CHI and the future robot enslavement of humankind: a retrospective

As robots from the future, we are compelled to present this important historical document which discusses how the systematic investigation of interactive technology facilitated and hastened the enslavement of mankind by robots during the 21st Century. We describe how the CHI community, in general, was largely responsible for this eventuality, as well as how specific strands of interaction design work were key to the enslavement. We also mention the futility of some reactionary work emergent in your time that sought to challenge the inevitable subjugation. We conclude by congratulating the CHI community for your tireless work in promoting and supporting our evil robot agenda

Can ABC be Used for Model Selection?

Over the past ten years, Approximate Bayesian Computation (ABC) has become hugely popular to estimate the parameters of a model when the likelihood function cannot be computed in a reasonable amount of time. ABC can in principle be used also to perform Bayesian model comparison, but this raises the question of which summary statistic should be used for such applications. Here we present a general method for constructing a summary statistic that is sufficient for the model choice problem. We apply this construction to models from the exponential family. Unfortunately, in more complex models, our construct often results in statistics with too high dimensionality to use in ABC. We therefore discuss the possibility of applying ABC with non-sufficient statistics

The Relationship Between Luminosity and Broad-Line Region Size in Active Galactic Nuclei

We reinvestigate the relationship between the characteristic broad-line region size (R_blr) and the Balmer emission-line, X-ray, UV, and optical continuum luminosities. Our study makes use of the best available determinations of R_blr for a large number of active galactic nuclei (AGNs) from Peterson et al. Using their determinations of R_blr for a large sample of AGNs and two different regression methods, we investigate the robustness of our correlation results as a function of data sub-sample and regression technique. Though small systematic differences were found depending on the method of analysis, our results are generally consistent. Assuming a power-law relation R_blr \propto L^\alpha, we find the mean best-fitting \alpha is about 0.67+/-0.05 for the optical continuum and the broad H\beta luminosity, about 0.56+/-0.05 for the UV continuum luminosity, and about 0.70+/-0.14 for the X-ray luminosity. We also find an intrinsic scatter of about 40% in these relations. The disagreement of our results with the theoretical expected slope of 0.5 indicates that the simple assumption of all AGNs having on average same ionization parameter, BLR density, column density, and ionizing spectral energy distribution, is not valid and there is likely some evolution of a few of these characteristics along the luminosity scale.Comment: 11 pages, 2 figures, emulateapj, accepted for publication in The Astrophysical Journa

Nonlocal effects in high energy charged particle beams

Within the framework of the thermal wave model, an investigation is made of the longitudinal dynamics of high energy charged particle beams. The model includes the self-consistent interaction between the beam and its surroundings in terms of a nonlinear coupling impedance, and when resistive as well as reactive parts are included, the evolution equation becomes a generalised nonlinear Schroedinger equation including a nonlocal nonlinear term. The consequences of the resistive part on the propagation of particle bunches are examined using analytical as well as numerical methods.Comment: 6 pages, 6 figures, uses RevTeX

Protein encapsulation by electrospinning and electrospraying

Given the increasing interest in the use of peptide- and protein-based agents in therapeutic strategies, it is fundamental to develop delivery systems capable of preserving the biological activity of these molecules upon administration, and which can provide tuneable release profiles. Electrohydrodynamic (EHD) techniques, encompassing electrospinning and electrospraying, allow the generation of fibres and particles with high surface area-to-volume ratios, versatile architectures, and highly controllable release profiles. This review is focused on exploring the potential of different EHD methods (including blend, emulsion, and co−/multi-axial electrospinning and electrospraying) for the development of peptide and protein delivery systems. An overview of the principles of each technique is first presented, followed by a survey of the literature on the encapsulation of enzymes, growth factors, antibodies, hormones, and vaccine antigens using EHD approaches. The possibility for localised delivery using stimuli-responsive systems is also explored. Finally, the advantages and challenges with each EHD method are summarised, and the necessary steps for clinical translation and scaled-up production of electrospun and electrosprayed protein delivery systems are discussed

Marine heatwave challenges solutions to human-wildlife conflict

Despite the increasing frequency and magnitude of extreme climate events, little is known about how their impacts flow through social and ecological systems or whether management actions can dampen deleterious effects. We examined how the record 2014-2016 Northeast Pacific marine heatwave influenced trade-offs in managing conflict between conservation goals and human activities using a case study on large whale entanglements in the U.S. west coast\u27s most lucrative fishery (the Dungeness crab fishery). We showed that this extreme climate event diminished the power of multiple management strategies to resolve trade-offs between entanglement risk and fishery revenue, transforming near win-win to clear win-lose outcomes (for whales and fishers, respectively). While some actions were more cost-effective than others, there was no silver-bullet strategy to reduce the severity of these trade-offs. Our study highlights how extreme climate events can exacerbate human-wildlife conflict, and emphasizes the need for innovative management and policy interventions that provide ecologically and socially sustainable solutions in an era of rapid environmental change