Os memes e a deselitização do acesso à literatura: uma análise da página @funkeiroscults

This article seeks to investigate the relationship between Instagram and literature, in order to analyze how prose and poetry are "memefied" in this social network, specifically published on the @funkeiroscult page, and to verify how peripheral Brazilian communities contribute to combat the belief that literature is only intended for the elite.Este artigo busca investigar a relação entre Instagram e literatura, de modo a analisar como a prosa e a poesia são “memeficadas” nessa rede social, especificamente na página @funkeiroscults, e verificar como as comunidades periféricas brasileiras contribuem para combater a crença de que a literatura seria destinada apenas a camadas sociais de maior poder aquisitivo

Deproteinized bovine bone graft remodeling pattern in alveolar socket: an immunohistological evaluation

The biologic pattern of bone remodeling is well defined in several in vivo and in vitro studies, but the influence of bone substitutes on individual healing pattern in human is not completely defined and described. Several grafts are available on the market, homologous, heterologous and synthetic bone substitutes. Deproteinized bovine bone (Bio-Oss®, Geistlich Pharma AG, Switzerland) (DBB) is a heterologous substitute derived from bovine bone deprived of all the organic components and reduced in porous grains of different dimensions (0.25 - 2 mm). Preclinical and clinical studies widely described the biocompatibility of deproteinized bovine bone and the integration of this biomaterial in the regenerated bone, but several papers underlined the low rate resorption of the material, that still remains in situ until 11 years after regeneration procedures. This characteristic was also investigated in vitro in osteoblasts, unraveling the ability of DBB particles in down-regulating BMP-2, BMP- 7, TNF-alpha and IL6 genic expression in the early phase of healing but, to the best of our knowledge, no studies checked the same parameters in vivo. The aim of the present study is to describe the remodeling pattern of DBB in human socket alveolar preservation in the late phase of healing. Ten patients that needed tooth extraction and implant placement were recruited. At the time of the extraction a bone biopsy (T0) was collected and the alveolar socket was filled with DBB and covered with a membrane (Bio-Guide®, Geistlich Pharma AG, Switzerland). After 6 months, before implant placement, another bone biopsy was collected (T1). All specimens were processed for immunohistochemistry to mark BMP-2, BMP-7, ALP, IL6 and TNF-alpha. Every section was mapped at 200X total magnification and the presence of these factors was quantified using a standardized method with Adobe Photoshop PS5. For every marking the normalized delta between T1 and T0 was calculated and the results were respectively: BMP2 0.67 + 0.43, BMP7 0.36 + 0.23, ALP -0.28 + 0.18, IL6 0.81 + 0.60, TNF-alpha 1.09 + 0.85. The Wilcoxon paired test revealed highly significant differences between T0 and T1 for all markers (p<0.05 for IL6 and p<0.01 for the others). Differently from what expressed in “in vitro” studies, these data underline that DBB in late phases of healing does influence bone turnover by stimulating the production of morphogenetic proteins and inducing the expression of other catabolic and anabolic markers involved in bone remodeling, thus confirming its role as a valid bone substitute

Maxillary sinus lift with or without biomaterials in humans: radiographic and histomorphometric evaluation

Biomaterials are frequently used for sinus lift procedures at the time of implant installation in the posterior upper jaw. Nevertheless, some authors have reported the possibility of leaving an empty space, in order to exploit the regenerative potential of the residual periosteal and bony walls following the Schneiderian membrane elevation. The aim of this study was to compare the radiographic changes and histological characteristics of newly formed bone following sinus lift without any biomaterials or Bio-Oss®. Fifteen patients with edentulousness of the maxillary molar-premolar area and a residual crest thickness < 6 mm, were randomly allocated to a test group (sinus lift without biomaterial) or a control group (with Bio-Oss®). Two submerged Astra Tech implants were placed in the most mesial and distal portion of the augmented area. Six months later, a bone biopsy was harvested in the area between the 2 previously placed fixtures, where a third central implant was placed. Standard radiographies were taken before sinus lift and 6 months later in order to measure and compare the vertical bone changes. The biopsies were processed for ground sectioning. All implants but one case were successful. Radiographically, the basic level of bone tissue in the test group (n=5) was 5 ± 0.86 mm and 3.5 ± 0.57 mm in the control group (n=10); in the test group the bone tissue was increased vertically of 10 ± 2.53 (range 7-13), in the control group 13 ± 1.41 (range 12-14). At histological observation, all samples showed new bone formation without signs of inflammation. Bone remodeling was observed in the apical portion of both groups. Residual particles of biomaterial were embedded in mineralized new bone. Histometric results for the control group were: LB 38.8% ± 8.1, WB 9.2% ± 2.4, BM 30.2% ± 7.5, BO 21.7% ± 8.9; for the test group: LB 54.5% ± 2.1, WB 115.5% ± 6.1 and BM 33.5% ± 6.4. A clinically significant bone increase was achieved both with and without the use of biomaterials. The implants showed similar performances when inserted at sites augmented with or without biomaterials. The success of such procedure might depend on the anatomical conformation of the crest and on the level of surgical experience of the surgeon

Susceptibility zoning to occurrence of mass movements. Micro basins Agua Blanca and La Laja. Venezuelan Andes

Se aplicó una metodología bajo un enfoque heurístico basado en la combinación de factores, para zonificar áreas susceptibles a la ocurrencia de movimientos de masa en las microcuencas Agua Blanca y La Laja del estado Táchira, que actualmente presentan periódicas manifestaciones de procesos geomorfológicos que se traducen en la ocurrencia de procesos gravitacionales, que causan el deterioro de la mayor parte de las infraestructuras. Los resultados permitieron conocer cuáles son los sitios más inestables y propensos a que ocurra este tipo de procesos, con el beneficio de consolidar información relevante para prever y planificar los correctivos que mitiguen los dañ[email protected]@ula.ve, [email protected]@hotmail.comsemestralA methodology under a heuristic approach, based on combination of factors, for zoning susceptible areas to occurrence of mass movement was applied in the micro-basins Agua Blanca and La Laja in Táchira State. These micro-basins are currently having manifestations of morphological processes that result in the occurrence of mass movements that have caused damage to most of infrastructures. The results allows us to know which are the most unstable and susceptible places to the occurrence of this type of process, with the benefit of consolidating relevant information to anticipate and plan corrections to mitigate damages

The role of baseline HIV-1 RNA, drug resistance, and regimen type as determinants of response to first-line antiretroviral therapy

The factors influencing virological response to first-line combined antiretroviral therapy (cART) in an Italian cohort of HIV-1-infected patients were examined. Eligible patients were those enrolled in a national prospective observational cohort (Antiretroviral Resistance Cohort Analysis), starting first-line cART between 2001 and 2011 and who had at least one follow-up of HIV-1 RNA. The primary endpoint was virological success, defined as the first viral load 100,000 copies/ml, virologic success was only associated with the use of integrase inhibitors in the first cART regimen. Independent predictors of immunological success were baseline CD4+ cell count and wGSS <3. High baseline HIV-1 RNA, predicted activity of the first-line regimen based on genotypic resistance testing, gender, and use of new agents were found to predict time to achieve virological success. The type of initial nucleoside analog backbone was not found to predict virological response

Resumos em andamento - Saúde Coletiva

Resumos em andamento - Saúde Coletiv

Resumos em andamento - Saúde Coletiva

Resumos em andamento - Saúde Coletiv