Photodegradation Mechanisms of Tetraphenyl Butadiene Coatings for Liquid Argon Detectors

We report on studies of degradation mechanisms of tetraphenyl butadiene (TPB) coatings of the type used in neutrino and dark matter liquid argon experiments. Using gas chromatography coupled to mass spectrometry we have detected the ultraviolet-blocking impurity benzophenone (BP). We monitored the drop in performance and increase of benzophenone concentration in TPB plates with exposure to ultraviolet (UV) light, and demonstrate the correlation between these two variables. Based on the presence and initially exponential increase in the concentration of benzophenone observed, we propose that TPB degradation is a free radical-mediated photooxidation reaction, which is subsequently confirmed by displaying delayed degradation using a free radical inhibitor. Finally we show that the performance of wavelength-shifting coatings of the type envisioned for the LBNE experiment can be improved by 10-20%, with significantly delayed UV degradation, by using a 20% admixture of 4-tert-Butylcatechol.Comment: 12 pages, 9 figures. Submitted to JINS

A Novel Use of Light Guides and Wavelength Shifting Plates for the Detection of Scintillation Photons in Large Liquid Argon Detectors

Scintillation light generated as charged particles traverse large liquid argon detectors adds valuable information to studies of weakly-interacting particles. This paper uses both laboratory measurements and cosmic ray data from the Blanche dewar facility at Fermilab to characterize the efficiency of the photon detector technology developed at Indiana University for the single phase far detector of DUNE. The efficiency of this technology was found to be 0.48% at the readout end when the detector components were characterized with laboratory measurements. A second determination of the efficiency using cosmic ray tracks is in reasonable agreement with the laboratory determination. The agreement of these two efficiency determinations supports the result that minimum ionizing muons generate ${\mathcal N}_{phot} = 40,000$ photons/MeV as they cross the LAr volume.Comment: Accepted version (without final editorial corrections

Anti-N-Methyl-D-Aspartate Receptor Encephalitis: A New Challenging Entity for Consultation-Liaison Psychiatrist.

BACKGROUND: Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is a relatively newly identified autoimmune neuropsychiatric disorder that predominantly affects children and young adults. Although psychiatric symptoms are highly prevalent and frequently severe, it has mainly been reported in neurological, but not psychiatric, literature. Understanding this form of encephalitis, its quick diagnosis and which treatment to provide are of utmost importance for consultation-liaison (C-L) psychiatrists. The aim of this paper was to describe a case of anti-NMDAR encephalitis with severe psychiatric manifestations, who showed impressive recovery but required intensive involvement of the C-L psychiatry team. We emphasise the behavioural aspects, psychiatric symptoms and challenges faced by the CL consultant across the different phases of the treatment. METHODS: We report the different treatment phases for a young woman with anti-NMDAR encephalitis who developed severe neuropsychiatric symptoms, with a focus on the role and challenges faced by the C-L psychiatrist. The literature is reviewed for each of these challenges. RESULTS: This case illustrated that even extremely severely affected patients may show impressive recovery, but require long lasting psychiatric care. C-L psychiatrists are faced with numerous challenges where only little literature is available. CONCLUSION: C-L psychiatrists play a pivotal role throughout the multidisciplinary care of patients with anti-NMDAR encephalitis and should be informed about this entity

The Golden Channel at a Neutrino Factory revisited: improved sensitivities from a Magnetised Iron Neutrino Detector

This paper describes the performance and sensitivity to neutrino mixing parameters of a Magnetised Iron Neutrino Detector (MIND) at a Neutrino Factory with a neutrino beam created from the decay of 10 GeV muons. Specifically, it is concerned with the ability of such a detector to detect muons of the opposite sign to those stored (wrong-sign muons) while suppressing contamination of the signal from the interactions of other neutrino species in the beam. A new more realistic simulation and analysis, which improves the efficiency of this detector at low energies, has been developed using the GENIE neutrino event generator and the GEANT4 simulation toolkit. Low energy neutrino events down to 1 GeV were selected, while reducing backgrounds to the $10^{-4}$ level. Signal efficiency plateaus of ~60% for $\nu_\mu$ and ~70% for $\bar{\nu}_\mu$ events were achieved starting at ~5 GeV. Contamination from the $\nu_\mu\rightarrow \nu_\tau$ oscillation channel was studied for the first time and was found to be at the level between 1% and 4%. Full response matrices are supplied for all the signal and background channels from 1 GeV to 10 GeV. The sensitivity of an experiment involving a MIND detector of 100 ktonnes at 2000 km from the Neutrino Factory is calculated for the case of $\sin^2 2\theta_{13}\sim 10^{-1}$. For this value of $\theta_{13}$, the accuracy in the measurement of the CP violating phase is estimated to be $\Delta \delta_{CP}\sim 3^\circ - 5^\circ$, depending on the value of $\delta_{CP}$, the CP coverage at $5\sigma$ is 85% and the mass hierarchy would be determined with better than $5\sigma$ level for all values of $\delta_{CP}$

A Dichotomy Theorem for the Approximate Counting of Complex-Weighted Bounded-Degree Boolean CSPs

We determine the computational complexity of approximately counting the total weight of variable assignments for every complex-weighted Boolean constraint satisfaction problem (or CSP) with any number of additional unary (i.e., arity 1) constraints, particularly, when degrees of input instances are bounded from above by a fixed constant. All degree-1 counting CSPs are obviously solvable in polynomial time. When the instance's degree is more than two, we present a dichotomy theorem that classifies all counting CSPs admitting free unary constraints into exactly two categories. This classification theorem extends, to complex-weighted problems, an earlier result on the approximation complexity of unweighted counting Boolean CSPs of bounded degree. The framework of the proof of our theorem is based on a theory of signature developed from Valiant's holographic algorithms that can efficiently solve seemingly intractable counting CSPs. Despite the use of arbitrary complex weight, our proof of the classification theorem is rather elementary and intuitive due to an extensive use of a novel notion of limited T-constructibility. For the remaining degree-2 problems, in contrast, they are as hard to approximate as Holant problems, which are a generalization of counting CSPs.Comment: A4, 10pt, 20 pages. This revised version improves its preliminary version published under a slightly different title in the Proceedings of the 4th International Conference on Combinatorial Optimization and Applications (COCOA 2010), Lecture Notes in Computer Science, Springer, Vol.6508 (Part I), pp.285--299, Kailua-Kona, Hawaii, USA, December 18--20, 201

Status epilepticus of inflammatory etiology: A cohort study.

OBJECTIVE: Inflammation-related epilepsy is increasingly recognized; however, studies on status epilepticus (SE) are very infrequent. We therefore aimed to determine the frequency of inflammatory etiologies in adult SE, and to assess related demographic features and outcomes. METHODS: This was a retrospective analysis of a prospective registry of adult patients with SE treated in our center, from January 2008 to June 2014, excluding postanoxic causes. We classified SE episodes into 3 etiologic categories: infectious, autoimmune, and noninflammatory. Demographic and clinical variables were analyzed regarding their relationship to etiologies and functional outcome. RESULTS: Among the 570 SE consecutive episodes, 33 (6%) were inflammatory (2.5% autoimmune; 3.3% infectious), without any change in frequency over the study period. Inflammatory SE episodes involved younger patients (mean age 53 vs 61 years, p = 0.015) and were more often refractory to initial antiepileptic treatment (58% vs 38%, odds ratio = 2.19, 95% confidence interval = 1.07-4.47, p = 0.041), despite similar clinical outcome. Subgroup analysis showed that, compared with infectious SE episodes, autoimmune SE involved younger adults (mean age 44 vs 60 years, p = 0.017) and was associated with lower morbidity (return to baseline conditions in 71% vs 32%, odds ratio = 5.41, 95% confidence interval = 1.19-24.52, p = 0.043) without any difference in mortality. CONCLUSIONS: Despite increasing awareness, inflammatory SE etiologies were relatively rare; their occurrence in younger individuals and higher refractoriness to treatment did not have any effect on outcome. Autoimmune SE episodes also occurred in younger patients, but tended to have better outcomes in survivors than infectious SE