Configuration Selection Based On Lifecycle Cost Of Subsea Production System: Case Of Indonesia Deepwater Field

Subsea tie back systems are important parts of oil and gas production project. The decision to select a subsea tie-back configuration with the objective goal of lowest lifecycle cost can be configured in multiple ways based on the field specifications and operator’s approach to operation. This paper presents an Analytic Hierarchy Process (AHP) method to determine economical levels of subsea tie-back wells configuration, based on lifecycle cost of subsea deepwater production systems with respect to wells number alternative. Field reservoir located in deepwater of eastern Indonesian with the depth of 1400 meters and field life 40 years is studied. From this study, it is identified that the most economical configuration in subsea production systems: satellite tie-back configuration to develop small field with 6 numbers of wells; for 12 numbers of wells, template subsea tie-back configuration is the best

Data Combinations Accounting for LISA Spacecraft Motion

LISA is an array of three spacecraft in an approximately equilateral triangle configuration which will be used as a low-frequency gravitational wave detector. We present here new generalizations of the Michelson- and Sagnac-type time-delay interferometry data combinations. These combinations cancel laser phase noise in the presence of different up and down propagation delays in each arm of the array, and slowly varying systematic motion of the spacecraft. The gravitational wave sensitivities of these generalized combinations are the same as previously computed for the stationary cases, although the combinations are now more complicated. We introduce a diagrammatic representation to illustrate that these combinations are actually synthesized equal-arm interferometers.Comment: 10 pages, 3 figure

Implementation of Time-Delay Interferometry for LISA

We discuss the baseline optical configuration for the Laser Interferometer Space Antenna (LISA) mission, in which the lasers are not free-running, but rather one of them is used as the main frequency reference generator (the {\it master}) and the remaining five as {\it slaves}, these being phase-locked to the master (the {\it master-slave configuration}). Under the condition that the frequency fluctuations due to the optical transponders can be made negligible with respect to the secondary LISA noise sources (mainly proof-mass and shot noises), we show that the entire space of interferometric combinations LISA can generate when operated with six independent lasers (the {\it one-way method}) can also be constructed with the {\it master-slave} system design. The corresponding hardware trade-off analysis for these two optical designs is presented, which indicates that the two sets of systems needed for implementing the {\it one-way method}, and the {\it master-slave configuration}, are essentially identical. Either operational mode could therefore be implemented without major implications on the hardware configuration. We then.......Comment: 39 pages, 6 figures, 2 table

Clinical decision-making: An essential skill for 21st century pharmacy pratice

Clinical decision-making skills are recognized as a central component of professional competency but are underdeveloped in pharmacy compared to other health professions. There is an urgent need for a comprehensive understanding of how pharmacists can best develop and use therapeutic decision-making skills in clinical practice. The aims of this commentary are to define clinical decision-making in pharmacy practice, and to present a model for clinical decision-making that aligns with a philosophical framework for pharmacy practice. The model has utility in education programs for pharmacists and provides a framework for understanding patient- facing clinical services in practice.Peer Reviewe

Níveis de proteína bruta para juvenis de pirarucu

The objective of this work was to verify the effect of four protein levels on pirarucu, Arapaima gigas, growth performance. One hundred and twenty pirarucu juveniles, with an average weight of 120.6±3.5 g, were stocked into 12 floating cages with 1 m3 (ten fish per cage), in a complete randomized design with four treatments (32.7%, 39.3%, 43.4% and 48.6% crude protein), in three replicates each. After 45 days, results showed that diet with highest protein level (48.6%) produced a better weight gain, specific growth rate, and differentiated body composition. Feed conversion and protein efficiency ratios did not show any differences among treatments. The dietary protein level required to produce maximum growth is 48.6%

Physical activity attenuates the influence of FTO variants on obesity risk: A meta-analysis of 218,166 adults and 19,268 children

Background: The FTO gene harbors the strongest known susceptibility locus for obesity. While many individual studies have suggested that physical activity (PA) may attenuate the effect of FTO on obesity risk, other studies have not been able to confirm this interaction. To confirm or refute unambiguously whether PA attenuates the association of FTO with obesity risk, we meta-analyzed data from 45 studies of adults (n = 218,166) and nine studies of children and adolescents (n = 19,268). Methods and Findings: All studies identified to have data on the FTO rs9939609 variant (or any proxy [r2>0.8]) and PA were invited to participate, regardless of ethnicity or age of the participants. PA was standardized by categorizing it into a dichotomous variable (physically inactive versus active) in each study. Overall, 25% of adults and 13% of children were categorized as inactive. Interaction analyses were performed within each study by including the FTO×PA interaction term in an additive model, adjusting for age and sex. Subsequently, random effects meta-analysis was used to pool the interaction terms. In adults, the minor (A-) allele of rs9939609 increased the odds of obesity by 1.23-fold/allele (95% CI 1.20-1.26), but PA attenuated this effect (pinteraction= 0.001). More specifically, the minor allele of rs9939609 increased the odds of obesity less in the physically active group (odds ratio = 1.22/allele, 95% CI 1.19-1.25) than in the inactive group (odds ratio = 1.30/allele, 95% CI 1.24-1.36). No such interaction was found in children and adolescents. Concl