Economic Growth and Internet Usage Impact on Publication Productivity among ASEAN’s and World’s Best Universities

Measuring the number of papers which are published each year, publication productivity is the factor which shows the reputation of universities and countries. However, the effect of growing economy and using internet on the publication productivity in Asian countries has not been discovered yet. The present research is going to figure out the publication productivity among the elite universities in Asian countries and also ten top universities around the world in the last twenty years (from 1993 to 2012). Furthermore, the current research is aimed to study the relationship among publication, gross domestic product (GDP) and internet usage. It is worth to mention that the publication of the top Ten Malaysian Universities was regarded for the similar period of time. To get the exact numbers of documents like papers, conference articles, review papers and letters which are published by the universities in the last twenty years, the writer of the same paper used the Science Direct database. Moreover, the data for GDP and the number of internet usage was collected through the World Bank database (World Data Bank).To compare all kinds of publications,one-way ANOVA was used and to investigate the impact of economic growth and internet usage on publication productivity, multiple regression analysis was applied.The results showed that the rate of publication growth was 1.9, 20.9, and 65.5 in top universities in the world, ASEAN countries and Malaysia, respectively.The results also showed that there was a positive and significant correlation between GDP and the number of internet users with the number of publications in ASEAN and Malaysian universities. Internet usage had much more influence in comparison with the GDP in predicting the number of publications among these groups except for top ten Malaysian universities from 2003 to 2012. In summary, publication trends in top ten Malaysian and ASEAN universities are promising. However, policy makers and science managers should spend much more percentage of their GDP on Internet facilities and research studies that their outputs lead to more rapid economic growth and internet usage

A Crisis in “Open Access”: Should Communication Scholarly Outputs Take 77 Years to Become Open Access?

This study diachronically investigates the trend of the “open access” in the Web of Science (WoS) category of “communication.” To evaluate the trend, data were collected from 184 categories of WoS from 1980 to 2017. A total of 87,997,893 documents were obtained, of which 95,304 (0.10%) were in the category of “communication.” In average, 4.24% of the documents in all 184 categories were open access. While in communication, it was 3.29%, which ranked communication 116 out of 184. An Open Access Index (OAI) was developed to predict the trend of open access in communication. Based on the OAI, communication needs 77 years to fully reach open access, which undeniably can be considered as “crisis in scientific publishing” in this field. Given this stunning information, it is the time for a global call for “open access” by communication scholars across the world. Future research should investigate whether the current business models of publications in communication scholarships are encouraging open access or pose unnecessary restrictions on knowledge development

Phase I study of MLN8237—investigational Aurora A kinase inhibitor—in relapsed/refractory multiple myeloma, Non-Hodgkin lymphoma and chronic lymphocytic leukemia

Purpose Amplification or over-expression of the mitotic Aurora A kinase (AAK) has been reported in several heme-lymphatic malignancies. MLN8237 (alisertib) is a novel inhibitor of AAK that is being developed for the treatment of advanced malignancies. The objectives of this phase I study were to establish the safety, tolerability, and pharmacokinetic profiles of escalating doses of MLN8237 in patients with relapsed or refractory heme-lymphatic malignancies. Methods Sequential cohorts of patients received MLN8237 orally as either a powder-in-capsule (PIC) or enteric-coated tablet (ECT) formulation. Patients received MLN8237 PIC 25–90 mg for 14 or 21 consecutive days plus 14 or 7 days’ rest, respectively, or MLN8237 ECT, at a starting dose of 40 mg/day once-daily (QD) for 14 days plus 14 days’ rest, all in 28-day cycles. Subsequent cohorts received MLN8237 ECT 30–50 mg twice-daily (BID) for 7 days plus 14 days’ rest in 21-day cycles. Results Fifty-eight patients were enrolled (PIC n = 28, ECT n = 30). The most frequent grade ≥3 drug-related toxicities were neutropenia (45 %), thrombocytopenia (28 %), anemia (19 %), and leukopenia (19 %). The maximum tolerated dose on the ECT 7-day schedule was 50 mg BID. The terminal half-life of MLN8237 was approximately 19 h. Six (13 %) patients achieved partial responses and 13 (28 %) stable disease. Conclusion The recommended phase II dose of MLN8237 ECT is 50 mg BID for 7 days in 21-day cycles, which is currently being evaluated as a single agent in phase II/III trials in patients with peripheral T-cell lymphoma. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s10637-013-0050-9) contains supplementary material, which is available to authorized users

Aurora A Functional Single Nucleotide Polymorphism (SNP) Correlates With Clinical Outcome in Patients With Advanced Solid Tumors Treated With Alisertib, an Investigational Aurora A Kinase Inhibitor

BACKGROUND: Alisertib (MLN8237) is an investigational, oral, selective Aurora A kinase inhibitor. Aurora A contains two functional single nucleotide polymorphisms (SNPs; codon 31 [F/I] and codon 57 [V/I]) that lead to functional changes. This study investigated the prognostic and predictive significance of these SNPs. METHODS: This study evaluated associations between Aurora A SNPs and overall survival (OS) in The Cancer Genome Atlas (TCGA) database. The Aurora A SNPs were also evaluated as predictive biomarkers for clinical outcomes to alisertib in two phase 2 studies (NCT01045421 and NCT01091428). Aurora A SNP genotyping was obtained from 85 patients with advanced solid tumors receiving single-agent alisertib and 122 patients with advanced recurrent ovarian cancer treated with alisertib plus weekly paclitaxel (n=62) or paclitaxel alone (n=60). Whole blood was collected prior to treatment and genotypes were analyzed by PCR. FINDINGS: TCGA data suggested prognostic significance for codon 57 SNP; solid tumor patients with VV and VI alleles had significantly reduced OS versus those with II alleles (HR 1.9 [VI] and 1.8 [VV]; p<0.0001). In NCT01045421, patients carrying the VV alleles at codon 57 (n=53, 62%) had significantly longer progression-free survival (PFS) than patients carrying IV or II alleles (n=32, 38%; HR 0.5; p=0.0195). In NCT01091428, patients with the VV alleles at codon 57 who received alisertib plus paclitaxel (n=47, 39%) had a trend towards improved PFS (7.5months) vs paclitaxel alone (n=32, 26%; 3.8months; HR 0.618; p=0.0593). In the paclitaxel alone arm, patients with the VV alleles had reduced PFS vs modified intent-to-treat (mITT) patients (3.8 vs 5.1months), consistent with the TCGA study identifying the VV alleles as a poor prognostic biomarker. No significant associations were identified for codon 31 SNP from the same data set. INTERPRETATION: These findings suggest that Aurora A SNP at codon 57 may predict disease outcome and response to alisertib in patients with solid tumors. Further investigation is warranted

Phase 1 study of MLN8054, a selective inhibitor of Aurora A kinase in patients with advanced solid tumors

Aurora A kinase is critical in assembly and function of the mitotic spindle. It is overexpressed in various tumor types and implicated in oncogenesis and tumor progression. This trial evaluated the dose-limiting toxicities (DLTs) and maximum tolerated dose (MTD) of MLN8054, a selective small-molecule inhibitor of Aurora A kinase

Effect of Repeated Repair Metal Inert Gas Welding on Microstructural Properties, Corrosion Resistance, and Wear Behavior of 5083-H116 Aluminum Alloy

The effect of repeated repair welding, shielded with argon, on microstructural properties, corrosion resistance, and dry sliding wear behavior of aluminum alloy 5083/H116 were investigated. Samples were welded by metal inert gas welding method. 100% argon was used to protect fusion zone. Aluminum alloy 5356 was used as the filler metal. The samples for microstructure, corrosion, and wear tests were prepared from welded and repaired plates. To study the microstructural properties, the samples were mounted, polished, and then etched by the Keller's solution. Optical microscopy was used for metallurgical analysis. The corrosion behavior was evaluated in 3.5% NaCl solution and at a temperature of 25 °C using a potentiodynamic polarization and electrochemical impedance spectroscopy methods. Dry sliding wear behavior was evaluated by pin on disc method and scanning electron microscopy

Relationship among Economic Growth, Internet Usage and Publication Productivity: Comparison among ASEAN and World’s Best Countries

Publication productivity, as measured by the number of papers, has been regarded as one of the main indicators of reputation of countries and institutions. Nevertheless, the relationship among research publications, economic growth and World Wide Web in ASEAN countries is still unclear. The main intention of this study was to identify publication productivity among ASEAN and the world’s top ten countries in the last 16 years (1996-2011). This study also aimed at finding the relationship among publication, gross domestic product (GDP) and internet usage. Furthermore, the publication trend in the 10 first Malaysian universities was evaluated for the same periods. Scopus database was used to find the overall documents, overall citations, citations per document and international collaboration from 1996 to 2011 for each country. The World Bank database (World Data Bank) was used to collect the data for GDP and the number of internet users. Moreover, to evaluate 10 top Malaysian universities, the number of published articles, conferences, reviews, and letters for the same periods was collected. The results of this study showed significant differences among ASEAN and top 10 countries regarding publication productivity. Moreover, a positive and significant relationship was observed between indices, GDP and internet usage for these countries. Surprisingly, international collaboration had a significant and negative relationship with economic growth. Malaysia had fewer citations per document (7.64) and international collaboration (36.9) among ASEAN countries. In conclusion, international collaboration between academic institutes and researchers is influenced by economic growth and access to internet in the countries. Furthermore, publication trends in ASEAN countries are promising. However, policy makers and science managers should try to find different ways to increase the quality of the research publication and to raise citation per document