Changing the identity of a place by changing street names: The process of renaming the streets of Üsküdar between 1927-1934

Street names are part of our everyday lives. People constantly encounter street signs during their daily practices. Their visible position in the urban landscape makes street names suitable to use as visual/linguistic signifiers of cultures, histories, values, and ideologies. Renaming streets is one of the first actions of the new regimes to create their ideological hegemony in the territories they rule. It is essential to resolve the conflicts between urban memory and the sovereign’s history to legitimize their geographical claims by changing anything that does not match with their mental constructs in the urban landscape. This article provides a critical discourse analysis of the relationship between space, place, identity, urban memory, and street names by examining the alteration of street names in Üsküdar, a district of Istanbul, between 1927 and 1934. Even though Üsküdar was one of the regions where the minorities lived exceedingly in the Ottoman period, in the current Üsküdar identity, there are only a few traces left of its former inhabitants. Hence, in terms of redefining identity, Üsküdar can be considered a prominent example compared to the other regions the minorities lived in Istanbul. The primary source for this inquiry is Osman Nuri Ergin’s İstanbul Şehri Rehberi (Istanbul City Guide), which was published in 1934. Archival documents and newspaper articles about street name changes are also used in this research. The relationship between socio-political transformation in Üsküdar and changes in urban toponymy is investigated in this study

ACOX2 deficiency: A disorder of bile acid synthesis with transaminase elevation, liver fibrosis, ataxia, and cognitive impairment

Acyl CoA Oxidase 2 (ACOX2) encodes branched-chain acyl-CoA oxidase, a peroxisomal enzyme believed to be involved in the metabolism of branched-chain fatty acids and bile acid intermediates. Deficiency of this enzyme has not been described previously. We report an 8-y-old male with intermittently elevated transaminase levels, liver fibrosis, mild ataxia, and cognitive impairment. Exome sequencing revealed a previously unidentified homozygous premature termination mutation (p.Y69*) in ACOX2 Immunohistochemistry confirmed the absence of ACOX2 expression in the patient's liver, and biochemical analysis showed marked elevation of intermediate bile acids upstream of ACOX2. These findings define a potentially treatable inborn error of bile acid biosynthesis caused by ACOX2 deficiency

7th Drug hypersensitivity meeting: part two

No abstract availabl

Rare disorders can be an underlying cause of cyclic vomiting: Familial Mediterranean fever, Helicobacter pylori gastritis, and cavernous transformation of the portal vein

Considering the etiology of cyclic vomiting syndrome (CVS) in childhood, a variety of underlying organic causes has been clearly identified in the literature. The aim of this study was to emphasize that endoscopic evaluation in the first step may help diagnosis and treatment in patients with CVS, unlike the CVS-related "North American Society for Pediatric Gastroenterology, Hepatology and Nutrition" (NASPGHAN) consensus statement in 2008

Evaluation of human leukocyte antigen class I and II antigens in Helicobacter pylori-positive pediatric patients with active gastritis and duodenal ulcer

ABSTRACT BACKGROUND: As being the first bacteria determined to be carcinogenic, Helicobacter pylori (H. pylori) is a pathogen localized in the stomach in more than half of the world population. Some earlier studies have found a relation between tissue histocompatibility antigens and gastric cancers depending on the regions. OBJECTIVE: The present study aimed to determine the distribution of human leukocyte antigen (HLA) class I and class II antigens in H. pylori-positive pediatric patients with active gastritis and duodenal ulcer, excluding cancer cases, in our center. METHODS: The study included 40 patients diagnosed with H. pylori-positive active gastritis and duodenal ulcer and 100 controls consisting of healthy donor candidates. The HLA class I and class II antigens were studied in the isolated DNA samples using the polymerase chain reaction sequence-specific oligonucleotide probes. RESULTS: The frequency of HLA-B*51 antigen was significantly higher in the patient group than in the control group (40% vs 17%; P=0.003). There was no difference between the two groups in terms of the frequencies of HLA-A, HLA-C, HLA-DR, and HLA-DQ antigens. CONCLUSION: It was determined that HLA-B*51 plays a critical role in H. pylori infection