In vivo imaging through the entire thickness of human cornea by full-field optical coherence tomography

Despite obvious improvements in visualization of the in vivo cornea through the faster imaging speeds and higher axial resolutions, cellular imaging stays unresolvable task for OCT, as en face viewing with a high lateral resolution is required. The latter is possible with FFOCT, a method that relies on a camera, moderate numerical aperture (NA) objectives and an incoherent light source to provide en face images with a micrometer-level resolution. Recently, we for the first time demonstrated the ability of FFOCT to capture images from the in vivo human cornea1. In the current paper we present an extensive study of appearance of healthy in vivo human corneas under FFOCT examination. En face corneal images with a micrometer-level resolution were obtained from the three healthy subjects. For each subject it was possible to acquire images through the entire corneal depth and visualize the epithelium structures, Bowman's layer, sub-basal nerve plexus (SNP) fibers, anterior, middle and posterior stroma, endothelial cells with nuclei. Dimensions and densities of the structures visible with FFOCT, are in agreement with those seen by other cornea imaging methods. Cellular-level details in the images obtained together with the relatively large field-of-view (FOV) and contactless way of imaging make this device a promising candidate for becoming a new tool in ophthalmological diagnostics

Using X-ray spectroscopy of relativistic laser plasma interaction to reveal parametric decay instabilities : A modeling tool for astrophysics

By analyzing profiles of experimental x-ray spectral lines of Si XIV and Al XIII, we found that both Langmuir and ion acoustic waves developed in plasmas produced via irradiation of thin Si foils by relativistic laser pulses (intensities ∼1021 W/cm2). We prove that these waves are due to the parametric decay instability (PDI). This is the first time that the PDI-induced ion acoustic turbulence was discovered by the x-ray spectroscopy in laser-produced plasmas. These conclusions are also supported by PIC simulations. Our results can be used for laboratory modeling of physical processes in astrophysical objects and a better understanding of intense laser-plasma interactions

In-depth study of intra-Stark spectroscopy in the x-ray range in relativistic laser-plasma interactions

Intra-Stark spectroscopy (ISS) is the spectroscopy within the quasistatic Stark profile of a spectral line. The present paper advances the ISS-based study of the relativistic laser-plasma interaction from our previous paper (Oks et al 2017 Opt. Express 25 1958). By improving the experimental conditions and the diagnostics, it provides an in-depth spectroscopic study of the simultaneous production of the Langmuir waves and of the ion acoustic turbulence at the surface of the relativistic critical density. It demonstrates a reliable reproducibility of the Langmuir-wave-induced dips at the same locations in the experimental profiles of Si XIV Ly-beta line, as well as of the deduced parameters (fields) of the Langmuir waves and ion acoustic turbulence in several individual 1 ps laser pulses and of the peak irradiances of 1-3 ×1020 W cm-2. Besides, this study employs for the first time the most rigorous condition of the dynamic resonance, on which the ISS phenomenon is based, compared to all previous studies in all kinds of plasmas in a wide range of electron densities. It shows how different interplays between the Langmuir wave field and the field of the ion acoustic turbulence lead to distinct spectral line profiles, including the disappearance of the Langmuir-wave-induced dips

X-ray spectroscopy of super-intense laser-produced plasmas for the study of nonlinear processes. Comparison with PIC simulations

We present X-ray spectroscopic diagnostics in femto-second laser-driven experiments revealing nonlinear phenomena caused by the strong coupling of the laser radiation with the created plasma. Among those nonlinear phenomena, we found the signatures of the Two Plasmon Decay (TPD) instability in a laser-driven CO2 cluster-based plasma by analyzing the Langmuir dips in the profile of the O VIII Lyϵ line, caused by the Langmuir waves created at the high laser intensity 3 1018Wcm-2. With similar laser intensities, we reveal also the nonlinear phenomenon of the Second Harmonic Generation (SHG) of the laser frequency by analyzing the nonlinear phenomenon of satellites of Lyman δ and ϵ lines of Ar XVII. In the case of relativistic laser-plasma interaction we discovered the Parametric Decay Instability (PDI)-induced ion acoustic turbulence produced simultaneously with Langmuir waves via irradiation of thin Si foils by laser intensities of 1021Wcm-2

Effects of ultraintense magnetic fields due to relativistic laser-plasma interactions on Langmuir-wave-caused dips in x-ray spectral line profiles

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Optical Transitions and Charge-Exchange in Highly Charged Quasi-Molecules

The interaction between quasimolecular states produces not only nonadiabatic transitions but also some exotic features in the wings of the spectral profiles emitted by the ions in collision. Although this concept has been fruitfully used for neutral species, some new highlighted experimental data on quasimolecular optical transitions in hot dense plasma have renewed the interest to the concept in the recent years. The present review deals with highly charged quasimolecules and it is dedicated specifically to quasimolecules formed by two bare nuclei and one bound electron. The reason for this choice is that, for such quasimolecules, the energy terms and the dipole moments of the optical transitions can be obtained straightforwardly in nonrelativistic case without any approximation that are typical for neutrals. Although the results obtained in the frame of the approach developed here are directly applicable to the case of single collisions or to low-density plasmas, they form a reasonable initial approximation for the problem of optical profiles in hot dense plasmas and can be regarded as a safe framework for qualitative discussions of profiles in those environments

Experimental validation of a bayesian model of visual acuity

Based on standard procedures used in optometry clinics, we compare measurements of visual acuity for 10 subjects (11 eyes tested) in the presence of natural ocular aberrations and different degrees of induced defocus, with the predictions given by a Bayesian model customized with aberrometric data of the eye. The absolute predictions of the model, without any adjustment, show good agreement with the experimental data, in terms of correlation and absolute error. The efficiency of the model is discussed in comparison with image quality metrics and other customized visual process models. An analysis of the importance and customization of each stage of the model is also given; it stresses the potential high predictive power from precise modeling of ocular and neural transfer functions

Experimental validation of a bayesian model of visual acuity

Based on standard procedures used in optometry clinics, we compare measurements of visual acuity for 10 subjects (11 eyes tested) in the presence of natural ocular aberrations and different degrees of induced defocus, with the predictions given by a Bayesian model customized with aberrometric data of the eye. The absolute predictions of the model, without any adjustment, show good agreement with the experimental data, in terms of correlation and absolute error. The efficiency of the model is discussed in comparison with image quality metrics and other customized visual process models. An analysis of the importance and customization of each stage of the model is also given; it stresses the potential high predictive power from precise modeling of ocular and neural transfer functions

Experimental validation of a bayesian model of visual acuity

Based on standard procedures used in optometry clinics, we compare measurements of visual acuity for 10 subjects (11 eyes tested) in the presence of natural ocular aberrations and different degrees of induced defocus, with the predictions given by a Bayesian model customized with aberrometric data of the eye. The absolute predictions of the model, without any adjustment, show good agreement with the experimental data, in terms of correlation and absolute error. The efficiency of the model is discussed in comparison with image quality metrics and other customized visual process models. An analysis of the importance and customization of each stage of the model is also given; it stresses the potential high predictive power from precise modeling of ocular and neural transfer functions