'I Just Express My Views & Leave Them to Work': Olive Schreiner as a Feminist Protagonist in a Masculine Political Landscape with Figures

There are disturbances as well as regularities in the gender order, including challenges to and re-workings of conventional hierarchies. An example of such re-workings provides the focus of discussion: the political interventions of South African feminist writer and social theorist Olive Schreiner (18551920). Discussion of Schreiners letters to a number of important white political figures is organised around an epistemological question: can Schreiners political influencewithin the masculine political landscape of the Cape in the latenineteenth and early-twentieth centuries be convincingly demonstrated by concrete epistolary examples and compelling evidence? Discussed here regarding womens presence in a masculine political landscape, this epistemological question exercises historiography more generally: with what certainty can knowledgeclaims about the past be advanced? The ideas context in which these questions are explored is feminist historiography concerning gender and in particular separate spheres, which were particularly troubled and complex in the South African context. We argue that the performative dimensions of letter writing need to be encompassed within notions of influence and proof, rather than this being conceived as always lying outside the text: texts and words can have powerful effects, with the evidence in Schreiners case pointing strongly to her significant political influence. Chapters © 2013 The Authors. Book compilation © 2013 Blackwell Publishing Ltd

‘Going on with our little movement in the hum drum-way which alone is possible in a land like this’: Olive Schreiner and suffrage networks in Britain and South Africa, 1905-1913

This article explores the letters of South African feminist writer Olive Schreiner (1855–1920) to illuminate connections and tensions between suffrage movements in the imperial metropole and on the colonial periphery. Schreiner's letters shed fascinating light on how she used her contacts in the global suffrage movement to advance local suffrage work. They indicate key differences Schreiner identified between the British and South African suffrage movements, including that the latter should be focused on educating women to want the vote. Schreiner's emphasis on universal suffrage also brought her into conflict with local suffrage organisations which were willing to accept a racial franchise, and also with key figures in the international suffrage movement

‘Stories That Find their Place’: Retelling the Protest at Brandfort, 1901-1949

This paper concerns eight women's testimonies produced over a period of some fifty years, which describe a protest about meat rations at Brandfort concentration camp in November 1901, during the 1899-1902 South African War. The focus here is not the ‘event itself’, which cannot now be recovered except in its archival or documentary forms, but on the subsequent re/telling of this incident, and on the politicised, (proto-) nationalist content and tone of the Brandfort protest testimonies. While proto-nationalism is present from the earliest extant testimony, the development of this is traced over time, showing how the later testimonies evince a strongly triumphalist nationalist tone. The retrospectively inscribed testimonies of the protest are examined to show how, over time, the story of the Brandfort protest became universalised, retold well away from specificities of time and place. If nationalism depends on the creation of 'stories that find their place', then it was partly through the construction and repetition of what Van Heyningen has called 'costly mythologies' about women's concentration camp experiences that Afrikaner national unity was achieved. This also supports Bradford's important claim that the 1899-1902 war regendered Afrikaner nationalism

AAPT Diagnostic Criteria for Chronic Sickle Cell Disease Pain

Pain in sickle cell disease (SCD) is associated with increased morbidity, mortality, and high health care costs. Although episodic acute pain is the hallmark of this disorder, there is an increasing awareness that chronic pain is part of the pain experience of many older adolescents and adults. A common set of criteria for classifying chronic pain associated with SCD would enhance SCD pain research efforts in epidemiology, pain mechanisms, and clinical trials of pain management interventions, and ultimately improve clinical assessment and management. As part of the collaborative effort between the Analgesic, Anesthetic, and Addiction Clinical Trial Translations Innovations Opportunities and Networks public-private partnership with the U.S. Food and Drug Administration and the American Pain Society, the Analgesic, Anesthetic, and Addiction Clinical Trial Translations Innovations Opportunities and Networks-American Pain Society Pain Taxonomy initiative developed the outline of an optimal diagnostic system for chronic pain conditions. Subsequently, a working group of experts in SCD pain was convened to generate core diagnostic criteria for chronic pain associated with SCD. The working group synthesized available literature to provide evidence for the dimensions of this disease-specific pain taxonomy. A single pain condition labeled chronic SCD pain was derived with 3 modifiers reflecting different clinical features. Future systematic research is needed to evaluate the feasibility, validity, and reliability of these criteria. Perspective: An evidence-based classification system for chronic SCD pain was constructed for the Analgesic, Anesthetic, and Addiction Clinical Trial Translations Innovations Opportunities and Networks-American Pain Society Pain Taxonomy initiative. Applying this taxonomy may improve assessment and management of SCD pain and accelerate research on epidemiology, mechanisms, and treatments for chronic SCD pain

Assessing the quality of life of children with sickle cell anaemia using self-, parent-proxy and healthcare professional-proxy reports

Objectives The quality of life (QoL) of children with sickle cell anaemia (SCA) in the United Kingdom has not been examined, and a discrepancy measure based on Gap theory has rarely been used. This study investigated whether (1) child self-reports of QoL using a discrepancy measure (the Generic Children's QoL Measure; GCQ) are lower than those from healthy children, (2) proxy reports from parents and health care professionals are lower than child self-reports, and (3) demographic and disease severity indicators are related to QoL. Design and methods An interdependent groups, cross-sectional design was implemented. Seventy-four children with SCA, their parent, and members of their health care team completed the GCQ. Demographic and disease severity indicators were recorded. GCQ data from healthy children were obtained from the UK Data Archive. Results Contrary to past research, when examining generic discrepancy QoL, children with SCA did not report a lower QoL than healthy children, and parent- and health care professional-proxy reports were not lower than child self-reports. Few of the demographic and disease severity indicators were related to QoL. Conclusions Proxy reports may be used to gain a more complete picture of QoL, but should not be a substitute for self-reports. The explanation for the relatively high levels of QoL reported is not clear, but children with SCA may have realistic expectations about their ideal-self, place greater emphasis on aspects other than health in shaping their QoL, and define achievements within the limits of their illness. Future research should focus on psychological factors in explaining QoL

Cyclin D1 integrates G9a-mediated histone methylation.

Lysine methylation of histones and non-histone substrates by the SET domain containing protein lysine methyltransferase (KMT) G9a/EHMT2 governs transcription contributing to apoptosis, aberrant cell growth, and pluripotency. The positioning of chromosomes within the nuclear three-dimensional space involves interactions between nuclear lamina (NL) and the lamina-associated domains (LAD). Contact of individual LADs with the NL are dependent upon H3K9me2 introduced by G9a. The mechanisms governing the recruitment of G9a to distinct subcellular sites, into chromatin or to LAD, is not known. The cyclin D1 gene product encodes the regulatory subunit of the holoenzyme that phosphorylates pRB and NRF1 thereby governing cell-cycle progression and mitochondrial metabolism. Herein, we show that cyclin D1 enhanced H3K9 dimethylation though direct association with G9a. Endogenous cyclin D1 was required for the recruitment of G9a to target genes in chromatin, for G9a-induced H3K9me2 of histones, and for NL-LAD interaction. The finding that cyclin D1 is required for recruitment of G9a to target genes in chromatin and for H3K9 dimethylation, identifies a novel mechanism coordinating protein methylation

S03RS SGR No. 14 (Online Voting)

A RESOLUTION To create the Student Government Commission on Online Voting

F02RS SGR No. 7 (Emmerit)

A RESOLUTION To clarify student support for Chancellor Mark Emmerit