothelial cells. Endothelial infection may contribute to lung damage observed during Legionnaires' disease and to systemic spread of this organism

Ernst Freund as Precursor of the Rational Study of Corporate Law

Gindis, David, Ernst Freund as Precursor of the Rational Study of Corporate Law (October 27, 2017). Journal of Institutional Economics, Forthcoming. Available at SSRN: https://ssrn.com/abstract=2905547, doi: https://dx.doi.org/10.2139/ssrn.2905547The rise of large business corporations in the late 19th century compelled many American observers to admit that the nature of the corporation had yet to be understood. Published in this context, Ernst Freund's little-known The Legal Nature of Corporations (1897) was an original attempt to come to terms with a new legal and economic reality. But it can also be described, to paraphrase Oliver Wendell Holmes, as the earliest example of the rational study of corporate law. The paper shows that Freund had the intuitions of an institutional economist, and engaged in what today would be called comparative institutional analysis. Remarkably, his argument that the corporate form secures property against insider defection and against outsiders anticipated recent work on entity shielding and capital lock-in, and can be read as an early contribution to what today would be called the theory of the firm.Peer reviewe

A proposal for a coordinated effort for the determination of brainwide neuroanatomical connectivity in model organisms at a mesoscopic scale

In this era of complete genomes, our knowledge of neuroanatomical circuitry remains surprisingly sparse. Such knowledge is however critical both for basic and clinical research into brain function. Here we advocate for a concerted effort to fill this gap, through systematic, experimental mapping of neural circuits at a mesoscopic scale of resolution suitable for comprehensive, brain-wide coverage, using injections of tracers or viral vectors. We detail the scientific and medical rationale and briefly review existing knowledge and experimental techniques. We define a set of desiderata, including brain-wide coverage; validated and extensible experimental techniques suitable for standardization and automation; centralized, open access data repository; compatibility with existing resources, and tractability with current informatics technology. We discuss a hypothetical but tractable plan for mouse, additional efforts for the macaque, and technique development for human. We estimate that the mouse connectivity project could be completed within five years with a comparatively modest budget.Comment: 41 page