A spectrum of ozone from 760 to 5800 cm-1

An atlas of O3 lines between 760 and 5800/cm obtained from a low pressure, long-path-length sample of O3 at 296K is presented. Many of the line centers are marked and their positions tabulated

Designing Interfaces with Social Presence: Using Vividness and Extraversion to Create Social Recommendation Agents

Interfaces now employ a variety of media-rich, social, and advanced decision-making components, including recommendation agents (RA) designed to assist users with their tasks. Social presence has been identified as a key consideration in website design to overcome the lack of warmth, social cues, and face-to-face interaction, but few studies have investigated the interface features that may increase social presence. Recent research on RAs has similarly acknowledged social presence as a key factor in the design of online RAs and in building trust in this technology, but there has been limited empirical work on the topic. In this study an experiment was conducted to explore how social technology cues, media capabilities, and individual differences influence social presence and trust in an RA. RA personality (extraversion), vividness (text, voice, and animation), and computer playfulness were found to influence social presence, with social presence serving in a mediating role and increasing user trust in the RA. Vividness also had a moderating effect on the relationship between RA extraversion and social presence such that increased levels of vividness strengthen this relationship

A Look at How Levels of Vividness and Social Presence Affect Trust in a Decision Aid

Building on past research on trust and social presence, this study explores how multimedia vividness and social presence affect trusting beliefs and subsequently trusting intentions of a computer-based decision aid. An experiment involving 550 subjects examines the effect that decision aid personality and increased levels of vividness (text, voice, and animation) have on social presence, and downstream trust-related constructs including trusting beliefs and trusting intentions. The effect of a user’s computer playfulness on social presence is also investigated. Past research on trust and social presence provide the theoretical foundation for the study and suggest that increased vividness may moderate the effect of decision aid personality on perceptions of social presence, with social presence consequently affecting trusting beliefs

A case control study reveals that polyomaviruria is significantly associated with interstitial cystitis and vesical ulceration

Objectives: To investigate whether polyomaviruses contribute to interstitial cystitis pathogenesis. Subjects and Methods: A prospective study was performed with 50 interstitial cystitis cases compared with 50 age-matched, disease-free controls for the frequency of polyomaviruria. Associations between polyomaviruria and disease characteristics were analysed in cases. Polyomavirus in urine and bladder tissue was detected with species (JC virus vs. BK virus) specific, real-time PCR. Results: Case patients were reflective of interstitial cystitis epidemiology with age range from 26–88 years (median 58) and female predominance (41/50 F). There was a significant increase in the frequency of polyomavirus shedding between cases and controls (p<0.02). Polyomavirus shedding, in particular BK viruria, was associated with vesical ulceration, a marker of disease severity, among interstitial cystitis cases after adjustment for age and sex (OR 6.8, 95% CI 1.89–24.4). There was a significant association among cases between the presence of BK viruria and response to intravesical Clorpactin therapy (OR 4.50, 95% CI 1.17–17.4). Conclusion: The presence of polyomaviruria was found to be associated with the ulcerative form of interstitial cystitis. Clorpactin, which has anti-DNA virus activity, was more likely to improve symptoms in the presence of BK viruria. These data from this pilot study suggest associations between polyomaviruria and interstitial cystitis warranting further investigation

CFTR and Wnt/beta-catenin signaling in lung development

<p>Abstract</p> <p>Background</p> <p>Cystic fibrosis transmembrane conductance regulator (CFTR) was shown previously to modify stretch induced differentiation in the lung. The mechanism for CFTR modulation of lung development was examined by <it>in utero </it>gene transfer of either a sense or antisense construct to alter CFTR expression levels.</p> <p>The BAT-gal transgenic reporter mouse line, expressing β-galactosidase under a canonical Wnt/β-catenin-responsive promoter, was used to assess the relative roles of CFTR, Wnt, and parathyroid hormone-related peptide (PTHrP) in lung organogenesis. Adenoviruses containing full-length CFTR, a short anti-sense CFTR gene fragment, or a reporter gene as control were used in an intra-amniotic gene therapy procedure to transiently modify CFTR expression in the fetal lung.</p> <p>Results</p> <p>A direct correlation between CFTR expression levels and PTHrP levels was found. An inverse correlation between CFTR and Wnt signaling activities was demonstrated.</p> <p>Conclusion</p> <p>These data are consistent with CFTR participating in the mechanicosensory process essential to regulate Wnt/β-Catenin signaling required for lung organogenesis.</p

Single molecule microscopy to profile the effect of zinc status on transcription factor dynamics

The regulation of transcription is a complex process that involves binding of transcription factors (TFs) to specific sequences, recruitment of cofactors and chromatin remodelers, assembly of the pre-initiation complex and recruitment of RNA polymerase II. Increasing evidence suggests that TFs are highly dynamic and interact only transiently with DNA. Single molecule microscopy techniques are powerful approaches for tracking individual TF molecules as they diffuse in the nucleus and interact with DNA. Here we employ multifocus microscopy and highly inclined laminated optical sheet microscopy to track TF dynamics in response to perturbations in labile zinc inside cells. We sought to define whether zinc-dependent TFs sense changes in the labile zinc pool by determining whether their dynamics and DNA binding can be modulated by zinc. We used fluorescently tagged versions of the glucocorticoid receptor (GR), with two C4 zinc finger domains, and CCCTC-binding factor (CTCF), with eleven C2H2 zinc finger domains. We found that GR was largely insensitive to perturbations of zinc, whereas CTCF was significantly affected by zinc depletion and its dwell time was affected by zinc elevation. These results indicate that at least some transcription factors are sensitive to zinc dynamics, revealing a potential new layer of transcriptional regulation. &nbsp;</p

Biomass Blending and Densification: Impacts on Feedstock Supply and Biochemical Conversion Performance

The success of lignocellulosic biofuels and biochemical industries depends on an economic and reliable supply of high‐quality biomass. However, research and development efforts have been historically focused on the utilization of agriculturally derived cellulosic feedstocks, without considerations of their low energy density, high variations in compositions and potential supply risks in terms of availability and affordability. This chapter demonstrated a strategy of feedstock blending and densification to address the supply chain challenges. Blending takes advantage of low‐cost feedstock to avoid the prohibitive costs incurred through reliance on a single feedstock resource, while densification produces feedstocks with increased bulk density and desirable feed handling properties, as well as reduced transportation cost. We also review recent research on the blending and densification dealing with various types of feedstocks with a focus on the impacts of these preprocessing steps on biochemical conversion, that is, various thermochemical pretreatment chemistries and enzymatic hydrolysis, into fermentable sugars for biofuel production

Stable Magnetostatic Solitons in Yttrium Iron Garnet Film Waveguides for Tilted in-Plane Magnetic Fields

The possibility of nonlinear pulses generation in Yttrium Iron Garnet thin films for arbitrary direction between waveguide and applied static in-plane magnetic field is considered. Up to now only the cases of in-plane magnetic fields either perpendicular or parallel to waveguide direction have been studied both experimentally and theoretically. In the present paper it is shown that also for other angles (besides 0 or 90 degrees) between a waveguide and static in-plane magnetic field the stable bright or dark (depending on magnitude of magnetic field) solitons could be created.Comment: Phys. Rev. B (accepted, April 1, 2002

The lesbian, gay, bisexual and transgender community online: discussions of bullying and self-disclosure in YouTube videos

Computer-mediated communication has become a popular platform for identity construction and experimentation as well as social interaction for those who identify as lesbian, gay, bisexual or transgender (LGBT). The creation of user-generated videos has allowed content creators to share experiences on LGBT topics. With bullying becoming more common amongst LGBT youth, it is important to obtain a greater understanding of this phenomenon. In our study, we report on the analysis of 151 YouTube videos which were identified as having LGBT- and bullying-related content. The analysis reveals how content creators openly disclose personal information about themselves and their experiences in a non-anonymous rhetoric with an unknown public. These disclosures could indicate a desire to seek friendship, support and provide empathy