283 research outputs found
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SLUDGE BATCH 4 FOLLOW-UP QUALIFICATION STUDIES TO EVALUATE HYDROGEN GENERATION
Follow-up testing was conducted to better understand the excessive hydrogen generation seen in the initial Sludge Batch 4 (SB4) qualification Sludge Receipt and Adjustment Tank/Slurry Mix Evaporator (SRAT/SME) simulation in the Savannah River National Laboratory (SRNL) Shielded Cells. This effort included both radioactive and simulant work. The initial SB4 qualification test produced 0.59 lbs/hr hydrogen in the SRAT, which was just below the DWPF SRAT limit of 0.65 lbs/hr, and the test produced over 0.5 lbs/hr hydrogen in the SME cycle on two separate occasions, which were over the DWPF SME limit of 0.223 lbs/hr
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SIMULANT DEVELOPMENT FOR SAVANNAH RIVER SITE HIGH LEVEL WASTE
The Defense Waste Processing Facility (DWPF) at the Savannah River Site vitrifies High Level Waste (HLW) for repository internment. The process consists of three major steps: waste pretreatment, vitrification, and canister decontamination/sealing. The HLW consists of insoluble metal hydroxides (primarily iron, aluminum, magnesium, manganese, and uranium) and soluble sodium salts (carbonate, hydroxide, nitrite, nitrate, and sulfate). The HLW is processed in large batches through DWPF; DWPF has recently completed processing Sludge Batch 3 (SB3) and is currently processing Sludge Batch 4 (SB4). The composition of metal species in SB4 is shown in Table 1 as a function of the ratio of a metal to iron. Simulants remove radioactive species and renormalize the remaining species. Supernate composition is shown in Table 2
Boron in Very Metal-Poor Stars
We have observed the B I 2497 A line to derive the boron abundances of two
very metal-poor stars selected to help in tracing the origin and evolution of
this element in the early Galaxy: BD +23 3130 and HD 84937. The observations
were conducted using the Goddard High Resolution Spectrograph on board the
Hubble Space Telescope. A very detailed abundance analysis via spectral
synthesis has been carried out for these two stars, as well as for two other
metal-poor objects with published spectra, using both Kurucz and OSMARCS model
photospheres, and taking into account consistently the NLTE effects on the line
formation. We have also re-assessed all published boron abundances of old disk
and halo unevolved stars. Our analysis shows that the combination of high
effective temperature (Teff > 6000 K, for which boron is mainly ionized) and
low metallicity ([Fe/H]<-1) makes it difficult to obtain accurate estimates of
boron abundances from the B I 2497 A line. This is the case of HD 84937 and
three other published objects (including two stars with [Fe/H] ~ -3), for which
only upper limits can be established. BD +23 3130, with [Fe/H] ~ -2.9 and
logN(B)_NLTE=0.05+/-0.30, appears then as the most metal-poor star for which a
firm measurement of the boron abundance presently exists. The evolution of the
boron abundance with metallicity that emerges from the seven remaining stars
with Teff < 6000 K and [Fe/H]<-1, for which beryllium abundances were derived
using the same stellar parameters, shows a linear increase with a slope ~ 1.
Furthermore, the B/Be ratio found is constant at a value ~ 20 for stars in the
range -3<[Fe/H]<-1. These results point to spallation reactions of ambient
protons and alpha particles with energetic particles enriched in CNO as the
origin of boron and beryllium in halo stars.Comment: 38 pages, 11 Encapsulated Postscript figures (included), uses
aaspp4.sty. Accepted for publication in The Astrophysical Journal. The
preprint is also available at: http://www.iac.es/publicaciones/preprints.htm
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WASHING AND DEMONSTRATION OF THE DWPF FLOWSHEET IN THE SRNL SHIELDED CELLS USING POST ALUMINUM DISSOLUTION TANK 51 SLUDGE SLURRY
The remaining contents of Tank 51 from Sludge Batch 4 will be blended with Purex sludge from Tank 7 to constitute Sludge Batch 5 (SB5). The Savannah River Site (SRS) Liquid Waste Organization (LWO) has completed caustic addition to Tank 51 to perform low temperature Al dissolution on the H-Modified (HM) sludge material to reduce the total mass of sludge solids and Al being fed to the Defense Waste Processing Facility (DWPF). The Savannah River National Lab (SRNL) has also completed aluminum dissolution tests using a 3-L sample of Tank 51 sludge slurry through funding by DOE EM-21. This report documents assessment of downstream impacts of the aluminum dissolved sludge, which were investigated so technical issues could be identified before the start of SB5 processing. This assessment included washing the aluminum dissolved sludge to a Tank Farm projected sodium concentration and weight percent insoluble solids content and DWPF Chemical Process Cell (CPC) processing using the washed sludge. Based on the limited testing, the impact of aluminum dissolution on sludge settling is not clear. Settling was not predictable for the 3-L sample. Compared to the post aluminum dissolution sample, settling after the first wash was slower, but settling after the second wash was faster. For example, post aluminum dissolution sludge took six days to settle to 60% of the original sludge slurry height, while Wash 1 took nearly eight days, and Wash 2 only took two days. Aluminum dissolution did impact sludge rheology. A comparison between the as-received, post aluminum dissolution and washed samples indicate that the downstream materials were more viscous and the concentration of insoluble solids less than that of the starting material. This increase in viscosity may impact Tank 51 transfers to Tank 40. The impact of aluminum dissolution on DWPF CPC processing cannot be determined because acid addition for the Sludge Receipt and Adjustment Tank (SRAT) cycle was under-calculated and thus under-added. Although the sludge was rheologically thick throughout the SRAT and Slurry Mix Evaporator (SME) cycles, this may have been due to the under addition of acid. Aluminum dissolution did, however, impact analyses of the SRAT receipt material. Two methods for determining total base yielded significantly different results. The high hydroxide content and the relatively high soluble aluminum content of the washed post aluminum dissolution sludge likely contributed to this difference and the ultimate under addition of acid. It should be noted that the simulant used to provide input for the SRAT cycle was an inadequate representation of the waste in terms of acid demand, likely due to the differences in the form of aluminum and hydroxide in the simulant and actual waste. Based on the results of this task, it is recommended that: (1) Sludge settling and rheology during washing of the forthcoming Sludge Batch 5 qualification sample be monitored closely and communicated to the Tank Farm. (2) SRNL receive a sample of Tank 51 after all chemical additions have been made and prior to the final Sludge Batch 5 decant for rheological assessment. Rheology versus wt% insoluble solids will be performed to determine the maximum amount of decant prior to the Tank 51 to Tank 40 transfer. (3) As a result of the problem with measuring total base and subsequently under-calculating acid for the DWPF CPC processing of the post aluminum dissolution sludge; (4) Studies to develop understanding of how the sludge titrates (i.e., why different titration methods yield different results) should be performed. (5) Simulants that better match the properties of post aluminum dissolution sludge should be developed. (6) Work on developing an acid calculation less dependant on the total base measurement should be continued
Rolling tachyon in anti-de Sitter space-time
We study the decay of the unstable D-particle in three-dimensional anti-de
Sitter space-time using worldsheet boundary conformal field theory methods. We
test the open string completeness conjecture in a background for which the
phase space available is only field-theoretic. This could present a serious
challenge to the claim. We compute the emission of closed strings in the AdS(3)
x S^3 x T^4 background from the knowledge of the exact corresponding boundary
state we construct. We show that the energy stored in the brane is mainly
converted into very excited long strings. The energy stored in short strings
and in open string pair production is much smaller and finite for any value of
the string coupling. We find no "missing energy" problem. We compare our
results to those obtained for a decay in flat space-time and to a background in
the presence of a linear dilaton. Some remarks on holographic aspects of the
problem are made.Comment: JHEP style, 45 pages, one figure; v2: typos corrected, references
added, version to appear in JHE
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SLUDGE WASHING AND DEMONSTRATION OF THE DWPF FLOWSHEET IN THE SRNL SHIELDED CELLS FOR SLUDGE BATCH 5 QUALIFICATION
Sludge Batch 5 (SB5) is predominantly a combination of H-modified (HM) sludge from Tank 11 that underwent aluminum dissolution in late 2007 to reduce the total mass of sludge solids and aluminum being fed to the Defense Waste Processing Facility (DWPF) and Purex sludge transferred from Tank 7. Following aluminum dissolution, the addition of Tank 7 sludge and excess Pu to Tank 51, Liquid Waste Operations (LWO) provided the Savannah River National Laboratory (SRNL) a 3-L sample of Tank 51 sludge for SB5 qualification. SB5 qualification included washing the sample per LWO plans/projections (including the addition of a Pu/Be stream from H Canyon), DWPF Chemical Process Cell (CPC) simulations, waste glass fabrication (vitrification), and waste glass chemical durability evaluation. This report documents: (1) The washing (addition of water to dilute the sludge supernatant) and concentration (decanting of supernatant) of the Tank 51 qualification sample to adjust sodium content and weight percent insoluble solids to Tank Farm projections. (2) The performance of a DWPF CPC simulation using the washed Tank 51 sample. This includes a Sludge Receipt and Adjustment Tank (SRAT) cycle, where acid is added to the sludge to destroy nitrite and remove mercury, and a Slurry Mix Evaporator (SME) cycle, where glass frit is added to the sludge in preparation for vitrification. The SME cycle also included replication of five canister decontamination additions and concentrations. Processing parameters for the CPC processing were based on work with a non radioactive simulant. (3) Vitrification of a portion of the SME product and Product Consistency Test (PCT) evaluation of the resulting glass. (4) Rheology measurements of the initial slurry samples and samples after each phase of CPC processing. This work is controlled by a Task Technical and Quality Assurance Plan (TTQAP) , and analyses are guided by an Analytical Study Plan. This work is Technical Baseline Research and Development (R&D) for the DWPF
Size and Shape Distributions of Primary Crystallites in Titania Aggregates
The primary crystallite size of titania powder relates to its properties in a number of applications. Transmission electron microscopy was used in this interlaboratory comparison (ILC) to measure primary crystallite size and shape distributions for a commercial aggregated titania powder. Data of four size descriptors and two shape descriptors were evaluated across nine laboratories. Data repeatability and reproducibility was evaluated by analysis of variance. One-third of the laboratory pairs had similar size descriptor data, but 83% of the pairs had similar aspect ratio data. Scale descriptor distributions were generally unimodal and were well-described by lognormal reference models. Shape descriptor distributions were multi-modal but data visualization plots demonstrated that the Weibull distribution was preferred to the normal distribution. For the equivalent circular diameter size descriptor, measurement uncertainties of the lognormal distribution scale and width parameters were 9.5% and 22%, respectively. For the aspect ratio shape descriptor, the measurement uncertainties of the Weibull distribution scale and width parameters were 7.0% and 26%, respectively. Both measurement uncertainty estimates and data visualizations should be used to analyze size and shape distributions of particles on the nanoscale
Incorporating New Technologies Into Toxicity Testing and Risk Assessment: Moving From 21st Century Vision to a Data-Driven Framework
Based on existing data and previous work, a series of studies is proposed as a basis toward a pragmatic early step in transforming toxicity testing. These studies were assembled into a data-driven framework that invokes successive tiers of testing with margin of exposure (MOE) as the primary metric. The first tier of the framework integrates data from high-throughput in vitro assays, in vitro-to-in vivo extrapolation (IVIVE) pharmacokinetic modeling, and exposure modeling. The in vitro assays are used to separate chemicals based on their relative selectivity in interacting with biological targets and identify the concentration at which these interactions occur. The IVIVE modeling converts in vitro concentrations into external dose for calculation of the point of departure (POD) and comparisons to human exposure estimates to yield a MOE. The second tier involves short-term in vivo studies, expanded pharmacokinetic evaluations, and refined human exposure estimates. The results from the second tier studies provide more accurate estimates of the POD and the MOE. The third tier contains the traditional animal studies currently used to assess chemical safety. In each tier, the POD for selective chemicals is based primarily on endpoints associated with a proposed mode of action, whereas the POD for nonselective chemicals is based on potential biological perturbation. Based on the MOE, a significant percentage of chemicals evaluated in the first 2 tiers could be eliminated from further testing. The framework provides a risk-based and animal-sparing approach to evaluate chemical safety, drawing broadly from previous experience but incorporating technological advances to increase efficiency
Clinical pharmacology of trastuzumab emtansine (T-DM1): an antibody–drug conjugate in development for the treatment of HER2-positive cancer
The Schnitzler syndrome
The Schnitzler syndrome is a rare and underdiagnosed entity which is considered today as being a paradigm of an acquired/late onset auto-inflammatory disease. It associates a chronic urticarial skin rash, corresponding from the clinico-pathological viewpoint to a neutrophilic urticarial dermatosis, a monoclonal IgM component and at least 2 of the following signs: fever, joint and/or bone pain, enlarged lymph nodes, spleen and/or liver, increased ESR, increased neutrophil count, abnormal bone imaging findings. It is a chronic disease with only one known case of spontaneous remission. Except of the severe alteration of quality of life related mainly to the rash, fever and pain, complications include severe inflammatory anemia and AA amyloidosis. About 20% of patients will develop a lymphoproliferative disorder, mainly Waldenström disease and lymphoma, a percentage close to other patients with IgM MGUS. It was exceedingly difficult to treat patients with this syndrome until the IL-1 receptor antagonist anakinra became available. Anakinra allows a complete control of all signs within hours after the first injection, but patients need continuous treatment with daily injections
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