Decay Phase Cooling and Inferred Heating of M- and X-class Solar Flares

In this paper, the cooling of 72 M- and X-class flares is examined using GOES/XRS and SDO/EVE. The observed cooling rates are quantified and the observed total cooling times are compared to the predictions of an analytical 0-D hydrodynamic model. It is found that the model does not fit the observations well, but does provide a well defined lower limit on a flare's total cooling time. The discrepancy between observations and the model is then assumed to be primarily due to heating during the decay phase. The decay phase heating necessary to account for the discrepancy is quantified and found be ~50% of the total thermally radiated energy as calculated with GOES. This decay phase heating is found to scale with the observed peak thermal energy. It is predicted that approximating the total thermal energy from the peak is minimally affected by the decay phase heating in small flares. However, in the most energetic flares the decay phase heating inferred from the model can be several times greater than the peak thermal energy.Comment: Published in the Astrophysical Journal, 201

Radiation-reaction-induced evolution of circular orbits of particles around Kerr Black Holes

It is demonstrated that, in the adiabatic approximation, non-Equatorial circular orbits of particles in the Kerr metric (i.e. orbits of constant Boyer-Lindquist radius) remain circular under the influence of gravitational radiation reaction. A brief discussion is given of conditions for breakdown of adiabaticity and of whether slightly non-circular orbits are stable against the growth of eccentricity.Comment: 23 pages. Revtex 3.0. Inquiries to [email protected]

Analysis of β-globin chromatin micro-environment using a novel 3C variant, 4Cv

Copyright: © 2010 Pink et al.Higher order chromatin folding is critical to a number of developmental processes, including the regulation of gene expression. Recently developed biochemical techniques such as RNA TRAP and chromosome conformation capture (3C) have provided us with the tools to probe chromosomal structures. These techniques have been applied to the β-globin locus, revealing a complex pattern of interactions with regions along the chromosome that the gene resides on. However, biochemical and microscopy data on the nature of β-globin interactions with other chromosomes is contradictory. Therefore we developed a novel 4C variant, Complete-genome 3C by vectorette amplification (4Cv), which allows an unbiased and quantitative method to examine chromosomal structure. We have used 4Cv to study the microenvironment of the β-globin locus in mice and show that a significant proportion of the interactions of β-globin are inter-chromosomal. Furthermore, our data show that in the liver, where the gene is active, β-globin is more likely to interact with other chromosomes, compared to the brain where the gene is silent and is more likely to interact with other regions along the same chromosome. Our data suggest that transcriptional activation of the β-globin locus leads to a change in nuclear position relative to the chromosome territory.Ryan Pink is supported by a grant from Action Medical Research; Daniel Caley is supported by a grant from The Dunhill Medical Trust; David Carter is supported by a grant from the British Society for Haematology

Differential Effects of Buffer pH On Ca\u3csup\u3e2+\u3c/sup\u3e-Induced ROS Emission with Inhibited Mitochondrial Complexes I and III

Excessive mitochondrial reactive oxygen species (ROS) emission is a critical component in the etiology of ischemic injury. Complex I and complex III of the electron transport chain are considered the primary sources of ROS emission during cardiac ischemia and reperfusion (IR) injury. Several factors modulate ischemic ROS emission, such as an increase in extra-matrix Ca2+, a decrease in extra-matrix pH, and a change in substrate utilization. Here we examined the combined effects of these factors on ROS emission from respiratory complexes I and III under conditions of simulated IR injury. Guinea pig heart mitochondria were suspended in experimental buffer at a given pH and incubated with or without CaCl2. Mitochondria were then treated with either pyruvate, a complex I substrate, followed by rotenone, a complex I inhibitor, or succinate, a complex II substrate, followed by antimycin A, a complex III inhibitor. H2O2 release rate and matrix volume were compared with and without adding CaCl2 and at pH 7.15, 6.9, or 6.5 with pyruvate + rotenone or succinate + antimycin A to simulate conditions that may occur during in vivo cardiac IR injury. We found a large increase in H2O2 release with high [CaCl2] and pyruvate + rotenone at pH 6.9, but not at pHs 7.15 or 6.5. Large increases in H2O2 release rate also occurred at each pH with high [CaCl2] and succinate + antimycin A, with the highest levels observed at pH 7.15. The increases in H2O2 release were associated with significant mitochondrial swelling, and both H2O2 release and swelling were abolished by cyclosporine A, a desensitizer of the mitochondrial permeability transition pore (mPTP). These results indicate that ROS production by complex I and by complex III is differently affected by buffer pH and Ca2+ loading with mPTP opening. The study suggests that changes in the levels of cytosolic Ca2+ and pH during IR alter the relative amounts of ROS produced at mitochondrial respiratory complex I and complex III

Quasi-Periodic Pulsations during the Impulsive and Decay phases of an X-class Flare

Quasi-periodic pulsations (QPP) are often observed in X-ray emission from solar flares. To date, it is unclear what their physical origins are. Here, we present a multi-instrument investigation of the nature of QPP during the impulsive and decay phases of the X1.0 flare of 28 October 2013. We focus on the character of the fine structure pulsations evident in the soft X-ray time derivatives and compare this variability with structure across multiple wavelengths including hard X-ray and microwave emission. We find that during the impulsive phase of the flare, high correlations between pulsations in the thermal and non-thermal emissions are seen. A characteristic timescale of ~20s is observed in all channels and a second timescale of ~55s is observed in the non-thermal emissions. Soft X-ray pulsations are seen to persist into the decay phase of this flare, up to 20 minutes after the non-thermal emission has ceased. We find that these decay phase thermal pulsations have very small amplitude and show an increase in characteristic timescale from ~40s up to ~70s. We interpret the bursty nature of the co-existing multi-wavelength QPP during the impulsive phase in terms of episodic particle acceleration and plasma heating. The persistent thermal decay phase QPP are most likely connected with compressive MHD processes in the post-flare loops such as the fast sausage mode or the vertical kink mode.Comment: 7 pages, 4 figures, 1 tabl

A geometrical approach to the dynamics of spinor condensates I: Hydrodynamics

In this work, we derive the equations of motion governing the hydrodynamics of spin-F spinor condensates. We pursue a description based on standard physical variables (total density and superfluid velocity), alongside 2F `spin-nodes': unit vectors that describe the spin F state, and also exhibit the point-group symmetry of a spinor condensate's mean-field ground state. The hydrodynamic equations of motion consist of a mass continuity equation, 2F Landau-Lifshitz equations for the spin-nodes, and a modified Euler equation. In particular, we provide a generalization of the Mermin-Ho relation to spin one, and find an analytic solution for the skyrmion texture in the incompressible regime of a spin-half condensate. These results exhibit a beautiful geometrical structure that underlies the dynamics of spinor condensates.Comment: 12 pages. First paper in two-part serie

Active Transport of Peptides Across the Intact Human Tympanic Membrane.

We previously identified peptides that are actively transported across the intact tympanic membrane (TM) of rats with infected middle ears. To assess the possibility that this transport would also occur across the human TM, we first developed and validated an assay to evaluate transport in vitro using fragments of the TM. Using this assay, we demonstrated the ability of phage bearing a TM-transiting peptide to cross freshly dissected TM fragments from infected rats or from uninfected rats, guinea pigs and rabbits. We then evaluated transport across fragments of the human TM that were discarded during otologic surgery. Human trans-TM transport was similar to that seen in the animal species. Finally, we found that free peptide, unconnected to phage, was transported across the TM at a rate comparable to that seen for peptide-bearing phage. These studies provide evidence supporting the concept of peptide-mediated drug delivery across the intact TM and into the middle ears of patients

The Thermal Properties of Solar Flares Over Three Solar Cycles Using GOES X-ray Observations

Solar flare X-ray emission results from rapidly increasing temperatures and emission measures in flaring active region loops. To date, observations from the X-Ray Sensor (XRS) onboard the Geostationary Operational Environmental Satellite (GOES) have been used to derive these properties, but have been limited by a number of factors, including the lack of a consistent background subtraction method capable of being automatically applied to large numbers of flares. In this paper, we describe an automated temperature and emission measure-based background subtraction method (TEBBS), which builds on the methods of Bornmann (1990). Our algorithm ensures that the derived temperature is always greater than the instrumental limit and the pre-flare background temperature, and that the temperature and emission measure are increasing during the flare rise phase. Additionally, TEBBS utilizes the improved estimates of GOES temperatures and emission measures from White et al. (2005). TEBBS was successfully applied to over 50,000 solar flares occurring over nearly three solar cycles (1980-2007), and used to create an extensive catalog of the solar flare thermal properties. We confirm that the peak emission measure and total radiative losses scale with background subtracted GOES X-ray flux as power-laws, while the peak temperature scales logarithmically. As expected, the peak emission measure shows an increasing trend with peak temperature, although the total radiative losses do not. While these results are comparable to previous studies, we find that flares of a given GOES class have lower peak temperatures and higher peak emission measures than previously reported. The resulting TEBBS database of thermal flare plasma properties is publicly available on Solar Monitor (www.solarmonitor.org/TEBBS/) and will be available on Heliophysics Integrated Observatory (www.helio-vo.eu)